Safe automatic one-lead electrocardiogram analysis in screening for atrial fibrillation
ConclusionAutomatic ECG screening using a computerized algorithm safely identifies normal ECGs in Lead I and reduces the need for manual evaluation of individual ECGs with>85% with 100% sensitivity on an individual basis. (Source: Europace)
Source: Europace - October 6, 2016 Category: Cardiology Source Type: research

Left univentricular pacing for cardiac resynchronization therapy
AbstractThis review describes the rationale and published evidence for left univentricular pacing for cardiac resynchronization therapy, gives an overview of the existing optimization algorithms featuring this mode, and discusses future perspectives. (Source: Europace)
Source: Europace - October 6, 2016 Category: Cardiology Source Type: research

The clinical value of T-wave alternans derived from Holter monitoring
Microvolt-level T-wave alternans (TWA) assessed by spectral method during an exercise stress test has been widely studied for risk stratification. Several studies have documented the association of a positive TWA with total mortality and arrhythmic events. Nevertheless, the need to achieve an elevated and stabilized heart rate resulting in a considerable proportion of indeterminate test results constitutes one of the main limitations of this method. It is well recognized that arrhythmic events may be triggered not only by physical but also by mental stress and are not necessarily associated with exercise. Detection of TWA ...
Source: Europace - October 6, 2016 Category: Cardiology Source Type: research

Emerging molecular therapies targeting myocardial infarction-related arrhythmias
Cardiac disease is the leading cause of death in the developed world. Ventricular arrhythmias associated with myocardial ischaemia and/or infarction are a major contributor to cardiovascular mortality, and require improved prevention and treatment. Drugs, devices, and radiofrequency catheter ablation have made important inroads, but have significant limitations ranging from incomplete success to undesired toxicities and major side effects. These limitations derive from the nature of the intervention. Drugs are frequently ineffective, target the entire heart, and often do not deal with the specific arrhythmia trigger or sub...
Source: Europace - October 6, 2016 Category: Cardiology Source Type: research

Functional improvement after successful catheter ablation for long-standing persistent atrial fibrillation
AbstractAimsIdentifying patients who benefit from restored sinus rhythm (SR) would optimize the selection of candidates for ablation of long-standing persistent atrial fibrillation (LSPAF). This prospective study sought to identify the hitherto unknown factors associated with global functional improvement after successful radiofrequency catheter ablation of LSPAF.Methods and resultsIn 171 LSPAF patients (84% of the total consecutive 203 patients) who were examined in SR 12 months after ablation, the individual per cent change from baseline value in maximum oxygen consumption at exercise test (VO2 max), left ventricular eje...
Source: Europace - October 5, 2016 Category: Cardiology Source Type: research

Outcomes of lead extraction without subsequent device reimplantation
AbstractAimsOutcomes among patients who do not receive device reimplantation after cardiovascular implantable electronic device (CIED) extraction have not been well studied. The present study aims to investigate the outcomes of patients without device reimplantation after lead extraction and device removal.Methods and resultsWe retrospectively searched for consecutive patients who underwent CIED extraction at Mayo Clinic, Rochester, MN and University of California San Diego Medical Center from 2001 through 2012. Among the patients identified, we compared characteristics of those who did and did not have device reimplantati...
Source: Europace - October 5, 2016 Category: Cardiology Source Type: research

Improved patient selection for cardiac resynchronization therapy by normalization of QRS duration to left ventricular dimension
This study evaluates the relative importance of two components of QRS prolongation, myocardial conduction velocity and travel distance of the electrical wave front (i.e. path length), for the prediction of acute response to cardiac resynchronization therapy (CRT) in left bundle branch block (LBBB) patients.Methods and resultsThirty-two CRT candidates (ejection fraction
Source: Europace - October 5, 2016 Category: Cardiology Source Type: research

(T peak − T end )/QRS and (T peak − T end )/(QT × QRS): novel markers for predicting arrhythmic risk in the Brugada syndrome
(Source: Europace)
Source: Europace - October 5, 2016 Category: Cardiology Source Type: research

Frequent atrial extrasystolic beats predict atrial fibrillation in patients with congenital heart defects
This study therefore examined the predictive ability of atrial extrasystole (AES) for development of AF in CHD patients.Methods and resultsAdult CHD patients who had a 24 h Holter registration were followed to determine who developed AF. A total of 573 patients (49% male, mean age 35 ± 12 years) were included; they had a simple/complete repaired CHD (n = 279), complex repaired CHD (n = 251), or univentricular heart (UVH,n = 43). Ageing (P
Source: Europace - October 4, 2016 Category: Cardiology Source Type: research

Patterns of physical activity and survival following cardiac resynchronization therapy implantation: the ALTITUDE activity study
AbstractAimsCardiac resynchronization therapy with implantable defibrillator backup (CRT-D) improves outcomes, but predictors and markers of response remain limited. Physical activity information collected by CRT devices may provide insights to CRT response and the relationship between activity changes and survival.Methods and resultsPatients entered into the LATITUDE remote monitoring system from 2008 to 2012 after receipt of a new CRT-D were eligible. Mean daily activity was calculated from LATITUDE uploads at baseline (first 3 –10 days following implant) and 6 months (180–210 days). Pairwise differences for ...
Source: Europace - October 4, 2016 Category: Cardiology Source Type: research

Left atrial model reconstruction in atrial fibrillation ablation: reliability of new mapping and complex impedance systems
ConclusionsRecent 3D mapping tools allow outstanding anatomical rendering and are key in complex ablation procedure set-up. This study shows that 3D anatomical reconstruction of LA, PVs, and their variable branches is not only safe and fast but also accurate and reliable. (Source: Europace)
Source: Europace - October 4, 2016 Category: Cardiology Source Type: research

Electrophysiological features and catheter ablation of symptomatic frequent premature atrial contractions
This study aimed to explore the electrophysiological features of PACs with and without inducing AF and to evaluate the effectiveness of catheter ablation for PACs.Methods and resultsThirty-five consecutive patients with symptomatic, frequent, and drug-refractory PACs in the absence of AF (group A) and 35 patients with PACs-induced AF (group B) were enrolled. Coupling intervals (CoIs) of PACs were compared. Premature atrial contractions were mapped by the point-by-point and/or circular mapping technique. Focal ablation or pulmonary vein/superior vena cava isolation was applied as appropriate. A total of 35 ectopic foci were...
Source: Europace - October 4, 2016 Category: Cardiology Source Type: research

Contemporary rates and outcomes of single- vs. dual-coil implantable cardioverter defibrillator lead implantation: data from the Israeli ICD Registry
ConclusionReal-life rates of single-coil lead implantation are rising while adding no additional risk. These results of single-coil safety are reassuring and obtained, despite low and contemporary rates of DFT testing. (Source: Europace)
Source: Europace - October 4, 2016 Category: Cardiology Source Type: research

The slope of the initial temperature drop predicts acute pulmonary vein isolation using the second-generation cryoballoon
AbstractAimsThere is no objective, early indicator of occlusion quality, and efficacy of cryoballoon pulmonary vein isolation. As previous experience suggests that the initial cooling rate correlates with these parameters, we investigated the slope of the initial temperature drop as an objective measure.Methods and resultsA systematic evaluation of 523 cryoapplications in 105 patients using a serial ROC-AUC analysis was performed. We found the slope of a linear regression of the temperature –time function to be a good predictor (PPV 0.9, specificity 0.72, sensitivity 0.71, and ROC-AUC 0.75) of acute isolation. It als...
Source: Europace - October 4, 2016 Category: Cardiology Source Type: research

Reduction of falls and fractures after permanent pacemaker implantation in elderly patients with sinus node dysfunction
AbstractAimsElderly patients with sinus node dysfunction (SND) are at increased risk of falls with possible injuries. However, the incidence of these adverse events and its reduction after permanent pacemaker (PPM) implantation are not known.Methods and resultsEighty-seven patients (mean [SD] age 75.4 [8.3] years, 51% women) with SND and an indication for cardiac pacing were included and were examined by a standardized interview targeting fall history. The incidence and total number of falls, falls with injury, falls requiring treatment, and falls resulting in a fracture were assessed for the time period of 12 months befor...
Source: Europace - October 4, 2016 Category: Cardiology Source Type: research

Antiadrenergic autoimmunity in postural tachycardia syndrome
ConclusionThese data confirm a strong relationship between adrenergic autoantibodies and POTS. They support the concept that allosteric-mediated shifts in the α1AR and β1AR responsiveness are important in the pathophysiology of postural tachycardia. (Source: Europace)
Source: Europace - October 4, 2016 Category: Cardiology Source Type: research

Time matters: adenosine testing immediately after pulmonary vein isolation does not substitute a waiting period
ConclusionAdenosine testing immediately after PVAI does not reliably exclude later spontaneous or adenosine-induced PV reconnection. Adenosine testing should be performed after an appropriate observation period to reduce risk of PV reconnection. (Source: Europace)
Source: Europace - October 4, 2016 Category: Cardiology Source Type: research

Atrial fibrillation detection using a novel three-vector cardiac implantable monitor: the atrial fibrillation detect study
ConclusionContinuous monitoring using this novel device, equipped with a dedicated detection algorithm, yields an accurate and reliable detection of AF episodes. The ICM is a promising tool for tailoring individual AF patient management. Further long-term prospective studies are necessary to confirm these encouraging results. (Source: Europace)
Source: Europace - October 4, 2016 Category: Cardiology Source Type: research

Traditional and novel electrocardiographic conduction and repolarization markers of sudden cardiac death
Sudden cardiac death, frequently due to ventricular arrhythmias, is a significant problem globally. Most affected individuals do not arrive at hospital in time for medical treatment. Therefore, there is an urgent need to identify the most-at-risk patients for insertion of prophylactic implantable cardioverter defibrillators. Clinical risk markers derived from electrocardiography are important for this purpose. They can be based on repolarization, including corrected QT (QTc) interval, QT dispersion (QTD), interval from the peak to the end of the T-wave (Tpeak– Tend), (Tpeak– Tend)/QT, T-wave alternans (TWA), an...
Source: Europace - October 4, 2016 Category: Cardiology Source Type: research

Antiarrhythmic effect of vernakalant in an experimental model of Long-QT-syndrome
AimsThe antiarrhythmic drug vernakalant exerts antiarrhythmic effects in atrial fibrillation. Recent experimental data suggest interactions with the late sodium current and antiarrhythmic effects in ventricular arrhythmias. We aimed at investigating whether treatment with vernakalant reduces polymorphic ventricular tachycardia (VT) in an experimental model of Long-QT-syndrome (LQTS).Methods and resultsTwenty-nine isolated rabbit hearts were assigned to two groups and treated with erythromycin (300 µM,n = 15) or veratridine (0.5 µM,n = 14) after obtaining baseline data. Thereafter, vernakalant (10 µM) was ...
Source: Europace - October 4, 2016 Category: Cardiology Source Type: research

Death after ablation of atrial flutter: are we doing the right thing?
This editorial refers to ‘Death and thrombo-embolic risk after ablation of atrial flutter compared with atrial fibrillation: a nationwide cohort study’ by H. Vadmannet al., doi:10.1093/europace/euw107. (Source: Europace)
Source: Europace - October 4, 2016 Category: Cardiology Source Type: research

Time to implement fitness and reduction of fatness in atrial fibrillation therapy
This editorial refers to ‘Self-reported physical activity and major adverse events in patients with atrial fibrillation: a report from the EURObservational Research Programme Pilot Survey on Atrial Fibrillation (EORP-AF) General Registry’ by M. Proiettiet al., on pages 535 –543. (Source: Europace)
Source: Europace - October 4, 2016 Category: Cardiology Source Type: research

The wearable cardioverter-defibrillator: current technology and evolving indications
The wearable cardioverter-defibrillator has been available for over a decade and now is frequently prescribed for patients deemed at high arrhythmic risk in whom the underlying pathology is potentially reversible or who are awaiting an implantable cardioverter-defibrillator. The use of the wearable cardioverter-defibrillator is included in the new 2015 ESC guidelines for the management of ventricular arrhythmias and prevention of sudden cardiac death. The present review provides insight into the current technology and an overview of this approach. (Source: Europace)
Source: Europace - October 3, 2016 Category: Cardiology Source Type: research

Cryoballoon vs. radiofrequency ablation for paroxysmal atrial fibrillation: an updated meta-analysis of randomized and observational studies
AimsRadiofrequency (RF) ablation represents a standard of care for pulmonary vein isolation in patients with drug-refractory paroxysmal atrial fibrillation (AF). In this setting, cryoballoon (CB) ablation has emerged as alternative therapy. However, the efficacy and safety of CB vs. RF ablation in patients with paroxysmal AF remain a matter of debate.Methods and resultsWe searched electronic scientific databases for studies of CB vs. RF ablation in patients with paroxysmal AF. Aggregate data were pooled to perform a meta-analysis. The primary efficacy and safety outcomes were the recurrence of any atrial arrhythmia and pro...
Source: Europace - October 3, 2016 Category: Cardiology Source Type: research

Fluoxetine vs. placebo for the treatment of recurrent vasovagal syncope with anxiety sensitivity
AimsThe optimal medical therapy of patients with vasovagal syncope (VVS) remains controversial. Fluoxetine is effective against anxiety and panic disorders, while its use has shown promising results for VVS. Anxiety sensitivity is a personality trait observed in a considerable proportion of patients with VVS, associated with predisposition to anxiety and panic disorders. Our aim was to examine whether fluoxetine exerts beneficial effects regarding VVS prevention in the subset of patients with anxiety sensitivity.Methods and resultsWe assessed 106 patients with typical history of recurrent VVS, without other comorbidities, ...
Source: Europace - October 3, 2016 Category: Cardiology Source Type: research

Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure
Aims Clinical studies have shown differences in the propensity for malignant ventricular arrhythmias between women and men suffering from cardiomyopathies and heart failure (HF). This is clinically relevant as it impacts therapies like prophylactic implantable cardioverter-defibrillator implantation but the pathomechanisms are unknown. As an increased sarcoplasmic reticulum (SR) Ca2+ leak is arrhythmogenic, it could represent a cellular basis for this paradox. Methods/Results We evaluated the SR Ca2+ leak with respect to sex differences in (i) afterload-induced cardiac hypertrophy (Hy) with preserved left ventricular (LV)...
Source: Europace - August 30, 2016 Category: Cardiology Authors: Fischer, T. H., Herting, J., Eiringhaus, J., Pabel, S., Hartmann, N. H., Ellenberger, D., Friedrich, M., Renner, A., Gummert, J., Maier, L. S., Zabel, M., Hasenfuss, G., Sossalla, S. Tags: BASIC SCIENCE Source Type: research

Implantation of subcutaneous implantable cardioverter defibrillators in Europe: results of the European Heart Rhythm Association survey
Aims The purpose of this European Heart Rhythm Association (EHRA) survey is to provide an overview of the current use of subcutaneous cardioverter defibrillators (S-ICDs) across a broad range of European centres. Methods and results A questionnaire was sent via the internet to centres participating in the EHRA electrophysiology research network. Questions included standards of care and policies used for patient management, indications, and techniques of implantation of the S-ICDs. In total, 52 centres replied to the questionnaire. More than one-fourth of the responding centres does not implant the S-ICD (n = 14, 27%). The...
Source: Europace - August 30, 2016 Category: Cardiology Authors: Boveda, S., Lenarczyk, R., Haugaa, K., Fumagalli, S., Madrid, A. H., Defaye, P., Broadhurst, P., Dagres, N. Tags: EP WIRE Source Type: research

Twiddler's syndrome with a baroreflex stimulator device
(Source: Europace)
Source: Europace - August 30, 2016 Category: Cardiology Authors: Galand, V., Martins, R. P., Leclercq, C. Tags: CASE EXPRESS REPORTS Source Type: research

Standardized algorithm for cardiac pacing in older patients affected by severe unpredictable reflex syncope: 3-year insights from the Syncope Unit Project 2 (SUP 2) study
Conclusion The benefit of cardiac pacing is maintained at 3 years, irrespective of the index diagnostic test, and is maximum in patients with negative TT. Clinical trial registration URL: http://www.clinicaltrials.gov. Unique identifier: NCT01509534. (Source: Europace)
Source: Europace - August 30, 2016 Category: Cardiology Authors: Brignole, M., Arabia, F., Ammirati, F., Tomaino, M., Quartieri, F., Rafanelli, M., Del Rosso, A., Rita Vecchi, M., Russo, V., Gaggioli, G., on behalf of the Syncope Unit Project 2 (SUP 2) investigators Tags: Syncope and event loop recorders Source Type: research

Novel electrocardiographic criteria for the diagnosis of arrhythmogenic right ventricular cardiomyopathy
Conclusion The terminal S wave length and area in the right precordial leads are diagnostically useful and suitable for automatic analysis in ARVC. The CF leads are diagnostically superior to the unipolar precordial leads. (Source: Europace)
Source: Europace - August 30, 2016 Category: Cardiology Authors: Batchvarov, V. N., Bastiaenen, R., Postema, P. G., Clark, E. N., Macfarlane, P. W., Wilde, A. A. M., Behr, E. R. Tags: Channelopathies Source Type: research

Brugada syndrome: clinical presentation and genotype--correlation with magnetic resonance imaging parameters
Conclusion Brugada syndrome patients with an SCN5A mutation reveal distinct changes in RV volumes and function when compared with those without an SCN5A mutation. Furthermore, mutation-positive patients have a higher likelihood of a spontaneous type 1 BrS-ECG, which is associated with a higher incidence of clinical events. Cardiovascular magnetic resonance may provide additional insight to distinguish between SCN5A mutation-positive and -negative BrS patients. (Source: Europace)
Source: Europace - August 30, 2016 Category: Cardiology Authors: Rudic, B., Schimpf, R., Veltmann, C., Doesch, C., Tülümen, E., Schoenberg, S. O., Borggrefe, M., Papavassiliu, T. Tags: Channelopathies Source Type: research

Evaluation of a new very low dose imaging protocol: feasibility and impact on X-ray dose levels in electrophysiology procedures
This study presents and evaluates the impact of a new lowest-dose fluoroscopy protocol (Siemens AG), especially designed for electrophysiology (EP) procedures, on X-ray dose levels. Methods and results From October 2014 to March 2015, 140 patients underwent an EP study on an Artis zee angiography system. The standard low-dose protocol was operated at 23 nGy (fluoroscopy) and at 120 nGy (cine-loop), the new lowest-dose protocol was operated at 8 nGy (fluoroscopy) and at 36 nGy (cine-loop). Procedural data, X-ray times, and doses were analysed in 100 complex left atrial and in 40 standard EP procedures. The resulting dose&n...
Source: Europace - August 30, 2016 Category: Cardiology Authors: Bourier, F., Reents, T., Ammar-Busch, S., Buiatti, A., Kottmaier, M., Semmler, V., Telishevska, M., Brkic, A., Grebmer, C., Lennerz, C., Kolb, C., Hessling, G., Deisenhofer, I. Tags: Cardiac electrophysiology Source Type: research

Pacing and sensing optimization of permanent His-bundle pacing in cardiac resynchronization therapy/implantable cardioverter defibrillators patients: value of integrated bipolar configuration
Aims The clinical implementation of His-bundle pacing (HBP) has been limited by concern over higher capture thresholds (CTs) and lower R-wave amplitudes (RWAs), when compared with right ventricular (RV) pacing. The aim of this study was to assess the optimal pacing configuration for HBP lead when incorporated with cardiac resynchronization therapy/implantable cardioverter defibrillators (CRT-D/ICD) by testing of an integrated bipolar configuration. Methods and results HBP was achieved in 25 CRT-D and 13 ICD patients at implantation. Their RWA, CT@0.5 ms and impedance with His-bundle (HB) tip-RV coil, and HB unipolar and b...
Source: Europace - August 30, 2016 Category: Cardiology Authors: Su, L., Xu, L., Wu, S.-j., Huang, W.-j. Tags: Pacing and resynchronization therapy Source Type: research

Reduction of inappropriate anti-tachycardia pacing therapies and shocks by a novel suite of detection algorithms in heart failure patients with cardiac resynchronization therapy defibrillators: a historical comparison of a prospective database
Aims Implantable cardioverter defibrillators improve survival of patients at risk for ventricular arrhythmias, but inappropriate shocks occur in up to 30% of patients and have been associated with worse quality of life and prognosis. In heart failure patients with cardiac resynchronization therapy defibrillators (CRT-Ds), we evaluated whether a new generation of detection and discrimination algorithms reduces inappropriate shocks. Methods and results We analysed 1983 Medtronic CRT-D patients (80% male, 67 ± 10 years), 1368 with standard devices (Control CRT-D) and 615 with new generation devices (New CRT-D). Expert...
Source: Europace - August 30, 2016 Category: Cardiology Authors: Lunati, M., Proclemer, A., Boriani, G., Landolina, M., Locati, E., Rordorf, R., Daleffe, E., Ricci, R. P., Catanzariti, D., Tomasi, L., Gulizia, M., Baccillieri, M. S., Molon, G., Gasparini, M., on behalf of the ClinicalService Cardiological Centres Tags: Pacing and resynchronization therapy Source Type: research

Serum amine-based metabolites and their association with outcomes in primary prevention implantable cardioverter-defibrillator patients
Conclusion Utilizing metabolic profiling in two independent prospective cohorts of patients undergoing ICD implantation for primary prevention of SCD, we identified several novel amine markers that were associated with appropriate shock and mortality. These findings shed insight into the potential biologic pathways leading to adverse events in ICD patients. Further studies are needed to confirm the prognostic value of these findings. (Source: Europace)
Source: Europace - August 30, 2016 Category: Cardiology Authors: Zhang, Y., Blasco-Colmenares, E., Harms, A. C., London, B., Halder, I., Singh, M., Dudley, S. C., Gutmann, R., Guallar, E., Hankemeier, T., Tomaselli, G. F., Cheng, A. Tags: Sudden death and ICDs Source Type: research

Reduced long-term overall mortality in heart failure patients with prolonged QRS treated with CRT combined with ICD vs. heart failure patients with narrow QRS treated with ICD only
Conclusion In HF patients treated with ICD, the subgroup of patients with prolonged QRS who receive CRT-D displays better long-term survival than narrow QRS ICD recipients, owing to their reduced HF mortality. (Source: Europace)
Source: Europace - August 30, 2016 Category: Cardiology Authors: Palmisano, P., Accogli, M., Pisano, E. C. L., Zaccaria, M., De Blasi, S., Ponzetta, M. A., Valsecchi, S., Milanese, G., Lauretti, M., Magliari, F. Tags: Sudden death and ICDs Source Type: research

Battery drain in daily practice and medium-term projections on longevity of cardioverter-defibrillators: an analysis from a remote monitoring database
Aims The longevity of generators is a crucial determinant of the cost-effectiveness of therapy with implantable cardioverter-defibrillators (ICDs) and cardiac resynchronization therapy defibrillators (CRT-D). We evaluated the trend of device-measured residual battery capacity and longevity projections over 5-year follow-up. We also investigated possible factors associated with battery drain. Methods and results Data from 4851 patients in the European LATITUDE® database who were followed up for a minimum of 3 years were analysed. The factors associated with battery drain (i.e. year-to-year decrease in residual battery ...
Source: Europace - August 30, 2016 Category: Cardiology Authors: Boriani, G., Ritter, P., Biffi, M., Ziacchi, M., Diemberger, I., Martignani, C., Valzania, C., Valsecchi, S., Padeletti, L., Gadler, F. Tags: Sudden death and ICDs Source Type: research

Incidence and outcomes of cerebrovascular events complicating catheter ablation for atrial fibrillation
Conclusion Cerebrovascular complications related to catheter ablation of AF are relatively infrequent and typically occur early either during the procedure or within the first 24 h after AF ablation. Previous ischaemic stroke, mechanical valve replacement, and CHA2DS2-VASc score ≥3 are independent predictors of such complications. The majority of these events are ischaemic stroke with a benign clinical outcome, while ICH may correlate with poor prognosis. (Source: Europace)
Source: Europace - August 30, 2016 Category: Cardiology Authors: Liu, Y., Zhan, X., Xue, Y., Deng, H., Fang, X., Liao, H., Huang, J., Liu, F., Liang, Y., Wei, W., Wu, S. Tags: Ablation for atrial fibrillation Source Type: research

Who is the operator, that is the question: a multicentre study of catheter ablation of atrial fibrillation
Aims A worldwide survey reported that the success rate of atrial fibrillation (AF) ablation was higher in high-volume centers compared with low-volume centers. We tested whether the procedure volume of each operator was associated with the outcome of AF ablation in high-volume centres. Methods and results We studied 471 patients with paroxysmal AF who underwent pulmonary vein (PV) isolation for the first time in three cardiovascular centers where the annual AF ablation volume was>100 procedures. We classified a total of 10 primary operators according to their operation volume on the basis of ACC/AHA/ACP CLINICAL COMPET...
Source: Europace - August 30, 2016 Category: Cardiology Authors: Sairaku, A., Yoshida, Y., Nakano, Y., Maeda, M., Hirayama, H., Hashimoto, H., Kihara, Y. Tags: Ablation for atrial fibrillation Source Type: research

Intracardiac drifting iceberg: a worrisome incident during cryoablation
(Source: Europace)
Source: Europace - August 30, 2016 Category: Cardiology Authors: Fontenla, A., Villagraz, L., Lopez-Gil, M. Tags: IMAGES IN ELECTROPHYSIOLOGY Source Type: research

Outcomes after cryoablation vs. radiofrequency in patients with paroxysmal atrial fibrillation: impact of pulmonary veins anatomy
Conclusion Our findings suggest that mid-term outcomes of cryoballoon ablation for paroxysmal AF ablation are similar to those of radiofrequency, regardless of PV anatomy. The presence of anatomical variants of PVs should not discourage the referral of patients with paroxysmal AF for cryoballoon ablation. (Source: Europace)
Source: Europace - August 30, 2016 Category: Cardiology Authors: Khoueiry, Z., Albenque, J.- P., Providencia, R., Combes, S., Combes, N., Jourda, F., Sousa, P. A., Cardin, C., Pasquie, J.- L., Cung, T. T., Massin, F., Marijon, E., Boveda, S. Tags: Ablation for atrial fibrillation Source Type: research

High-density biatrial activation mapping during typical atrial flutter after bicavopulmonary bypass
(Source: Europace)
Source: Europace - August 30, 2016 Category: Cardiology Authors: Maury, P., Capellino, S., Hascoet, S. Tags: CASE EXPRESS REPORTS Source Type: research

Five-year efficacy of pulmonary vein antrum isolation as a primary ablation strategy for atrial fibrillation: a single-centre cohort study
Conclusion Five-year freedom of atrial tachyarrhythmia could be achieved by PVAI as primary ablation strategy in 58.3% of patients. Additional substrate modification only moderately increased overall success. (Source: Europace)
Source: Europace - August 30, 2016 Category: Cardiology Authors: Teunissen, C., Kassenberg, W., van der Heijden, J. F., Hassink, R. J., van Driel, V. J. H. M., Zuithoff, N. P. A., Doevendans, P. A., Loh, P. Tags: Ablation for atrial fibrillation Source Type: research

Cystic tumour of the atrioventricular node: can an electrophysiological study predict sudden death?
(Source: Europace)
Source: Europace - August 30, 2016 Category: Cardiology Authors: Ueda, K., Tagusari, O., Kasao, M. Tags: CASE EXPRESS REPORTS Source Type: research

Von Willebrand factor is associated with atrial fibrillation development in ischaemic patients after cardiac surgery
Conclusion Plasma vWF levels are associated with tissue fibrosis in patients undergoing cardiac surgery and with post-surgical AF development in ischaemic patients. These findings suggest an association among vWF levels, atrial remodelling, and AF development. It is supported by higher vWF expression in right atrial tissue in ischaemic patients, who developed post-surgical AF. (Source: Europace)
Source: Europace - August 30, 2016 Category: Cardiology Authors: Hernandez-Romero, D., Lahoz, A., Roldan, V., Jover, E., Romero-Aniorte, A. I., Martinez, C. M., Jara-Rubio, R., Arribas, J. M., Garcia-Alberola, A., Canovas, S., Valdes, M., Marin, F. Tags: Atrial fibrillation Source Type: research

A useful irrigated tip to cannulate distal coronary sinus
(Source: Europace)
Source: Europace - August 30, 2016 Category: Cardiology Authors: Fedida, J., Lepiece, C., Knecht, S. Tags: CASE EXPRESS REPORTS Source Type: research

Effectiveness and safety of dabigatran versus acenocoumarol in 'real-world patients with atrial fibrillation
Conclusion In ‘real-world’ patients with AF, dabigatran appears to be as effective, but significantly safer than acenocoumarol. (Source: Europace)
Source: Europace - August 30, 2016 Category: Cardiology Authors: Korenstra, J., Wijtvliet, E. P. J., Veeger, N. J. G. M., Geluk, C. A., Bartels, G. L., Posma, J. L., Piersma-Wichers, M., Van Gelder, I. C., Rienstra, M., Tieleman, R. G. Tags: Atrial fibrillation Source Type: research

Antithrombotic therapy use in patients with atrial fibrillation before the era of non-vitamin K antagonist oral anticoagulants: the Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation (GLORIA-AF) Phase I cohort
Conclusion Phase I of GLORIA-AF shows that VKAs were mostly used in patients with persistent/permanent (vs. paroxysmal) AF and in those with high stroke risk. Furthermore, there were meaningful geographical differences in the use of VKA therapy in the era before the availability of NOACs, including a much lower use of VKAs in China, where most patients either received antiplatelet agents or no antithrombotic treatment. (Source: Europace)
Source: Europace - August 30, 2016 Category: Cardiology Authors: Huisman, M. V., Ma, C. S., Diener, H.-C., Dubner, S. J., Halperin, J. L., Rothman, K. J., Teutsch, C., Schoof, N., Kleine, E., Bartels, D. B., Lip, G. Y. H., for the GLORIA-AF Investigators Tags: Atrial fibrillation Source Type: research

Extra-cardiac stimulators: what do cardiologists need to know?
For several decades, treating patients with pacemakers has been the privilege of cardiologists. However, in the last 30 years, researchers have found new targets for electrical stimulation in different clinical subspecialities, such as deep brain stimulation (for the treatment of Parkinson's disease, essential tremor, dystonia, and some psychiatric illnesses); spinal cord stimulation (for refractory angina, chronic pain, and peripheral artery disease); and sacral (for diverse urologic and proctologic conditions), vagal (for epilepsy), and phrenic nerve stimulation (for sleep apnoea). The purpose of this article is to famil...
Source: Europace - August 30, 2016 Category: Cardiology Authors: Guinand, A., Noble, S., Frei, A., Renard, J., Tramer, M. R., Burri, H. Tags: REVIEWS Source Type: research

Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop
Both biomedical research and clinical practice rely on complex datasets for the physiological and genetic characterization of human hearts in health and disease. Given the complexity and variety of approaches and recordings, there is now growing recognition of the need to embed computational methods in cardiovascular medicine and science for analysis, integration and prediction. This paper describes a Workshop on Computational Cardiovascular Science that created an international, interdisciplinary and inter-sectorial forum to define the next steps for a human-based approach to disease supported by computational methodologi...
Source: Europace - August 30, 2016 Category: Cardiology Authors: Rodriguez, B., Carusi, A., Abi-Gerges, N., Ariga, R., Britton, O., Bub, G., Bueno-Orovio, A., Burton, R. A. B., Carapella, V., Cardone-Noott, L., Daniels, M. J., Davies, M. R., Dutta, S., Ghetti, A., Grau, V., Harmer, S., Kopljar, I., Lambiase, P., Lu, H. Tags: REVIEWS Source Type: research