Evolution of P-wave indices during long-term follow-up as markers of atrial substrate progression in arrhythmogenic right ventricular cardiomyopathy
ConclusionInitial ARVC progression was associated with P-wave flattening in right precordial leads and in later disease stages an increased prevalence of aPTF-V1 was seen. (Source: Europace)
Source: Europace - March 4, 2021 Category: Cardiology Source Type: research
Pulmonary vein isolation in a real-world population does not influence QTc interval
ConclusionBased on our data a routine PVI does not result in a prolongation of QTc in a real-world population. These findings, therefore, suggest that there is no need to intensify post-PVI QT-interval monitoring. (Source: Europace)
Source: Europace - March 4, 2021 Category: Cardiology Source Type: research
Novel CineECG enables anatomical 3D localization and classification of bundle branch blocks
ConclusionCineECG provided the anatomical localization of different BBBs and accurately differentiated between normal, LBBB and RBBB, and iRBBB.CineECG may aid clinical diagnostic work-up, potentially contributing to the difficult discrimination between normal, iRBBB, and Brugada patients. (Source: Europace)
Source: Europace - March 4, 2021 Category: Cardiology Source Type: research
Automatic reconstruction of the left atrium activation from sparse intracardiac contact recordings by inverse estimate of fibre structure and anisotropic conduction in a patient-specific model
ConclusionPersonalized Inverse Eikonal model from cardiac Electro-Anatomical Maps offers a novel approach to extrapolate the activation in unmapped regions and to assess conduction properties of the atria. It could be seamlessly integrated into existing electro-anatomic mapping systems. Personalized Inverse Eikonal model from cardiac Electro-Anatomical Maps also enables personalization of cardiac electrophysiology models. (Source: Europace)
Source: Europace - March 4, 2021 Category: Cardiology Source Type: research
Atlas-based methods for efficient characterization of patient-specific ventricular activation patterns
ConclusionAtlases of activation and VCGs represent a new method of identifying and relating the features of these high-dimensional signals that capture the major sources of variation between patients and may aid in identifying novel clinical indices of arrhythmia risk or therapeutic outcome. (Source: Europace)
Source: Europace - March 4, 2021 Category: Cardiology Source Type: research
Exploring the cause of conduction delays in patients with repaired Tetralogy of Fallot
ConclusionThe results of the present study indicate that the delayed activation in the right ventricle of rToF patients is predominantly due to block(s) in the Purkinje system and that conduction in RV tissue is fairly normal. (Source: Europace)
Source: Europace - March 4, 2021 Category: Cardiology Source Type: research
Electromechanical substrate characterization in arrhythmogenic cardiomyopathy using imaging-based patient-specific computer simulations
ConclusionRegional RV deformation abnormalities in AC mutation carriers were related to reduced regional contractile function and tissue compliance. In clinically advanced disease stages, a characteristic apex-to-base heterogeneity of tissue abnormalities was present in the majority of the subjects, with most pronounced disease in the basal region of the RVfw. (Source: Europace)
Source: Europace - March 4, 2021 Category: Cardiology Source Type: research
Simulation of diffuse and stringy fibrosis in a bilayer interconnected cable model of the left atrium
ConclusionInterconnected cable models enable the study of microstructure in organ-size models despite limitations in the description of transmural structures. (Source: Europace)
Source: Europace - March 4, 2021 Category: Cardiology Source Type: research
Efficient identification of scars using heterogeneous model hierarchies
ConclusionIn several situations, scar reconstruction based on eikonal and monodomain models differ significantly, suggesting the use of the more involved monodomain model for this purpose. Eikonal models can accelerate the computations considerably, enabling the use of complex electrophysiology models for estimating myocardial scars from endocardial mapping data. (Source: Europace)
Source: Europace - March 4, 2021 Category: Cardiology Source Type: research
Cycle length statistics during human atrial fibrillation reveal refractory properties of the underlying substrate: a combined in silico and clinical test of concept study
ConclusionCycle length mapping is capable of highlighting regions of pathologic refractory properties. In combination with complementary substrate mapping approaches, the method fosters confidence to enhance the treatment of atrial fibrillation beyond pulmonary vein isolation particularly in patients with complex activation patterns. (Source: Europace)
Source: Europace - March 4, 2021 Category: Cardiology Source Type: research
Synergistic antiarrhythmic effect of inward rectifier current inhibition and pulmonary vein isolation in a 3D computer model for atrial fibrillation
ConclusionNewly developed blockers of atrial-specific inward rectifier currents, such asIKAch, might prevent AF occurrences and when combined with PVI effectively supress AF recurrences in human. (Source: Europace)
Source: Europace - March 4, 2021 Category: Cardiology Source Type: research
Fully coupled dynamic simulations of bioprosthetic aortic valves based on an embedded strategy for fluid –structure interaction with contact
ConclusionThe presented FSI approach can be used for analysing the mechanical and haemodynamic performance of a BHV. Our study suggests that stresses concentrate in the regions where leaflets are attached to the stent and in the portion of the aortic root where the BHV is placed. The results from this study may inspire new BHV designs that can provide a better stress distribution. (Source: Europace)
Source: Europace - March 4, 2021 Category: Cardiology Source Type: research
Incidence, prevalence, and trajectories of repetitive conduction patterns in human atrial fibrillation
ConclusionHigh-density epicardial contact mapping in AF patients reveals frequent repetitive conduction patterns. In persistent AF patients, repetitive patterns were less frequent, smaller, and more variable than in paroxysmal AF patients. Future research should elucidate whether these patterns can help in finding AF ablation targets. (Source: Europace)
Source: Europace - March 4, 2021 Category: Cardiology Source Type: research
Human biventricular electromechanical simulations on the progression of electrocardiographic and mechanical abnormalities in post-myocardial infarction
ConclusionOur human-based multiscale modelling and simulation framework enables mechanistic investigations into patho-physiological electrophysiological and mechanical behaviour and can serve as testbed to guide the optimization of pharmacological and electrical therapies. (Source: Europace)
Source: Europace - March 4, 2021 Category: Cardiology Source Type: research
Comprehensive multicomponent cardiac rehabilitation in cardiac implantable electronic devices recipients: a consensus document from the European Association of Preventive Cardiology (EAPC; Secondary prevention and rehabilitation section) and European Heart Rhythm Association (EHRA)
AbstractCardiac rehabilitation (CR) is a multidisciplinary intervention including patient assessment and medical actions to promote stabilization, management of cardiovascular risk factors, vocational support, psychosocial management, physical activity counselling, and prescription of exercise training. Millions of people with cardiac implantable electronic devices live in Europe and their numbers are progressively increasing, therefore, large subsets of patients admitted in CR facilities have a cardiac implantable electronic device. Patients who are cardiac implantable electronic devices recipients are considered eligible...
Source: Europace - February 26, 2021 Category: Cardiology Source Type: research
