Experimental and Molecular Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.
The biogenesis, biological functions and modification of Circular RNAs
Exp Mol Pathol. 2023 May 13;131:104861. doi: 10.1016/j.yexmp.2023.104861. Online ahead of print.ABSTRACTCircular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self-translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent pos...
Source: Experimental and Molecular Pathology - May 8, 2023 Category: Pathology Authors: Sen Liu Xiang Yu Guo Qing Juan Shang Peng Gao Source Type: research
The biogenesis, biological functions and modification of Circular RNAs
Exp Mol Pathol. 2023 May 13;131:104861. doi: 10.1016/j.yexmp.2023.104861. Online ahead of print.ABSTRACTCircular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self-translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent pos...
Source: Experimental and Molecular Pathology - May 8, 2023 Category: Pathology Authors: Sen Liu Xiang Yu Guo Qing Juan Shang Peng Gao Source Type: research
The biogenesis, biological functions and modification of Circular RNAs
Exp Mol Pathol. 2023 May 13;131:104861. doi: 10.1016/j.yexmp.2023.104861. Online ahead of print.ABSTRACTCircular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self-translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent pos...
Source: Experimental and Molecular Pathology - May 8, 2023 Category: Pathology Authors: Sen Liu Xiang Yu Guo Qing Juan Shang Peng Gao Source Type: research
The biogenesis, biological functions and modification of Circular RNAs
Exp Mol Pathol. 2023 May 13;131:104861. doi: 10.1016/j.yexmp.2023.104861. Online ahead of print.ABSTRACTCircular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self-translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent pos...
Source: Experimental and Molecular Pathology - May 8, 2023 Category: Pathology Authors: Sen Liu Xiang Yu Guo Qing Juan Shang Peng Gao Source Type: research
The biogenesis, biological functions and modification of Circular RNAs
Exp Mol Pathol. 2023 May 13;131:104861. doi: 10.1016/j.yexmp.2023.104861. Online ahead of print.ABSTRACTCircular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self-translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent pos...
Source: Experimental and Molecular Pathology - May 8, 2023 Category: Pathology Authors: Sen Liu Xiang Yu Guo Qing Juan Shang Peng Gao Source Type: research
The biogenesis, biological functions and modification of Circular RNAs
Exp Mol Pathol. 2023 May 13;131:104861. doi: 10.1016/j.yexmp.2023.104861. Online ahead of print.ABSTRACTCircular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self-translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent pos...
Source: Experimental and Molecular Pathology - May 8, 2023 Category: Pathology Authors: Sen Liu Xiang Yu Guo Qing Juan Shang Peng Gao Source Type: research
The biogenesis, biological functions and modification of Circular RNAs
Exp Mol Pathol. 2023 May 13;131:104861. doi: 10.1016/j.yexmp.2023.104861. Online ahead of print.ABSTRACTCircular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self-translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent pos...
Source: Experimental and Molecular Pathology - May 8, 2023 Category: Pathology Authors: Sen Liu Xiang Yu Guo Qing Juan Shang Peng Gao Source Type: research
The biogenesis, biological functions and modification of Circular RNAs
Exp Mol Pathol. 2023 May 13;131:104861. doi: 10.1016/j.yexmp.2023.104861. Online ahead of print.ABSTRACTCircular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self-translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent pos...
Source: Experimental and Molecular Pathology - May 8, 2023 Category: Pathology Authors: Sen Liu Xiang Yu Guo Qing Juan Shang Peng Gao Source Type: research
The biogenesis, biological functions and modification of Circular RNAs
Exp Mol Pathol. 2023 May 13;131:104861. doi: 10.1016/j.yexmp.2023.104861. Online ahead of print.ABSTRACTCircular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self-translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent pos...
Source: Experimental and Molecular Pathology - May 8, 2023 Category: Pathology Authors: Sen Liu Xiang Yu Guo Qing Juan Shang Peng Gao Source Type: research
The biogenesis, biological functions and modification of Circular RNAs
Exp Mol Pathol. 2023 May 6:104861. doi: 10.1016/j.yexmp.2023.104861. Online ahead of print.ABSTRACTCircular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self-translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent post-tra...
Source: Experimental and Molecular Pathology - May 8, 2023 Category: Pathology Authors: Sen Liu Xiang Yu Guo Qing Juan Shang Peng Gao Source Type: research
The biogenesis, biological functions and modification of Circular RNAs
Exp Mol Pathol. 2023 May 6:104861. doi: 10.1016/j.yexmp.2023.104861. Online ahead of print.ABSTRACTCircular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self-translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent post-tra...
Source: Experimental and Molecular Pathology - May 8, 2023 Category: Pathology Authors: Sen Liu Xiang Yu Guo Qing Juan Shang Peng Gao Source Type: research
The biogenesis, biological functions and modification of Circular RNAs
Exp Mol Pathol. 2023 May 6:104861. doi: 10.1016/j.yexmp.2023.104861. Online ahead of print.ABSTRACTCircular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self-translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent post-tra...
Source: Experimental and Molecular Pathology - May 8, 2023 Category: Pathology Authors: Sen Liu Xiang Yu Guo Qing Juan Shang Peng Gao Source Type: research
The biogenesis, biological functions and modification of Circular RNAs
Exp Mol Pathol. 2023 May 6:104861. doi: 10.1016/j.yexmp.2023.104861. Online ahead of print.ABSTRACTCircular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self-translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent post-tra...
Source: Experimental and Molecular Pathology - May 8, 2023 Category: Pathology Authors: Sen Liu Xiang Yu Guo Qing Juan Shang Peng Gao Source Type: research
The biogenesis, biological functions and modification of Circular RNAs
Exp Mol Pathol. 2023 May 6:104861. doi: 10.1016/j.yexmp.2023.104861. Online ahead of print.ABSTRACTCircular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self-translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent post-tra...
Source: Experimental and Molecular Pathology - May 8, 2023 Category: Pathology Authors: Sen Liu Xiang Yu Guo Qing Juan Shang Peng Gao Source Type: research
Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder
In this study, we investigated CK20 on >2700 urothelial bladder carcinomas in a tissue microarray format by immunohistochemistry. Cytoplasmic and membranous CK20 staining was seen in 1319 (51.8%) cancers. The fraction of CK20 positive and especially strongly positive cases increased from pTaG2 low grade (44.5% strongly positive) and pTaG2 high grade (57.7%) to pTaG3 high grade (62.3%; p = 0.0006) but was lower in muscle-invasive (pT2-4) carcinomas (51.1% in all pTa vs. 29.6% in pT2-4; p < 0.0001). Within pT2-4 carcinomas, CK20 positivity was linked to nodal metastasis and lymphatic vessel invasion (p < 0.0001 each...
Source: Experimental and Molecular Pathology - March 30, 2023 Category: Pathology Authors: Paul Giacomo Bruch Henning Plage Sebastian Hofbauer Kira Kornienko Sarah Weinberger Florian Ro ßner Simon Schallenberg Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Slojewski Krystian Source Type: research