Lead-related infective endocarditis: factors influencing the formation of large vegetations
The objective of the present study was to evaluate risk factors of ILV and their impact on vegetation size.Methods and resultsClinical data of 500 patients with LRIE undergoing transvenous lead extraction in 2006 –15 were retrospectively analysed. The study population consisted of 352 patients with the presence of vegetations (giant,>3 cm; large, 2.0 –2.9 cm; moderate-sized, 1.0–1.9 cm; and small,
Source: Europace - June 29, 2016 Category: Cardiology Source Type: research

Non-vitamin K oral anticoagulants in patients with atrial fibrillation after cardiac surgery: the results of the European Heart Rhythm Association Survey
The purpose of this European Heart Rhythm Association survey was to assess the current practice concerning the use of oral anticoagulation in patients with post-operative atrial fibrillation (pre-existing or new-onset). The survey highlights the considerable heterogeneity of the type of anticoagulation, with 25% of the centres never using the non-vitamin K antagonist oral anticoagulants (NOACs) in this setting, as well the timing of oral anticoagulation initiation, the use and dosing of low-molecular-weight heparins, and the duration of anticoagulation when sinus rhythm is restored. One-third of the centres stated that the...
Source: Europace - June 28, 2016 Category: Cardiology Authors: Vranckx, P., Potpara, T., Dagres, N., Heidbuchel, H. Tags: EP WIRE Source Type: research

Tilt testing results are influenced by tilt protocol
Aims It is unknown how the return to supine position influences duration of loss of consciousness (LOC) and cardioinhibition during tilt test. Methods and results Retrospective analysis of two datasets containing records of patients who underwent tilt testing for unexplained syncope in two centres was performed. Patients, totalling 1232, were included in the study: 262 in a Swedish centre and 970 patients in a Polish centre. In Sweden, tilt table with tilt-down time (TDT) of 18 s was used (Group II). In Poland, two different tilt tables were used, one of them with TDT of 10 s (Group I, n = 325), and the other with TDT of ...
Source: Europace - June 28, 2016 Category: Cardiology Authors: Zysko, D., Fedorowski, A., Nilsson, D., Rudnicki, J., Gajek, J., Melander, O., Sutton, R. Tags: Syncope and event loop recorders Source Type: research

Modified criteria for carotid sinus hypersensitivity are associated with increased mortality in a population-based study
Conclusion Carotid sinus hypersensitivity defined according to Kerr criteria is associated with increased mortality. This raises an interesting question as to the suitability of the current criteria used to define CSH. (Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Authors: McDonald, C., Pearce, M. S., Newton, J. L., Kerr, S. R. J. Tags: Syncope and event loop recorders Source Type: research

Expert cardiologists cannot distinguish between Brugada phenocopy and Brugada syndrome electrocardiogram patterns
Conclusion Our results provide strong evidence that BrP and BrS ECG patterns are visually identical and indistinguishable. These findings support the use of systematic diagnostic criteria for differentiating BrP vs. BrS as an erroneous diagnosis may have a negative impact on patient morbidity and mortality. (Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Authors: Gottschalk, B. H., Anselm, D. D., Brugada, J., Brugada, P., Wilde, A. A., Chiale, P. A., Perez-Riera, A. R., Elizari, M. V., De Luna, A. B., Krahn, A. D., Tan, H. L., Postema, P. G., Baranchuk, A. Tags: Channelopathies Source Type: research

Phenotypic expression is a prerequisite for malignant arrhythmic events and sudden cardiac death in arrhythmogenic right ventricular cardiomyopathy
Conclusions The ARVC phenotypic expression is a prerequisite for the occurrence of life-threatening arrhythmias in DS-gene mutation carriers. The vast majority of malignant arrhythmic events occurred in patients with an overt disease phenotype and major risk factors suggesting that this subgroup most benefits from ICD therapy. (Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Authors: Zorzi, A., Rigato, I., Pilichou, K., Perazzolo Marra, M., Migliore, F., Mazzotti, E., Gregori, D., Thiene, G., Daliento, L., Iliceto, S., Rampazzo, A., Basso, C., Bauce, B., Corrado, D. Tags: Channelopathies Source Type: research

Standard heart rate variability spectral analysis: does it purely assess cardiac autonomic function?
(Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Authors: Sidorenko, L., Kraemer, J. F., Wessel, N. Tags: CASE EXPRESS REPORTS Source Type: research

T-wave area as biomarker of clinical response to cardiac resynchronization therapy
Aims There is increasing evidence that left bundle branch block (LBBB) morphology on the electrocardiogram is a positive predictor for response to cardiac resynchronization therapy (CRT). We previously demonstrated that the vectorcardiography (VCG)-derived T-wave area predicts echocardiographic CRT response in LBBB patients. In the present study, we investigate whether the T-wave area also predicts long-term clinical outcome to CRT. Methods and results This is a retrospective study consisting of 335 CRT recipients. Primary endpoint were the composite of heart failure (HF) hospitalization, heart transplantation, left ventr...
Source: Europace - June 28, 2016 Category: Cardiology Authors: Vegh, E. M., Engels, E. B., van Deursen, C. J. M., Merkely, B., Vernooy, K., Singh, J. P., Prinzen, F. W. Tags: Electrocardiology and risk stratification Source Type: research

A novel approach to detect phrenic nerve stimulation in cardiac resynchronization therapy
(Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Authors: Kiblboeck, D., Siostrzonek, P., Reisinger, J. Tags: CASE EXPRESS REPORTS Source Type: research

Non-sustained wide complex tachycardia: an underappreciated sign to aid in diagnosis
Aims The electrocardiographic (ECG) signs used to differentiate ventricular tachycardia (VT) from supraventricular tachycardia (SVT) with aberrancy are specific but not highly sensitive. The purpose of this study was to define the utility of an underappreciated form of atrioventricular (AV) dissociation at the onset of tachycardia, a single dissociated P wave, in the differentiation of non-sustained monomorphic wide complex tachycardia (WCT) in hospitalized patients. Methods and results We prospectively analysed tracings from 102 consecutive hospitalized patients who had an episode of non-sustained (≥5 beats,
Source: Europace - June 28, 2016 Category: Cardiology Authors: Padala, S. K., Sidhu, M. S., Brown, J. R., Zipursky, J. S., Steckman, D. A., Parikh, D. R., Greenberg, M. L. Tags: Electrocardiology and risk stratification Source Type: research

Focal atrial tachycardia originating from the septal mitral annulus: electrocardiographic and electrophysiological characteristics and radiofrequency ablation
This study sought to investigate electrocardiographic characteristics, electrophysiological features, and radiofrequency ablation in patients with focal atrial tachycardia (AT) originating from the septal mitral annulus. Methods and results In 13 patients with AT originating from the septal mitral annulus, activation mapping was performed to identify the earliest activation site. Successful ablation was performed through either a transseptal (n = 12) or a retrograde aortic approach (n = 1). As confirmed by electrogram recordings, fluoroscopy, and three-dimensional (3D) mapping, successful ablation sites were located in th...
Source: Europace - June 28, 2016 Category: Cardiology Authors: Wang, Y., Li, D., Zhang, J., Han, Z., Wang, Y., Ren, X., Li, X., Chen, F. Tags: Cardiac electrophysiology Source Type: research

Transbaffle catheter ablation of atrial re-entrant tachycardia within the pulmonary venous atrium in adult patients with congenital heart disease
Conclusion Transbaffle access to the PVA for ablation of atrial re-entrant tachycardia is feasible, less invasive than alternative approaches and can be safely applied in patients after Mustard procedure or with a Fontan circulation. However, the rigidity of prosthetic material may preclude baffle puncture at least in a subset of those patients. (Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Authors: Krause, U., Backhoff, D., Klehs, S., Schneider, H. E., Paul, T. Tags: Cardiac electrophysiology Source Type: research

Incidence, predictors, and outcome of inadvertent malposition of transvenous pacing or defibrillation lead in the left heart
Aims Inadvertent lead malposition (ILM) in the left heart is a potential cause of thromboembolism and, therefore, a complication of heart rhythm device implantation [HRDI: pacemaker, implantable cardioverter defibrillator (ICD), cardiac resynchronization therapy (CRT)]. The aim of the study was to report the incidence and clinical outcome of ILM. Methods and results Postoperative lateral and posterior–anterior chest X-rays of all consecutive patients undergoing HRDI from 2007 through 2012 were retrospectively analysed. During the study period, 2579 patients underwent HRDI at our institution. ILM was present in six p...
Source: Europace - June 28, 2016 Category: Cardiology Authors: Ohlow, M.-A., Roos, M., Lauer, B., Von Korn, H., Geller, J. C. Tags: Leads and lead extraction Source Type: research

Initial experience with the TightRail™ Rotating Mechanical Dilator Sheath for transvenous lead extraction
Conclusion Our preliminary data with small sample size show that TightRail™ Mechanical Dilator Sheath is a new useful tool for chronically implanted pacemaker (PM)/ICD leads. Continued investigation including large patient cohort is required to evaluate success and complication rates in comparison to other tools and techniques. (Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Authors: Aytemir, K., Yorgun, H., Canpolat, U., Sahiner, M. L., Kaya, E. B., Evranos, B., Özer, N. Tags: Leads and lead extraction Source Type: research

Pacemakers implantation and radiofrequency catheter ablation procedures during medical missions in Morocco: an 8-year experience
Conclusion Radiofrequency catheter ablation for arrhythmias in developing countries is technically challenging but feasible, despite technical and cultural difficulties. (Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Authors: Bun, S.-S., Latcu, D. G., Errahmouni, A., Zarqane, N., Yaïci, K., Moustaghfir, A., Tazi-Mezalek, A., Saoudi, N. Tags: Pacing and resynchronization therapy Source Type: research

Perimitral atrial flutter ablation by transaortic radiofrequency application
(Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Authors: Estrada, A., Doiny, D., Merino, J. L. Tags: CASE EXPRESS REPORTS Source Type: research

Bifocal left ventricular stimulation or the optimal left ventricular stimulation site in cardiac resynchronization therapy: a pressure-volume loop study
Conclusion Stimulation at the optimal LV site showed a significantly higher pump function improvement compared with bifocal LV stimulation. Mechanical activation at the optimal LV site was significantly more delayed compared with the non-optimal LV site. In general, these results suggest that implantation of a second LV lead yields no additional benefit over implantation of one optimally placed LV lead. However, a bifocal approach might be beneficial in the individual patient. (Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Authors: de Roest, G. J., Wu, L., de Cock, C. C., Delnoy, P.-P. H. M., Hendriks, M. L., van Rossum, A. C., Allaart, C. P. Tags: Pacing and resynchronization therapy Source Type: research

Effects of right ventricular pacing sites on blood pressure variation in upright posture: a comparison of septal vs. apical pacing sites
Aims Large variations in blood pressure (BP) in the upright position are a major cause of pacemaker syndrome, observed in up to 80% of patients paced non-physiologically at the right ventricular (RV) apex. We hypothesized that the magnitude of BP variations might be influenced by the RV pacing site. To assess this, we compared haemodynamic findings during supine and upright posture with RV apical vs. septal pacing. Methods and results The study population comprised a retrospective cohort of 24 dual-chamber pacemaker patients with advanced or complete atrioventricular block, in which 11 were randomly chosen from those with...
Source: Europace - June 28, 2016 Category: Cardiology Authors: Kohno, R., Abe, H., Nakajima, H., Hayashi, K., Oginosawa, Y., Benditt, D. G. Tags: Pacing and resynchronization therapy Source Type: research

Outcomes following the implantation of cardioverter-defibrillator for primary prevention in transposition of the great arteries after intra-atrial baffle repair: a single-centre experience
Conclusion Atrial arrhythmias were the most common cause for ICD shocks in a primary prevention population, while ventricular tachycardia was infrequent. The association between elevated end-diastolic pressures and the occurrence of arrhythmias demonstrates the close mechano-electrical relationship in D-TGA and may be an important predictor of arrhythmic events. (Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Authors: Buber, J., Ackley, T. J., Daniels, C. J., Roble, S. L., Mah, M. L., Kamp, A. N., Kertesz, N. J. Tags: Sudden death and ICDs Source Type: research

The learning curve associated with the introduction of the subcutaneous implantable defibrillator
Aims The subcutaneous implantable cardioverter defibrillator (S-ICD) was introduced to overcome complications related to transvenous leads. Adoption of the S-ICD requires implanters to learn a new implantation technique. The aim of this study was to assess the learning curve for S-ICD implanters with respect to implant-related complications, procedure time, and inappropriate shocks (IASs). Methods and results In a pooled cohort from two clinical S-ICD databases, the IDE Trial and the EFFORTLESS Registry, complications, IASs at 180 days follow-up and implant procedure duration were assessed. Patients were grouped in quarti...
Source: Europace - June 28, 2016 Category: Cardiology Authors: Knops, R. E., Brouwer, T. F., Barr, C. S., Theuns, D. A., Boersma, L., Weiss, R., Neuzil, P., Scholten, M., Lambiase, P. D., Leon, A. R., Hood, M., Jones, P. W., Wold, N., Grace, A. A., Olde Nordkamp, L. R. A., Burke, M. C., on behalf of the IDE and EFFOR Tags: Sudden death and ICDs Source Type: research

Blood alcohol in victims of sudden cardiac death in northern Finland
Aims Momentary intake of large quantity of alcohol provokes ventricular ectopic activity increasing electrical instability. The present study was aimed to assess the prevalence of alcohol intake prior to a sudden cardiac death (SCD) event. Methods and results Victims of unexpected SCD [n = 2363, age 61 ± 12 years, males 1940 (82%)] included in the Finnish study of genotype and phenotype profiles of SCD (FINGESTURE) had a thorough interview of family members, medico-legal autopsy, and determination of blood alcohol concentration. Because of the Finnish law, all unexpected deaths undergo medico-legal autopsy. Patient...
Source: Europace - June 28, 2016 Category: Cardiology Authors: Perkiömäki, J., Hookana, E., Kaikkonen, K., Junttila, J., Kortelainen, M.-L., Huikuri, H. Tags: Sudden death and ICDs Source Type: research

Are implantable cardiac monitors the 'gold standard for atrial fibrillation detection? A prospective randomized trial comparing atrial fibrillation monitoring using implantable cardiac monitors and DDDRP permanent pacemakers in post atrial fibrillation ablation patients
Aims Implantable devices are widely accepted, but not proven, to be the most reliable monitoring method to assess atrial fibrillation (AF) therapies. We compared REVEAL®XT implantable cardiac monitors (ICMs) and permanent pacemakers (PPMs). Methods and results Fifty patients with paroxysmal AF were randomized to ICM or PPM implant 6 weeks prior to pulmonary vein isolation. Permanent pacemakers were programmed to monitoring only (ODO). Device downloads were performed at 0, 3, 6, 9, and 12 months. All patients underwent 7-day external loop recorder. Device ECGs and EGMs were compared for AF burden. A total of 20 744 and...
Source: Europace - June 28, 2016 Category: Cardiology Authors: Podd, S. J., Sugihara, C., Furniss, S. S., Sulke, N. Tags: Ablation for atrial fibrillation Source Type: research

Interventional management of recurrent paroxysmal atrial fibrillation despite isolated pulmonary veins: impact of an ablation strategy targeting inducible atrial tachyarrhythmias
Conclusion In patients with recurrence of PAF despite isolated PV, termination of induced atrial arrhythmias can be achieved in most patients by defragmentation and AT ablation. Moreover, this ablation strategy results in favourable mid-term outcome results. (Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Authors: Sultan, A., Lüker, J., Hoffmann, B., Servatius, H., Schäffer, B., Steven, D., Willems, S. Tags: Ablation for atrial fibrillation Source Type: research

One-year follow-up after second-generation cryoballoon ablation for atrial fibrillation in a large cohort of patients: a single-centre experience
In this study, we assessed the single-procedure outcome on a 1-year follow-up period in a large sample of patients having undergone PVI for drug-resistant atrial fibrillation (AF) using the CB-Adv. Methods and Results A total of 393 patients (122 female, 31%; mean age 57.7 ± 12.9 years) with drug-refractory AF undergoing PVI using the novel CB-Adv were enrolled. Follow-up was based on outpatient clinic visits including Holter electrocardiograms. Recurrence of atrial tachyarrhythmias (ATas) was defined as a symptomatic or documented episode>30 s. A total of 1572 pulmonary veins (PVs) were identified and successfu...
Source: Europace - June 28, 2016 Category: Cardiology Authors: Irfan, G., de Asmundis, C., Mugnai, G., Poelaert, J., Verborgh, C., Umbrain, V., Beckers, S., Hacioglu, E., Hunuk, B., Velagic, V., Stroker, E., Brugada, P., Chierchia, G.-B. Tags: Ablation for atrial fibrillation Source Type: research

Cost effectiveness of left atrial appendage closure with the Watchman device for atrial fibrillation patients with absolute contraindications to warfarin
Conclusions This analysis demonstrates that LAAC with the Watchman device is a cost-effective and cost-saving solution for stroke risk reduction in patients with non-valvular AF who are at risk for stroke but have contraindications to warfarin. (Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Authors: Reddy, V. Y., Akehurst, R. L., Armstrong, S. O., Amorosi, S. L., Brereton, N., Hertz, D. S., Holmes, D. R. Tags: Atrial fibrillation Source Type: research

Long-term evaluation of dabigatran 150 vs. 110 mg twice a day in patients with non-valvular atrial fibrillation
Conclusion Annualized rates of all outcomes were constant with better efficacy of D150, less major bleeding with D110, and low intracerebral haemorrhage rates for both doses. There were no additional safety concerns. This is the longest continuous randomized experience of a novel anticoagulant. (Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Authors: Ezekowitz, M. D., Eikelboom, J., Oldgren, J., Reilly, P. A., Brueckmann, M., Kent, A. P., Pogue, J., Spahr, J., Clemens, A., Noack, H., Diener, H.-C., Wallentin, L., Yusuf, S., Connolly, S. J. Tags: Atrial fibrillation Source Type: research

Giant epsilon waves in 12 leads in a patient with severe arrhythmogenic cardiomyopathy
(Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Authors: Lopez-Moreno, E., Jimenez-Jaimez, J., Tercedor, L. Tags: CASE EXPRESS REPORTS Source Type: research

Arrhythmogenic right ventricular cardiomyopathy, clinical manifestations, and diagnosis
This review aims to give an update on the pathogenesis, clinical manifestations, and diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC). Arrhythmogenic right ventricular cardiomyopathy is mainly an autosomal dominant inherited disease linked to mutations in genes encoding desmosomes or desmosome-related proteins. Classic symptoms include palpitations, cardiac syncope, and aborted cardiac arrest due to ventricular arrhythmias. Heart failure may develop in later stages. Diagnosis is based on the presence of major and minor criteria from the Task Force Criteria revised in 2010 (TFC 2010), which includes evalu...
Source: Europace - June 28, 2016 Category: Cardiology Authors: Haugaa, K. H., Haland, T. F., Leren, I. S., Saberniak, J., Edvardsen, T. Tags: REVIEWS Source Type: research

Anticoagulation reversal in the era of the non-vitamin K oral anticoagulants
In recent years, non-vitamin K oral anticoagulants (NOACs) have emerged as an alternative to warfarin for the prevention and treatment of thrombo-embolic disease. Large randomized trials have demonstrated that these agents, which act by directly targeting thrombin (dabigatran) and factor Xa (rivaroxaban, apixaban, and edoxaban), are at least as effective as warfarin, with lower rates of bleeding and fewer interactions with food and drugs. In addition, NOACs have a more predictable anticoagulant effect, allowing a fixed dose regimen and obviating the need for routine anticoagulation monitoring. Since the introduction of NOA...
Source: Europace - June 28, 2016 Category: Cardiology Authors: Enriquez, A., Lip, G. Y. H., Baranchuk, A. Tags: REVIEWS Source Type: research

Arrhythmogenic right ventricular dysplasia/cardiomyopathy: arrhythmogenesis in the apparently normal heart?
(Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Authors: Hauer, R. N. Tags: EDITORIAL Source Type: research

Impact of surround flow catheter tip irrigation in contact force ablation on the incidence of asymptomatic oesophageal lesions after atrial fibrillation ablation: a prospective comparative study
ConclusionAccording to these preliminary results, the use of an improved ablation catheter irrigation technology (surround flow) in conjunction with contact force measurement was associated with a higher but not statistically significant probability of oesophageal thermal lesions. Further studies including larger patient cohorts are needed. (Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Source Type: research

Long-term benefit of first-line peri-implantable cardioverter –defibrillator implant ventricular tachycardia-substrate ablation in secondary prevention patients
This study assessed the benefit of peri-implantable cardioverter –defibrillator implant ventricular tachycardia (VT)-substrate ablation in patients with structural heart disease (SHD).Methods and resultsPatients with SHD and indication for secondary prevention ICD implant were prospectively included. Patients presenting with incessant and/or slow VT or frequent ( ≥2) VT episodes who underwent peri-ICD VT-substrate ablation (the scar dechannelling technique) were compared with those who received ICD alone and did not meet ablation criteria. The primary endpoint was any sustained VT/ICD therapy during follow-up. Of ...
Source: Europace - June 28, 2016 Category: Cardiology Source Type: research

Long-term outcomes after event-free cardioverter defibrillator implantation: comparison between patients discharged within 24 h and routinely hospitalized patients in the German DEVICE registry
ConclusionData from a large-scale registry reflecting current day-to-day practice in Germany suggest that most patients can be discharged safely within 24 h of successful ICD implantation if there are no procedure-related events. Follow-up data up to 1.5 years after implantation did not raise long-term safety concerns. (Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Source Type: research

Diagnosis and management of iatrogenic cardiac perforation caused by pacemaker and defibrillator leads
ConclusionIn the setting of cardiac perforation, CT is the imaging modality of choice. Transvenous lead extraction can be recommended as a safe, efficacious, and versatile intervention. (Source: Europace)
Source: Europace - June 28, 2016 Category: Cardiology Source Type: research

Wound haematoma following defibrillator implantation: incidence and predictors in the Shockless Implant Evaluation (SIMPLE) trial
This study included 2500 patients receiving an ICD in the SIMPLE trial. A clinically significant pocket haematoma was defined as a haematoma that required re-operation or interruption of oral anticoagulation (OAC) therapy. Clinically significant pocket haematoma occurred in 56 of 2500 patients (2.2%) of which 6 (10.7%) developed device-related infection. Patients who developed pocket haematoma were older (mean age 67.6 ± 8.8 years vs. 62.7 ± 11.6 years,P
Source: Europace - June 28, 2016 Category: Cardiology Source Type: research

Electrocardiographic differentiation of idiopathic right ventricular outflow tract ectopy from early arrhythmogenic right ventricular cardiomyopathy
ConclusionsIn patients with RVOT VEBs and no major electrocardiographic or echocardiographic abnormalities, the ectopic QRS morphology aids in the differential diagnosis between idiopathic RVOT arrhythmias and early ARVC. (Source: Europace)
Source: Europace - June 23, 2016 Category: Cardiology Source Type: research

Addictive drugs, arrhythmias, and cardiac inward rectifiers
In many addictive drugs including alcohol and nicotine, proarrhythmic effects were reported. This review provides an overview of the current knowledge in this field (with a focus on the inward rectifier potassium currents) to promote the lacking data and appeal for their completion, thus, to improve understanding of the proarrhythmic potential of addictive drugs. (Source: Europace)
Source: Europace - June 13, 2016 Category: Cardiology Source Type: research

Differential effects of ganglionic plexi ablation in a patient with neurally mediated syncope and intermittent atrioventricular block: a commentary
This editorial refers to ‘Differential effect of ganglionic plexi ablation in a patient with neurally mediated syncope and intermittent atrioventricular block’ by M. Fukunaga et al., on pages 119–126. (Source: Europace)
Source: Europace - June 13, 2016 Category: Cardiology Source Type: research

Conduction over and around the atrioventricular node: author's reply
(Source: Europace)
Source: Europace - June 12, 2016 Category: Cardiology Authors: Katritsis, D. G., Josephson, M. E. Tags: LETTERS TO THE EDITOR Source Type: research

Characterizing fast pathway in typical and atypical atrioventricular nodal re-entrant tachycardia by atrial-His and His-atrial: more to consider
(Source: Europace)
Source: Europace - June 12, 2016 Category: Cardiology Authors: Sun, H., Lakin, R., He, Y., Yang, P. Tags: LETTERS TO THE EDITOR Source Type: research

Temperature-limited applications of mini-electrode catheter: authors' reply
(Source: Europace)
Source: Europace - June 12, 2016 Category: Cardiology Authors: Iwasawa, J., Miyazaki, S., Iesaka, Y. Tags: LETTERS TO THE EDITOR Source Type: research

Importance of anatomy in cavotricuspid isthmus
(Source: Europace)
Source: Europace - June 12, 2016 Category: Cardiology Authors: Caldwell, J. C., Hobson, N., Redfearn, D. Tags: LETTERS TO THE EDITOR Source Type: research

Replacement of implantable cardioverter defibrillators and cardiac resynchronization therapy devices: results of the European Heart Rhythm Association survey
The aim of this EP Wire was to assess the management, indications, and techniques for implantable cardioverter defibrillator (ICD) and cardiac resynchronization therapy (CRT) device replacement in Europe. A total of 24 centres in 14 European countries completed the questionnaire. All centres were members of the European Heart Rhythm Association Electrophysiology Research Network. Replacement procedures were performed by electrophysiologists in 52% of the centres, by cardiologists in 33%, and both in the remaining centres. In the majority of centres, the procedures were performed during a short hospitalization (
Source: Europace - June 12, 2016 Category: Cardiology Authors: Tilz, R., Boveda, S., Deharo, J.-C., Dobreanu, D., Haugaa, K. H., Dagres, N. Tags: EP WIRE Source Type: research

QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology
This consensus guideline discusses the electrocardiographic phenomenon of beat-to-beat QT interval variability (QTV) on surface electrocardiograms. The text covers measurement principles, physiological basis, and clinical value of QTV. Technical considerations include QT interval measurement and the relation between QTV and heart rate variability. Research frontiers of QTV include understanding of QTV physiology, systematic evaluation of the link between QTV and direct measures of neural activity, modelling of the QTV dependence on the variability of other physiological variables, distinction between QTV and general T wave...
Source: Europace - June 12, 2016 Category: Cardiology Authors: Baumert, M., Porta, A., Vos, M. A., Malik, M., Couderc, J.-P., Laguna, P., Piccirillo, G., Smith, G. L., Tereshchenko, L. G., Volders, P. G. A. Tags: EHRA POSITION PAPER Source Type: research

Cost comparison of two implantable cardiac monitors in two different settings: Reveal XT in a catheterization laboratory vs. Reveal LINQ in a procedure room
Conclusion Inserting the miniaturized version of the ICM is simpler and faster, and the procedure can take place outside the cath lab in a less resource intensive environment. Hospitals save resources when the higher price of the Reveal LINQ does not outweigh these savings. (Source: Europace)
Source: Europace - June 12, 2016 Category: Cardiology Authors: Kanters, T. A., Wolff, C., Boyson, D., Kouakam, C., Dinh, T., Hakkaart, L., Rutten-Van Mölken, M. P. M. H. Tags: Syncope and event loop recorders Source Type: research

The benefit of a remotely monitored implantable loop recorder as a first line investigation in unexplained syncope: the EaSyAS II trial
Conclusions Implantable loop recorder monitoring achieved a more rapid diagnosis in unexplained syncope than usual care. Conventional management of syncope failed to achieve an ECG diagnosis despite a large number of investigative tests. Syncope Clinic and provocative tilt testing delivered a rapid ECG diagnosis, but did not prevent recurrent syncope. Implantable loop recorders offered rapid diagnosis, increased the likelihood of syncope being reported, demonstrated a high rate of intermittent bradycardia requiring pacing, and reduced recurrent syncope. (Source: Europace)
Source: Europace - June 12, 2016 Category: Cardiology Authors: Sulke, N., Sugihara, C., Hong, P., Patel, N., Freemantle, N. Tags: Electrocardiology and risk stratification Source Type: research

Novel SCN10A variants associated with Brugada syndrome
Conclusion In six BrS probands who carried SCN10A variants, most experienced severe arrhythmic attacks. It is of clinical importance to screen SCN10A mutations in BrS, although the functional significance of these variants remains unclear. (Source: Europace)
Source: Europace - June 12, 2016 Category: Cardiology Authors: Fukuyama, M., Ohno, S., Makiyama, T., Horie, M. Tags: Channelopathies Source Type: research

A Brugada syndrome proband with compound heterozygote SCN5A mutations identified from a Chinese family in Singapore
Aims Brugada syndrome (BrS) is a rare heritable ventricular arrhythmia. Genetic defects in SCN5A, a gene that encodes the α-subunit of the sodium ion channel Nav1.5, are present in 15–30% of BrS cases. SCN5A remains by far, the highest yielding gene for BrS. We studied a young male who presented with syncope at age 11. This proband was screened for possible disease causing SCN5A mutations. The inheritance pattern was also examined amongst his first-degree family members. Methods and results The proband had a baseline electrocardiogram that showed Type 2 BrS changes, which escalated to a characteristic Type I B...
Source: Europace - June 12, 2016 Category: Cardiology Authors: Tan, B. Y., Yong, R. Y. Y., Barajas-Martinez, H., Dumaine, R., Chew, Y. X., Wasan, P. S., Ching, C. K., Ho, K. L., Gan, L. S. H., Morin, N., Chong, A. P. L., Yap, S. H., Neo, J. L., Yap, E. P. H., Moochhala, S., Chong, D. T. T., Chow, W., Seow, S. C., Hu, Tags: Channelopathies Source Type: research

Purkinje-related ventricular fibrillation associated with a homozygous H558R polymorphism in the sodium channel SCN5A gene
(Source: Europace)
Source: Europace - June 12, 2016 Category: Cardiology Authors: Reithmann, C., Beckmann, B.-M., Kääb, S. Tags: EP CASE EXPRESS Source Type: research

Diagnostic yield of molecular autopsy in patients with sudden arrhythmic death syndrome using targeted exome sequencing
Aims The targeted genetic screening of Sudden Arrhythmic Death Syndrome (SADS) probands in a molecular autopsy has a diagnostic yield of up to 35%. Exome sequencing has the potential to improve this yield. The primary aim of this study is to examine the feasibility and diagnostic utility of targeted exome screening in SADS victims, utilizing familial clinical screening whenever possible. Methods and results To determine the feasibility and diagnostic yield of targeted exome sequencing deoxyribonucleic acid (DNA) was isolated from 59 SADS victims (mean age 25 years, range 1–51 years). Targeted exome sequencing of 135...
Source: Europace - June 12, 2016 Category: Cardiology Authors: Nunn, L. M., Lopes, L. R., Syrris, P., Murphy, C., Plagnol, V., Firman, E., Dalageorgou, C., Zorio, E., Domingo, D., Murday, V., Findlay, I., Duncan, A., Carr-White, G., Robert, L., Bueser, T., Langman, C., Fynn, S. P., Goddard, M., White, A., Bundgaard, Tags: Channelopathies Source Type: research