Differences in metabolic characteristics between Metabolically Healthy Obesity (MHO) and Metabolically Unhealthy Obesity (MUO) in weight reduction therapy
Endocr J. 2023 Oct 3. doi: 10.1507/endocrj.EJ23-0189. Online ahead of print.ABSTRACTMetabolically Healthy Obesity (MHO) is generally recognized as the absence of any metabolic disorders and cardiovascular diseases, including type 2 diabetes, dyslipidemia, and hypertension, in obese individuals; however, it is not clearly defined. Therefore, the present study investigated differences in metabolic characteristics between individuals with MHO and Metabolically Unhealthy Obesity (MUO) during weight reduction therapy. The key factors defining MHO and the importance of weight reduction therapy for MHO were also examined. Cohort ...
Source: Endocrine Journal - October 4, 2023 Category: Endocrinology Authors: Shiori Kawai Hajime Yamakage Kazuhiko Kotani Mitsuhiko Noda Noriko Satoh-Asahara Koshi Hashimoto Source Type: research
Active surveillance for adult low-risk papillary thyroid microcarcinoma-a review focused on the 30-year experience of Kuma Hospital
Endocr J. 2023 Oct 4. doi: 10.1507/endocrj.EJ23-0395. Online ahead of print.ABSTRACTActive surveillance (AS) for low-risk papillary thyroid microcarcinoma (PTMC), which was initiated at Kuma Hospital (Kobe, Japan) in 1993 and Cancer Institute Hospital (Tokyo) in 1995, is now gradually being adopted worldwide, and several prospective studies have described the favorable outcomes of PTMC patients who underwent AS. The most important factor predicting PTMC growth is young age, and PTMC enlargement in young patients may be affected by high serum levels of thyroid-stimulating hormone. This review notes that one patient showed l...
Source: Endocrine Journal - October 4, 2023 Category: Endocrinology Authors: Yasuhiro Ito Akira Miyauchi Makoto Fujishima Masashi Yamamoto Takahiro Sasaki Source Type: research
Relationship between Ca < sup > 2+ < /sup > and cAMP as second messengers in ACTH-induced cortisol production in bovine adrenal fasciculata cells
Endocr J. 2023 Oct 4. doi: 10.1507/endocrj.EJ23-0253. Online ahead of print.ABSTRACTIn adrenal fasciculata cells stimulated by ACTH, Ca2+ and cAMP play indispensable roles as second messengers in cortisol production. However, whether their second messengers cooperatively or independently participate in steroid production remains unclear. We focused on the roles of Ca2+ and cAMP in cortisol production in bovine adrenal fasciculata cells stimulated by ACTH for a relatively short period (1 h). Incubation of the cells with 100 pM ACTH in Ca2+-containing (normal) medium for 1 h increased cortisol production without affecting cA...
Source: Endocrine Journal - October 4, 2023 Category: Endocrinology Authors: Masahiko Kutsukake Naoko Kuwabara Yoshikazu Miyate Kenzo Kudo Shoko Goto Eiichi Taira Eiichi Tachikawa Source Type: research
Differences in metabolic characteristics between Metabolically Healthy Obesity (MHO) and Metabolically Unhealthy Obesity (MUO) in weight reduction therapy
Endocr J. 2023 Oct 3. doi: 10.1507/endocrj.EJ23-0189. Online ahead of print.ABSTRACTMetabolically Healthy Obesity (MHO) is generally recognized as the absence of any metabolic disorders and cardiovascular diseases, including type 2 diabetes, dyslipidemia, and hypertension, in obese individuals; however, it is not clearly defined. Therefore, the present study investigated differences in metabolic characteristics between individuals with MHO and Metabolically Unhealthy Obesity (MUO) during weight reduction therapy. The key factors defining MHO and the importance of weight reduction therapy for MHO were also examined. Cohort ...
Source: Endocrine Journal - October 4, 2023 Category: Endocrinology Authors: Shiori Kawai Hajime Yamakage Kazuhiko Kotani Mitsuhiko Noda Noriko Satoh-Asahara Koshi Hashimoto Source Type: research
Active surveillance for adult low-risk papillary thyroid microcarcinoma-a review focused on the 30-year experience of Kuma Hospital
Endocr J. 2023 Oct 4. doi: 10.1507/endocrj.EJ23-0395. Online ahead of print.ABSTRACTActive surveillance (AS) for low-risk papillary thyroid microcarcinoma (PTMC), which was initiated at Kuma Hospital (Kobe, Japan) in 1993 and Cancer Institute Hospital (Tokyo) in 1995, is now gradually being adopted worldwide, and several prospective studies have described the favorable outcomes of PTMC patients who underwent AS. The most important factor predicting PTMC growth is young age, and PTMC enlargement in young patients may be affected by high serum levels of thyroid-stimulating hormone. This review notes that one patient showed l...
Source: Endocrine Journal - October 4, 2023 Category: Endocrinology Authors: Yasuhiro Ito Akira Miyauchi Makoto Fujishima Masashi Yamamoto Takahiro Sasaki Source Type: research
Relationship between Ca < sup > 2+ < /sup > and cAMP as second messengers in ACTH-induced cortisol production in bovine adrenal fasciculata cells
Endocr J. 2023 Oct 4. doi: 10.1507/endocrj.EJ23-0253. Online ahead of print.ABSTRACTIn adrenal fasciculata cells stimulated by ACTH, Ca2+ and cAMP play indispensable roles as second messengers in cortisol production. However, whether their second messengers cooperatively or independently participate in steroid production remains unclear. We focused on the roles of Ca2+ and cAMP in cortisol production in bovine adrenal fasciculata cells stimulated by ACTH for a relatively short period (1 h). Incubation of the cells with 100 pM ACTH in Ca2+-containing (normal) medium for 1 h increased cortisol production without affecting cA...
Source: Endocrine Journal - October 4, 2023 Category: Endocrinology Authors: Masahiko Kutsukake Naoko Kuwabara Yoshikazu Miyate Kenzo Kudo Shoko Goto Eiichi Taira Eiichi Tachikawa Source Type: research
Differences in metabolic characteristics between Metabolically Healthy Obesity (MHO) and Metabolically Unhealthy Obesity (MUO) in weight reduction therapy
Endocr J. 2023 Oct 3. doi: 10.1507/endocrj.EJ23-0189. Online ahead of print.ABSTRACTMetabolically Healthy Obesity (MHO) is generally recognized as the absence of any metabolic disorders and cardiovascular diseases, including type 2 diabetes, dyslipidemia, and hypertension, in obese individuals; however, it is not clearly defined. Therefore, the present study investigated differences in metabolic characteristics between individuals with MHO and Metabolically Unhealthy Obesity (MUO) during weight reduction therapy. The key factors defining MHO and the importance of weight reduction therapy for MHO were also examined. Cohort ...
Source: Endocrine Journal - October 4, 2023 Category: Endocrinology Authors: Shiori Kawai Hajime Yamakage Kazuhiko Kotani Mitsuhiko Noda Noriko Satoh-Asahara Koshi Hashimoto Source Type: research
Active surveillance for adult low-risk papillary thyroid microcarcinoma-a review focused on the 30-year experience of Kuma Hospital
Endocr J. 2023 Oct 4. doi: 10.1507/endocrj.EJ23-0395. Online ahead of print.ABSTRACTActive surveillance (AS) for low-risk papillary thyroid microcarcinoma (PTMC), which was initiated at Kuma Hospital (Kobe, Japan) in 1993 and Cancer Institute Hospital (Tokyo) in 1995, is now gradually being adopted worldwide, and several prospective studies have described the favorable outcomes of PTMC patients who underwent AS. The most important factor predicting PTMC growth is young age, and PTMC enlargement in young patients may be affected by high serum levels of thyroid-stimulating hormone. This review notes that one patient showed l...
Source: Endocrine Journal - October 4, 2023 Category: Endocrinology Authors: Yasuhiro Ito Akira Miyauchi Makoto Fujishima Masashi Yamamoto Takahiro Sasaki Source Type: research
Relationship between Ca < sup > 2+ < /sup > and cAMP as second messengers in ACTH-induced cortisol production in bovine adrenal fasciculata cells
Endocr J. 2023 Oct 4. doi: 10.1507/endocrj.EJ23-0253. Online ahead of print.ABSTRACTIn adrenal fasciculata cells stimulated by ACTH, Ca2+ and cAMP play indispensable roles as second messengers in cortisol production. However, whether their second messengers cooperatively or independently participate in steroid production remains unclear. We focused on the roles of Ca2+ and cAMP in cortisol production in bovine adrenal fasciculata cells stimulated by ACTH for a relatively short period (1 h). Incubation of the cells with 100 pM ACTH in Ca2+-containing (normal) medium for 1 h increased cortisol production without affecting cA...
Source: Endocrine Journal - October 4, 2023 Category: Endocrinology Authors: Masahiko Kutsukake Naoko Kuwabara Yoshikazu Miyate Kenzo Kudo Shoko Goto Eiichi Taira Eiichi Tachikawa Source Type: research
Differences in metabolic characteristics between Metabolically Healthy Obesity (MHO) and Metabolically Unhealthy Obesity (MUO) in weight reduction therapy
Endocr J. 2023 Oct 3. doi: 10.1507/endocrj.EJ23-0189. Online ahead of print.ABSTRACTMetabolically Healthy Obesity (MHO) is generally recognized as the absence of any metabolic disorders and cardiovascular diseases, including type 2 diabetes, dyslipidemia, and hypertension, in obese individuals; however, it is not clearly defined. Therefore, the present study investigated differences in metabolic characteristics between individuals with MHO and Metabolically Unhealthy Obesity (MUO) during weight reduction therapy. The key factors defining MHO and the importance of weight reduction therapy for MHO were also examined. Cohort ...
Source: Endocrine Journal - October 4, 2023 Category: Endocrinology Authors: Shiori Kawai Hajime Yamakage Kazuhiko Kotani Mitsuhiko Noda Noriko Satoh-Asahara Koshi Hashimoto Source Type: research
Active surveillance for adult low-risk papillary thyroid microcarcinoma-a review focused on the 30-year experience of Kuma Hospital
Endocr J. 2023 Oct 4. doi: 10.1507/endocrj.EJ23-0395. Online ahead of print.ABSTRACTActive surveillance (AS) for low-risk papillary thyroid microcarcinoma (PTMC), which was initiated at Kuma Hospital (Kobe, Japan) in 1993 and Cancer Institute Hospital (Tokyo) in 1995, is now gradually being adopted worldwide, and several prospective studies have described the favorable outcomes of PTMC patients who underwent AS. The most important factor predicting PTMC growth is young age, and PTMC enlargement in young patients may be affected by high serum levels of thyroid-stimulating hormone. This review notes that one patient showed l...
Source: Endocrine Journal - October 4, 2023 Category: Endocrinology Authors: Yasuhiro Ito Akira Miyauchi Makoto Fujishima Masashi Yamamoto Takahiro Sasaki Source Type: research
Relationship between Ca < sup > 2+ < /sup > and cAMP as second messengers in ACTH-induced cortisol production in bovine adrenal fasciculata cells
Endocr J. 2023 Oct 4. doi: 10.1507/endocrj.EJ23-0253. Online ahead of print.ABSTRACTIn adrenal fasciculata cells stimulated by ACTH, Ca2+ and cAMP play indispensable roles as second messengers in cortisol production. However, whether their second messengers cooperatively or independently participate in steroid production remains unclear. We focused on the roles of Ca2+ and cAMP in cortisol production in bovine adrenal fasciculata cells stimulated by ACTH for a relatively short period (1 h). Incubation of the cells with 100 pM ACTH in Ca2+-containing (normal) medium for 1 h increased cortisol production without affecting cA...
Source: Endocrine Journal - October 4, 2023 Category: Endocrinology Authors: Masahiko Kutsukake Naoko Kuwabara Yoshikazu Miyate Kenzo Kudo Shoko Goto Eiichi Taira Eiichi Tachikawa Source Type: research
Differences in metabolic characteristics between Metabolically Healthy Obesity (MHO) and Metabolically Unhealthy Obesity (MUO) in weight reduction therapy
Endocr J. 2023 Oct 3. doi: 10.1507/endocrj.EJ23-0189. Online ahead of print.ABSTRACTMetabolically Healthy Obesity (MHO) is generally recognized as the absence of any metabolic disorders and cardiovascular diseases, including type 2 diabetes, dyslipidemia, and hypertension, in obese individuals; however, it is not clearly defined. Therefore, the present study investigated differences in metabolic characteristics between individuals with MHO and Metabolically Unhealthy Obesity (MUO) during weight reduction therapy. The key factors defining MHO and the importance of weight reduction therapy for MHO were also examined. Cohort ...
Source: Endocrine Journal - October 4, 2023 Category: Endocrinology Authors: Shiori Kawai Hajime Yamakage Kazuhiko Kotani Mitsuhiko Noda Noriko Satoh-Asahara Koshi Hashimoto Source Type: research
Active surveillance for adult low-risk papillary thyroid microcarcinoma-a review focused on the 30-year experience of Kuma Hospital
Endocr J. 2023 Oct 4. doi: 10.1507/endocrj.EJ23-0395. Online ahead of print.ABSTRACTActive surveillance (AS) for low-risk papillary thyroid microcarcinoma (PTMC), which was initiated at Kuma Hospital (Kobe, Japan) in 1993 and Cancer Institute Hospital (Tokyo) in 1995, is now gradually being adopted worldwide, and several prospective studies have described the favorable outcomes of PTMC patients who underwent AS. The most important factor predicting PTMC growth is young age, and PTMC enlargement in young patients may be affected by high serum levels of thyroid-stimulating hormone. This review notes that one patient showed l...
Source: Endocrine Journal - October 4, 2023 Category: Endocrinology Authors: Yasuhiro Ito Akira Miyauchi Makoto Fujishima Masashi Yamamoto Takahiro Sasaki Source Type: research
Relationship between Ca < sup > 2+ < /sup > and cAMP as second messengers in ACTH-induced cortisol production in bovine adrenal fasciculata cells
Endocr J. 2023 Oct 4. doi: 10.1507/endocrj.EJ23-0253. Online ahead of print.ABSTRACTIn adrenal fasciculata cells stimulated by ACTH, Ca2+ and cAMP play indispensable roles as second messengers in cortisol production. However, whether their second messengers cooperatively or independently participate in steroid production remains unclear. We focused on the roles of Ca2+ and cAMP in cortisol production in bovine adrenal fasciculata cells stimulated by ACTH for a relatively short period (1 h). Incubation of the cells with 100 pM ACTH in Ca2+-containing (normal) medium for 1 h increased cortisol production without affecting cA...
Source: Endocrine Journal - October 4, 2023 Category: Endocrinology Authors: Masahiko Kutsukake Naoko Kuwabara Yoshikazu Miyate Kenzo Kudo Shoko Goto Eiichi Taira Eiichi Tachikawa Source Type: research
