Erratum
to: (Source: Europace)
Source: Europace - March 28, 2017 Category: Cardiology Source Type: research

A multicentre study of patients with Timothy syndrome
ConclusionTimothy syndrome is a rare disorder with a high attrition rate if undiagnosed. Perioperative cardiac arrests are common and not always amenable to resuscitation. Longer-term survival is possible, however, patients invariably require pacemaker or defibrillator implantation. (Source: Europace)
Source: Europace - March 24, 2017 Category: Cardiology Source Type: research

Oral loading of propafenone: restoring its role before restoring rhythm
The optimal way to convert recent onset atrial fibrillation (AF) to sinus rhythm is still a matter of interest for physicians. According to guidelines, usually the clinical strategy depends on patient's characteristics. Pharmacological cardioversion with Class I antiarrhythmic drugs is one of the main therapeutic options for restoring sinus rhythm in patients with recent onset and haemodynamically well-tolerated AF, in the absence of structural heart disease. (Source: Europace)
Source: Europace - March 24, 2017 Category: Cardiology Source Type: research

Acute right ventricular resynchronization improves haemodynamics in children after surgical repair of tetralogy of Fallot
AbstractAimsRight bundle branch block is associated with right ventricular (RV) electromechanical dyssynchrony, which may contribute to acute haemodynamic impairment after repair of tetralogy of Fallot (ToF). We sought to evaluate the effects of RV resynchronization on haemodynamics and tissue oxygenation during the first 24  h after surgery.Methods and resultsArterial pressures, cardiac output, and tissue oxygenation were measured in 28 consecutive patients (median age 10.1 months) during baseline sinus rhythm with right bundle branch block and after RV resynchronization by atrial-triggered RV free wall pacing in c...
Source: Europace - March 23, 2017 Category: Cardiology Source Type: research

Longitudinal association of short-term, metronome-paced heart rate variability and echocardiographically assessed cardiac structure at a 4-year follow-up: results from the prospective, population-based CARLA cohort
ConclusionIn the general population, LADS predicts 4-year alteration in SDNN and HF non-linearly. Because of the novelty of the result, analyses should be replicated in other populations. (Source: Europace)
Source: Europace - March 23, 2017 Category: Cardiology Source Type: research

Characterization of the arrhythmogenic substrate in patients with arrhythmogenic right ventricular cardiomyopathy undergoing ventricular tachycardia ablation
AbstractAimsArrhythmogenic right ventricular (RV) cardiomyopathy (ARVC) is associated with ventricular arrhythmias, even without RV structural disease. We aimed to characterize the RV substrate using electroanatomical mapping and to define outcomes following ventricular tachycardia (VT) ablation in patients with and without RV structural abnormalities.Methods and resultsTwenty-nine patients with definite or suspected ARVC undergoing VT ablation were classified as ‘electrical’ and ‘structural’ cardiomyopathy based on the absence or presence of major structural criteria. Right ventricular (RV) endocar...
Source: Europace - March 20, 2017 Category: Cardiology Source Type: research

Chronic total occlusion: a black-box?
This editorial refers to ‘Prognostic impact of chronic total coronary occlusion on long-term outcomes in implantable cardioverter-defibrillator recipients with ischaemic heart disease’ by T. Nishikawaet al., on pages 1153--1162. (Source: Europace)
Source: Europace - March 18, 2017 Category: Cardiology Source Type: research

Implantation of cardiac resynchronization therapy devices using three leads by cephalic vein dissection approach
ConclusionThe triple lead via cephalic vein technique is safe and effective when used as a first approach for CRT device implantation. (Source: Europace)
Source: Europace - March 17, 2017 Category: Cardiology Source Type: research

The unfinished issue of ischaemic stroke and embolic events during ablation for atrial fibrillation: the authors' reply
We thank Dr. Providenciaet al.1 for the concern and comments on our article.2 We agree with them that discontinuation of warfarin before catheter ablation for atrial fibrillation (AF) is likely associated with increased risk of periprocedural thrombo-embolic events. We cannot comment on the effects of different periprocedural anticoagulation strategy used in our cohort on thrombo-embolic events during AF ablation because of only a small minority of patients who were anti-coagulated with uninterrupted warfarin. Although several reports indicate that AF ablation can be performed safely with fewer stroke and bleeding complica...
Source: Europace - March 17, 2017 Category: Cardiology Source Type: research

The unfinished issue of ischaemic stroke and embolic events during catheter ablation of atrial fibrillation
We have read with interest the paper by Liuet al.,1 who report a very low incidence of ischaemic stroke (0.36%; 7 patients) in 1946 consecutive procedures of catheter ablation of atrial fibrillation (AF). Although these findings are noteworthy, we would like to comment on two aspects of the study that deserve reflection. (Source: Europace)
Source: Europace - March 17, 2017 Category: Cardiology Source Type: research

Atrioventricular nodal echoes over a wide echo window as a therapeutic end point for the catheter-guided radiofrequency ablation of atrioventricular nodal reentrant tachycardia: a prospective study
AbstractAimsIn previous retrospective studies, it was shown that the presence of residual single atrioventricular node (AVN) echoes with an echo zone longer than 30  ms may increase the rate of recurrence after radiofrequency ablation (RFA) of slow pathway in patients with AVN reentrant tachycardia (AVNRT). Based on that, some centres perform additional RFA in these patients. However, this opinion has never been tested prospectively and many centres do not pe rform re-ablation in these patients. The purpose of this study was to test whether persistence of a single AVN echo over a wide echo zone is a valid end point ...
Source: Europace - March 15, 2017 Category: Cardiology Source Type: research

Association of pre-ablation level of vitamin D with atrial fibrillation recurrence after catheter ablation
(Source: Europace)
Source: Europace - March 15, 2017 Category: Cardiology Source Type: research

Inappropriate inhibition of biventricular pacing due to diaphragmatic myopotentials amplified by the selectable sensing filter
A 66-year-old man with a cardiac resynchronization therapy defibrillator (CRT-D: Quadra Assura 3367-40QC, St. Jude Medical Inc.) experienced asymptomatic intermittent inhibition of biventricular pacing, mainly after meals. All measured parameters of the true bipolar ventricular lead (Durata 7122Q, St. Jude Medical Inc.) were in the normal range and general provocative maneuvers could not reproduce any noise. Only Valsalva maneuvers succeeded in reproducing the noise, showing the typical signal morphology of extracardiac myopotentials (Panel A); thus, oversensing of diaphragmatic myopotentials was diagnosed. After turning o...
Source: Europace - March 13, 2017 Category: Cardiology Source Type: research

European Heart Rhythm Association Young Electrophysiology Community: introducing our National Ambassadors of Italy, Turkey, and Poland
(Source: Europace)
Source: Europace - March 13, 2017 Category: Cardiology Source Type: research

A particular case of transient ST elevation during cryoballoon ablation of atrial fibrillation
The present case describes the occurrence of ST elevation during cryoballoon (CB) ablation secondary to the proximity of a coronary artery bypass graft (CABG) to the ostium of the left inferior pulmonary vein (LIPV). A 66-year-old female with drug-resistant paroxysmal atrial fibrillation underwent pulmonary vein (PV) isolation by means of second-generation CB ablation. During CB ablation of LIPV (at 102  s, −40°C), ST elevation in inferior leads was abruptly observed and cryo-application was immediately stopped; a few minutes later the ST elevation spontaneously reverted. Then, during a further cryo-applic...
Source: Europace - March 13, 2017 Category: Cardiology Source Type: research

Safety of fluoroscopy-guided transseptal approach for ablation of left-sided arrhythmias
This study analysed 4690 consecutive TP performed between 2000 and 2015: 3408 (72.6%) were ablation of AF, left-sided atrial flutter, or left-sided atrial tachycardia (non-AP group); 1153 (24.6%) were ablation of left-sided accessory pathway, AP group; and 129 (2.8%) were ablation of ventricular tachycardia. Transseptal puncture was done under fluoroscopy, pressure monitoring, and commonly using contrast media injection. In 27 procedures, ICE or TEE was used to guide the TP. We found 34 tamponades (Tx) that required pericardial drainage of which 28 (0.59%) could possibly be TP related and six could not. The total complicat...
Source: Europace - March 10, 2017 Category: Cardiology Source Type: research

Inappropriate shocks in single-chamber and subcutaneous implantable cardioverter-defibrillators: a systematic review and meta-analysis
AbstractAimsSingle-chamber (VR-ICD) and subcutaneous (S-ICD) implantable cardioverter-defibrillators are effective to protect patients against sudden death but expose them to higher risk of inappropriate shock (IS). We sought to quantify the annual rate and influencing factors of ISs in VR- and S-ICDs from the literature.Methods and resultsPubMed, Embase, and Cochrane Library were searched for full text articles with IS rates. Poisson distribution estimated proportion of patients with ISs; rates were annualized based on follow-up duration. Random effects meta-analysis accounted for study-to-study variation. Out of 3264 art...
Source: Europace - March 10, 2017 Category: Cardiology Source Type: research

Denervation of the extrinsic cardiac sympathetic nervous system as a treatment modality for arrhythmia
AbstractDenervation of the extrinsic cardiac sympathetic nervous system is a method of altering the autonomic tone experienced by the heart and vasculature. It has been studied and employed as a therapy for cardiac disease for decades. Currently, there is a high level of interest in using cardiac denervation for treatment of arrhythmias. This review describes the anatomy and physiology of the cardiac autonomic nervous system followed by a discussion of the mechanistic studies which provide a basis for the therapeutic use of sympathetic denervation. The clinical research supporting its use in human arrhythmias is then appra...
Source: Europace - March 10, 2017 Category: Cardiology Source Type: research

Long-term outcome of pulmonary vein isolation in patients with paroxysmal atrial fibrillation and Brugada syndrome
ConclusionCatheter ablation is a valid therapeutic choice for patients with BS and paroxysmal AF considering the high success rates, the limitations of the AADs and the safety of the procedure, and it should be taken into consideration especially in those patients presenting inappropriate ICD shocks due to rapid AF. (Source: Europace)
Source: Europace - March 9, 2017 Category: Cardiology Source Type: research

Left atrial appendage isolation in addition to pulmonary vein isolation in persistent atrial fibrillation: one-year clinical outcome after cryoballoon-based ablation
In this study, we sought to evaluate the safety and efficacy of cryoballoon (CB) based empirical left atrial appendage (LAA) isolation as an adjunct to pulmonary vein isolation (PVI) compared to the PVI-only strategy in patients with persistent AF.ObjectivesClinical outcomes of catheter ablation were less beneficial for persistent atrial fibrillation (AF) than paroxysmal AF.Methods and resultsA total of 100 consecutive patients with persistent AF underwent both PVI and additional LAA isolation using CB (Group II). As a control group (Group I), among persistent AF patients, we conducted a retrospective, propensity-score mat...
Source: Europace - March 9, 2017 Category: Cardiology Source Type: research

Dual- vs. single-chamber defibrillators for primary prevention of sudden cardiac death: long-term follow-up of the D éfibrillateur Automatique Implantable—Prévention Primaire registry
We examined whether dual-chamber (DC) ICDs confer a greater benefit than single-chamber (SC) ICDs, and compared the long-term outcomes of recipients of each type of device implanted for primary prevention.Methods and resultsBetween 2002 and 2012, the DAI-PP registry consecutively enrolled 1258 SC- and 1280 DC-ICD recipients at 12 French medical centres. The devices were interrogated at 4- to 6-month intervals during outpatient visits, with a focus on the therapies delivered. The study endpoints were incidence of appropriate therapies, ICD-related morbidity, and deaths from all and from specific causes. The mean age of the ...
Source: Europace - March 8, 2017 Category: Cardiology Source Type: research

Questioning the preference for dual- vs. single-chamber implantable defibrillator in primary prevention implantable cardioverter-defibrillator recipients
This editorial refers to ‘Dual- vs. single-chamber defibrillators for primary prevention of sudden cardiac death: long-term follow-up of theD éfibrillateur Automatique Implantable—Prévention Primaire registry ’ by P. Defayeet al., on pages1478 –1484. (Source: Europace)
Source: Europace - March 8, 2017 Category: Cardiology Source Type: research

High rate of subcutaneous implantable cardioverter-defibrillator sensing screening failure in patients with Brugada syndrome: a comparison with other inherited primary arrhythmia syndromes
AbstractAimsSubcutaneous implantable cardioverter-defibrillator (S-ICD) can avoid important complications associated with transvenous leads in patients with inherited primary arrhythmia syndromes, who do not need pacing therapy. Few data are available on the percentage of patients with inherited arrhythmia syndromes eligible for S-ICD implantation. Aim of this study was to analyse the eligibility for S-ICD in a series of patients with Brugada syndrome (BrS), and to compare it with patients with other channelopathies.Methods and resultsPatients presenting with BrS, long-QT syndrome (LQTS), early repolarization syndrome (ERS...
Source: Europace - March 7, 2017 Category: Cardiology Source Type: research

Image integration into 3-dimensional-electro-anatomical mapping system facilitates safe ablation of ventricular arrhythmias originating from the aortic root and its vicinity
ConclusionImage integration combining electroanatomical mapping and fluoroscopy allows assessment of the safety of a potential ablation site by continuous real-time monitoring of the spatial relations of the catheter tip to the coronary vessels prior to RF application. It aids ablation in anatomically complex regions like the SOV or the ventricular summit providing biplane angiograms merged into the three-dimensional electroanatomical map. (Source: Europace)
Source: Europace - March 7, 2017 Category: Cardiology Source Type: research

A call for safety during electrophysiological procedures: US in, why not US out? Authors' reply
The authors appreciate the insightful comments by de Sensiet al.1 in response to our manuscript. Despite the evidence-based benefits of ultrasound-guided vascular access (venous and arterial),2,3 it is clear that the adoption of the practice is not uniform or universal. Even in specialties that have seemingly embraced the technique, there is broad variation in use. Recent national surveys of intensivists, hospitalists, anaesthesiologists, and emergency physicians on the use of ultrasound guidance for vascular access reveal discrepancies in practice, abundant lack of training, and implementation gaps in clinical practice.4 ...
Source: Europace - March 7, 2017 Category: Cardiology Source Type: research

Pushing the limits: establishing an ultra-low framerate and antiscatter grid-less radiation protocol for left atrial ablations
AbstractAimsDespite the use of 3D mapping systems and new developments of non-fluoroscopic options, most centres still rely at least in part on fluoroscopy for catheter visualization during catheter ablations. The purpose of this study was to assess the feasibility of using an ultra-low frame rate and antiscatter grid-less radiation protocol during complex left atrial ablations to minimize radiation exposure for the patient and staff.Methods and resultsA total of 150 consecutive patients undergoing left atrial ablations in our hospital were included in the analysis. The procedures were performed between January 2015 and No...
Source: Europace - March 4, 2017 Category: Cardiology Source Type: research

Diagnosis-to-ablation time as a predictor of success: early choice for pulmonary vein isolation and long-term outcome in atrial fibrillation: results from the Middelheim-PVI Registry
AbstractAimsThe aim of the study is to define long-term outcome of pulmonary vein isolation (PVI) in atrial fibrillation (AF) and to determine whether time window between AF diagnosis and PVI affects outcome.Methods and resultsConsecutive AF patients undergoing PVI (2006 –14) were followed for 5 years. Primary outcome was clinical success, defined as freedom of documented AF without anti-arrhythmic drugs respecting a 1-month blanking period. A 1000 patients were included (age 60 ± 10 years, CHA2DS2-VASc score 1  ± 1). The cohort was divided in four quartiles (Q) according to ...
Source: Europace - March 2, 2017 Category: Cardiology Source Type: research

Single-site ventricular pacing via the coronary sinus in patients with tricuspid valve disease
ConclusionIn patients with normal LVEF, single-site ventricular pacing via the coronary sinus is a feasible, safe and reliable alternative to right ventricular pacing. (Source: Europace)
Source: Europace - March 1, 2017 Category: Cardiology Source Type: research

Association between right ventricular lead position and clinical outcomes in patients with cardiac resynchronization therapy
ConclusionA non-apical RV-LP is associated with lower risk of meeting the combined endpoint of mortality or hospitalization for HF in patients with CRT. In subgroup analysis, this association was present only in patients with non-IHD. (Source: Europace)
Source: Europace - March 1, 2017 Category: Cardiology Source Type: research

Intracardiac echocardiography catheter-guided zero fluoroscopy transeptal puncture technique for ablation of left-sided accessory pathway in a pregnant woman
Supraventricular tachycardia (ST) management may become a real challenge during pregnancy. Because of the potential risk for foetal damage with radiation exposure, ablation therapy in pregnancy is not encouraged in contemporary guidelines. On the other hand, antiarrhythmic drugs pose some risk of adverse effects or teratogenicity to the foetus. Moreover, a high rate of symptomatic ST during pregnancy has been described, especially those due to accessory pathway. (Source: Europace)
Source: Europace - March 1, 2017 Category: Cardiology Source Type: research

Very long-term outcome following transcatheter ablation of atrial fibrillation. Are results maintained after 10 years of follow up?
AbstractAimsAtrial fibrillation (AF) transcatheter ablation is a safe and effective procedure. However, outcome over 10 years of follow-up has never been reported. The aim of this study is to assess outcome, describe predictors of recurrences, and report on quality of life (QoL) the decade after an AF ablation.Methods and resultsPatients referred for AF ablation in a single high volume centre from June 2004 to June 2006 were enrolled and followed in a prospective fashion by yearly clinical assessment and Holter monitoring. Among 255 patients (42.7% paroxysmal AF, 77% males, after a follow-up of 125  ± ...
Source: Europace - February 28, 2017 Category: Cardiology Source Type: research

Long-term flecainide therapy in type 3 long QT syndrome
The objective of the current study was to evaluate the long-term safety and efficacy of flecainide therapy in patients with LQT3 who carry the D1790GSCN5A mutation.Methods and resultsThe study population comprised 30 D1790G carriers who were treated with flecainide and followed for 1 –215 months (mean 145 ± 54 months, median 140 months). The mean baseline (off-drug) QTc was 522 ± 45 ms, and shortened to 469 ± 36 ms with flecainide therapy, a mean decrease of 53 ms [10.1%] (P 
Source: Europace - February 28, 2017 Category: Cardiology Source Type: research

Epicardial ablation may not be necessary in all patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy and frequent ventricular tachycardia
We read with great interest the recent manuscript of Berruezo and colleagues who reported the results of a prospective multicentre study on ‘safety, long-term outcomes and predictors of recurrence after first-line combined endoepicardial ventricular tachycardia substrate ablation in arrhythmogenic cardiomyopathy’.1 With an aggressive approach of first-line combined endo- and epicardial ventricular tachycardia (VT) ablation in 41 patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) the authors observed recurrences of VT in 11 patients (26.8%) after a mean follow-up of 32.2  +&t...
Source: Europace - February 28, 2017 Category: Cardiology Source Type: research

Macroreentrant atrial tachycardia around the native common atrioventricular valve in a surgically corrected complete atrioventricular septal defect
A 32-year-old female, with a surgically corrected complete atrioventricular septal defect, developed an atrial tachycardia (Figure, ECG after adenosine inPanel A, bottom) after a mitral prosthetic valve implant. An ablation procedure was scheduled. (Source: Europace)
Source: Europace - February 28, 2017 Category: Cardiology Source Type: research

Pre-participation cardiovascular evaluation for athletic participants to prevent sudden cardiac death
The recent position article on pre-participation examination for athletic participants is appreciated.1 Most recommendations are in accordance with the EFSMA (European Federation of Sports Medicine Asssociations) statement.2 However, this position article1 requires some comments in order to avoid discouraging top and leisure time athletes from continuing intensive endurance training. The sensitivity and specificity of electrocardiogram (ECG) are based on the prevalence of a disease within the population. This holds true for resting and especially for stress testing ECG. The only reliable parameter, then, is predictive valu...
Source: Europace - February 28, 2017 Category: Cardiology Source Type: research

Left atrial and pulmonary vein flutter associated with double electrical connections after a lung transplantation
A 53-year-old man with a history of bilateral lung transplantation (LT) underwent electrophysiological testing of supraventricular tachycardia (SVT). Activation map revealed that the activation propagated from the right PV (RPV) cuff to the left atrium (LA) through a first conduction gap located at the superior aspect of the RPV cuff and from the LA back to the RPV cuff through a second conduction gap located at the inferior aspect of the RPV cuff (Panel-A), suggesting that the SVT should be a figure-of-8 type macroreentrant atrial flutter (AFL) associated with 2 conduction gaps between the donor RPV cuff and recipient LA....
Source: Europace - February 28, 2017 Category: Cardiology Source Type: research

Optimal method of measuring the T-peak to T-end interval for risk stratification in primary prevention
AbstractAimsSeveral published investigations demonstrated that a longer T-peak to T-end interval (Tpe) implies increased risk for ventricular tachyarrhythmia (VT/VF) and mortality. Tpe has been measured using diverse methods. We aimed to determine the optimal Tpe measurement method for screening purposes.Methods and resultsWe evaluated 305 patients with LVEF ≤ 35% and an implantable cardioverter-defibrillator implanted for primary prevention. Tpe was measured using seven different methods described in the literature, including six manual methods and the automated algorithm ‘12SL’, and was corrected for heart...
Source: Europace - February 27, 2017 Category: Cardiology Source Type: research

Post-mortem toxicology in young sudden cardiac death victims: a nationwide cohort study
AbstractAimsSeveral drugs increase the risk of ventricular fibrillation and sudden cardiac death (SCD). We aimed to investigate in detail the toxicological findings of all young SCD throughout Denmark.Methods and resultsDeaths in persons aged 1 –49 years were included over a 10-year period. Death certificates and autopsy reports were retrieved and read to identify cases of sudden death and establish cause of death. All medico-legal autopsied SCD were included and toxicological reports collected. Positive toxicology was defined as the pre sence of any substance (licit and/or illicit). All toxicological findings had pr...
Source: Europace - February 27, 2017 Category: Cardiology Source Type: research

Outcomes with single-coil versus dual-coil implantable cardioverter defibrillators: a meta-analysis
AbstractAimsDual-coil implantable cardioverter defibrillator (ICD) leads have traditionally been used over single-coil leads due to concerns regarding high defibrillation thresholds (DFT) and consequent poor shock efficacy. However, accumulating evidence suggests that this position may be unfounded and that dual-coil leads may also be associated with higher complication rates during lead extraction. This meta-analysis collates data comparing dual- and single-coil ICD leads.Methods and resultsElectronic databases were systematically searched for randomized controlled trials (RCT) and non-randomized studies comparing single-...
Source: Europace - February 27, 2017 Category: Cardiology Source Type: research

Outcomes of atrial arrhythmia radiofrequency catheter ablation in patients with Ebstein ’s anomaly
ConclusionCatheter ablation of atrial arrhythmias in patients with EA has a favorable outcome overall with an acceptable recurrence and safety profile; left-sided ablations are rarely necessary. Despite prior Maze and catheter ablation procedures, CTI-AFl and IART recurrences predominate. (Source: Europace)
Source: Europace - February 27, 2017 Category: Cardiology Source Type: research

Refining success of cardiac resynchronization therapy using a simple score predicting the amount of reverse ventricular remodelling: results from the Markers and Response to CRT (MARC) study
ConclusionsThe CAVIAR response score predicts the amount of reverse remodelling after CRT and may be used to improve patient selection. Clinical Trials: NCT01519908 (Source: Europace)
Source: Europace - February 27, 2017 Category: Cardiology Source Type: research

Intra-cardiac and peripheral levels of biochemical markers of fibrosis in patients undergoing catheter ablation for atrial fibrillation
AbstractAimsMeasurement of circulating biomarkers of fibrosis may have a role in selecting patients and treatment strategy for catheter ablation. Pro-collagen type III N-terminal pro-peptide (PIIINP), C-telopeptide of type I collagen (ICTP), fibroblast growth factor 23 (FGF-23), and galectin 3 (gal-3) have all been suggested as possible biomarkers for this indication, but studies assessing whether peripheral levels reflect intra-cardiac levels are scarce.Methods and resultsWe studied 93 patients undergoing ablation for paroxysmal atrial fibrillation (AF) (n = 63) or non-paroxysmal AF (n = 30). F...
Source: Europace - February 27, 2017 Category: Cardiology Source Type: research

Can we say anything about ganglionated plexus modification during radiofrequency pulmonary vein isolation and post-ablation arrhythmia recurrence at this time?
In this study, the authors evaluated whether coincidentally elicited vagal response (VR) during left atrial ablation are associated with lower atrial fibrillati on recurrence rates. Heart rate 5  s elicited during or immediately after radiofrequency (RF) energy application were defined as VR. We would like to take attention some issues related to the article. Firstly, the authors might use a little bit more specific cut-off values for the definition of VR. It is well known that basal hear t rate of the patients may be very different at the beginning of the procedure. For example, heart rate of 70 bpm during R...
Source: Europace - February 23, 2017 Category: Cardiology Source Type: research

Alcohol-related hospitalization is associated with increased risk of ischaemic stroke among low-risk patients with atrial fibrillation
ConclusionThe presence of a previous hospitalization with an alcohol-related disease was associated with a small but significant increase in the risk of stroke among low-risk AF patients. More research about relation between alcohol use and ischaemic stroke in AF patients is warranted. (Source: Europace)
Source: Europace - February 23, 2017 Category: Cardiology Source Type: research

The use of guideline recommended beta-blocker therapy in primary prevention implantable cardioverter defibrillator patients: insight from Danish nationwide registers
AbstractAimsWe aimed to examine the use of guideline recommended beta-blocker therapy prior to and after primary prevention implantable cardioverter defibrillator (ICD) implantation in a ‘real-life’ setting.Methods and resultsFrom the Danish Pacemaker and ICD Registry we identified all 1st-time primary prevention ICD and cardiac resynchronization therapy defibrillator (CRT-D) implantations in Denmark from 2007 –12 (n = 2935). Use of beta-blocker, type and dose was acquired through the Danish Prescription Registry. According to guideline recommendations, we defined target daily doses as&thins...
Source: Europace - February 20, 2017 Category: Cardiology Source Type: research

Extensive atrial fibrosis assessed by late gadolinium enhancement cardiovascular magnetic resonance associated with advanced interatrial block electrocardiogram pattern
(Source: Europace)
Source: Europace - February 18, 2017 Category: Cardiology Source Type: research

Downstream overdrive pacing and intracardiac concealed fusion to guide rapid identification of atrial tachycardia after atrial fibrillation ablation
ConclusionReentry could be demonstrated in a substantial majority of AF ablation-related AT. A stepwise diagnostic approach using DOP and recognition of intracardiac concealed fusion can be used to rapidly identify and ablate reentrant AT. (Source: Europace)
Source: Europace - February 17, 2017 Category: Cardiology Source Type: research

Marked bradycardia elicited during pulmonary vein isolation: not a sign of success —Authors' reply
We would like to thank Dr. Aksu1 for his interesting comments on our paper.2 Some of them were actually a matter of thorough consideration for us upon planning this post hoc study analysis. (Source: Europace)
Source: Europace - February 17, 2017 Category: Cardiology Source Type: research

Corrigendum
to: Important reduction of the radiation dose for pulmonary vein isolation using amultimodal approach [Europace doi:10.1093/europace/euw334] (Source: Europace)
Source: Europace - February 17, 2017 Category: Cardiology Source Type: research

Isolation of the posterior left atrium for patients with persistent atrial fibrillation: routine adenosine challenge for dormant posterior left atrial conduction improves long-term outcome
AbstractAimsCatheter ablation to achieve posterior left atrial wall (PW) isolation may be performed as an adjunct to pulmonary vein isolation (PVI) in patients with persistent atrial fibrillation (AF). We aimed to determine whether routine adenosine challenge for dormant posterior wall conduction improved long-term outcome.Methods and resultsA total of 161 patients with persistent AF (mean age 59 ± 9 years, AF duration 6 ± 5 years) underwent catheter ablation involving circumferential PVI followed by PW isolation. Posterior left atrial wall isolation was performed with a roof and inferior wall line with the e...
Source: Europace - February 15, 2017 Category: Cardiology Source Type: research