Changes in TgAb and TPOAb titers are greater in thyrotoxicosis than isolated hypothyroidism induced by PD-1 blockade
Endocr J. 2024 Apr 11. doi: 10.1507/endocrj.EJ23-0480. Online ahead of print.ABSTRACTAnti-thyroglobulin antibodies (TgAb) and/or anti-thyroid peroxidase antibodies (TPOAb) positivity at baseline is a risk marker for thyroid immune-related adverse events (thyroid-irAEs) in anti-programmed cell death-1 antibody (PD-1-Ab) treatment; however, it is unknown if TgAb and TPOAb titers are associated with clinical characteristics of thyroid-irAEs. Among 586 patients treated with PD-1-Ab at Nagoya University Hospital between 2 November 2015 and 30 September 2021, 57 patients developed thyroid-irAEs (thyrotoxicosis [n = 38]; hypothyr...
Source: Endocrine Journal - April 10, 2024 Category: Endocrinology Authors: Ayana Yamagami Shintaro Iwama Tomoko Kobayashi Xin Zhou Yoshinori Yasuda Takayuki Okuji Masaaki Ito Tetsushi Izuchi Masahiko Ando Takeshi Onoue Takashi Miyata Mariko Sugiyama Daisuke Hagiwara Hidetaka Suga Ryoichi Banno Hiroshi Arima Source Type: research
Promising horizons in achondroplasia along with the development of new drugs
Endocr J. 2024 Apr 4. doi: 10.1507/endocrj.EJ24-0109. Online ahead of print.ABSTRACTAchondroplasia (ACH) is a representative skeletal disorder characterized by rhizomelic shortened limbs and short stature. ACH is classified as belonging to the fibroblast growth factor receptor 3 (FGFR3) group. The downstream signal transduction of FGFR3 consists of STAT1 and RAS/RAF/MEK/ERK pathways. The mutant FGFR3 found in ACH is continuously phosphorylated and activates downstream signals, resulting in abnormal proliferation and differentiation of chondrocytes in the growth plate and cranial base synchondrosis. A patient registry has b...
Source: Endocrine Journal - April 3, 2024 Category: Endocrinology Authors: Keiichi Ozono Takuo Kubota Toshimi Michigami Source Type: research
Phosphate-sensing mechanisms and functions of phosphate as a first messenger
Endocr J. 2024 Mar 29. doi: 10.1507/endocrj.EJ24-0082. Online ahead of print.ABSTRACTBone secrets the hormone, fibroblast growth factor 23 (FGF23), as an endocrine organ to regulate blood phosphate level. Phosphate is an essential mineral for the human body, and around 85% of phosphate is present in bone as a constituent of hydroxyapatite, Ca10(PO4)6(OH)2. Because hypophosphatemia induces rickets/osteomalacia, and hyperphosphatemia results in ectopic calcification, blood phosphate (inorganic form) level must be regulated in a narrow range (2.5 mg/dL to 4.5 me/dL in adults). However, as yet it is unknown how bone senses cha...
Source: Endocrine Journal - March 31, 2024 Category: Endocrinology Authors: Yuichi Takashi Source Type: research
Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet
In conclusion, SG improved cardiac function and glucose-lipid metabolism disorders in obese rats induced by a high-fat and high-sugar diet.PMID:38556321 | DOI:10.1507/endocrj.EJ23-0567 (Source: Endocrine Journal)
Source: Endocrine Journal - March 31, 2024 Category: Endocrinology Authors: Xiaojuan Li Luming Qiao Wei Wang Ying Shi Lei Yuan Zhiwei Zhai Source Type: research
Relationship between diabetes diet-related quality of life and dietary fiber intake among people with type 2 diabetes: a cross-sectional study
Endocr J. 2024 Mar 30. doi: 10.1507/endocrj.EJ23-0320. Online ahead of print.ABSTRACTDiet therapy is one of the most important treatments for people with type 2 diabetes (T2D). However, dietary restrictions due to diet therapy may reduce quality of life (QOL). This cross-sectional study aimed to investigate the association between diabetes diet-related QOL and dietary fiber intake in 238 people with T2D. The Diabetes Diet-related Quality of Life-Revised version (DDRQOL-9-R) and the brief-type self-administered diet history questionnaire were used to evaluate diabetes diet-related QOL and nutritional intake, respectively. H...
Source: Endocrine Journal - March 31, 2024 Category: Endocrinology Authors: Fuyuko Takahashi Yoshitaka Hashimoto Ayumi Kaji Ryosuke Sakai Yuka Kawate Yuriko Kondo Takuro Okamura Naoko Nakanishi Saori Majima Takafumi Osaka Hiroshi Okada Takafumi Senmaru Emi Ushigome Mai Asano Masahide Hamaguchi Masahiro Yamazaki Eiko Sato Michiaki Source Type: research
Phosphate-sensing mechanisms and functions of phosphate as a first messenger
Endocr J. 2024 Mar 29. doi: 10.1507/endocrj.EJ24-0082. Online ahead of print.ABSTRACTBone secrets the hormone, fibroblast growth factor 23 (FGF23), as an endocrine organ to regulate blood phosphate level. Phosphate is an essential mineral for the human body, and around 85% of phosphate is present in bone as a constituent of hydroxyapatite, Ca10(PO4)6(OH)2. Because hypophosphatemia induces rickets/osteomalacia, and hyperphosphatemia results in ectopic calcification, blood phosphate (inorganic form) level must be regulated in a narrow range (2.5 mg/dL to 4.5 me/dL in adults). However, as yet it is unknown how bone senses cha...
Source: Endocrine Journal - March 31, 2024 Category: Endocrinology Authors: Yuichi Takashi Source Type: research
Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet
In conclusion, SG improved cardiac function and glucose-lipid metabolism disorders in obese rats induced by a high-fat and high-sugar diet.PMID:38556321 | DOI:10.1507/endocrj.EJ23-0567 (Source: Endocrine Journal)
Source: Endocrine Journal - March 31, 2024 Category: Endocrinology Authors: Xiaojuan Li Luming Qiao Wei Wang Ying Shi Lei Yuan Zhiwei Zhai Source Type: research
Relationship between diabetes diet-related quality of life and dietary fiber intake among people with type 2 diabetes: a cross-sectional study
Endocr J. 2024 Mar 30. doi: 10.1507/endocrj.EJ23-0320. Online ahead of print.ABSTRACTDiet therapy is one of the most important treatments for people with type 2 diabetes (T2D). However, dietary restrictions due to diet therapy may reduce quality of life (QOL). This cross-sectional study aimed to investigate the association between diabetes diet-related QOL and dietary fiber intake in 238 people with T2D. The Diabetes Diet-related Quality of Life-Revised version (DDRQOL-9-R) and the brief-type self-administered diet history questionnaire were used to evaluate diabetes diet-related QOL and nutritional intake, respectively. H...
Source: Endocrine Journal - March 31, 2024 Category: Endocrinology Authors: Fuyuko Takahashi Yoshitaka Hashimoto Ayumi Kaji Ryosuke Sakai Yuka Kawate Yuriko Kondo Takuro Okamura Naoko Nakanishi Saori Majima Takafumi Osaka Hiroshi Okada Takafumi Senmaru Emi Ushigome Mai Asano Masahide Hamaguchi Masahiro Yamazaki Eiko Sato Michiaki Source Type: research
Phosphate-sensing mechanisms and functions of phosphate as a first messenger
Endocr J. 2024 Mar 29. doi: 10.1507/endocrj.EJ24-0082. Online ahead of print.ABSTRACTBone secrets the hormone, fibroblast growth factor 23 (FGF23), as an endocrine organ to regulate blood phosphate level. Phosphate is an essential mineral for the human body, and around 85% of phosphate is present in bone as a constituent of hydroxyapatite, Ca10(PO4)6(OH)2. Because hypophosphatemia induces rickets/osteomalacia, and hyperphosphatemia results in ectopic calcification, blood phosphate (inorganic form) level must be regulated in a narrow range (2.5 mg/dL to 4.5 me/dL in adults). However, as yet it is unknown how bone senses cha...
Source: Endocrine Journal - March 31, 2024 Category: Endocrinology Authors: Yuichi Takashi Source Type: research
Sleeve gastrectomy improves cardiac function and glucose-lipid metabolism disorder in obese rats induced by a high-fat and high-sugar diet
In conclusion, SG improved cardiac function and glucose-lipid metabolism disorders in obese rats induced by a high-fat and high-sugar diet.PMID:38556321 | DOI:10.1507/endocrj.EJ23-0567 (Source: Endocrine Journal)
Source: Endocrine Journal - March 31, 2024 Category: Endocrinology Authors: Xiaojuan Li Luming Qiao Wei Wang Ying Shi Lei Yuan Zhiwei Zhai Source Type: research
