Adjuvant treatments for locally advanced differentiated thyroid cancer: a nationwide survey in Japan
Endocr J. 2023 Sep 30. doi: 10.1507/endocrj.EJ23-0330. Online ahead of print.ABSTRACTThe role of adjuvant external-beam radiotherapy (EBRT) for locally advanced differentiated thyroid cancer (DTC) is controversial because of the lack of prospective data. To prepare for a clinical trial, this study investigated the current clinical practice of adjuvant treatments for locally advanced DTC. A survey on treatment selection criteria for hypothetical locally advanced DTC was administered to representative thyroid surgeons of facilities participating in the Japan Clinical Oncology Group Radiation Therapy Study Group. Of the 43 in...
Source: Endocrine Journal - October 1, 2023 Category: Endocrinology Authors: Terufumi Kawamoto Koichi Yasuda Yoshinori Ito Sadamoto Zenda Katsuyuki Sakanaka Naoto Shikama Naoki Nakamura Takashi Mizowaki Source Type: research
Associations between a polygenic risk score and the risk of gestational diabetes mellitus in a Chinese population: a case-control study
Endocr J. 2023 Sep 30. doi: 10.1507/endocrj.EJ23-0245. Online ahead of print.ABSTRACTOur objective was to construct a polygenic risk score (PRS) and assess its utility and effectiveness in predicting the risk of gestational diabetes mellitus (GDM) in a Chinese population. We performed a case-control study involving 638 patients with GDM and 1,062 healthy controls. Genotyping was conducted utilizing a genome-wide association study (GWAS), and a PRS was constructed. We identified 12 susceptibility loci that exhibited significant associations with the risk of GDM at a p-value threshold of ≤5.0 × 10-8, of which four loci we...
Source: Endocrine Journal - October 1, 2023 Category: Endocrinology Authors: Ying Li Mengjiao Yang Lu Yuan Ting Li Xinli Zhong Yanying Guo Source Type: research
Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases
In conclusion, histone H3 acetylation levels were associated with the development of AITD, even allowing for daily variation.PMID:37779085 | DOI:10.1507/endocrj.EJ23-0204 (Source: Endocrine Journal)
Source: Endocrine Journal - October 1, 2023 Category: Endocrinology Authors: Emi Haga Naoya Inoue Yoshinori Iwatani Yuya Arakawa Emi Morita Hidemi Hashimoto Yusuke Noguchi Yoh Hidaka Mikio Watanabe Source Type: research
Adjuvant treatments for locally advanced differentiated thyroid cancer: a nationwide survey in Japan
Endocr J. 2023 Sep 30. doi: 10.1507/endocrj.EJ23-0330. Online ahead of print.ABSTRACTThe role of adjuvant external-beam radiotherapy (EBRT) for locally advanced differentiated thyroid cancer (DTC) is controversial because of the lack of prospective data. To prepare for a clinical trial, this study investigated the current clinical practice of adjuvant treatments for locally advanced DTC. A survey on treatment selection criteria for hypothetical locally advanced DTC was administered to representative thyroid surgeons of facilities participating in the Japan Clinical Oncology Group Radiation Therapy Study Group. Of the 43 in...
Source: Endocrine Journal - October 1, 2023 Category: Endocrinology Authors: Terufumi Kawamoto Koichi Yasuda Yoshinori Ito Sadamoto Zenda Katsuyuki Sakanaka Naoto Shikama Naoki Nakamura Takashi Mizowaki Source Type: research
Associations between a polygenic risk score and the risk of gestational diabetes mellitus in a Chinese population: a case-control study
Endocr J. 2023 Sep 30. doi: 10.1507/endocrj.EJ23-0245. Online ahead of print.ABSTRACTOur objective was to construct a polygenic risk score (PRS) and assess its utility and effectiveness in predicting the risk of gestational diabetes mellitus (GDM) in a Chinese population. We performed a case-control study involving 638 patients with GDM and 1,062 healthy controls. Genotyping was conducted utilizing a genome-wide association study (GWAS), and a PRS was constructed. We identified 12 susceptibility loci that exhibited significant associations with the risk of GDM at a p-value threshold of ≤5.0 × 10-8, of which four loci we...
Source: Endocrine Journal - October 1, 2023 Category: Endocrinology Authors: Ying Li Mengjiao Yang Lu Yuan Ting Li Xinli Zhong Yanying Guo Source Type: research
Intraindividual variation in histone acetylation and its impact on autoimmune thyroid diseases
In conclusion, histone H3 acetylation levels were associated with the development of AITD, even allowing for daily variation.PMID:37779085 | DOI:10.1507/endocrj.EJ23-0204 (Source: Endocrine Journal)
Source: Endocrine Journal - October 1, 2023 Category: Endocrinology Authors: Emi Haga Naoya Inoue Yoshinori Iwatani Yuya Arakawa Emi Morita Hidemi Hashimoto Yusuke Noguchi Yoh Hidaka Mikio Watanabe Source Type: research
Assessment of factors associated with improved glycemic control after switching from intermittently scanned to real-time continuous glucose monitoring in Japanese patients with type 1 diabetes
Endocr J. 2023 Sep 26. doi: 10.1507/endocrj.EJ23-0125. Online ahead of print.ABSTRACTThe advantages of real-time continuous glucose monitoring (rtCGM) over intermittently scanned CGM (isCGM) reportedly include lower glycated hemoglobin (HbA1c) levels as well as reduced glycemic variability. However, there have been few studies of the effect of switching from isCGM to rtCGM on glycemic control, as well as the specific factors underlying any observed improvements. To that end, all patients with type 1 diabetes mellitus who used the DEXCOM rtCGM device (Terumo Corporation, Tokyo, Japan) at our institution were reviewed, and 1...
Source: Endocrine Journal - September 28, 2023 Category: Endocrinology Authors: Eijiro Yamada Yasuyo Nakajima Kazuhiko Horiguchi Shuichi Okada Masanobu Yamada Source Type: research
Pathology and gene mutations of aldosterone-producing lesions
Endocr J. 2023 Sep 26. doi: 10.1507/endocrj.EJ22-0492. Online ahead of print.ABSTRACTThe human adrenal cortex secretes aldosterone and cortisol as major corticosteroids. For their production, CYP11B2 and CYP11B1 catalyze the last steps in the syntheses of aldosterone and cortisol, respectively. In our previous study, CYP11B2 was the first successfully purified from rat adrenals and human clinical samples and then was proved to be aldosterone synthase. We demonstrated the immunohistochemistry for CYP11B2 of both rats and humans and applied it clinically to visualize the functional histology of aldosterone-producing adenoma ...
Source: Endocrine Journal - September 28, 2023 Category: Endocrinology Authors: Koshiro Nishimoto Tadashi Ogishima Yuki Sugiura Makoto Suematsu Kuniaki Mukai Source Type: research
Discover inspiring stories from the 100-year history of the Japan Endocrine Society; progress toward future successes
Endocr J. 2023;70(9):847-850. doi: 10.1507/endocrj.EJ20230323.NO ABSTRACTPMID:37766578 | DOI:10.1507/endocrj.EJ20230323 (Source: Endocrine Journal)
Source: Endocrine Journal - September 28, 2023 Category: Endocrinology Authors: Masatomo Mori Source Type: research
Erratum
Endocr J. 2023;70(9):941. doi: 10.1507/endocrj.EJ70-9_Erratum.NO ABSTRACTPMID:37766579 | DOI:10.1507/endocrj.EJ70-9_Erratum (Source: Endocrine Journal)
Source: Endocrine Journal - September 28, 2023 Category: Endocrinology Source Type: research
Assessment of factors associated with improved glycemic control after switching from intermittently scanned to real-time continuous glucose monitoring in Japanese patients with type 1 diabetes
Endocr J. 2023 Sep 26. doi: 10.1507/endocrj.EJ23-0125. Online ahead of print.ABSTRACTThe advantages of real-time continuous glucose monitoring (rtCGM) over intermittently scanned CGM (isCGM) reportedly include lower glycated hemoglobin (HbA1c) levels as well as reduced glycemic variability. However, there have been few studies of the effect of switching from isCGM to rtCGM on glycemic control, as well as the specific factors underlying any observed improvements. To that end, all patients with type 1 diabetes mellitus who used the DEXCOM rtCGM device (Terumo Corporation, Tokyo, Japan) at our institution were reviewed, and 1...
Source: Endocrine Journal - September 28, 2023 Category: Endocrinology Authors: Eijiro Yamada Yasuyo Nakajima Kazuhiko Horiguchi Shuichi Okada Masanobu Yamada Source Type: research
Pathology and gene mutations of aldosterone-producing lesions
Endocr J. 2023 Sep 26. doi: 10.1507/endocrj.EJ22-0492. Online ahead of print.ABSTRACTThe human adrenal cortex secretes aldosterone and cortisol as major corticosteroids. For their production, CYP11B2 and CYP11B1 catalyze the last steps in the syntheses of aldosterone and cortisol, respectively. In our previous study, CYP11B2 was the first successfully purified from rat adrenals and human clinical samples and then was proved to be aldosterone synthase. We demonstrated the immunohistochemistry for CYP11B2 of both rats and humans and applied it clinically to visualize the functional histology of aldosterone-producing adenoma ...
Source: Endocrine Journal - September 28, 2023 Category: Endocrinology Authors: Koshiro Nishimoto Tadashi Ogishima Yuki Sugiura Makoto Suematsu Kuniaki Mukai Source Type: research
Discover inspiring stories from the 100-year history of the Japan Endocrine Society; progress toward future successes
Endocr J. 2023;70(9):847-850. doi: 10.1507/endocrj.EJ20230323.NO ABSTRACTPMID:37766578 | DOI:10.1507/endocrj.EJ20230323 (Source: Endocrine Journal)
Source: Endocrine Journal - September 28, 2023 Category: Endocrinology Authors: Masatomo Mori Source Type: research
Erratum
Endocr J. 2023;70(9):941. doi: 10.1507/endocrj.EJ70-9_Erratum.NO ABSTRACTPMID:37766579 | DOI:10.1507/endocrj.EJ70-9_Erratum (Source: Endocrine Journal)
Source: Endocrine Journal - September 28, 2023 Category: Endocrinology Source Type: research
Assessment of factors associated with improved glycemic control after switching from intermittently scanned to real-time continuous glucose monitoring in Japanese patients with type 1 diabetes
Endocr J. 2023 Sep 26. doi: 10.1507/endocrj.EJ23-0125. Online ahead of print.ABSTRACTThe advantages of real-time continuous glucose monitoring (rtCGM) over intermittently scanned CGM (isCGM) reportedly include lower glycated hemoglobin (HbA1c) levels as well as reduced glycemic variability. However, there have been few studies of the effect of switching from isCGM to rtCGM on glycemic control, as well as the specific factors underlying any observed improvements. To that end, all patients with type 1 diabetes mellitus who used the DEXCOM rtCGM device (Terumo Corporation, Tokyo, Japan) at our institution were reviewed, and 1...
Source: Endocrine Journal - September 28, 2023 Category: Endocrinology Authors: Eijiro Yamada Yasuyo Nakajima Kazuhiko Horiguchi Shuichi Okada Masanobu Yamada Source Type: research
