Brown fat thermogenesis and branched-chain amino acids in metabolic disease
Endocr J. 2023 Nov 9. doi: 10.1507/endocrj.EJ23-0205. Online ahead of print.ABSTRACTSince the 1960s, researchers have recognized an association between elevated plasma branched chain amino acids (BCAA) and metabolic disease, including type 2 diabetes mellitus and obesity, but the cause for it remained poorly understood. Recent advances in metabolomics, advanced imaging techniques, and genetic analyses over the past decade have enabled newfound insights into the mechanism of BCAA metabolic dysregulation across a variety of peripheral tissues and its impact on metabolic disease, suggesting a key role for brown adipose tissue...
Source: Endocrine Journal - November 8, 2023 Category: Endocrinology Authors: Zachary Brown Takeshi Yoneshiro Source Type: research
Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events
Endocr J. 2023 Nov 7. doi: 10.1507/endocrj.EJ23-0524. Online ahead of print.ABSTRACTImmune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs) in several organs including endocrine glands. Among endocrine irAEs, thyroid and pituitary irAEs are frequently observed, followed by primary adrenal insufficiency, insulin-dependent diabetes mellitus, and hypoparathyroidism. These conditions could lead to life-threatening consequences, such as adrenal crisis and diabetic ketoacidosis. On the other hand, several types of irAEs including thyroid and pituitary irAEs are reported to be associated with better ov...
Source: Endocrine Journal - November 8, 2023 Category: Endocrinology Authors: Tomoko Kobayashi Shintaro Iwama Hiroshi Arima Source Type: research
Brown fat thermogenesis and branched-chain amino acids in metabolic disease
Endocr J. 2023 Nov 9. doi: 10.1507/endocrj.EJ23-0205. Online ahead of print.ABSTRACTSince the 1960s, researchers have recognized an association between elevated plasma branched chain amino acids (BCAA) and metabolic disease, including type 2 diabetes mellitus and obesity, but the cause for it remained poorly understood. Recent advances in metabolomics, advanced imaging techniques, and genetic analyses over the past decade have enabled newfound insights into the mechanism of BCAA metabolic dysregulation across a variety of peripheral tissues and its impact on metabolic disease, suggesting a key role for brown adipose tissue...
Source: Endocrine Journal - November 8, 2023 Category: Endocrinology Authors: Zachary Brown Takeshi Yoneshiro Source Type: research
Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events
Endocr J. 2023 Nov 7. doi: 10.1507/endocrj.EJ23-0524. Online ahead of print.ABSTRACTImmune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs) in several organs including endocrine glands. Among endocrine irAEs, thyroid and pituitary irAEs are frequently observed, followed by primary adrenal insufficiency, insulin-dependent diabetes mellitus, and hypoparathyroidism. These conditions could lead to life-threatening consequences, such as adrenal crisis and diabetic ketoacidosis. On the other hand, several types of irAEs including thyroid and pituitary irAEs are reported to be associated with better ov...
Source: Endocrine Journal - November 8, 2023 Category: Endocrinology Authors: Tomoko Kobayashi Shintaro Iwama Hiroshi Arima Source Type: research
Brown fat thermogenesis and branched-chain amino acids in metabolic disease
Endocr J. 2023 Nov 9. doi: 10.1507/endocrj.EJ23-0205. Online ahead of print.ABSTRACTSince the 1960s, researchers have recognized an association between elevated plasma branched chain amino acids (BCAA) and metabolic disease, including type 2 diabetes mellitus and obesity, but the cause for it remained poorly understood. Recent advances in metabolomics, advanced imaging techniques, and genetic analyses over the past decade have enabled newfound insights into the mechanism of BCAA metabolic dysregulation across a variety of peripheral tissues and its impact on metabolic disease, suggesting a key role for brown adipose tissue...
Source: Endocrine Journal - November 8, 2023 Category: Endocrinology Authors: Zachary Brown Takeshi Yoneshiro Source Type: research
Clinical characteristics and potential biomarkers of thyroid and pituitary immune-related adverse events
Endocr J. 2023 Nov 7. doi: 10.1507/endocrj.EJ23-0524. Online ahead of print.ABSTRACTImmune checkpoint inhibitors (ICIs) can cause immune-related adverse events (irAEs) in several organs including endocrine glands. Among endocrine irAEs, thyroid and pituitary irAEs are frequently observed, followed by primary adrenal insufficiency, insulin-dependent diabetes mellitus, and hypoparathyroidism. These conditions could lead to life-threatening consequences, such as adrenal crisis and diabetic ketoacidosis. On the other hand, several types of irAEs including thyroid and pituitary irAEs are reported to be associated with better ov...
Source: Endocrine Journal - November 8, 2023 Category: Endocrinology Authors: Tomoko Kobayashi Shintaro Iwama Hiroshi Arima Source Type: research
A retrospective study on tolvaptan prescription in clinical practice in patients with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) using the Japanese claims database
Endocr J. 2023 Oct 31. doi: 10.1507/endocrj.EJ23-0256. Online ahead of print.ABSTRACTWe aimed to survey the status of tolvaptan administration in routine clinical practice since the approval of a novel indication for treating syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in Japan. Data from a population of 3,152 patients aged ≥18 years and diagnosed with SIADH between July 1, 2020 and June 30, 2021 were extracted from a Japanese database. Tolvaptan was administered to 586 patients while 2,566 patients were followed up without tolvaptan. In the tolvaptan-treated group, the standard initial doses were...
Source: Endocrine Journal - November 1, 2023 Category: Endocrinology Authors: Daisuke Hagiwara Miyuki Matsukawa Junko Tasaki Yumiko Nakamura Hiroshi Arima Source Type: research
Region-specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes: a cross-sectional study
Endocr J. 2023 Nov 1. doi: 10.1507/endocrj.EJ23-0211. Online ahead of print.ABSTRACTTo examine the association between prediabetes/type 2 diabetes mellitus (T2DM) and hippocampal subfields and to investigate the effects of glycemic control (HbA1c and FBG)/diabetes duration on the volume of hippocampal subfields in T2DM patients. This cross-sectional study included 268 participants from Tianjin Union Medical Center between August 2019 and July 2022. The participants were divided into three groups: T2DM, prediabetes and no diabetes. All participants underwent brain MRI examination on a 3T MRI scanner. FreeSurfer was performe...
Source: Endocrine Journal - November 1, 2023 Category: Endocrinology Authors: Cuiping Bao Xuehuan Liu Yiming Li Jun Yang Feng Wei Yi Gong Zhihui Ma Jun Liu Source Type: research
A retrospective study on tolvaptan prescription in clinical practice in patients with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) using the Japanese claims database
Endocr J. 2023 Oct 31. doi: 10.1507/endocrj.EJ23-0256. Online ahead of print.ABSTRACTWe aimed to survey the status of tolvaptan administration in routine clinical practice since the approval of a novel indication for treating syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in Japan. Data from a population of 3,152 patients aged ≥18 years and diagnosed with SIADH between July 1, 2020 and June 30, 2021 were extracted from a Japanese database. Tolvaptan was administered to 586 patients while 2,566 patients were followed up without tolvaptan. In the tolvaptan-treated group, the standard initial doses were...
Source: Endocrine Journal - November 1, 2023 Category: Endocrinology Authors: Daisuke Hagiwara Miyuki Matsukawa Junko Tasaki Yumiko Nakamura Hiroshi Arima Source Type: research
Region-specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes: a cross-sectional study
Endocr J. 2023 Nov 1. doi: 10.1507/endocrj.EJ23-0211. Online ahead of print.ABSTRACTTo examine the association between prediabetes/type 2 diabetes mellitus (T2DM) and hippocampal subfields and to investigate the effects of glycemic control (HbA1c and FBG)/diabetes duration on the volume of hippocampal subfields in T2DM patients. This cross-sectional study included 268 participants from Tianjin Union Medical Center between August 2019 and July 2022. The participants were divided into three groups: T2DM, prediabetes and no diabetes. All participants underwent brain MRI examination on a 3T MRI scanner. FreeSurfer was performe...
Source: Endocrine Journal - November 1, 2023 Category: Endocrinology Authors: Cuiping Bao Xuehuan Liu Yiming Li Jun Yang Feng Wei Yi Gong Zhihui Ma Jun Liu Source Type: research
A retrospective study on tolvaptan prescription in clinical practice in patients with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) using the Japanese claims database
Endocr J. 2023 Oct 31. doi: 10.1507/endocrj.EJ23-0256. Online ahead of print.ABSTRACTWe aimed to survey the status of tolvaptan administration in routine clinical practice since the approval of a novel indication for treating syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in Japan. Data from a population of 3,152 patients aged ≥18 years and diagnosed with SIADH between July 1, 2020 and June 30, 2021 were extracted from a Japanese database. Tolvaptan was administered to 586 patients while 2,566 patients were followed up without tolvaptan. In the tolvaptan-treated group, the standard initial doses were...
Source: Endocrine Journal - November 1, 2023 Category: Endocrinology Authors: Daisuke Hagiwara Miyuki Matsukawa Junko Tasaki Yumiko Nakamura Hiroshi Arima Source Type: research
Region-specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes: a cross-sectional study
Endocr J. 2023 Nov 1. doi: 10.1507/endocrj.EJ23-0211. Online ahead of print.ABSTRACTTo examine the association between prediabetes/type 2 diabetes mellitus (T2DM) and hippocampal subfields and to investigate the effects of glycemic control (HbA1c and FBG)/diabetes duration on the volume of hippocampal subfields in T2DM patients. This cross-sectional study included 268 participants from Tianjin Union Medical Center between August 2019 and July 2022. The participants were divided into three groups: T2DM, prediabetes and no diabetes. All participants underwent brain MRI examination on a 3T MRI scanner. FreeSurfer was performe...
Source: Endocrine Journal - November 1, 2023 Category: Endocrinology Authors: Cuiping Bao Xuehuan Liu Yiming Li Jun Yang Feng Wei Yi Gong Zhihui Ma Jun Liu Source Type: research
A retrospective study on tolvaptan prescription in clinical practice in patients with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) using the Japanese claims database
Endocr J. 2023 Oct 31. doi: 10.1507/endocrj.EJ23-0256. Online ahead of print.ABSTRACTWe aimed to survey the status of tolvaptan administration in routine clinical practice since the approval of a novel indication for treating syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in Japan. Data from a population of 3,152 patients aged ≥18 years and diagnosed with SIADH between July 1, 2020 and June 30, 2021 were extracted from a Japanese database. Tolvaptan was administered to 586 patients while 2,566 patients were followed up without tolvaptan. In the tolvaptan-treated group, the standard initial doses were...
Source: Endocrine Journal - November 1, 2023 Category: Endocrinology Authors: Daisuke Hagiwara Miyuki Matsukawa Junko Tasaki Yumiko Nakamura Hiroshi Arima Source Type: research
Region-specific hippocampal atrophy is correlated with poor glycemic control in type 2 diabetes: a cross-sectional study
Endocr J. 2023 Nov 1. doi: 10.1507/endocrj.EJ23-0211. Online ahead of print.ABSTRACTTo examine the association between prediabetes/type 2 diabetes mellitus (T2DM) and hippocampal subfields and to investigate the effects of glycemic control (HbA1c and FBG)/diabetes duration on the volume of hippocampal subfields in T2DM patients. This cross-sectional study included 268 participants from Tianjin Union Medical Center between August 2019 and July 2022. The participants were divided into three groups: T2DM, prediabetes and no diabetes. All participants underwent brain MRI examination on a 3T MRI scanner. FreeSurfer was performe...
Source: Endocrine Journal - November 1, 2023 Category: Endocrinology Authors: Cuiping Bao Xuehuan Liu Yiming Li Jun Yang Feng Wei Yi Gong Zhihui Ma Jun Liu Source Type: research
A retrospective study on tolvaptan prescription in clinical practice in patients with syndrome of inappropriate secretion of antidiuretic hormone (SIADH) using the Japanese claims database
Endocr J. 2023 Oct 31. doi: 10.1507/endocrj.EJ23-0256. Online ahead of print.ABSTRACTWe aimed to survey the status of tolvaptan administration in routine clinical practice since the approval of a novel indication for treating syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in Japan. Data from a population of 3,152 patients aged ≥18 years and diagnosed with SIADH between July 1, 2020 and June 30, 2021 were extracted from a Japanese database. Tolvaptan was administered to 586 patients while 2,566 patients were followed up without tolvaptan. In the tolvaptan-treated group, the standard initial doses were...
Source: Endocrine Journal - November 1, 2023 Category: Endocrinology Authors: Daisuke Hagiwara Miyuki Matsukawa Junko Tasaki Yumiko Nakamura Hiroshi Arima Source Type: research
