Experimental and Molecular Pathology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Urinary exosomes from patients with diabetic kidney disease induced podocyte apoptosis via microRNA-145-5p/Srgap2 and the RhoA/ROCK pathway
This study aimed to explore whether urinary exosomes from type 2 diabetes patients with DKD could induce podocyte apoptosis and the underlying pathological mechanisms. The exosomes were isolated from the urine samples of patients with DKD (DKD-Exo). Later, they were taken up and internalized by MPC5 cells. MPC5 cells were co-cultured with DKD-Exo (45 μg/ml) for 24 h in the presence or absence of microRNA-145-5p (miR-145-5p) inhibitor, fasudil and pcDNA-Srgap2 transfection. MiR-145-5p and Srgap2 expression was evaluated using real-time quantitative PCR. The protein levels of Srgap2, Bcl-2, Bax, and cleaved caspase-3, as we...
Source: Experimental and Molecular Pathology - November 12, 2023 Category: Pathology Authors: Lulu Han Shenghai Wang Juan Li Lulu Zhao Hong Zhou Source Type: research

Corrigendum to "RAB5A effect on metastasis of hepatocellular carcinoma cell line via altering the pro-invasive content of exosomes" [Experimental and Molecular Pathology 120 (2021) 104632]
Exp Mol Pathol. 2023 Nov 2:104875. doi: 10.1016/j.yexmp.2023.104875. Online ahead of print.NO ABSTRACTPMID:37925247 | DOI:10.1016/j.yexmp.2023.104875 (Source: Experimental and Molecular Pathology)
Source: Experimental and Molecular Pathology - November 4, 2023 Category: Pathology Authors: Gilar Gorji-Bahri Hamid Reza Moghimi Atieh Hashemi Source Type: research

The MC160 protein of the molluscum contagiosum virus dampens cGAS/STING-induced interferon- β activation
In this study, we demonstrate that there are nuanced differences between both MC160 and MC159 in terms of how the viral proteins modulate the cGAS/STING and MAVS pathways. Specifically, MC160 expression, but not MC159 expression, dampens cGAS/STING-mediated induction of IFN in HEK 293 T cells. Further, MC160 expression prevented the K63-ubiquitination of both STING and TBK1, a kinase downstream of cGAS/STING. Ectopic expression of the MC160 protein, but not the MC159 protein, resulted in a measurable decrease in the TBK1 protein levels as detected via immunoblotting. Finally, using a panel of MC160 truncation mutants, we r...
Source: Experimental and Molecular Pathology - October 27, 2023 Category: Pathology Authors: Brian T Reiss Lissette Bouza Swagath Thomas Catherine D Suarez Erik R Hill Daniel Brian Nichols Source Type: research