Applicability of a risk score for prediction of the long-term benefit of the implantable cardioverter defibrillator in patients receiving cardiac resynchronization therapy
Conclusion A simple risk stratification score comprising five clinical risk factors may help identify CRT patients who are more likely to benefit from the presence of the defibrillator. (Source: Europace)
Source: Europace - August 5, 2016 Category: Cardiology Authors: Barra, S., Looi, K.-L., Gajendragadkar, P. R., Khan, F. Z., Virdee, M., Agarwal, S. Tags: Sudden death and ICDs Source Type: research

Entrapment of a diagnostic catheter in a novel multipolar basket catheter (Orion™) during right atrial mapping
(Source: Europace)
Source: Europace - August 5, 2016 Category: Cardiology Authors: Knecht, S., Novak, J., Kühne, M. Tags: CASE EXPRESS REPORTS Source Type: research

Fluoroscopic position of the second-generation cryoballoon during ablation in the right superior pulmonary vein as a predictor of phrenic nerve injury
Aims Phrenic nerve injury (PNI) is the most frequently observed complication during pulmonary vein isolation procedure using the second-generation cryoballoon (CB). Our objective was to analyse the correlation between the fluoroscopic position of the 28 mm CB during ablation in the right superior pulmonary vein (RSPV) and the occurrence of PNI. Methods and results A total of 165 patients having undergone the large 28 mm CB ablation were retrospectively reviewed. Positioning of the CB relative to the cardiac silhouette was classified under fluoroscopic guidance in antero-posterior projection during RSPV ablation. Regarding...
Source: Europace - August 5, 2016 Category: Cardiology Authors: Saitoh, Y., Ströker, E., Irfan, G., Mugnai, G., Ciconte, G., Hünük, B., Velagic, V., Overeinder, I., Tanaka, K., Brugada, P., de Asmundis, C., Chierchia, G.-B. Tags: Ablation for atrial fibrillation Source Type: research

One-year clinical outcome after ablation with a novel multipolar irrigated ablation catheter for treatment of atrial fibrillation: potential implications for clinical use
Aims Pulmonary vein isolation (PVI) is an established therapy for atrial fibrillation (AF). However, PVI remains a time-consuming procedure. A novel multipolar irrigated radiofrequency (RF) ablation catheter (nMARQ™) is aiming to improve PVI. We investigated the influence on procedural parameters and assessed clinical outcomes after PVI using this novel catheter. Methods and results Fifty-eight consecutive patients with paroxysmal AF were equally allocated (n = 29/group) to PVI treatment with (i) the novel multipolar ablation catheter (nMARQ™) and (ii) a standard single-tip ablation catheter (SAC). Study endpo...
Source: Europace - August 5, 2016 Category: Cardiology Authors: Wakili, R., Siebermair, J., Fichtner, S., Sinner, M. F., Klocker, E., Olesch, L., Hilberath, J. N., Sarai, S., Clauss, S., Sattler, S., Kääb, S., Estner, H. L. Tags: Ablation for atrial fibrillation Source Type: research

Safety and efficacy of the nMARQ catheter for paroxysmal and persistent atrial fibrillation
Conclusion The nMARQ catheter is a highly effective tool for treatment of paroxysmal and persistent AF. Nevertheless, the occurrence of life-threatening oesophageal fistulas is of major concern and requires further investigation. (Source: Europace)
Source: Europace - August 5, 2016 Category: Cardiology Authors: Vurma, M., Dang, L., Brunner-La Rocca, H.-P., Sütsch, G., Attenhofer-Jost, C. H., Duru, F., Scharf, C. Tags: Ablation for atrial fibrillation Source Type: research

Incidence of real-time recordings of pulmonary vein potentials using the third-generation short-tip cryoballoon
Conclusion The rate of visualization of RT recordings is significantly high during third-generation CB-ST ablation. Real-time recordings can be visualized in ~87.1% of veins with this novel cryoballoon. (Source: Europace)
Source: Europace - August 5, 2016 Category: Cardiology Authors: Chierchia, G.-B., Mugnai, G., Ströker, E., Velagic, V., Hünük, B., Moran, D., Hacioglu, E., Poelaert, J., Verborgh, C., Umbrain, V., Beckers, S., Ruggiero, D., Brugada, P., de Asmundis, C. Tags: Ablation for atrial fibrillation Source Type: research

Real-world persistence and adherence to oral anticoagulation for stroke risk reduction in patients with atrial fibrillation
Aim To assess persistence and adherence to rivaroxaban, dabigatran, and vitamin K antagonist (VKA) treatment in primary care patients with non-valvular atrial fibrillation (AF) newly starting anticoagulant therapy. Methods and results Prescription data for oral anticoagulants were obtained from 7265 eligible patients from primary care practices across Germany. Persistence with and adherence to anticoagulation were assessed in anticoagulant-naïve patients with AF newly treated with dabigatran, rivaroxaban, or VKA during follow-up periods of at least 180 days, respectively 360 days after the prescription date. Persistence...
Source: Europace - August 5, 2016 Category: Cardiology Authors: Beyer-Westendorf, J., Ehlken, B., Evers, T. Tags: Atrial fibrillation Source Type: research

Serum 25-hydroxyvitamin D and the incidence of atrial fibrillation: the Atherosclerosis Risk in Communities (ARIC) study
Conclusion Low serum 25(OH)D was not associated with incident AF in a community-based cohort and in a meta-analysis of prospective studies. A possible association in younger individuals warrants further investigation. (Source: Europace)
Source: Europace - August 5, 2016 Category: Cardiology Authors: Alonso, A., Misialek, J. R., Michos, E. D., Eckfeldt, J., Selvin, E., Soliman, E. Z., Chen, L. Y., Gross, M. D., Lutsey, P. L. Tags: Atrial fibrillation Source Type: research

Hospitalizations in patients with atrial fibrillation: an analysis from ROCKET AF
We described the frequency of and reasons for hospitalization during study follow-up and utilized Cox proportional hazards models to assess for baseline characteristics associated with all-cause hospitalization. Of 14 171 patients, 14% were hospitalized at least once. Of 2614 total hospitalizations, 41% were cardiovascular including 4% for AF; of the remaining, 12% were for bleeding. Compared with patients not hospitalized, hospitalized patients were older (74 vs. 72 years), and more frequently had diabetes (46 vs. 39%), prior MI (23 vs. 16%), and paroxysmal AF (19 vs. 17%), but less frequently had prior transient ischaemi...
Source: Europace - August 5, 2016 Category: Cardiology Authors: DeVore, A. D., Hellkamp, A. S., Becker, R. C., Berkowitz, S. D., Breithardt, G., Hacke, W., Halperin, J. L., Hankey, G. J., Mahaffey, K. W., Nessel, C. C., Singer, D. E., Fox, K. A. A., Patel, M. R., Piccini, J. P., on behalf of the ROCKET AF Steering Com Tags: Atrial fibrillation Source Type: research

Current and future developments in the field of central sleep apnoea
Central sleep apnoea (CSA) occurs in ~30–50% of patients with heart failure (HF) with reduced left ventricular ejection fraction (LVEF) and in as much as in 18–30% of patients with preserved LVEF. In HF patients, it is characterized by periodic breathing also known as the Cheyne–Stokes respiration followed by pauses of breathing. Central sleep apnoea remains often unrecognized due to its chronic and insidious incidences. Patients may report excessive daytime somnolence, poor sleep quality, nocturnal angina, recurrent arrhythmias, refractory HF symptoms, or demonstrate abnormal respiratory pattern or apnoe...
Source: Europace - August 5, 2016 Category: Cardiology Authors: Bekfani, T., Abraham, W. T. Tags: REVIEW Source Type: research

Catheter ablation for atrial fibrillation in congestive heart failure: consider the upside, consider the downside
(Source: Europace)
Source: Europace - August 5, 2016 Category: Cardiology Authors: Wong, G. R., Kalman, J. M. Tags: EDITORIALS Source Type: research

Last call on nMARQ™ safety
(Source: Europace)
Source: Europace - August 5, 2016 Category: Cardiology Authors: Dekker, L. R. Tags: EDITORIALS Source Type: research

Challenges in atrial fibrillation beyond stroke prevention: keeping patients out of the hospital
(Source: Europace)
Source: Europace - August 5, 2016 Category: Cardiology Authors: Pokorney, S. D., Steinberg, B. A. Tags: EDITORIALS Source Type: research

Do we need intracardiac echo to guide ablation of ventricular arrhythmias from the papillary muscles?
This editorial refers to ‘Intracardiac echo-facilitated 3D electroanatomical mapping of ventricular arrhythmias from the papillary muscles: assessing the “fourth dimension” during ablation’ by R. Proiettiet al., on pages21 –28. (Source: Europace)
Source: Europace - August 2, 2016 Category: Cardiology Source Type: research

Intracardiac echo-facilitated 3D electroanatomical mapping of ventricular arrhythmias from the papillary muscles: assessing the ‘fourth dimension’ during ablation
ConclusionAn echo-facilitated 3D electroanatomical mapping allows for real-time creation of precise geometries of cardiac chambers and endocavitary structures. This is useful during procedures such as catheter ablation of VAs originating from PMs, which require detailed representation of anatomical landmarks. Routine adoption of this technique should be considered to improve outcomes of PM VA ablation. (Source: Europace)
Source: Europace - August 2, 2016 Category: Cardiology Source Type: research

Cardiac resynchronization therapy: mechanisms of action and scope for further improvement in cardiac function
AbstractAimsCardiac resynchronization therapy (CRT) may exert its beneficial haemodynamic effect by improving ventricular synchrony and improving atrioventricular (AV) timing. The aim of this study was to establish the relative importance of the mechanisms through which CRT improves cardiac function and explore the potential for additional improvements with improved ventricular resynchronization.Methods and ResultsWe performed simulations using the CircAdapt haemodynamic model and performed haemodynamic measurements while adjusting AV delay, at low and high heart rates, in 87 patients with CRT devices. We assessed QRS dura...
Source: Europace - July 13, 2016 Category: Cardiology Source Type: research

J-Wave syndromes expert consensus conference report: Emerging concepts and gaps in knowledge
Sudden cardiac deathJ waveBrugada syndromeEarly repolarization syndromeCardiac arrhythmiaVentricular fibrillationInherited cardiac arrhythmia syndrome (Source: Europace)
Source: Europace - July 13, 2016 Category: Cardiology Source Type: research

Strategies for prediction and early detection of atrial fibrillation: present and future
This editorial refers to ‘CHA2DS2-VASc score and blood biomarkers to identify patients with atrial high-rate episodes and paroxysmal atrial fibrillation’ by P. Wakulaet al., on pages 544 –551. (Source: Europace)
Source: Europace - July 7, 2016 Category: Cardiology Source Type: research

Association of pre-ablation level of potential blood markers with atrial fibrillation recurrence after catheter ablation: a meta-analysis
ConclusionIncreased pre-ablation level of ANP, BNP, NT-pro-BNP, IL-6, C-reactive protein, LDL, and TIMP-2 was associated with greater risk of AF recurrence after RFCA. (Source: Europace)
Source: Europace - July 7, 2016 Category: Cardiology Source Type: research

Predictors of sinus rhythm after electrical cardioversion of atrial fibrillation: results from a data mining project on the Flec-SL trial data set
ConclusionsPharmacological conversion of persistent AF with flecainide without the need for electrical cardioversion is a powerful and independent predictor of maintenance of SR. A strategy of flecainide pretreatment for 48 h prior to planned electrical cardioversion may be a useful planning of a strategy of long-term rhythm control. (Source: Europace)
Source: Europace - July 2, 2016 Category: Cardiology Source Type: research

Contact-force-guided vs. contact-force-blinded catheter ablation of typical atrial flutter: a prospective study
ConclusionsCatheter ablation of AFL guided by real-time CF assessment results in a significant reduction in total RF delivery time. Real-time CF measurements facilitate the maintenance of homogenous efficient contact all along the CTI, particularly in the anterior segment where CF is generally lower. (Source: Europace)
Source: Europace - July 2, 2016 Category: Cardiology Source Type: research

Smart detection of atrial fibrillation †
ConclusionThe algorithm tested reliably discriminated between SR and AF based on pulse wave signals from a smartphone camera only. Implementation of this algorithm into a smartwatch is the next logical step. (Source: Europace)
Source: Europace - July 1, 2016 Category: Cardiology Source Type: research

Reliability of luminal oesophageal temperature monitoring during radiofrequency ablation of atrial fibrillation: insights from probe visualization and oesophageal reconstruction using magnetic resonance imaging
ConclusionDue to the unknown exact lateral position of the LET probe within the oesophagus, the measured temperature does not necessarily reflect the maximal LET. The absence of LET increase does not rule out significant temperature increase within the oesophagus. Consequently, the temperature information of the linear multipolar probe should be used with caution. (Source: Europace)
Source: Europace - June 29, 2016 Category: Cardiology Source Type: research

Lead-related infective endocarditis: factors influencing the formation of large vegetations
The objective of the present study was to evaluate risk factors of ILV and their impact on vegetation size.Methods and resultsClinical data of 500 patients with LRIE undergoing transvenous lead extraction in 2006 –15 were retrospectively analysed. The study population consisted of 352 patients with the presence of vegetations (giant,>3 cm; large, 2.0 –2.9 cm; moderate-sized, 1.0–1.9 cm; and small,
Source: Europace - June 29, 2016 Category: Cardiology Source Type: research

Non-vitamin K oral anticoagulants in patients with atrial fibrillation after cardiac surgery: the results of the European Heart Rhythm Association Survey
The purpose of this European Heart Rhythm Association survey was to assess the current practice concerning the use of oral anticoagulation in patients with post-operative atrial fibrillation (pre-existing or new-onset). The survey highlights the considerable heterogeneity of the type of anticoagulation, with 25% of the centres never using the non-vitamin K antagonist oral anticoagulants (NOACs) in this setting, as well the timing of oral anticoagulation initiation, the use and dosing of low-molecular-weight heparins, and the duration of anticoagulation when sinus rhythm is restored. One-third of the centres stated that the...
Source: Europace - June 29, 2016 Category: Cardiology Authors: Vranckx, P., Potpara, T., Dagres, N., Heidbuchel, H. Tags: EP WIRE Source Type: research

Tilt testing results are influenced by tilt protocol
Aims It is unknown how the return to supine position influences duration of loss of consciousness (LOC) and cardioinhibition during tilt test. Methods and results Retrospective analysis of two datasets containing records of patients who underwent tilt testing for unexplained syncope in two centres was performed. Patients, totalling 1232, were included in the study: 262 in a Swedish centre and 970 patients in a Polish centre. In Sweden, tilt table with tilt-down time (TDT) of 18 s was used (Group II). In Poland, two different tilt tables were used, one of them with TDT of 10 s (Group I, n = 325), and the other with TDT of ...
Source: Europace - June 29, 2016 Category: Cardiology Authors: Zysko, D., Fedorowski, A., Nilsson, D., Rudnicki, J., Gajek, J., Melander, O., Sutton, R. Tags: Syncope and event loop recorders Source Type: research

Modified criteria for carotid sinus hypersensitivity are associated with increased mortality in a population-based study
Conclusion Carotid sinus hypersensitivity defined according to Kerr criteria is associated with increased mortality. This raises an interesting question as to the suitability of the current criteria used to define CSH. (Source: Europace)
Source: Europace - June 29, 2016 Category: Cardiology Authors: McDonald, C., Pearce, M. S., Newton, J. L., Kerr, S. R. J. Tags: Syncope and event loop recorders Source Type: research

Expert cardiologists cannot distinguish between Brugada phenocopy and Brugada syndrome electrocardiogram patterns
Conclusion Our results provide strong evidence that BrP and BrS ECG patterns are visually identical and indistinguishable. These findings support the use of systematic diagnostic criteria for differentiating BrP vs. BrS as an erroneous diagnosis may have a negative impact on patient morbidity and mortality. (Source: Europace)
Source: Europace - June 29, 2016 Category: Cardiology Authors: Gottschalk, B. H., Anselm, D. D., Brugada, J., Brugada, P., Wilde, A. A., Chiale, P. A., Perez-Riera, A. R., Elizari, M. V., De Luna, A. B., Krahn, A. D., Tan, H. L., Postema, P. G., Baranchuk, A. Tags: Channelopathies Source Type: research

Phenotypic expression is a prerequisite for malignant arrhythmic events and sudden cardiac death in arrhythmogenic right ventricular cardiomyopathy
Conclusions The ARVC phenotypic expression is a prerequisite for the occurrence of life-threatening arrhythmias in DS-gene mutation carriers. The vast majority of malignant arrhythmic events occurred in patients with an overt disease phenotype and major risk factors suggesting that this subgroup most benefits from ICD therapy. (Source: Europace)
Source: Europace - June 29, 2016 Category: Cardiology Authors: Zorzi, A., Rigato, I., Pilichou, K., Perazzolo Marra, M., Migliore, F., Mazzotti, E., Gregori, D., Thiene, G., Daliento, L., Iliceto, S., Rampazzo, A., Basso, C., Bauce, B., Corrado, D. Tags: Channelopathies Source Type: research

Standard heart rate variability spectral analysis: does it purely assess cardiac autonomic function?
(Source: Europace)
Source: Europace - June 29, 2016 Category: Cardiology Authors: Sidorenko, L., Kraemer, J. F., Wessel, N. Tags: CASE EXPRESS REPORTS Source Type: research

T-wave area as biomarker of clinical response to cardiac resynchronization therapy
Aims There is increasing evidence that left bundle branch block (LBBB) morphology on the electrocardiogram is a positive predictor for response to cardiac resynchronization therapy (CRT). We previously demonstrated that the vectorcardiography (VCG)-derived T-wave area predicts echocardiographic CRT response in LBBB patients. In the present study, we investigate whether the T-wave area also predicts long-term clinical outcome to CRT. Methods and results This is a retrospective study consisting of 335 CRT recipients. Primary endpoint were the composite of heart failure (HF) hospitalization, heart transplantation, left ventr...
Source: Europace - June 29, 2016 Category: Cardiology Authors: Vegh, E. M., Engels, E. B., van Deursen, C. J. M., Merkely, B., Vernooy, K., Singh, J. P., Prinzen, F. W. Tags: Electrocardiology and risk stratification Source Type: research

A novel approach to detect phrenic nerve stimulation in cardiac resynchronization therapy
(Source: Europace)
Source: Europace - June 29, 2016 Category: Cardiology Authors: Kiblboeck, D., Siostrzonek, P., Reisinger, J. Tags: CASE EXPRESS REPORTS Source Type: research

Non-sustained wide complex tachycardia: an underappreciated sign to aid in diagnosis
Aims The electrocardiographic (ECG) signs used to differentiate ventricular tachycardia (VT) from supraventricular tachycardia (SVT) with aberrancy are specific but not highly sensitive. The purpose of this study was to define the utility of an underappreciated form of atrioventricular (AV) dissociation at the onset of tachycardia, a single dissociated P wave, in the differentiation of non-sustained monomorphic wide complex tachycardia (WCT) in hospitalized patients. Methods and results We prospectively analysed tracings from 102 consecutive hospitalized patients who had an episode of non-sustained (≥5 beats,
Source: Europace - June 29, 2016 Category: Cardiology Authors: Padala, S. K., Sidhu, M. S., Brown, J. R., Zipursky, J. S., Steckman, D. A., Parikh, D. R., Greenberg, M. L. Tags: Electrocardiology and risk stratification Source Type: research

Focal atrial tachycardia originating from the septal mitral annulus: electrocardiographic and electrophysiological characteristics and radiofrequency ablation
This study sought to investigate electrocardiographic characteristics, electrophysiological features, and radiofrequency ablation in patients with focal atrial tachycardia (AT) originating from the septal mitral annulus. Methods and results In 13 patients with AT originating from the septal mitral annulus, activation mapping was performed to identify the earliest activation site. Successful ablation was performed through either a transseptal (n = 12) or a retrograde aortic approach (n = 1). As confirmed by electrogram recordings, fluoroscopy, and three-dimensional (3D) mapping, successful ablation sites were located in th...
Source: Europace - June 29, 2016 Category: Cardiology Authors: Wang, Y., Li, D., Zhang, J., Han, Z., Wang, Y., Ren, X., Li, X., Chen, F. Tags: Cardiac electrophysiology Source Type: research

Transbaffle catheter ablation of atrial re-entrant tachycardia within the pulmonary venous atrium in adult patients with congenital heart disease
Conclusion Transbaffle access to the PVA for ablation of atrial re-entrant tachycardia is feasible, less invasive than alternative approaches and can be safely applied in patients after Mustard procedure or with a Fontan circulation. However, the rigidity of prosthetic material may preclude baffle puncture at least in a subset of those patients. (Source: Europace)
Source: Europace - June 29, 2016 Category: Cardiology Authors: Krause, U., Backhoff, D., Klehs, S., Schneider, H. E., Paul, T. Tags: Cardiac electrophysiology Source Type: research

Incidence, predictors, and outcome of inadvertent malposition of transvenous pacing or defibrillation lead in the left heart
Aims Inadvertent lead malposition (ILM) in the left heart is a potential cause of thromboembolism and, therefore, a complication of heart rhythm device implantation [HRDI: pacemaker, implantable cardioverter defibrillator (ICD), cardiac resynchronization therapy (CRT)]. The aim of the study was to report the incidence and clinical outcome of ILM. Methods and results Postoperative lateral and posterior–anterior chest X-rays of all consecutive patients undergoing HRDI from 2007 through 2012 were retrospectively analysed. During the study period, 2579 patients underwent HRDI at our institution. ILM was present in six p...
Source: Europace - June 29, 2016 Category: Cardiology Authors: Ohlow, M.-A., Roos, M., Lauer, B., Von Korn, H., Geller, J. C. Tags: Leads and lead extraction Source Type: research

Initial experience with the TightRail™ Rotating Mechanical Dilator Sheath for transvenous lead extraction
Conclusion Our preliminary data with small sample size show that TightRail™ Mechanical Dilator Sheath is a new useful tool for chronically implanted pacemaker (PM)/ICD leads. Continued investigation including large patient cohort is required to evaluate success and complication rates in comparison to other tools and techniques. (Source: Europace)
Source: Europace - June 29, 2016 Category: Cardiology Authors: Aytemir, K., Yorgun, H., Canpolat, U., Sahiner, M. L., Kaya, E. B., Evranos, B., Özer, N. Tags: Leads and lead extraction Source Type: research

Pacemakers implantation and radiofrequency catheter ablation procedures during medical missions in Morocco: an 8-year experience
Conclusion Radiofrequency catheter ablation for arrhythmias in developing countries is technically challenging but feasible, despite technical and cultural difficulties. (Source: Europace)
Source: Europace - June 29, 2016 Category: Cardiology Authors: Bun, S.-S., Latcu, D. G., Errahmouni, A., Zarqane, N., Yaïci, K., Moustaghfir, A., Tazi-Mezalek, A., Saoudi, N. Tags: Pacing and resynchronization therapy Source Type: research

Perimitral atrial flutter ablation by transaortic radiofrequency application
(Source: Europace)
Source: Europace - June 29, 2016 Category: Cardiology Authors: Estrada, A., Doiny, D., Merino, J. L. Tags: CASE EXPRESS REPORTS Source Type: research

Bifocal left ventricular stimulation or the optimal left ventricular stimulation site in cardiac resynchronization therapy: a pressure-volume loop study
Conclusion Stimulation at the optimal LV site showed a significantly higher pump function improvement compared with bifocal LV stimulation. Mechanical activation at the optimal LV site was significantly more delayed compared with the non-optimal LV site. In general, these results suggest that implantation of a second LV lead yields no additional benefit over implantation of one optimally placed LV lead. However, a bifocal approach might be beneficial in the individual patient. (Source: Europace)
Source: Europace - June 29, 2016 Category: Cardiology Authors: de Roest, G. J., Wu, L., de Cock, C. C., Delnoy, P.-P. H. M., Hendriks, M. L., van Rossum, A. C., Allaart, C. P. Tags: Pacing and resynchronization therapy Source Type: research

Effects of right ventricular pacing sites on blood pressure variation in upright posture: a comparison of septal vs. apical pacing sites
Aims Large variations in blood pressure (BP) in the upright position are a major cause of pacemaker syndrome, observed in up to 80% of patients paced non-physiologically at the right ventricular (RV) apex. We hypothesized that the magnitude of BP variations might be influenced by the RV pacing site. To assess this, we compared haemodynamic findings during supine and upright posture with RV apical vs. septal pacing. Methods and results The study population comprised a retrospective cohort of 24 dual-chamber pacemaker patients with advanced or complete atrioventricular block, in which 11 were randomly chosen from those with...
Source: Europace - June 29, 2016 Category: Cardiology Authors: Kohno, R., Abe, H., Nakajima, H., Hayashi, K., Oginosawa, Y., Benditt, D. G. Tags: Pacing and resynchronization therapy Source Type: research

Outcomes following the implantation of cardioverter-defibrillator for primary prevention in transposition of the great arteries after intra-atrial baffle repair: a single-centre experience
Conclusion Atrial arrhythmias were the most common cause for ICD shocks in a primary prevention population, while ventricular tachycardia was infrequent. The association between elevated end-diastolic pressures and the occurrence of arrhythmias demonstrates the close mechano-electrical relationship in D-TGA and may be an important predictor of arrhythmic events. (Source: Europace)
Source: Europace - June 29, 2016 Category: Cardiology Authors: Buber, J., Ackley, T. J., Daniels, C. J., Roble, S. L., Mah, M. L., Kamp, A. N., Kertesz, N. J. Tags: Sudden death and ICDs Source Type: research

The learning curve associated with the introduction of the subcutaneous implantable defibrillator
Aims The subcutaneous implantable cardioverter defibrillator (S-ICD) was introduced to overcome complications related to transvenous leads. Adoption of the S-ICD requires implanters to learn a new implantation technique. The aim of this study was to assess the learning curve for S-ICD implanters with respect to implant-related complications, procedure time, and inappropriate shocks (IASs). Methods and results In a pooled cohort from two clinical S-ICD databases, the IDE Trial and the EFFORTLESS Registry, complications, IASs at 180 days follow-up and implant procedure duration were assessed. Patients were grouped in quarti...
Source: Europace - June 29, 2016 Category: Cardiology Authors: Knops, R. E., Brouwer, T. F., Barr, C. S., Theuns, D. A., Boersma, L., Weiss, R., Neuzil, P., Scholten, M., Lambiase, P. D., Leon, A. R., Hood, M., Jones, P. W., Wold, N., Grace, A. A., Olde Nordkamp, L. R. A., Burke, M. C., on behalf of the IDE and EFFOR Tags: Sudden death and ICDs Source Type: research

Blood alcohol in victims of sudden cardiac death in northern Finland
Aims Momentary intake of large quantity of alcohol provokes ventricular ectopic activity increasing electrical instability. The present study was aimed to assess the prevalence of alcohol intake prior to a sudden cardiac death (SCD) event. Methods and results Victims of unexpected SCD [n = 2363, age 61 ± 12 years, males 1940 (82%)] included in the Finnish study of genotype and phenotype profiles of SCD (FINGESTURE) had a thorough interview of family members, medico-legal autopsy, and determination of blood alcohol concentration. Because of the Finnish law, all unexpected deaths undergo medico-legal autopsy. Patient...
Source: Europace - June 29, 2016 Category: Cardiology Authors: Perkiömäki, J., Hookana, E., Kaikkonen, K., Junttila, J., Kortelainen, M.-L., Huikuri, H. Tags: Sudden death and ICDs Source Type: research

Are implantable cardiac monitors the 'gold standard for atrial fibrillation detection? A prospective randomized trial comparing atrial fibrillation monitoring using implantable cardiac monitors and DDDRP permanent pacemakers in post atrial fibrillation ablation patients
Aims Implantable devices are widely accepted, but not proven, to be the most reliable monitoring method to assess atrial fibrillation (AF) therapies. We compared REVEAL®XT implantable cardiac monitors (ICMs) and permanent pacemakers (PPMs). Methods and results Fifty patients with paroxysmal AF were randomized to ICM or PPM implant 6 weeks prior to pulmonary vein isolation. Permanent pacemakers were programmed to monitoring only (ODO). Device downloads were performed at 0, 3, 6, 9, and 12 months. All patients underwent 7-day external loop recorder. Device ECGs and EGMs were compared for AF burden. A total of 20 744 and...
Source: Europace - June 29, 2016 Category: Cardiology Authors: Podd, S. J., Sugihara, C., Furniss, S. S., Sulke, N. Tags: Ablation for atrial fibrillation Source Type: research

Interventional management of recurrent paroxysmal atrial fibrillation despite isolated pulmonary veins: impact of an ablation strategy targeting inducible atrial tachyarrhythmias
Conclusion In patients with recurrence of PAF despite isolated PV, termination of induced atrial arrhythmias can be achieved in most patients by defragmentation and AT ablation. Moreover, this ablation strategy results in favourable mid-term outcome results. (Source: Europace)
Source: Europace - June 29, 2016 Category: Cardiology Authors: Sultan, A., Lüker, J., Hoffmann, B., Servatius, H., Schäffer, B., Steven, D., Willems, S. Tags: Ablation for atrial fibrillation Source Type: research

One-year follow-up after second-generation cryoballoon ablation for atrial fibrillation in a large cohort of patients: a single-centre experience
In this study, we assessed the single-procedure outcome on a 1-year follow-up period in a large sample of patients having undergone PVI for drug-resistant atrial fibrillation (AF) using the CB-Adv. Methods and Results A total of 393 patients (122 female, 31%; mean age 57.7 ± 12.9 years) with drug-refractory AF undergoing PVI using the novel CB-Adv were enrolled. Follow-up was based on outpatient clinic visits including Holter electrocardiograms. Recurrence of atrial tachyarrhythmias (ATas) was defined as a symptomatic or documented episode>30 s. A total of 1572 pulmonary veins (PVs) were identified and successfu...
Source: Europace - June 29, 2016 Category: Cardiology Authors: Irfan, G., de Asmundis, C., Mugnai, G., Poelaert, J., Verborgh, C., Umbrain, V., Beckers, S., Hacioglu, E., Hunuk, B., Velagic, V., Stroker, E., Brugada, P., Chierchia, G.-B. Tags: Ablation for atrial fibrillation Source Type: research

Cost effectiveness of left atrial appendage closure with the Watchman device for atrial fibrillation patients with absolute contraindications to warfarin
Conclusions This analysis demonstrates that LAAC with the Watchman device is a cost-effective and cost-saving solution for stroke risk reduction in patients with non-valvular AF who are at risk for stroke but have contraindications to warfarin. (Source: Europace)
Source: Europace - June 29, 2016 Category: Cardiology Authors: Reddy, V. Y., Akehurst, R. L., Armstrong, S. O., Amorosi, S. L., Brereton, N., Hertz, D. S., Holmes, D. R. Tags: Atrial fibrillation Source Type: research

Long-term evaluation of dabigatran 150 vs. 110 mg twice a day in patients with non-valvular atrial fibrillation
Conclusion Annualized rates of all outcomes were constant with better efficacy of D150, less major bleeding with D110, and low intracerebral haemorrhage rates for both doses. There were no additional safety concerns. This is the longest continuous randomized experience of a novel anticoagulant. (Source: Europace)
Source: Europace - June 29, 2016 Category: Cardiology Authors: Ezekowitz, M. D., Eikelboom, J., Oldgren, J., Reilly, P. A., Brueckmann, M., Kent, A. P., Pogue, J., Spahr, J., Clemens, A., Noack, H., Diener, H.-C., Wallentin, L., Yusuf, S., Connolly, S. J. Tags: Atrial fibrillation Source Type: research

Giant epsilon waves in 12 leads in a patient with severe arrhythmogenic cardiomyopathy
(Source: Europace)
Source: Europace - June 29, 2016 Category: Cardiology Authors: Lopez-Moreno, E., Jimenez-Jaimez, J., Tercedor, L. Tags: CASE EXPRESS REPORTS Source Type: research