Experimental and Molecular Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

DNA methylation of HOX genes and its clinical implications in cancer
Exp Mol Pathol. 2023 Sep 12;134:104871. doi: 10.1016/j.yexmp.2023.104871. Online ahead of print.ABSTRACTHomeobox (HOX) genes encode highly conserved transcription factors that play vital roles in embryonic development. DNA methylation is a pivotal regulatory epigenetic signaling mark responsible for regulating gene expression. Abnormal DNA methylation is largely associated with the aberrant expression of HOX genes, which is implicated in a broad range of human diseases, including cancer. Numerous studies have clarified the mechanisms of DNA methylation in both physiological and pathological processes. In this review, we fo...
Source: Experimental and Molecular Pathology - September 11, 2023 Category: Pathology Authors: Xin Hu Yong Wang Xiaoyu Zhang Chensheng Li Xikun Zhang Dongxia Yang Yuanyuan Liu Lianlian Li Source Type: research

DNA methylation of HOX genes and its clinical implications in cancer
Exp Mol Pathol. 2023 Sep 9:104871. doi: 10.1016/j.yexmp.2023.104871. Online ahead of print.ABSTRACTHomeobox (HOX) genes encode highly conserved transcription factors that play vital roles in embryonic development. DNA methylation is a pivotal regulatory epigenetic signaling mark responsible for regulating gene expression. Abnormal DNA methylation is largely associated with the aberrant expression of HOX genes, which is implicated in a broad range of human diseases, including cancer. Numerous studies have clarified the mechanisms of DNA methylation in both physiological and pathological processes. In this review, we focus o...
Source: Experimental and Molecular Pathology - September 11, 2023 Category: Pathology Authors: Xin Hu Yong Wang Xiaoyu Zhang Chensheng Li Xikun Zhang Dongxia Yang Yuanyuan Liu Lianlian Li Source Type: research

Effects of bisphenol A on murine salivary glands and human tumor cell lines
Exp Mol Pathol. 2023 Sep 8:104870. doi: 10.1016/j.yexmp.2023.104870. Online ahead of print.ABSTRACTBisphenol A (BPA) is an endocrine-disrupting chemical with a potential role in endocrine cancers. However, the effects of BPA on the salivary glands have been barely explored. We investigated the impact of in vivo sub-chronic exposure to BPA and its in vitro effects on human salivary gland mucoepidermoid carcinoma cell lines. Male and female mice were exposed to BPA (30 mg/kg/day). Sublingual and submandibular salivary glands from an estrogen-deficiency model were also analyzed. BPA concentration in salivary glands was evalua...
Source: Experimental and Molecular Pathology - September 10, 2023 Category: Pathology Authors: Gabriela Kelly da Silva Jos é Alcides Almeida de Arruda Tatiana Fernandes Ara újo Almeida Sic ília Rezende Oliveira Paula Alves da Silva Rocha Ricardo Alves Mesquita Zenilda de Lourdes Cardeal Helv écio Costa Menezes Ivana M árcia Alves Diniz Soraia Source Type: research

Inhibition of integrin alpha v/beta 5 mitigates the protective effect induced by irisin in hemorrhage
CONCLUSION: Integrin αvβ5 plays an important role for irisin in modulating the protective effect during hemorrhage.PMID:37690529 | DOI:10.1016/j.yexmp.2023.104869 (Source: Experimental and Molecular Pathology)
Source: Experimental and Molecular Pathology - September 10, 2023 Category: Pathology Authors: Lijiang Wang Supaporn Kulthinee John Slate-Romano Thomas Zhao Hamsa Shanmugam Patrycja Dubielecka-Szczerba Ling X Zhang Gangjian Qin Shougang Zhuang Y Eugene Chin Ting C Zhao Source Type: research

Roots remain
Exp Mol Pathol. 2023 Sep 7:104868. doi: 10.1016/j.yexmp.2023.104868. Online ahead of print.NO ABSTRACTPMID:37689097 | DOI:10.1016/j.yexmp.2023.104868 (Source: Experimental and Molecular Pathology)
Source: Experimental and Molecular Pathology - September 9, 2023 Category: Pathology Authors: Marco Giudici Source Type: research

Characterization of human umbilical cord blood-derived mast cells using high-throughput expression profiling and next-generation knowledge discovery platforms
Exp Mol Pathol. 2023 Aug 31;132-133:104867. doi: 10.1016/j.yexmp.2023.104867. Online ahead of print.ABSTRACTMast cells (MCs) are tissue-resident innate immune cells that express the high-affinity receptor for immunoglobulin E and are responsible for host defense and an array of diseases related to immune system. We aimed in this study to characterize the pathways and gene signatures of human cord blood-derived MCs (hCBMCs) in comparison to cells originating from CD34- progenitors using next-generation knowledge discovery methods. CD34+ cells were isolated from human umbilical cord blood using magnetic activated cell sortin...
Source: Experimental and Molecular Pathology - August 27, 2023 Category: Pathology Authors: Sherin Bakhashab Ghalya H Banafea Farid Ahmed Haneen Alsehli Huda F AlShaibi Nadia Bagatian Ohoud Subhi Kalamegam Gauthaman Mahmood Rasool Hans-Juergen Schulten Peter Natesan Pushparaj Source Type: research