Antiarrhythmic effect of 9-week hybrid cardiac telerehabilitation - subanalysis of the TELEREHabilitation in Heart Failure patients - TELEREH-HF randomized clinical trial
Conclusions. Significant improvement in physical capacity after 9 weeks of HCTR did not correlate with the antiarrhythmic effect in terms of incidence of nsVT or PVCs ≥10. An antiarrhythmic effect after the 9-week HCTR affected long term cardiovascular mortality in HF patients. Abstract Figure (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research
Management and perinatal outcomes of cardiac arrhythmias in pregnancy
Conclusionssupraventricular tachycardia and premature beats are common in pregnancy. Spontaneous vaginal delivery is more likely in this patients. Major maternal and fetal adverse outcomes are infrequent in pregnant women with arrhythmias. (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research
Buccal mucosa cells as a diagnostic tool in patients with arrhythmogenic cardiomyopathy
ConclusionOn the population level, there is a significant reduction of plakoglobin protein in BMC membranes of ACM patients but not for patients bearing the PLNR14Del mutation when compared to healthy controls. However, for clinical diagnosis of the individual patient, this method is most likely not discriminative enough to distinguish patients from healthy controls, because of the high interindividual variability. (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research
Fibrosis biomarkers as a predictive tool for clinical outcome in PLNR14Del patients
ConclusionHigh PICP/ICTP ratios correlate with clinical outcome in PLN patients, such as T wave inversion and PVCs. However, the size and heterogeneity of the patient group resulted in weak to moderate correlation coefficients and might therefore currently precludes to use PICP and ICTP levels as biomarker. (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research
Non-algorithmic approach to accessory pathway localization based on a mobile app
ConclusionsA novel method, easy to use, not requiring to remember any algorithmic steps, and based on an analysis of by far the largest cohort of over accessory pathways (in comparison with published algorithms) was developed. Prospective validation of the localization application seems warranted. Abstract Figure. (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research
Development and validation of an algorithm to assist in the interpretation of the electrocardiogram
ConclusionsWe have validated an ECG algorithm through a rigorous development and review process in a multi-institutional and multi-national Modified Delphi study. The completed expert reviewed algorithm may be a safe, informative tool for novice users to improve ECG interpretation. However, further validation in user groups is now mandated to refine the tool. Abstract Figure 1- Algorithm one of three (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research
Instrumental markers of frequent symptomatic atrial fibrillation in patients with arterial hypertension
ConclusionsAs the most informative ECG markers of frequent symptomatic AF in patients with AH is combination of frequent SPBs (> 330 episodes/day) with pair and group SPBs and asymptomatic episodes SVPT/AF (R = 0,52, p = 0.00002 ), while echocardiography combination of markers is ratio of LAV/LVMM> 0.23 ml/g + LA> 40 mm + presence of mitral regurgitation (R = 0.49, p = 0.00009). (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research
Remote operation for non-fluoroscopic navigation of complex tachycardias
ConclusionsRemote System Operation allowed full teleoperation of a non-fluoroscopic navigation system (keyboard, mouse and screen) as well as bidirectional real time audio/video feedback with the operating physician, providing a fully autonomous remote assistance in 50 complex ablation procedures. This technology ensures workflow continuity and optimal workforce flexibility and has relevant and promising implications in the field of training, teaching and resource optimization that deserves further development. Latency measurements.Hospital LocationPamplonaPamplonaPamplonaRemote operator locationBilbaoMadridTarragonaT1(s/m...
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research
Very (70W) vs. LSI guided (5-6) high power short duration ablation in patients with paroxysmal atrial fibrillation undergoing pulmonary vein vs. pulmonary vein and posterior wall isolation
Conclusion: a shorter RF time is associated with v-HPSD vs. LSI-HPSD strategy, although procedural time did not differ. TELs are a relative rare finding, and only numerically higher when isolation of the PW is pursu ed in addition to PV isolation. (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research
Three-dimensional late gadolinium enhancement increases the diagnostic yield of cardiovascular magnetic resonance to detect low voltage in the right ventricular outflow tract
ConclusionCMR using 3-D LGE techniques showed an increased power to diagnose structural abnormalities. This technique may be a better choice in initial stages of RVOT disease. All sampleN = 223D-LGE CMRN = 112D-LGE CMRN = 11p-valueAge in years, median (Q1-Q3)47 (35-68)62 (34-55)42 (34-55)0.243Male gender, n (%)8 (36)3 (27)5 (46)0.330PVCs RVOT/LVOT17/59/28/30.500N º points in the map, median (Q1-Q3)344 (242-450)350 (259-450)300 (158-345)0.076Low voltage areas, n (%)18 (82)9 (82)9 (82)0.707Abstract Figure. (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research
Assessment of wavefront propagation speed on the right ventricular outflow tract: deceleration zones associated with the presence of low voltage areas
ConclusionsThe velocity of the wavefront propagation was slower and DZs were more frequently present in patients with PVCs and were associated with presence of LVAs. All sampleN= 42PVCsN = 29ControlsN = 13p-valueAge in years, median (Q1-Q3)56 (35-65)58 (38-66)53 (28-67)0.648Male gender, n (%)19 (45)14 (48)5 (39)0.401N º points in the map, median (Q1-Q3)410 (338-589)467 (345-660)345 (333-465)0.056Activation duration in ms, median (Q1-Q3)41.8 (36-61)56 (41-66)39 (35-41)0.001N º isochrones, median (Q1-Q3)4 (4-6)5 (4-6)4 (4-4)0.037Presence of DZs, n (%)20 (48)20 (69)0 (0)<0.0001Presence of LVAs, n(%)21 (50)21 (72...
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research
Implantable loop recorders in patients with a structural or electrical heart disease: comparison of the clinical value in patients with and without a history of syncope
Conclusion Our results show no differences in ILR yield in patients with structural or electrical heart disease who present with any suspected arrhythmia-related symptom, including those with non-syncopal symptoms. Abstract Figure. (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research
Correlation between body mass index and electrocardiogram parameters in healthy adults
ConclusionWe concluded that BMI caused a significant modification in several ECG parameters in healthy adults. Increased BMI leads to lengthening of conduction times and ventricular repolarization. Largest investigation on the use of BMI ‐specific ECG norms is warranted. Table 1ECG parametersBMIR-value P valueHR -0,0410,590P wave duration0,2220,003PR Interval0,2000,008QRS duration0,2350,002QT Interval0,1520,045QTcorrected (QTc)0,1500,049Sokolow index0,1020,182Pearson correlation coefficients of various ECG parameters with BMI in the study population (n = 174) (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research
A candidate genetic modifier and autosomal recessive cause of Brugada syndrome that may alter the circadian expression of SCN5A
ConclusionThis haplotype has previously been reported to modulate BrS severity in a large family with a pathogenic SCN5A variant and has demonstrated a trend towards reduced SCN5A expression in murine cardiomyocytes – a molecular mechanism that slows cardiac conduction, predisposing individuals to BrS. Therefore, this 2-variant haplotype, or 1 variant therein, in the SCN5A promoter is a putative genetic modifier and autosomal recessive cause of BrS.Future work includes functional assay in human cardiomyocytes to characterise its molecular consequences on SCN5A expression and the circadian clock. (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research
Comparative effectiveness of ventricular tachycardia ablation versus escalated antiarrhythmic drug therapy by location of myocardial infarction: A sub-study of the VANISH trial
CONCLUSIONThe effectiveness of VT ablation versus escalated pharmacological therapy varies based on the location of the MI. Patients with MI scars located only in non-inferior regions of the ventricles derive greater benefit from VT ablation in reducing VT-related events. Further studies are required to explore reasons for this finding and to assess the impact of VT treatment strategies based on MI location in optimizing outcomes. (Source: Europace)
Source: Europace - May 24, 2021 Category: Cardiology Source Type: research
