Comparison of geographic workflow preferences with real-time dynamic regional mapping data during catheter ablation
ConclusionsWhile there is a geographical difference in ablation workflow, common settings and patterns can be observed in all three regions. This data suggests that minimal workflow changes are required to incorporate the use of dynamic data into routine procedures. Adaptation of LiveView can help improve procedure efficiency and efficacy by reducing the need for full chamber maps, identifying areas that were under ablated, and confirming ablation endpoints. Further control study examining procedure efficiency and efficacy associated with dynamic mapping may be warranted. (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research

Second and fourth generation Cryoballoon based left atrial appendage isolation for the treatment of persistent atrial fibrillation
ConclusionsHere we used – to our knowledge – for the first time a CB4 for LAAI, followed by a combined check for LAAI and LAA-closure after 6 weeks, compared to the CB2. LAAI was successfully isolated by both cryo-balloons in the majority of patients. Hence the use of newest cryo-balloon generation for LAAI seems a saf e and successful procedure compared to earlier balloon generations. However, a relatively high rate of LAA-Thrombus was detected after LAAI. Therefore, LAA closure is mandatory in this population. (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research

11-year follow-up outcomes of catheter ablation of para-hisian accessory pathways
ConclusionsConsidering the long-term safety of ablation of para-hisian AP, proper extension of ablation time and increase of ablation power could be applied during operation. (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research

Late gadolinium enhancement as a predictor of arrhythmias in patients with hypertrophic cardiomyopathy
ConclusionSupraventricular and ventricular Arrhythmias are frequent in patients with HCM, with the most frequents being NSVT and AF. The LGE burden (>5 segments) and location (median inferior IVS, median anterior IVS, median anterior wall, basal anterior IVS, apical anterior wall, median inferior wall, apical anterior wall and basal inferior IVS) were correlated with arrhythmic events. Abstract Figure. (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research

Diagnosing arrhythmogenic ventricular cardiomyopathy: a re-appraisal of the role and normal range of the signal-averaged ECG
ConclusionThe SAECG is useful in family screening as it is frequently the only test to show an abnormality. However, the current TFC reference values lack specificity. By redefining an abnormal fQRS as ≥118ms with the requirement of a 2nd abnormal parameter, specificity is increased to 96%, with no significant change in sensitivity. Abstract Figure. SAECG Parameters in Family Members (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research

Three-dimensional vectorcardiographic characteristics of breast cancer patients treated with chemotherapy
Conclusions 3D-VCGs can be used to detect electrophysiological abnormalities in BC patients receiving chemotherapy. Subclinical cardiac dysfunction can be revealed by 3D-VCGs before alterations in traditional echocardiographic parameters. (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research

Diagnostic value of ECG characteristics in precordial leads V1-V3 for the diagnosis of the origin of outflow tract ventricular arrhythmias with a lead V3 precordial transition
Conclusions. Although it has been poorly analyzed in previous studies on the origin of OTVAs, the morphological characteristics of lead V3 seem to provide valid elements for the creation of diagnostic algorithms. Abstract Figure. Comparison of ECG characteristics (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research

Pulmonary vein isolation for AF: does technique influence outcome?
ConclusionsPBP, PVAC and cryoballoon AF ablation all appeared equally efficacious in an unselected population, though PVAC and cryoballoon procedures were shorter. All procedures were associated with a low adverse event rate. Prospective examination is required to substantiate this finding. Table 1CARTOn= 123Cryoballoonn= 131PVACn  = 75p-valueAge/years61.7 ± 9.259.5 ± 10.661.7 ± 9.70.14Male92 (74.8)88 (67.2)49 (61.3)0.80Paroxysmal AF70 (56.9)106 (78.6)62 (82.7)0.14Cardiovascular risk factors Hypertension Diabetes Ischaemic heart disease Cerebrovascular disease Heart failure Dyslipidaemia73 (59.3)23 (18.7)40 (32.5)2 ...
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research

Optimized radiofrequency lesions through local impedance guidance for effective cavo-tricuspid isthmus ablation in typical right atrial flutter: data from the CHARISMA registry
ConclusionIn our preliminary experience, a LI-guided approach of CTI seems to be safe and effective in RAFL ablation. The magnitude of LI drop was associated with effective lesion formation and conduction block and could be used as a marker of ablation efficacy. (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research

Relationship between heart rhythm turbulence and ventricular arrhythmia in patients with multivessel lesion of coronary arteries
AbstractFunding AcknowledgementsType of funding sources: Public grant(s) – National budget only. Main funding source(s): MoH Research Grant "Development of methods for differentiated prevention and treatment of potentially dangerous heart rhythm disorders"Prediction of adverse outcomes in patients after myocardial infarction (MI) remains a serious and not completely re solved problem, which pushes researchers to search for new technologies. One of the relatively promising new non-invasive methods for predicting sudden coronary death in patients with coronary heart disease and ventricular arrhythmias (VA) may be an assess...
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research

The impact of hydroxychloroquine and azithromycin on the corrected qt interval in patients with the novel coronavirus disease 2019
Conclusion: Patients who received HCQ for COVID-19 were at high risk of QTc prolongation, and concurrent treatment with AZT was associated with greater changes in QTc. Comparison of baseline characteristics aCharacteristicTotal (n  = 155)Hydroxychloroquine (n = 102)Hydroxychloroquine /Azithromycin (n = 53)P valueLength of stay at ward, SD9.54 ± 4.289.64 ± 4.319.31 ± 4.250.88Length of stay Intensive care unite,SD7.92 ± 3.767.18 ± 3.188.46 ± 4.150.29Radiographic findings of pneumo nia118(76.1%)76(74.5%)42(49.2%)0.32Mechanically ventilation16(10.3%)7(6.9%)9(17.0%)0.049In hospital de...
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research

Prevalence and clinical characteristics of patients presenting with phase 4 atrioventricular block
ConclusionThe exact prevalence of 4AVB is not rare (12 %), and may be underestimated. 4AVB is usually observed in an elderly population, treated for arterial hypertension, and with baseline conduction disorders. Abstract Figure. Phase 4 AVB induced by PAC (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research

Oral procainamide as pharmacological treatment of recurrent and refractory ventricular tachyarrhythmias
ConclusionsProcainamide was associated with a significant decrease of ICD therapies and ventricular arrhythmias showing an optimal profile of tolerability. (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research

Main determinants of physician-driven amiodarone discontinuation in clinical practice
ConclusionStudy showed that within the first two years of treatment, despite persistent indication, amiodarone was discontinued in 1 out of 10 patients in the absence of side effects, mostly in younger patients with less comorbidities, which may not always be justified. There is a need for qualitative research to elucidate the reasons for such physicians ’ decisions. Table.Multivariable Cox Proportional HAZARD Regression analysis of permanent Amiodarone discontinuation due to physician decisionVariableHR95% CIP valueAge0.9700.95-0.990.003VT/VF/electrical storm0.1390.04-0.450.001VKA therapy0.5980.38-0.940.026Ablation of A...
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research

Result of electrophysiological study in patients with undocumented suspected paroxysmal supraventricular tachycardia: the BELIEVE-SVT registry
AbstractFunding AcknowledgementsType of funding sources: None.IntroductionParoxysmal supraventricular tachycardias (PSVT) are common arrhythmias and catheter ablation is considered its first-line treatment. However, the duration of the episodes frequently precludes ECG documentation. Thus, patients may not be referred for ablation until the tachycardia is documented, leading to recurrences, emergency room visits and often unnecessary tests or treatments.  Our objective was to evaluate the results of electrophysiological study (EPS) followed or not by ablation in patients with suspected but not documented PSVT.MethodsMulti...
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research