Upper loop re-entrant flutter
(Source: Europace)
Source: Europace - July 16, 2019 Category: Cardiology Source Type: research

Bariatric surgery and atrial fibrillation: does the end justify the means?
This editorial refers to ‘Association between pre-ablation bariatric surgery and atrial fibrillation recurrence in morbidly obese patients undergoing atrial fibrillation ablation’ by E. Donnellanet al., on pages 1476--1483. (Source: Europace)
Source: Europace - July 15, 2019 Category: Cardiology Source Type: research

Association between pre-ablation bariatric surgery and atrial fibrillation recurrence in morbidly obese patients undergoing atrial fibrillation ablation
AbstractAimsObesity decreases arrhythmia-free survival after atrial fibrillation (AF) ablation by mechanisms that are not fully understood. We investigated the impact of pre-ablation bariatric surgery (BS) on AF recurrence after ablation.Methods and resultsIn this retrospective observational cohort study, 239 consecutive morbidly obese patients (body mass index ≥40 kg/m2 or ≥35 kg/m2 with obesity-related complications) were followed for a mean of 22  months prior to ablation. Of these patients, 51 had BS prior to ablation, and our primary outcome was whether BS was associated with a lower rate of...
Source: Europace - July 15, 2019 Category: Cardiology Source Type: research

The entirely subcutaneous ICDTM system in patients with congenital heart disease: experience from a large single-centre analysis
ConclusionThe S-ICDTM seems to be a valuable option for the prevention of SCD in patients with various CHDs and complex anatomical anomalies. The S-ICDTM is safe and works effectively, also in these complex patients. Inadequate shock delivery was rare and could be managed by reprogramming. (Source: Europace)
Source: Europace - July 13, 2019 Category: Cardiology Source Type: research

Corrigendum to: 2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias
[Europace 2019;21:1143 –1144] (Source: Europace)
Source: Europace - July 13, 2019 Category: Cardiology Source Type: research

Arrhythmogenic substrate delineation in persistent atrial fibrillation: are we tilting at windmills?
This editorial refers to ‘Extent and spatial distribution of left atrial arrhythmogenic sites, late gadolinium enhancement at MRI and low-voltage areas in patients with persistent atrial fibrillation: comparison of imaging vs. electrical parameters of fibrosis and arrhythmogenesis’ by J. Chenet al., on pages 1484--1493. (Source: Europace)
Source: Europace - July 11, 2019 Category: Cardiology Source Type: research

Comparable clinical characteristics in Brugada syndrome patients harboring SCN5A or novel SCN10A variants
ConclusionFuture studies are warranted to further characterize the role of these specificSCN10A variants. (Source: Europace)
Source: Europace - July 10, 2019 Category: Cardiology Source Type: research

Vernakalant for cardioversion of recent-onset atrial fibrillation: a systematic review and meta-analysis
ConclusionVernakalant should be a first line option for the pharmacological cardioversion of patients with haemodynamically stable recent-onset AF without severe structural heart disease. (Source: Europace)
Source: Europace - July 10, 2019 Category: Cardiology Source Type: research

Sex-related differences in catheter ablation of atrial fibrillation: a systematic review and meta-analysis
AbstractAimsThe sex-related differences in the clinical outcomes of rhythm and safety after catheter ablation remain unclear. The purpose of this study was to compare the clinical outcomes of catheter ablation for atrial fibrillation (AF) in women and men.Methods and resultsThe Medline and EMBASE databases were searched for published articles up to December 2018. Studies that met our predefined inclusion criteria were included. The primary endpoints were freedom from AF/atrial tachycardia (AT) recurrence, stroke/transient ischaemic attack (TIA), and all-cause mortality. After literature search and detailed assessment, 19 o...
Source: Europace - July 8, 2019 Category: Cardiology Source Type: research

Extent and spatial distribution of left atrial arrhythmogenic sites, late gadolinium enhancement at magnetic resonance imaging, and low-voltage areas in patients with persistent atrial fibrillation: comparison of imaging vs. electrical parameters of fibrosis and arrhythmogenesis
AbstractAimsAtrial fibrosis contributes to arrhythmogenesis in atrial fibrillation and can be detected by MRI or electrophysiological mapping. The current study compares the spatial correlation between delayed enhancement (DE) areas to low-voltage areas (LVAs) and to arrhythmogenic areas with spatio-temporal dispersion (ST-Disp) or continuous activity (CA) in atrial fibrillation (AF).Methods and resultsSixteen patients with persistent AF (nine long-standing) underwent DE-magnetic resonance imaging (1.25 mm × 1.25 mm × 2.5 mm) prior to pulmonary vein isolation. Left atrial (LA) voltage mapping was acquired in AF...
Source: Europace - July 5, 2019 Category: Cardiology Source Type: research

Electrically vs. imaging-guided left ventricular lead placement in cardiac resynchronization therapy: a randomized controlled trial
ConclusionElectrically guided CRT implantation appeared non-inferior to an imaging-guided strategy considering the outcomes of change in LVEF, LV reverse remodelling and clinical response. Larger long-term studies are warranted to investigate the effect of an electrically guided CRT strategy. (Source: Europace)
Source: Europace - July 4, 2019 Category: Cardiology Source Type: research

Apixaban enhances endogenous fibrinolysis in patients with atrial fibrillation
AbstractAimsApproximately 20% of ischaemic stroke patients exhibit spontaneous arterial recanalization, attributable to endogenous fibrinolysis, which strongly relates to improved functional outcome. The impact of oral anticoagulants on endogenous fibrinolysis is unknown. Our aim was to test the hypothesis that apixaban enhances endogenous fibrinolysis in non-valvular atrial fibrillation (NVAF).Methods and resultsIn a prospective cross-sectional analysis, we compared endogenous fibrinolysis in NVAF patients (n = 180) taking aspirin, warfarin, or apixaban. In a prospective longitudinal study, patients were tes...
Source: Europace - June 25, 2019 Category: Cardiology Source Type: research

Thromboembolism after electrical isolation of the left atrial appendage: a new indication for interventional closure?
ConclusionAfter electrical LAAI for rhythm control in AF patients, interventional LAAC was associated with fewer thromboembolic complications when compared with OAC. (Source: Europace)
Source: Europace - June 23, 2019 Category: Cardiology Source Type: research

His-bundle pacing: impact of social media
(Source: Europace)
Source: Europace - June 23, 2019 Category: Cardiology Source Type: research

Evaluation of a real-time magnetic resonance imaging-guided electrophysiology system for structural and electrophysiological ventricular tachycardia substrate assessment
ConclusionLow-voltage zones and regions of delayed conduction determined using a real-time MR-EP system are moderately associated with LGE areas identified on MRI. (Source: Europace)
Source: Europace - June 20, 2019 Category: Cardiology Source Type: research

Real-life outcome of implantable cardioverter-defibrillator and cardiac resynchronization defibrillator replacement/upgrade in a contemporary population: observations from the multicentre DECODE registry
ConclusionsAdverse events following CIED replacement/upgrade are lower than previously reported, possibly owing to improved patients care. Hospitalization in the month prior to the procedure, upgrade, and clinical profile (anticoagulation, ischaemic cardiomyopathy) hint to increased risk, suggesting an individualized planning of the procedure to minimize overall AEs.Clinical trial registrationURL:http://clinicaltrials.gov/ Identifier: NCT02076789. (Source: Europace)
Source: Europace - June 17, 2019 Category: Cardiology Source Type: research

Clinical practice and implementation of guidelines for the prevention, diagnosis and management of cardiac implantable electronic device infections: results of a worldwide survey under the auspices of the European Heart Rhythm Association
ConclusionClinical practices for prevention and management of CIED do not fully comply with current recommendations and demonstrate considerable regional disparities. Further education and programmes for improved implementation of guidelines are mandatory. (Source: Europace)
Source: Europace - June 17, 2019 Category: Cardiology Source Type: research

Outcomes of cryoballoon or radiofrequency ablation in symptomatic paroxysmal or persistent atrial fibrillation
AbstractAimsTo evaluate the effectiveness and safety of cryoballoon ablation (CBA) compared with radiofrequency ablation (RFA) for symptomatic paroxysmal or drug-refractory persistent atrial fibrillation (AF).Methods and resultsProspective cluster cohort study in experienced CBA and RFA centres. Primary endpoint was ‘atrial arrhythmia recurrence’, secondary endpoints were as follows: procedural results, safety, and clinical course. A total of 4189 patients were included: CBA 2329 (55.6%) and RFA 1860 (44.4%). Cryoballoon ablation population was younger, with fewer comorbidities. Procedure time was longer in the...
Source: Europace - June 14, 2019 Category: Cardiology Source Type: research

Micra pacemaker implant after cardiac implantable electronic device extraction: feasibility and long-term outcomes
ConclusionMicra implant is an effective and safe procedure in patients still requiring a ventricular pacing after TLE, with similar electrical performance and outcome compared with na ïve patients at long-term follow-up. (Source: Europace)
Source: Europace - June 10, 2019 Category: Cardiology Source Type: research

Prediction of ventricular arrhythmias in patients with a spontaneous Brugada type 1 pattern: the key is in the electrocardiogram
AbstractAimsThere is currently no reliable tool to quantify the risks of ventricular fibrillation or sudden cardiac arrest (VF/SCA) in patients with spontaneous Brugada type 1 pattern (BrT1). Previous studies showed that electrocardiographic (ECG) markers of depolarization or repolarization disorders might indicate elevated risk. We aimed to design a VF/SCA risk prediction model based on ECG analyses for adult patients with spontaneous BrT1.Methods and resultsThis retrospective multicentre international study analysed ECG data from 115 patients (mean age 45.1  ± 12.8 years, 105 males) with spont...
Source: Europace - June 9, 2019 Category: Cardiology Source Type: research

Prevalence of atrial fibrillation in the Italian elderly population and projections from 2020 to 2060 for Italy and the European Union: the FAI Project
ConclusionsOur findings indicate a high burden of AF in coming decades, especially among the oldest-old, who carry the higher AF-related risk of stroke and medical complications. (Source: Europace)
Source: Europace - June 6, 2019 Category: Cardiology Source Type: research

Effect of remote monitoring on patient-reported outcomes in European heart failure patients with an implantable cardioverter-defibrillator: primary results of the REMOTE-CIED randomized trial
AbstractAimsThe European REMOTE-CIED study is the first randomized trial primarily designed to evaluate the effect of remote patient monitoring (RPM) on patient-reported outcomes in the first 2 years after implantation of an implantable cardioverter-defibrillator (ICD).Methods and resultsThe sample consisted of 595 European heart failure patients implanted with an ICD compatible with the Boston Scientific LATITUDE® RPM system. Patients were randomized to RPM plus a yearly in-clinic ICD check-up vs. 3 –6-month in-clinic check-ups alone. At five points during the 2-year follow-up, patients completed questionnaires ...
Source: Europace - June 5, 2019 Category: Cardiology Source Type: research

Efficacy of catheter ablation for atrial fibrillation in patients with congenital heart disease
ConclusionWhile ablation may be a valid option for the treatment of AF in CHD patients, multiple procedures are likely to be required. Early referral and careful patient selection are essential to optimize the results of AF ablation, achieving a low rate of recurrence. Further studies are needed to validate our prognostic model and guide clinical practice. (Source: Europace)
Source: Europace - June 5, 2019 Category: Cardiology Source Type: research

Lyme carditis atrioventricular block: management strategies —Authors’ reply
We would like to thank Crinionet al.1 at Queen ’s university for their interest in our case report2 and for taking the time to contribute to the discussion. Crinionet al.1 discusses the role of permanent pacing in Lyme carditis and puts forth a systematic approach in such cases. (Source: Europace)
Source: Europace - June 5, 2019 Category: Cardiology Source Type: research

Lyme carditis atrioventricular block: management strategies
We read with great interest the recently published case report by Isathet al.1 entitled; ‘Leadless pacemaker used as long-term temporary therapy in Lyme carditis with high-grade atrioventricular block’. They report a novel pacing strategy to manage the unpredictable recovery of the cardiac conduction system in Lyme disease. Increased detection and climate factors have resulted in a marked increase in the global incidence of Lyme disease.2 However, pacing guidelines have yet to adequately address these challenging cases. Our device clinic is located in South Eastern Ontario, the region which reports the highest ...
Source: Europace - June 5, 2019 Category: Cardiology Source Type: research

Long-term single-centre large volume experience with transseptal endocardial left ventricular lead implantation
AbstractAimsThe aim of our study was to investigate the long-term efficacy and safety of transseptal endocardial left ventricular lead implantation (TELVLI).Methods and resultsTransseptal endocardial left ventricular lead implantation was performed in 54 patients (44 men, median age 69, New York Heart Association III –IV stage) between 2007 and 2017 in a single centre. In 36 cases, the transseptal puncture (TP) was performed via the femoral vein, and in 18 cases, the TP and also the left ventricular (LV) lead placement were performed via the subclavian vein. An electrophysiological deflectable catheter was use d to r...
Source: Europace - June 5, 2019 Category: Cardiology Source Type: research

Unusual response to ajmaline test in Brugada syndrome patient leads to extracorporeal membrane oxygenator support
A 41-year-old man with recurrent episodes of ventricular fibrillation (VF), with previous percutaneous coronary intervention of the left anterior descending artery, and Brugada syndrome underwent epicardial ablation. Ajmaline (0.7 mg/kg) unmasked a coved-type electrocardiogram pattern. Immediately after electrophysiological mapping, the QRS complex suddenly widened and a rapidly progressive ST elevation developed in almost all leads. A ventricular ectopy triggered monomorphic ventricular tachycardia degenerating into VF, resistant to external cardioversion. Cardiopulmonary resuscitation (CPR) and isoproterenol were adminis...
Source: Europace - June 3, 2019 Category: Cardiology Source Type: research

A case of wide complex tachycardia with regular fusion beats
A 90-year-old man was admitted with palpitation and chest tightness for 2 h. He was known to have persistent atrial fibrillation (AF) and had a single chamber pacemaker (VVIR) implantation 9 years ago. His echocardiogram, about a year ago, showed moderate left ventricular dysfunction and moderate aortic stenosis. (Source: Europace)
Source: Europace - June 3, 2019 Category: Cardiology Source Type: research

A validation study of the European Society of Cardiology guidelines for risk stratification of sudden cardiac death in childhood hypertrophic cardiomyopathy
ConclusionsThe incidence of MACE is higher for patients with increasing numbers of clinical RFs. However, the current ESC guidelines have a low ability to discriminate between high- and low-risk individuals. (Source: Europace)
Source: Europace - June 1, 2019 Category: Cardiology Source Type: research

Time-to-isolation-guided cryoballoon ablation reduces oesophageal and mediastinal alterations detected by endoscopic ultrasound: results of the MADE-PVI trial
ConclusionThe present prospective study demonstrates a significant impact of freeze protocol on oesophago-mediastinal alterations. A TTI-guided protocol reduces mediastino-oesophageal lesions and may reduce short- and long-term complications of cryoballoon PVI. (Source: Europace)
Source: Europace - May 29, 2019 Category: Cardiology Source Type: research

Cardiovascular magnetic resonance imaging in patients with cardiac implantable electronic devices: best practice and real-world experience
ConclusionWith adherence to a standardized protocol and established exclusion criteria CMR imaging could safely be performed in patients with a CIED. The potential risks of device malfunction necessitate the presence of a device trained individual during the entire CMR examination. If there is a history of VT storm the attendance of an experienced cardiologist, should be mandatory. (Source: Europace)
Source: Europace - May 25, 2019 Category: Cardiology Source Type: research

Age-related regulation and region-specific distribution of ion channel subunits promoting atrial fibrillation in human left and right atria
Conclusion  Features of electrical remodelling in man occur in a qualitatively similar manner in both human atria. Age-related miR-328 dysregulation and reducedICa,L may contribute to increased AF susceptibility with age. (Source: Europace)
Source: Europace - May 25, 2019 Category: Cardiology Source Type: research

Incidence and predictors of implantable cardioverter-defibrillator therapy and its complications in idiopathic ventricular fibrillation patients
ConclusionImplantable cardioverter-defibrillator therapy is an effective treatment in IVF, treating recurrences of potentially lethal VAs in approximately one-third of patients during long-term follow-up. However, device-related complications and inappropriate shocks were also frequent. We found significant predictors for appropriate ICD therapy. This may imply that these patients require additional management to prevent recurrent events. (Source: Europace)
Source: Europace - May 21, 2019 Category: Cardiology Source Type: research

Innovative implantation of a leadless pacemaker in a 19  kg paediatric patient via the right internal jugular vein
Discussion occurred regarding risks and benefits of ventricular only pacing. Her right internal jugular vein (RIJ) diameter was 12 mm. Given her comorbidities/future infection risk, parents opted for leadless pacing instead of epicardial/transvenous pacing. The Micra deployment sheath was placed via RIJ access after serial dilation by 2-Fr steps (6–27-Fr delivery sheath). Due to small right ventricular size, anteroseptal position was obtained by minimal contrast and fluoroscopy guidance. One deployment was made with threshold of 1 V@0.24 ms, R-wave 5 mV, and impeda nce 480 Ohms (Fig...
Source: Europace - May 21, 2019 Category: Cardiology Source Type: research

Machine learning in ‘big data’: handle with care
This commentary refers to ‘A novel atrial fibrillation prediction model for Chinese subjects: a nationwide cohort investigation of 682 237 study participants with random forest model’, by W.-S. Huet al., on pages 1307--1312. (Source: Europace)
Source: Europace - May 18, 2019 Category: Cardiology Source Type: research

Harnessing big data for identifying atrial fibrillation
This commentary refers to ‘A novel atrial fibrillation prediction model for Chinese subjects: a nationwide cohort investigation of 682 237 study participants with random forest model’, by W.-S. Huet al., on pages 1307--1312. (Source: Europace)
Source: Europace - May 18, 2019 Category: Cardiology Source Type: research

A cellular model of Brugada syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes
ConclusionPatient-specific hiPSC-CMs are able to recapitulate single-cell phenotype features of BrS withSCN10A mutations and may provide novel opportunities to further elucidate the cellular disease mechanism. (Source: Europace)
Source: Europace - May 18, 2019 Category: Cardiology Source Type: research

Agreement between gadolinium-enhanced cardiac magnetic resonance and electro-anatomical maps in patients with non-ischaemic dilated cardiomyopathy and ventricular arrhythmias
AbstractAimsWe sought to investigate the overlap between late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR) and electro-anatomical maps (EAM) of patients with non-ischaemic dilated cardiomyopathy (NIDCM) and how it relates with the outcomes after catheter ablation of ventricular arrhythmias (VA).Methods and resultsWe identified 50 patients with NIDCM who received CMR and ablation for VA. Late gadolinium enhancement was detected in 16 (32%) patients, mostly in those presenting with sustained ventricular tachycardia (VT): 15 patients. Low-voltage areas (
Source: Europace - May 18, 2019 Category: Cardiology Source Type: research

Corrigendum to: Goldenberg I, et al. Risk of death without appropriate defibrillator shock in patients with advanced renal dysfunction
[Europace 2019;21:459 –464] (Source: Europace)
Source: Europace - May 18, 2019 Category: Cardiology Source Type: research

Deep sedation for transvenous lead extraction: a large single-centre experience
ConclusionTransvenous lead extraction under DS in the EP laboratory is a safe procedure with high success rates when performed by experienced staff. (Source: Europace)
Source: Europace - May 18, 2019 Category: Cardiology Source Type: research

2019 HRS/EHRA/APHRS/LAHRS focused update to 2015 expert consensus statement on optimal implantable cardioverter-defibrillator programming and testing
AbstractThe2015 HRS/EHRA/APHRS/SOLAECE Expert Consensus Statement on Optimal Implantable Cardioverter-De fibrillator Programming and Testing provided guidance on bradycardia programming, tachycardia detection, tachycardia therapy, and defibrillation testing for implantable cardioverter-de fibrillator (ICD) patient treatment. The 32 recommendations represented the consensus opinion of the writing group, graded by Class of Recommendation and Level of Evidence. In addition, Appendix B provided manufacturer-specific translations of these recommendations into clinical practice consistent with the recommendations within the pa...
Source: Europace - May 15, 2019 Category: Cardiology Source Type: research

A visually striking calcific band causing monomorphic ventricular tachycardia as a first presentation of constrictive pericarditis
Constrictive pericarditis is a rare condition caused by thickening and stiffening of the pericardium manifesting in diastolic dysfunction and enhanced interventricular dependence. (Source: Europace)
Source: Europace - May 15, 2019 Category: Cardiology Source Type: research

Implantable cardioverter-defibrillators and survival in advanced heart failure patients with continuous-flow left ventricular assist devices: a systematic review and meta-analysis
ConclusionImplantable cardioverter-defibrillator use was not associated with improved survival in advanced HF patients with CF-LVADs. These findings underscore the need to formally study the efficacy of ICDs in this population in a dedicated randomized controlled study. (Source: Europace)
Source: Europace - May 13, 2019 Category: Cardiology Source Type: research

High resolution map of aortic root tachycardia
A 63-year-old woman without structural heart disease was referred with frequent, sustained episodes of atrial tachycardia. The episodes had terminated spontaneously before vagal manoeuvres or acute pharmacological intervention could be tried. Tachycardia with a cycle length 390 –420 ms was induced. High-density electroanatomic mapping using the Carto mapping system and a pentaray mapping catheter revealed earliest right atrial activation close to the His bundle. The earliest left atrial activation was in an adjacent position at similar timing, but mapping in the aortic root revealed earlier activation than obt...
Source: Europace - May 11, 2019 Category: Cardiology Source Type: research

2019 HRS/EHRA/APHRS/LAHRS expert consensus statement on catheter ablation of ventricular arrhythmias
AbstractVentricular arrhythmias are an important cause of morbidity and mortality and come in a variety of forms, from single premature ventricular complexes to sustained ventricular tachycardia and fibrillation. Rapid developments have taken place over the past decade in our understanding of these arrhythmias and in our ability to diagnose and treat them. The field of catheter ablation has progressed with the development of new methods and tools, and with the publication of large clinical trials. Therefore, global cardiac electrophysiology professional societies undertook to outline recommendations and best practices for ...
Source: Europace - May 10, 2019 Category: Cardiology Source Type: research

Optimum lesion set and predictors of outcome in persistent atrial fibrillation ablation: a meta-regression analysis
Conclusion  Linear ablation, PWI, and CFAE ablation improves intraprocedural AF termination, but such termination does not predict better long-term outcomes. Study arms including PWI or LAA isolation in the lesion set were associated with improved outcomes in terms of freedom from AF; however, further randomized trials are required before these can be routinely recommended. Left atrial size is the most important marker of AF chronicity influencing outcomes. (Source: Europace)
Source: Europace - May 9, 2019 Category: Cardiology Source Type: research

Evaluation of a simple technique aiming at optimizing point-by-point isolation of the left pulmonary veins: a randomized study
AbstractAimsWe sought to evaluate the efficacy and the safety of a simple technique for stabilizing the ablation catheter during anterior pulmonary vein (PV) encirclement in patients ablated for paroxysmal atrial fibrillation. This consisted of bending the ablation catheter in the left atrium, creating a loop that was cautiously advanced together with the long sheath at the ostium and then within the left superior PV. The curve was then progressively released to reach a stable contact with the anterior part of the left PVs.Methods and resultsEighty consecutive patients (age 64  ± 11 years, left ...
Source: Europace - May 5, 2019 Category: Cardiology Source Type: research

Atrial fibrillation screening with photo-plethysmography through a smartphone camera
AbstractAimsThis cross-sectional study was set up to assess the feasibility of mass screening for atrial fibrillation (AF) with only the use of a smartphone.Methods and resultsA local newspaper published an article, allowing to subscribe for a 7-day screening period to detect AF. Screening was performed through an application that uses photo-plethysmography (PPG) technology by exploiting a smartphone camera. Participants received instructions on how to perform correct measurements twice daily, with notifications pushed through the application ’s software. In case of heart rhythm irregularities, raw PPG signals underw...
Source: Europace - May 5, 2019 Category: Cardiology Source Type: research

Non-paroxysmal atrial fibrillation mapping: characterization of the electrophysiological substrate using a novel integrated mapping technique
AbstractAimsClinical outcomes after radiofrequency catheter ablation (RFCA) remain suboptimal in the treatment of non-paroxysmal atrial fibrillation (AF). Electrophysiological mapping may improve understanding of the underlying mechanisms. To describe the arrhythmia substrate in patients with persistent (Pers) and long-standing persistent (LSPers) AF, undergoing RFCA, using an integrated mechanism mapping technique.Methods and resultsPatients underwent high-density electroanatomical mapping before and after catheter ablation. Integrated maps characterized electrogram (EGM) cycle length (CL) in regions with repetitive &ndas...
Source: Europace - May 5, 2019 Category: Cardiology Source Type: research

Electrocardiographic optimization techniques in resynchronization therapy
AbstractCardiac resynchronization therapy (CRT) is a cornerstone of therapy for patients with heart failure, reduced left ventricular (LV) ejection fraction, and a wide QRS complex. However, not all patients respond to CRT: 30% of CRT implanted patients are currently considered clinical non-responders and up to 40% do not achieve LV reverse remodelling. In order to achieve the best CRT response, appropriate patient selection, device implantation, and programming are important factors. Optimization of CRT pacing intervals may improve results, increasing the number of responders, and the magnitude of the response. Echocardio...
Source: Europace - April 30, 2019 Category: Cardiology Source Type: research