Experimental and Molecular Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The MC160 protein of the molluscum contagiosum virus dampens cGAS/STING-induced interferon- β activation
In this study, we demonstrate that there are nuanced differences between both MC160 and MC159 in terms of how the viral proteins modulate the cGAS/STING and MAVS pathways. Specifically, MC160 expression, but not MC159 expression, dampens cGAS/STING-mediated induction of IFN in HEK 293 T cells. Further, MC160 expression prevented the K63-ubiquitination of both STING and TBK1, a kinase downstream of cGAS/STING. Ectopic expression of the MC160 protein, but not the MC159 protein, resulted in a measurable decrease in the TBK1 protein levels as detected via immunoblotting. Finally, using a panel of MC160 truncation mutants, we r...
Source: Experimental and Molecular Pathology - October 27, 2023 Category: Pathology Authors: Brian T Reiss Lissette Bouza Swagath Thomas Catherine D Suarez Erik R Hill Daniel Brian Nichols Source Type: research

The MC160 protein of the molluscum contagiosum virus dampens cGAS/STING-induced interferon- β activation
In this study, we demonstrate that there are nuanced differences between both MC160 and MC159 in terms of how the viral proteins modulate the cGAS/STING and MAVS pathways. Specifically, MC160 expression, but not MC159 expression, dampens cGAS/STING-mediated induction of IFN in HEK 293 T cells. Further, MC160 expression prevented the K63-ubiquitination of both STING and TBK1, a kinase downstream of cGAS/STING. Ectopic expression of the MC160 protein, but not the MC159 protein, resulted in a measurable decrease in the TBK1 protein levels as detected via immunoblotting. Finally, using a panel of MC160 truncation mutants, we r...
Source: Experimental and Molecular Pathology - October 27, 2023 Category: Pathology Authors: Brian T Reiss Lissette Bouza Swagath Thomas Catherine D Suarez Erik R Hill Daniel Brian Nichols Source Type: research

The MC160 protein of the molluscum contagiosum virus dampens cGAS/STING-induced interferon- β activation
In this study, we demonstrate that there are nuanced differences between both MC160 and MC159 in terms of how the viral proteins modulate the cGAS/STING and MAVS pathways. Specifically, MC160 expression, but not MC159 expression, dampens cGAS/STING-mediated induction of IFN in HEK 293 T cells. Further, MC160 expression prevented the K63-ubiquitination of both STING and TBK1, a kinase downstream of cGAS/STING. Ectopic expression of the MC160 protein, but not the MC159 protein, resulted in a measurable decrease in the TBK1 protein levels as detected via immunoblotting. Finally, using a panel of MC160 truncation mutants, we r...
Source: Experimental and Molecular Pathology - October 27, 2023 Category: Pathology Authors: Brian T Reiss Lissette Bouza Swagath Thomas Catherine D Suarez Erik R Hill Daniel Brian Nichols Source Type: research

The MC160 protein of the molluscum contagiosum virus dampens cGAS/STING-induced interferon- β activation
In this study, we demonstrate that there are nuanced differences between both MC160 and MC159 in terms of how the viral proteins modulate the cGAS/STING and MAVS pathways. Specifically, MC160 expression, but not MC159 expression, dampens cGAS/STING-mediated induction of IFN in HEK 293 T cells. Further, MC160 expression prevented the K63-ubiquitination of both STING and TBK1, a kinase downstream of cGAS/STING. Ectopic expression of the MC160 protein, but not the MC159 protein, resulted in a measurable decrease in the TBK1 protein levels as detected via immunoblotting. Finally, using a panel of MC160 truncation mutants, we r...
Source: Experimental and Molecular Pathology - October 27, 2023 Category: Pathology Authors: Brian T Reiss Lissette Bouza Swagath Thomas Catherine D Suarez Erik R Hill Daniel Brian Nichols Source Type: research

SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons
Exp Mol Pathol. 2023 Sep 30;134:104874. doi: 10.1016/j.yexmp.2023.104874. Online ahead of print.ABSTRACTAn increasing number of patients experiences prolonged symptoms, whose profile and timeline remain uncertain, a condition that has been defined as post COVID. The majority of recovered hospitalized patients manifests at least one persistent symptom even sixty days after the first clinical manifestation's onset. Particularly, in light of the COVID-19-related symptomatology, it has been hypothesized that SARS-CoV-2 might affect the dopamine pathway. However, no scientific evidence has been produced so far. To this end, hum...
Source: Experimental and Molecular Pathology - September 29, 2023 Category: Pathology Authors: G Cappelletti E V Carsana G Lunghi S Breviario C Vanetti A B Di Fonzo E Frattini M Magni S Zecchini M Clerici M Aureli C Fenizia Source Type: research

SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons
Exp Mol Pathol. 2023 Sep 30;134:104874. doi: 10.1016/j.yexmp.2023.104874. Online ahead of print.ABSTRACTAn increasing number of patients experiences prolonged symptoms, whose profile and timeline remain uncertain, a condition that has been defined as post COVID. The majority of recovered hospitalized patients manifests at least one persistent symptom even sixty days after the first clinical manifestation's onset. Particularly, in light of the COVID-19-related symptomatology, it has been hypothesized that SARS-CoV-2 might affect the dopamine pathway. However, no scientific evidence has been produced so far. To this end, hum...
Source: Experimental and Molecular Pathology - September 29, 2023 Category: Pathology Authors: G Cappelletti E V Carsana G Lunghi S Breviario C Vanetti A B Di Fonzo E Frattini M Magni S Zecchini M Clerici M Aureli C Fenizia Source Type: research

SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons
Exp Mol Pathol. 2023 Sep 30;134:104874. doi: 10.1016/j.yexmp.2023.104874. Online ahead of print.ABSTRACTAn increasing number of patients experiences prolonged symptoms, whose profile and timeline remain uncertain, a condition that has been defined as post COVID. The majority of recovered hospitalized patients manifests at least one persistent symptom even sixty days after the first clinical manifestation's onset. Particularly, in light of the COVID-19-related symptomatology, it has been hypothesized that SARS-CoV-2 might affect the dopamine pathway. However, no scientific evidence has been produced so far. To this end, hum...
Source: Experimental and Molecular Pathology - September 29, 2023 Category: Pathology Authors: G Cappelletti E V Carsana G Lunghi S Breviario C Vanetti A B Di Fonzo E Frattini M Magni S Zecchini M Clerici M Aureli C Fenizia Source Type: research

SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons
Exp Mol Pathol. 2023 Sep 30;134:104874. doi: 10.1016/j.yexmp.2023.104874. Online ahead of print.ABSTRACTAn increasing number of patients experiences prolonged symptoms, whose profile and timeline remain uncertain, a condition that has been defined as post COVID. The majority of recovered hospitalized patients manifests at least one persistent symptom even sixty days after the first clinical manifestation's onset. Particularly, in light of the COVID-19-related symptomatology, it has been hypothesized that SARS-CoV-2 might affect the dopamine pathway. However, no scientific evidence has been produced so far. To this end, hum...
Source: Experimental and Molecular Pathology - September 29, 2023 Category: Pathology Authors: G Cappelletti E V Carsana G Lunghi S Breviario C Vanetti A B Di Fonzo E Frattini M Magni S Zecchini M Clerici M Aureli C Fenizia Source Type: research

SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons
Exp Mol Pathol. 2023 Sep 30;134:104874. doi: 10.1016/j.yexmp.2023.104874. Online ahead of print.ABSTRACTAn increasing number of patients experiences prolonged symptoms, whose profile and timeline remain uncertain, a condition that has been defined as post COVID. The majority of recovered hospitalized patients manifests at least one persistent symptom even sixty days after the first clinical manifestation's onset. Particularly, in light of the COVID-19-related symptomatology, it has been hypothesized that SARS-CoV-2 might affect the dopamine pathway. However, no scientific evidence has been produced so far. To this end, hum...
Source: Experimental and Molecular Pathology - September 29, 2023 Category: Pathology Authors: G Cappelletti E V Carsana G Lunghi S Breviario C Vanetti A B Di Fonzo E Frattini M Magni S Zecchini M Clerici M Aureli C Fenizia Source Type: research

SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons
Exp Mol Pathol. 2023 Sep 30;134:104874. doi: 10.1016/j.yexmp.2023.104874. Online ahead of print.ABSTRACTAn increasing number of patients experiences prolonged symptoms, whose profile and timeline remain uncertain, a condition that has been defined as post COVID. The majority of recovered hospitalized patients manifests at least one persistent symptom even sixty days after the first clinical manifestation's onset. Particularly, in light of the COVID-19-related symptomatology, it has been hypothesized that SARS-CoV-2 might affect the dopamine pathway. However, no scientific evidence has been produced so far. To this end, hum...
Source: Experimental and Molecular Pathology - September 29, 2023 Category: Pathology Authors: G Cappelletti E V Carsana G Lunghi S Breviario C Vanetti A B Di Fonzo E Frattini M Magni S Zecchini M Clerici M Aureli C Fenizia Source Type: research

SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons
Exp Mol Pathol. 2023 Sep 30;134:104874. doi: 10.1016/j.yexmp.2023.104874. Online ahead of print.ABSTRACTAn increasing number of patients experiences prolonged symptoms, whose profile and timeline remain uncertain, a condition that has been defined as post COVID. The majority of recovered hospitalized patients manifests at least one persistent symptom even sixty days after the first clinical manifestation's onset. Particularly, in light of the COVID-19-related symptomatology, it has been hypothesized that SARS-CoV-2 might affect the dopamine pathway. However, no scientific evidence has been produced so far. To this end, hum...
Source: Experimental and Molecular Pathology - September 29, 2023 Category: Pathology Authors: G Cappelletti E V Carsana G Lunghi S Breviario C Vanetti A B Di Fonzo E Frattini M Magni S Zecchini M Clerici M Aureli C Fenizia Source Type: research

SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons
Exp Mol Pathol. 2023 Sep 30;134:104874. doi: 10.1016/j.yexmp.2023.104874. Online ahead of print.ABSTRACTAn increasing number of patients experiences prolonged symptoms, whose profile and timeline remain uncertain, a condition that has been defined as post COVID. The majority of recovered hospitalized patients manifests at least one persistent symptom even sixty days after the first clinical manifestation's onset. Particularly, in light of the COVID-19-related symptomatology, it has been hypothesized that SARS-CoV-2 might affect the dopamine pathway. However, no scientific evidence has been produced so far. To this end, hum...
Source: Experimental and Molecular Pathology - September 29, 2023 Category: Pathology Authors: G Cappelletti E V Carsana G Lunghi S Breviario C Vanetti A B Di Fonzo E Frattini M Magni S Zecchini M Clerici M Aureli C Fenizia Source Type: research

SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons
Exp Mol Pathol. 2023 Sep 30;134:104874. doi: 10.1016/j.yexmp.2023.104874. Online ahead of print.ABSTRACTAn increasing number of patients experiences prolonged symptoms, whose profile and timeline remain uncertain, a condition that has been defined as post COVID. The majority of recovered hospitalized patients manifests at least one persistent symptom even sixty days after the first clinical manifestation's onset. Particularly, in light of the COVID-19-related symptomatology, it has been hypothesized that SARS-CoV-2 might affect the dopamine pathway. However, no scientific evidence has been produced so far. To this end, hum...
Source: Experimental and Molecular Pathology - September 29, 2023 Category: Pathology Authors: G Cappelletti E V Carsana G Lunghi S Breviario C Vanetti A B Di Fonzo E Frattini M Magni S Zecchini M Clerici M Aureli C Fenizia Source Type: research

SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons
Exp Mol Pathol. 2023 Sep 30;134:104874. doi: 10.1016/j.yexmp.2023.104874. Online ahead of print.ABSTRACTAn increasing number of patients experiences prolonged symptoms, whose profile and timeline remain uncertain, a condition that has been defined as post COVID. The majority of recovered hospitalized patients manifests at least one persistent symptom even sixty days after the first clinical manifestation's onset. Particularly, in light of the COVID-19-related symptomatology, it has been hypothesized that SARS-CoV-2 might affect the dopamine pathway. However, no scientific evidence has been produced so far. To this end, hum...
Source: Experimental and Molecular Pathology - September 29, 2023 Category: Pathology Authors: G Cappelletti E V Carsana G Lunghi S Breviario C Vanetti A B Di Fonzo E Frattini M Magni S Zecchini M Clerici M Aureli C Fenizia Source Type: research

SARS-CoV-2 hampers dopamine production in iPSC-derived dopaminergic neurons
Exp Mol Pathol. 2023 Sep 30;134:104874. doi: 10.1016/j.yexmp.2023.104874. Online ahead of print.ABSTRACTAn increasing number of patients experiences prolonged symptoms, whose profile and timeline remain uncertain, a condition that has been defined as post COVID. The majority of recovered hospitalized patients manifests at least one persistent symptom even sixty days after the first clinical manifestation's onset. Particularly, in light of the COVID-19-related symptomatology, it has been hypothesized that SARS-CoV-2 might affect the dopamine pathway. However, no scientific evidence has been produced so far. To this end, hum...
Source: Experimental and Molecular Pathology - September 29, 2023 Category: Pathology Authors: G Cappelletti E V Carsana G Lunghi S Breviario C Vanetti A B Di Fonzo E Frattini M Magni S Zecchini M Clerici M Aureli C Fenizia Source Type: research