Genetic and biochemical analysis of severe hypertriglyceridemia complicated with acute pancreatitis or with low post-heparin lipoprotein lipase mass
In this study, exome sequencing and biochemical analyses were performed in 4 patients with hypertriglyceridemia complicated by obesity or diabetes with a history of AP or decreased post-heparin LPL mass. In a patient with a history of AP, SNP rs199953320 resulting in LMF1 nonsense mutation and APOE rs7412 causing apolipoprotein E2 were both found in heterozygous form. Three patients were homozygous for APOA5 rs2075291, and one was heterozygous. ELISA and Western blot analysis of the serum revealed the existence of apolipoprotein A-V in the lipoprotein-free fraction regardless of the presence or absence of rs2075291; furthe...
Source: Endocrine Journal - February 12, 2024 Category: Endocrinology Authors: Takashi Suzuki Makoto Kurano Akari Isono Takuya Uchino Yohei Sayama Honami Tomomitsu Daiki Mayumi Ruriko Shibayama Toru Sekiguchi Naoki Edo Kiyoko Uno-Eder Kenji Uno Koji Morita Toshio Ishikawa Kazuhisa Tsukamoto Source Type: research
Recurrent nocturnal hypoglycemic hemiplegia: a case report and review of the literature
Endocr J. 2024 Feb 9. doi: 10.1507/endocrj.EJ23-0324. Online ahead of print.ABSTRACTA 67-year-old man with type 1 diabetes, Cronkhite-Canada syndrome, and membranous nephropathy who received insulin therapy was admitted to our hospital with right hemiplegia and dysarthria. Brain magnetic resonance imaging revealed a lesion with a high diffusion-weighted imaging signal and low apparent diffusion coefficient signal in the posterior limb of the left internal capsule. He was hypoglycemic with a blood glucose level of 56 mg/dL (3.1 mmol/L). Following glucose administration, the patient's symptoms resolved within several hours. ...
Source: Endocrine Journal - February 12, 2024 Category: Endocrinology Authors: Hanako Toyama Kazuyuki Takahashi Tatsunori Shimizu Izumi Otaka Sakiko Abe Shunsuke Kato Sayaka Ando Takehiro Sato Tsukasa Morii Hiroki Fujita Hironori Waki Source Type: research
A machine learning approach for predicting treatment response of hyponatremia
Endocr J. 2024 Feb 2. doi: 10.1507/endocrj.EJ23-0561. Online ahead of print.ABSTRACTHyponatremia leads to severe central nervous system disorders and requires immediate treatment in some cases. However, a rapid increase in serum sodium (s-Na) concentration could cause osmotic demyelination syndrome. To achieve a safety hyponatremia treatment, we develop a prediction model of s-Na concentration using a machine learning. Among the 341 and 47 patients admitted to two tertiary hospitals for hyponatremia treatment (s-Na <130 mEq/L), those who were admitted to the general unit with urine sodium <20 mEq/L or treated with de...
Source: Endocrine Journal - February 4, 2024 Category: Endocrinology Authors: Tamaki Kinoshita Shintaro Oyama Daisuke Hagiwara Yoshinori Azuma Hiroshi Arima Source Type: research
The humanistic and societal impact of obesity in Japan: a targeted literature review
Endocr J. 2024 Feb 3. doi: 10.1507/endocrj.EJ23-0416. Online ahead of print.ABSTRACTObesity is a focus of Japanese public health policy, due to Japanese individuals' high susceptibility to weight-related conditions. In contrast to global definitions, obesity is defined as a body-mass-index (BMI) of ≥25 kg/m2 in Japan. Despite public efforts, rates of obesity have not decreased over the past decade. To better understand its societal impact, we examined the economic, quality of life (QoL), and complications burden of obesity in Japan. Electronic databases were searched for English and Japanese-language publications from 20...
Source: Endocrine Journal - February 4, 2024 Category: Endocrinology Authors: Wataru Ogawa Palvi Gupta Source Type: research
Comparison of pathophysiology in subclinical hyperthyroidism with different etiologies
Endocr J. 2024 Jan 31. doi: 10.1507/endocrj.EJ23-0497. Online ahead of print.ABSTRACTSubclinical hyperthyroidism (SHyper) is defined as normal levels of free thyroxine (fT4) and free triiodothyronine (fT3) with suppressed levels of TSH. Previous studies have reported the individual pathophysiology of endogenous SHyper patients and athyreotic patients receiving TSH suppression therapy with levothyroxine; however, apparently no studies have compared the two conditions. Five-hundred-forty untreated endogenous SHyper patients and 1,024 patients receiving TSH suppression therapy who underwent total thyroidectomy for papillary t...
Source: Endocrine Journal - January 31, 2024 Category: Endocrinology Authors: Hanna Deguchi-Horiuchi Mitsuru Ito Sawako Takahashi Kazuyoshi Kousaka Mako Hisakado Shuji Fukata Takumi Kudo Eijun Nishihara Mitsushige Nishikawa Akira Miyauchi Takashi Akamizu Source Type: research
Clinical impact of proteinuria on renal function and treatment outcomes in patients with radioiodine-refractory thyroid cancer treated with lenvatinib
In conclusion, the proteinuria grade was not significantly associated with decreased eGFR under UPCR monitoring in our study. Therefore, lenvatinib can carefully be continued targeting UPCR of less than 3.5 g/gCre.PMID:38296547 | DOI:10.1507/endocrj.EJ23-0378 (Source: Endocrine Journal)
Source: Endocrine Journal - January 31, 2024 Category: Endocrinology Authors: Naoki Fukuda Kazuhisa Toda Hirotaka Suto Ryosuke Oki Xiaofei Wang Tetsuya Urasaki Yasuyoshi Sato Kenji Nakano Makiko Ono Junichi Tomomatsu Hiroki Mitani Shunji Takahashi Source Type: research
My Pituitary Research as Pathology and Endocrinology
Endocr J. 2024;71(1):1-6. doi: 10.1507/endocrj.EJ20230711.NO ABSTRACTPMID:38281755 | DOI:10.1507/endocrj.EJ20230711 (Source: Endocrine Journal)
Source: Endocrine Journal - January 28, 2024 Category: Endocrinology Authors: Robert Yoshiyuki Osamura Source Type: research
Cell-specific functions of androgen receptor in skeletal muscles
Endocr J. 2024 Jan 27. doi: 10.1507/endocrj.EJ23-0691. Online ahead of print.ABSTRACTAndrogens play a vital role not only in promoting the development of male sexual characteristics but also in exerting diverse physiological effects, including the regulation of skeletal muscle growth and function. Given that the effects of androgens are mediated through androgen receptor (AR) binding, an understanding of AR functionality is crucial for comprehending the mechanisms of androgen action on skeletal muscles. Drawing from insights gained using conditional knockout mouse models facilitated by Cre/loxP technology, we review the ce...
Source: Endocrine Journal - January 28, 2024 Category: Endocrinology Authors: Hiroshi Sakai Yuuki Imai Source Type: research
Secondary vs. primary pituitary xanthogranulomas: Which yellow is more mellow?
Endocr J. 2024 Jan 27. doi: 10.1507/endocrj.EJ23-0398. Online ahead of print.ABSTRACTPituitary xanthogranulomatomas (XG) are a rare pathological entity caused by accumulation of lipid laden macrophages and reactive granuloma formation usually triggered by cystic fluid leakage or hemorrhage. Our aim was to compare clinical characteristics and presenting features of patients with secondary etiology of XG and those with no identifiable founding lesion (primary -"pure" XG) in order to gain new insights into this rare pituitary pathology. In a retrospective review of 714 patients operated for sellar masses, at tertiary center, ...
Source: Endocrine Journal - January 28, 2024 Category: Endocrinology Authors: Dragana Miljic Sandra Pekic Mirjana Doknic Marko Stojanovic Sasa Ilic Marina Nikolic Djurovic Zvezdana Jemuovic Toplica Milojevic Mihailo Milicevic Marija Jovanovic Milica Medic Stojanoska Bojana Cari ć Nevena Radic Sanja Medenica Emilija Manojlovic Gaci Source Type: research
Risk factors for mediastinal lymph node metastasis and lung metastasis in papillary thyroid carcinoma patients: who benefits from preoperative computed tomography?
Endocr J. 2024 Jan 19. doi: 10.1507/endocrj.EJ23-0413. Online ahead of print.ABSTRACTIn papillary thyroid carcinoma (PTC) patients with mediastinal lymph nodes (LN) and lung metastases, adding preoperative computed tomography (CT) to ultrasound is useful for planning surgery. We identified risk factors (RFs) for mediastinal lymph node metastasis (MLNM) and lung metastasis in PTC patients. Frequencies of MLNM and lung metastases were compared in 478 patients. Relative risk (RR) was calculated based on RFs. MLNM and lung metastases were detected in 1.2% and 3.3% of patients, respectively. cT3-4, cN1, central LN metastasis, a...
Source: Endocrine Journal - January 21, 2024 Category: Endocrinology Authors: Yoko Omi Juro Yanagida Yusaku Yoshida Kiyomi Horiuchi Takahiro Okamoto Source Type: research
New onset of isolated adrenocorticotropin deficiency associated with encephalopathy following coronavirus disease 2019 in a healthy elderly man
We report the case of a 65-year-old Japanese man who developed isolated adrenocorticotropic hormone (ACTH) deficiency and encephalopathy following SARS-CoV-2 infection. Two weeks after his COVID-19 diagnosis, he was emergently admitted to our hospital because of subacute-onset delirium. On admission, he presented hyponatremia (128 mEq/L) and secondary adrenal insufficiency (ACTH <1.5 pg/mL, cortisol 0.53 μg/dL). Brain imaging and laboratory examinations including SARS-CoV-2 polymerase chain reaction testing in the cerebrospinal fluid revealed no abnormalities. His consciousness level worsened despite the amelioration o...
Source: Endocrine Journal - January 21, 2024 Category: Endocrinology Authors: Yusuke Yamasaki Ichiro Horie Riyoko Shigeno Shinpei Nishikido Toshiyuki Ikeoka Takuro Hirayama Yohei Tateishi Akira Tsujino Atsushi Kawakami Source Type: research
Protective effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve of rats with diabetic peripheral neuropathy
In this study, the effect of alirocumab, a PCSK9 inhibitor, on the sciatic nerve in rats with diabetic peripheral neuropathy and its underlying mechanisms were investigated. The diabetic peripheral neuropathy rat model was established by using a high-fat diet combined with streptozotocin injection, and experimental subjects were divided into normal, diabetic peripheral neuropathy, and alirocumab groups. The results showed that Alirocumab improved nerve conduction, morphological changes, and small fiber deficits in rats with DPN, possibly related to its amelioration of oxidative stress and the inflammatory response.PMID:382...
Source: Endocrine Journal - January 17, 2024 Category: Endocrinology Authors: Na Cui Yonghao Feng Ming Wang Xiuyan Lu Yongmei Huang Yinghui Chen Xiaohong Shi Source Type: research
Single-cell and spatial transcriptomics in endocrine research
Endocr J. 2024 Jan 13. doi: 10.1507/endocrj.EJ23-0457. Online ahead of print.ABSTRACTAccumulating evidence suggests that cellular heterogeneity in organs and cell-cell and tissue-tissue interactions are crucial for maintaining physical homeostasis and disease progression. Endocrine organs also exhibit cellular heterogeneity and comprise multiple cell types. For instance, the pituitary gland comprises five types of pituitary hormone-producing cells as well as non-hormone-producing supporting cells, such as fibroblasts, endothelial cells, and folliculostellate cells. However, the functional roles of the interactions between ...
Source: Endocrine Journal - January 14, 2024 Category: Endocrinology Authors: Ryusaku Matsumoto Takuya Yamamoto Source Type: research
Effects of plant- and animal-based-protein meals for a day on serum nitric oxide and peroxynitrite levels in healthy young men
Endocr J. 2024 Jan 13. doi: 10.1507/endocrj.EJ23-0355. Online ahead of print.ABSTRACTPlant-based diets that replace animal-based proteins with plant-based proteins have received increased attention for cardiovascular protection. Nitric oxide (NO) plays an essential role in the maintenance of endothelial function. However, under higher oxidative stress, NO generation produces peroxynitrite, a powerful oxidant and vasoconstrictor. Diet-replaced protein sources has been reported to decrease oxidative stress. However, the effects of plant-based protein on NO and peroxynitrite have not yet been clarified. Therefore, this study ...
Source: Endocrine Journal - January 14, 2024 Category: Endocrinology Authors: Tomoko Kaneko Masaki Yoshioka Futo Kawahara Natsumi Nishitani Shoya Mori Jiyeon Park Takashi Tarumi Keisei Kosaki Seiji Maeda Source Type: research
Amphibian newts as experimental models for studying weight gain after castration
We examined whether the Iberian ribbed newt, which has recently become a popular experimental model for amphibian research, could serve as a model for analyzing changes in body shape after castration. In newts, new testes can be regenerated after removal of differentiated testes. We analyzed changes in body shape by removing the testes under conditions in which they could regenerate or conditions in which they could not regenerate. Removal of the testes reduced blood testosterone levels. The body weight and abdominal girth of the newts were increased compared with normal male newts. Transcriptome analysis of the liver show...
Source: Endocrine Journal - January 14, 2024 Category: Endocrinology Authors: Mai Takehara Mitsuki Kyakuno Kazuko Okamoto Ichiro Tazawa Nobuaki Furuno Megumi Furumitsu Kazuyoshi Ukena Takuya Imamura Takashi Takeuchi Toshinori Hayashi Source Type: research
