Genomic and phenotypic-based safety assessment and probiotic properties of Streptococcus thermophilus FUA329, a urolithin A-producing bacterium of human milk origin
Genomics. 2023 Oct 9:110724. doi: 10.1016/j.ygeno.2023.110724. Online ahead of print.ABSTRACTStreptococcus thermophilus FUA329, a urolithin A-producing bacterium, is isolated from human breast milk. The complete genome sequence of FUA329 did not contain any plasmids and at least 20 proteins were related to extreme environment resistance. Phenotypic assay results demonstrated that FUA329 was susceptible to 12 kinds of antibiotics and did not exhibit any hemolytic or nitrate reductase activity. Three free radical scavenging assays revealed that FUA329 have high antioxidant capability. FUA329 exhibited a cell surface hydropho...
Source: Genomics - October 11, 2023 Category: Genetics & Stem Cells Authors: Qitong Liu Yingying Bian Shuting Mu Meng Chen Shu Liu Guang Yang Yichen Huang Xiaoyue Hou Yaowei Fang Source Type: research
Dynamic alterations of the transcriptome-wide m < sup > 6 < /sup > A methylome in cytogenetically normal acute myeloid leukaemia during initial diagnosis and relapse
This study demonstrates a novel relationship between m6A modification and AML relapse and paves the way for further studies aimed at elucidating the epigenic mechanisms involved in the relapse of AML.PMID:37820824 | DOI:10.1016/j.ygeno.2023.110725 (Source: Genomics)
Source: Genomics - October 11, 2023 Category: Genetics & Stem Cells Authors: Jinjing Zhang Tong Liu Yue Wang Xiaojing Yan Yan Li Feng Xu Rui Zhang Source Type: research
Genomic and phenotypic-based safety assessment and probiotic properties of Streptococcus thermophilus FUA329, a urolithin A-producing bacterium of human milk origin
Genomics. 2023 Oct 9:110724. doi: 10.1016/j.ygeno.2023.110724. Online ahead of print.ABSTRACTStreptococcus thermophilus FUA329, a urolithin A-producing bacterium, is isolated from human breast milk. The complete genome sequence of FUA329 did not contain any plasmids and at least 20 proteins were related to extreme environment resistance. Phenotypic assay results demonstrated that FUA329 was susceptible to 12 kinds of antibiotics and did not exhibit any hemolytic or nitrate reductase activity. Three free radical scavenging assays revealed that FUA329 have high antioxidant capability. FUA329 exhibited a cell surface hydropho...
Source: Genomics - October 11, 2023 Category: Genetics & Stem Cells Authors: Qitong Liu Yingying Bian Shuting Mu Meng Chen Shu Liu Guang Yang Yichen Huang Xiaoyue Hou Yaowei Fang Source Type: research
Dynamic alterations of the transcriptome-wide m < sup > 6 < /sup > A methylome in cytogenetically normal acute myeloid leukaemia during initial diagnosis and relapse
This study demonstrates a novel relationship between m6A modification and AML relapse and paves the way for further studies aimed at elucidating the epigenic mechanisms involved in the relapse of AML.PMID:37820824 | DOI:10.1016/j.ygeno.2023.110725 (Source: Genomics)
Source: Genomics - October 11, 2023 Category: Genetics & Stem Cells Authors: Jinjing Zhang Tong Liu Yue Wang Xiaojing Yan Yan Li Feng Xu Rui Zhang Source Type: research
Genomic and phenotypic-based safety assessment and probiotic properties of Streptococcus thermophilus FUA329, a urolithin A-producing bacterium of human milk origin
Genomics. 2023 Oct 9:110724. doi: 10.1016/j.ygeno.2023.110724. Online ahead of print.ABSTRACTStreptococcus thermophilus FUA329, a urolithin A-producing bacterium, is isolated from human breast milk. The complete genome sequence of FUA329 did not contain any plasmids and at least 20 proteins were related to extreme environment resistance. Phenotypic assay results demonstrated that FUA329 was susceptible to 12 kinds of antibiotics and did not exhibit any hemolytic or nitrate reductase activity. Three free radical scavenging assays revealed that FUA329 have high antioxidant capability. FUA329 exhibited a cell surface hydropho...
Source: Genomics - October 11, 2023 Category: Genetics & Stem Cells Authors: Qitong Liu Yingying Bian Shuting Mu Meng Chen Shu Liu Guang Yang Yichen Huang Xiaoyue Hou Yaowei Fang Source Type: research
Dynamic alterations of the transcriptome-wide m < sup > 6 < /sup > A methylome in cytogenetically normal acute myeloid leukaemia during initial diagnosis and relapse
This study demonstrates a novel relationship between m6A modification and AML relapse and paves the way for further studies aimed at elucidating the epigenic mechanisms involved in the relapse of AML.PMID:37820824 | DOI:10.1016/j.ygeno.2023.110725 (Source: Genomics)
Source: Genomics - October 11, 2023 Category: Genetics & Stem Cells Authors: Jinjing Zhang Tong Liu Yue Wang Xiaojing Yan Yan Li Feng Xu Rui Zhang Source Type: research
Symmetric expression of ohnologs encoding conserved antiviral responses in tetraploid common carp suggest absence of subgenome dominance after whole genome duplication
Genomics. 2023 Oct 5:110723. doi: 10.1016/j.ygeno.2023.110723. Online ahead of print.ABSTRACTAllopolyploids often experience subgenome dominance, with one subgenome showing higher levels of gene expression and greater gene retention. Here, we address the functionality of both subgenomes of allotetraploid common carp (Cyprinus carpio) by analysing a functional network of interferon-stimulated genes (ISGs) crucial in anti-viral immune defence. As an indicator of subgenome dominance we investigated retainment of a core set of ohnologous ISGs. To facilitate our functional genomic analysis a high quality genome was assembled (W...
Source: Genomics - October 7, 2023 Category: Genetics & Stem Cells Authors: A Blasweiler H-J Megens M R G Goldman R Tadmor-Levi J Lighten M A M Groenen R P Dirks H J Jansen H P Spaink L David P Boudinot G F Wiegertjes Source Type: research
Symmetric expression of ohnologs encoding conserved antiviral responses in tetraploid common carp suggest absence of subgenome dominance after whole genome duplication
Genomics. 2023 Oct 5:110723. doi: 10.1016/j.ygeno.2023.110723. Online ahead of print.ABSTRACTAllopolyploids often experience subgenome dominance, with one subgenome showing higher levels of gene expression and greater gene retention. Here, we address the functionality of both subgenomes of allotetraploid common carp (Cyprinus carpio) by analysing a functional network of interferon-stimulated genes (ISGs) crucial in anti-viral immune defence. As an indicator of subgenome dominance we investigated retainment of a core set of ohnologous ISGs. To facilitate our functional genomic analysis a high quality genome was assembled (W...
Source: Genomics - October 7, 2023 Category: Genetics & Stem Cells Authors: A Blasweiler H-J Megens M R G Goldman R Tadmor-Levi J Lighten M A M Groenen R P Dirks H J Jansen H P Spaink L David P Boudinot G F Wiegertjes Source Type: research
Symmetric expression of ohnologs encoding conserved antiviral responses in tetraploid common carp suggest absence of subgenome dominance after whole genome duplication
Genomics. 2023 Oct 5:110723. doi: 10.1016/j.ygeno.2023.110723. Online ahead of print.ABSTRACTAllopolyploids often experience subgenome dominance, with one subgenome showing higher levels of gene expression and greater gene retention. Here, we address the functionality of both subgenomes of allotetraploid common carp (Cyprinus carpio) by analysing a functional network of interferon-stimulated genes (ISGs) crucial in anti-viral immune defence. As an indicator of subgenome dominance we investigated retainment of a core set of ohnologous ISGs. To facilitate our functional genomic analysis a high quality genome was assembled (W...
Source: Genomics - October 7, 2023 Category: Genetics & Stem Cells Authors: A Blasweiler H-J Megens M R G Goldman R Tadmor-Levi J Lighten M A M Groenen R P Dirks H J Jansen H P Spaink L David P Boudinot G F Wiegertjes Source Type: research
Development of genomic markers associated to growth-related traits and sex determination in lumpfish (Cyclopterus lumpus)
In this study we analysed a lumpfish population for the identification of genomic markers linked to production traits. Sequencing of RAD libraries allowed us to identify, 7193 informative markers within the sampled individuals. Genome wide association analysis for sex, weight, condition factor and standard length was performed. One single major QTL region was identified for sex, while nine QTL regions were detected for weight, and three QTL regions for standard length. A total of 177 SNP markers of interest (from QTL regions) and 399 high Fst SNP markers were combined in a low-density panel, useful to obtain relevant genet...
Source: Genomics - September 28, 2023 Category: Genetics & Stem Cells Authors: Alejandro P Gutierrez Sarah-Louise Counter Selly Samuel M Pountney John B Taggart Panagiotis Kokkinias Thomas Cavrois-Rogacki Eduardo Jimenez Fernandez Herve Migaud Ingrid Lein Andrew Davie Micha ël Bekaert Source Type: research
Development of genomic markers associated to growth-related traits and sex determination in lumpfish (Cyclopterus lumpus)
In this study we analysed a lumpfish population for the identification of genomic markers linked to production traits. Sequencing of RAD libraries allowed us to identify, 7193 informative markers within the sampled individuals. Genome wide association analysis for sex, weight, condition factor and standard length was performed. One single major QTL region was identified for sex, while nine QTL regions were detected for weight, and three QTL regions for standard length. A total of 177 SNP markers of interest (from QTL regions) and 399 high Fst SNP markers were combined in a low-density panel, useful to obtain relevant genet...
Source: Genomics - September 28, 2023 Category: Genetics & Stem Cells Authors: Alejandro P Gutierrez Sarah-Louise Counter Selly Samuel M Pountney John B Taggart Panagiotis Kokkinias Thomas Cavrois-Rogacki Eduardo Jimenez Fernandez Herve Migaud Ingrid Lein Andrew Davie Micha ël Bekaert Source Type: research
Development of genomic markers associated to growth-related traits and sex determination in lumpfish (Cyclopterus lumpus)
In this study we analysed a lumpfish population for the identification of genomic markers linked to production traits. Sequencing of RAD libraries allowed us to identify, 7193 informative markers within the sampled individuals. Genome wide association analysis for sex, weight, condition factor and standard length was performed. One single major QTL region was identified for sex, while nine QTL regions were detected for weight, and three QTL regions for standard length. A total of 177 SNP markers of interest (from QTL regions) and 399 high Fst SNP markers were combined in a low-density panel, useful to obtain relevant genet...
Source: Genomics - September 28, 2023 Category: Genetics & Stem Cells Authors: Alejandro P Gutierrez Sarah-Louise Counter Selly Samuel M Pountney John B Taggart Panagiotis Kokkinias Thomas Cavrois-Rogacki Eduardo Jimenez Fernandez Herve Migaud Ingrid Lein Andrew Davie Micha ël Bekaert Source Type: research
Development of genomic markers associated to growth-related traits and sex determination in lumpfish (Cyclopterus lumpus)
In this study we analysed a lumpfish population for the identification of genomic markers linked to production traits. Sequencing of RAD libraries allowed us to identify, 7193 informative markers within the sampled individuals. Genome wide association analysis for sex, weight, condition factor and standard length was performed. One single major QTL region was identified for sex, while nine QTL regions were detected for weight, and three QTL regions for standard length. A total of 177 SNP markers of interest (from QTL regions) and 399 high Fst SNP markers were combined in a low-density panel, useful to obtain relevant genet...
Source: Genomics - September 28, 2023 Category: Genetics & Stem Cells Authors: Alejandro P Gutierrez Sarah-Louise Counter Selly Samuel M Pountney John B Taggart Panagiotis Kokkinias Thomas Cavrois-Rogacki Eduardo Jimenez Fernandez Herve Migaud Ingrid Lein Andrew Davie Micha ël Bekaert Source Type: research
Development of genomic markers associated to growth-related traits and sex determination in lumpfish (Cyclopterus lumpus)
In this study we analysed a lumpfish population for the identification of genomic markers linked to production traits. Sequencing of RAD libraries allowed us to identify, 7193 informative markers within the sampled individuals. Genome wide association analysis for sex, weight, condition factor and standard length was performed. One single major QTL region was identified for sex, while nine QTL regions were detected for weight, and three QTL regions for standard length. A total of 177 SNP markers of interest (from QTL regions) and 399 high Fst SNP markers were combined in a low-density panel, useful to obtain relevant genet...
Source: Genomics - September 28, 2023 Category: Genetics & Stem Cells Authors: Alejandro P Gutierrez Sarah-Louise Counter Selly Samuel M Pountney John B Taggart Panagiotis Kokkinias Thomas Cavrois-Rogacki Eduardo Jimenez Fernandez Herve Migaud Ingrid Lein Andrew Davie Micha ël Bekaert Source Type: research
Development of genomic markers associated to growth-related traits and sex determination in lumpfish (Cyclopterus lumpus)
In this study we analysed a lumpfish population for the identification of genomic markers linked to production traits. Sequencing of RAD libraries allowed us to identify, 7193 informative markers within the sampled individuals. Genome wide association analysis for sex, weight, condition factor and standard length was performed. One single major QTL region was identified for sex, while nine QTL regions were detected for weight, and three QTL regions for standard length. A total of 177 SNP markers of interest (from QTL regions) and 399 high Fst SNP markers were combined in a low-density panel, useful to obtain relevant genet...
Source: Genomics - September 28, 2023 Category: Genetics & Stem Cells Authors: Alejandro P Gutierrez Sarah-Louise Counter Selly Samuel M Pountney John B Taggart Panagiotis Kokkinias Thomas Cavrois-Rogacki Eduardo Jimenez Fernandez Herve Migaud Ingrid Lein Andrew Davie Micha ël Bekaert Source Type: research
