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Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder
In this study, we investigated CK20 on >2700 urothelial bladder carcinomas in a tissue microarray format by immunohistochemistry. Cytoplasmic and membranous CK20 staining was seen in 1319 (51.8%) cancers. The fraction of CK20 positive and especially strongly positive cases increased from pTaG2 low grade (44.5% strongly positive) and pTaG2 high grade (57.7%) to pTaG3 high grade (62.3%; p = 0.0006) but was lower in muscle-invasive (pT2-4) carcinomas (51.1% in all pTa vs. 29.6% in pT2-4; p < 0.0001). Within pT2-4 carcinomas, CK20 positivity was linked to nodal metastasis and lymphatic vessel invasion (p < 0.0001 each...
Source: Experimental and Molecular Pathology - March 30, 2023 Category: Pathology Authors: Paul Giacomo Bruch Henning Plage Sebastian Hofbauer Kira Kornienko Sarah Weinberger Florian Ro ßner Simon Schallenberg Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Slojewski Krystian Source Type: research

Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder
In this study, we investigated CK20 on >2700 urothelial bladder carcinomas in a tissue microarray format by immunohistochemistry. Cytoplasmic and membranous CK20 staining was seen in 1319 (51.8%) cancers. The fraction of CK20 positive and especially strongly positive cases increased from pTaG2 low grade (44.5% strongly positive) and pTaG2 high grade (57.7%) to pTaG3 high grade (62.3%; p = 0.0006) but was lower in muscle-invasive (pT2-4) carcinomas (51.1% in all pTa vs. 29.6% in pT2-4; p < 0.0001). Within pT2-4 carcinomas, CK20 positivity was linked to nodal metastasis and lymphatic vessel invasion (p < 0.0001 each...
Source: Experimental and Molecular Pathology - March 30, 2023 Category: Pathology Authors: Paul Giacomo Bruch Henning Plage Sebastian Hofbauer Kira Kornienko Sarah Weinberger Florian Ro ßner Simon Schallenberg Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Slojewski Krystian Source Type: research

Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder
In this study, we investigated CK20 on >2700 urothelial bladder carcinomas in a tissue microarray format by immunohistochemistry. Cytoplasmic and membranous CK20 staining was seen in 1319 (51.8%) cancers. The fraction of CK20 positive and especially strongly positive cases increased from pTaG2 low grade (44.5% strongly positive) and pTaG2 high grade (57.7%) to pTaG3 high grade (62.3%; p = 0.0006) but was lower in muscle-invasive (pT2-4) carcinomas (51.1% in all pTa vs. 29.6% in pT2-4; p < 0.0001). Within pT2-4 carcinomas, CK20 positivity was linked to nodal metastasis and lymphatic vessel invasion (p < 0.0001 each...
Source: Experimental and Molecular Pathology - March 30, 2023 Category: Pathology Authors: Paul Giacomo Bruch Henning Plage Sebastian Hofbauer Kira Kornienko Sarah Weinberger Florian Ro ßner Simon Schallenberg Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Slojewski Krystian Source Type: research

Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder
In this study, we investigated CK20 on >2700 urothelial bladder carcinomas in a tissue microarray format by immunohistochemistry. Cytoplasmic and membranous CK20 staining was seen in 1319 (51.8%) cancers. The fraction of CK20 positive and especially strongly positive cases increased from pTaG2 low grade (44.5% strongly positive) and pTaG2 high grade (57.7%) to pTaG3 high grade (62.3%; p = 0.0006) but was lower in muscle-invasive (pT2-4) carcinomas (51.1% in all pTa vs. 29.6% in pT2-4; p < 0.0001). Within pT2-4 carcinomas, CK20 positivity was linked to nodal metastasis and lymphatic vessel invasion (p < 0.0001 each...
Source: Experimental and Molecular Pathology - March 30, 2023 Category: Pathology Authors: Paul Giacomo Bruch Henning Plage Sebastian Hofbauer Kira Kornienko Sarah Weinberger Florian Ro ßner Simon Schallenberg Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Slojewski Krystian Source Type: research

Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder
In this study, we investigated CK20 on >2700 urothelial bladder carcinomas in a tissue microarray format by immunohistochemistry. Cytoplasmic and membranous CK20 staining was seen in 1319 (51.8%) cancers. The fraction of CK20 positive and especially strongly positive cases increased from pTaG2 low grade (44.5% strongly positive) and pTaG2 high grade (57.7%) to pTaG3 high grade (62.3%; p = 0.0006) but was lower in muscle-invasive (pT2-4) carcinomas (51.1% in all pTa vs. 29.6% in pT2-4; p < 0.0001). Within pT2-4 carcinomas, CK20 positivity was linked to nodal metastasis and lymphatic vessel invasion (p < 0.0001 each...
Source: Experimental and Molecular Pathology - March 30, 2023 Category: Pathology Authors: Paul Giacomo Bruch Henning Plage Sebastian Hofbauer Kira Kornienko Sarah Weinberger Florian Ro ßner Simon Schallenberg Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Slojewski Krystian Source Type: research

Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder
In this study, we investigated CK20 on >2700 urothelial bladder carcinomas in a tissue microarray format by immunohistochemistry. Cytoplasmic and membranous CK20 staining was seen in 1319 (51.8%) cancers. The fraction of CK20 positive and especially strongly positive cases increased from pTaG2 low grade (44.5% strongly positive) and pTaG2 high grade (57.7%) to pTaG3 high grade (62.3%; p = 0.0006) but was lower in muscle-invasive (pT2-4) carcinomas (51.1% in all pTa vs. 29.6% in pT2-4; p < 0.0001). Within pT2-4 carcinomas, CK20 positivity was linked to nodal metastasis and lymphatic vessel invasion (p < 0.0001 each...
Source: Experimental and Molecular Pathology - March 30, 2023 Category: Pathology Authors: Paul Giacomo Bruch Henning Plage Sebastian Hofbauer Kira Kornienko Sarah Weinberger Florian Ro ßner Simon Schallenberg Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Slojewski Krystian Source Type: research

Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder
In this study, we investigated CK20 on >2700 urothelial bladder carcinomas in a tissue microarray format by immunohistochemistry. Cytoplasmic and membranous CK20 staining was seen in 1319 (51.8%) cancers. The fraction of CK20 positive and especially strongly positive cases increased from pTaG2 low grade (44.5% strongly positive) and pTaG2 high grade (57.7%) to pTaG3 high grade (62.3%; p = 0.0006) but was lower in muscle-invasive (pT2-4) carcinomas (51.1% in all pTa vs. 29.6% in pT2-4; p < 0.0001). Within pT2-4 carcinomas, CK20 positivity was linked to nodal metastasis and lymphatic vessel invasion (p < 0.0001 each...
Source: Experimental and Molecular Pathology - March 30, 2023 Category: Pathology Authors: Paul Giacomo Bruch Henning Plage Sebastian Hofbauer Kira Kornienko Sarah Weinberger Florian Ro ßner Simon Schallenberg Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Slojewski Krystian Source Type: research

Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder
In this study, we investigated CK20 on >2700 urothelial bladder carcinomas in a tissue microarray format by immunohistochemistry. Cytoplasmic and membranous CK20 staining was seen in 1319 (51.8%) cancers. The fraction of CK20 positive and especially strongly positive cases increased from pTaG2 low grade (44.5% strongly positive) and pTaG2 high grade (57.7%) to pTaG3 high grade (62.3%; p = 0.0006) but was lower in muscle-invasive (pT2-4) carcinomas (51.1% in all pTa vs. 29.6% in pT2-4; p < 0.0001). Within pT2-4 carcinomas, CK20 positivity was linked to nodal metastasis and lymphatic vessel invasion (p < 0.0001 each...
Source: Experimental and Molecular Pathology - March 30, 2023 Category: Pathology Authors: Paul Giacomo Bruch Henning Plage Sebastian Hofbauer Kira Kornienko Sarah Weinberger Florian Ro ßner Simon Schallenberg Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Slojewski Krystian Source Type: research

Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder
In this study, we investigated CK20 on >2700 urothelial bladder carcinomas in a tissue microarray format by immunohistochemistry. Cytoplasmic and membranous CK20 staining was seen in 1319 (51.8%) cancers. The fraction of CK20 positive and especially strongly positive cases increased from pTaG2 low grade (44.5% strongly positive) and pTaG2 high grade (57.7%) to pTaG3 high grade (62.3%; p = 0.0006) but was lower in muscle-invasive (pT2-4) carcinomas (51.1% in all pTa vs. 29.6% in pT2-4; p < 0.0001). Within pT2-4 carcinomas, CK20 positivity was linked to nodal metastasis and lymphatic vessel invasion (p < 0.0001 each...
Source: Experimental and Molecular Pathology - March 30, 2023 Category: Pathology Authors: Paul Giacomo Bruch Henning Plage Sebastian Hofbauer Kira Kornienko Sarah Weinberger Florian Ro ßner Simon Schallenberg Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Slojewski Krystian Source Type: research

Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder
In this study, we investigated CK20 on >2700 urothelial bladder carcinomas in a tissue microarray format by immunohistochemistry. Cytoplasmic and membranous CK20 staining was seen in 1319 (51.8%) cancers. The fraction of CK20 positive and especially strongly positive cases increased from pTaG2 low grade (44.5% strongly positive) and pTaG2 high grade (57.7%) to pTaG3 high grade (62.3%; p = 0.0006) but was lower in muscle-invasive (pT2-4) carcinomas (51.1% in all pTa vs. 29.6% in pT2-4; p < 0.0001). Within pT2-4 carcinomas, CK20 positivity was linked to nodal metastasis and lymphatic vessel invasion (p < 0.0001 each...
Source: Experimental and Molecular Pathology - March 30, 2023 Category: Pathology Authors: Paul Giacomo Bruch Henning Plage Sebastian Hofbauer Kira Kornienko Sarah Weinberger Florian Ro ßner Simon Schallenberg Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Slojewski Krystian Source Type: research

Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder
In this study, we investigated CK20 on >2700 urothelial bladder carcinomas in a tissue microarray format by immunohistochemistry. Cytoplasmic and membranous CK20 staining was seen in 1319 (51.8%) cancers. The fraction of CK20 positive and especially strongly positive cases increased from pTaG2 low grade (44.5% strongly positive) and pTaG2 high grade (57.7%) to pTaG3 high grade (62.3%; p = 0.0006) but was lower in muscle-invasive (pT2-4) carcinomas (51.1% in all pTa vs. 29.6% in pT2-4; p < 0.0001). Within pT2-4 carcinomas, CK20 positivity was linked to nodal metastasis and lymphatic vessel invasion (p < 0.0001 each...
Source: Experimental and Molecular Pathology - March 30, 2023 Category: Pathology Authors: Paul Giacomo Bruch Henning Plage Sebastian Hofbauer Kira Kornienko Sarah Weinberger Florian Ro ßner Simon Schallenberg Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Slojewski Krystian Source Type: research

Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder
In this study, we investigated CK20 on >2700 urothelial bladder carcinomas in a tissue microarray format by immunohistochemistry. Cytoplasmic and membranous CK20 staining was seen in 1319 (51.8%) cancers. The fraction of CK20 positive and especially strongly positive cases increased from pTaG2 low grade (44.5% strongly positive) and pTaG2 high grade (57.7%) to pTaG3 high grade (62.3%; p = 0.0006) but was lower in muscle-invasive (pT2-4) carcinomas (51.1% in all pTa vs. 29.6% in pT2-4; p < 0.0001). Within pT2-4 carcinomas, CK20 positivity was linked to nodal metastasis and lymphatic vessel invasion (p < 0.0001 each...
Source: Experimental and Molecular Pathology - March 30, 2023 Category: Pathology Authors: Paul Giacomo Bruch Henning Plage Sebastian Hofbauer Kira Kornienko Sarah Weinberger Florian Ro ßner Simon Schallenberg Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Slojewski Krystian Source Type: research

Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder
In this study, we investigated CK20 on >2700 urothelial bladder carcinomas in a tissue microarray format by immunohistochemistry. Cytoplasmic and membranous CK20 staining was seen in 1319 (51.8%) cancers. The fraction of CK20 positive and especially strongly positive cases increased from pTaG2 low grade (44.5% strongly positive) and pTaG2 high grade (57.7%) to pTaG3 high grade (62.3%; p = 0.0006) but was lower in muscle-invasive (pT2-4) carcinomas (51.1% in all pTa vs. 29.6% in pT2-4; p < 0.0001). Within pT2-4 carcinomas, CK20 positivity was linked to nodal metastasis and lymphatic vessel invasion (p < 0.0001 each...
Source: Experimental and Molecular Pathology - March 30, 2023 Category: Pathology Authors: Paul Giacomo Bruch Henning Plage Sebastian Hofbauer Kira Kornienko Sarah Weinberger Florian Ro ßner Simon Schallenberg Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Slojewski Krystian Source Type: research

Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder
In this study, we investigated CK20 on >2700 urothelial bladder carcinomas in a tissue microarray format by immunohistochemistry. Cytoplasmic and membranous CK20 staining was seen in 1319 (51.8%) cancers. The fraction of CK20 positive and especially strongly positive cases increased from pTaG2 low grade (44.5% strongly positive) and pTaG2 high grade (57.7%) to pTaG3 high grade (62.3%; p = 0.0006) but was lower in muscle-invasive (pT2-4) carcinomas (51.1% in all pTa vs. 29.6% in pT2-4; p < 0.0001). Within pT2-4 carcinomas, CK20 positivity was linked to nodal metastasis and lymphatic vessel invasion (p < 0.0001 each...
Source: Experimental and Molecular Pathology - March 30, 2023 Category: Pathology Authors: Paul Giacomo Bruch Henning Plage Sebastian Hofbauer Kira Kornienko Sarah Weinberger Florian Ro ßner Simon Schallenberg Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Slojewski Krystian Source Type: research

Cytokeratin 20 expression is linked to stage progression and to poor prognosis in advanced (pT4) urothelial carcinoma of the bladder
In this study, we investigated CK20 on >2700 urothelial bladder carcinomas in a tissue microarray format by immunohistochemistry. Cytoplasmic and membranous CK20 staining was seen in 1319 (51.8%) cancers. The fraction of CK20 positive and especially strongly positive cases increased from pTaG2 low grade (44.5% strongly positive) and pTaG2 high grade (57.7%) to pTaG3 high grade (62.3%; p = 0.0006) but was lower in muscle-invasive (pT2-4) carcinomas (51.1% in all pTa vs. 29.6% in pT2-4; p < 0.0001). Within pT2-4 carcinomas, CK20 positivity was linked to nodal metastasis and lymphatic vessel invasion (p < 0.0001 each...
Source: Experimental and Molecular Pathology - March 30, 2023 Category: Pathology Authors: Paul Giacomo Bruch Henning Plage Sebastian Hofbauer Kira Kornienko Sarah Weinberger Florian Ro ßner Simon Schallenberg Martina Kluth Maximilian Lennartz Niclas C Blessin Andreas H Marx Henrik Samtleben Margit Fisch Michael Rink Marcin Slojewski Krystian Source Type: research