Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism
We examined the mRNA level and methylation status of the HSD11B1 promoter region in the adipose tissue of patients with primary aldosteronism (PA). We compared 10 tissue specimens from patients with PA caused by aldosterone-producing adenoma (APA) with 8 adipose tissue specimens from patients with subclinical Cushing's syndrome (SCS) caused by cortisol-producing adenomas, 4 tissue specimens from patients with Cushing's adenoma (Cu), or 7 tissue specimens from patients with non-functioning adrenal adenoma (NFA). PA, SCS, and Cu were diagnosed according to the guideline of the Japan Endocrine Society. The mRNA level of HSD11...
Source: Endocrine Journal - December 24, 2023 Category: Endocrinology Authors: Yoshimichi Takeda Masashi Demura Mitsuhiro Kometani Shigehiro Karashima Daisuke Aono Seigo Konishi Shin-Ichi Horike Makiko Meguro-Horike Takashi Yoneda Yoshiyu Takeda Source Type: research
Encapsulated human islets in alginate fiber maintain long-term functionality
Endocr J. 2023 Dec 22. doi: 10.1507/endocrj.EJ23-0474. Online ahead of print.ABSTRACTMaintenance of islet function after in vitro culture is crucial for both transplantation and research. Here we evaluated the effects of encapsulation in alginate fiber on the function of human islets which were distributed by the Alberta Islet Distribution Program. Encapsulated human islets from 15 deceased donors were cultured under 5.5 or 25 mM glucose conditions in vitro. The amounts of C-peptide and glucagon secreted from encapsulated islets into the culture media were measured periodically, and immunohistochemical studies were perform...
Source: Endocrine Journal - December 24, 2023 Category: Endocrinology Authors: Junko Nishida Takahiro Tsuno Shigeharu G Yabe Tatsuya Kin Satsuki Fukuda Fujie Takeda Jun Shirakawa Hitoshi Okochi Source Type: research
Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism
We examined the mRNA level and methylation status of the HSD11B1 promoter region in the adipose tissue of patients with primary aldosteronism (PA). We compared 10 tissue specimens from patients with PA caused by aldosterone-producing adenoma (APA) with 8 adipose tissue specimens from patients with subclinical Cushing's syndrome (SCS) caused by cortisol-producing adenomas, 4 tissue specimens from patients with Cushing's adenoma (Cu), or 7 tissue specimens from patients with non-functioning adrenal adenoma (NFA). PA, SCS, and Cu were diagnosed according to the guideline of the Japan Endocrine Society. The mRNA level of HSD11...
Source: Endocrine Journal - December 24, 2023 Category: Endocrinology Authors: Yoshimichi Takeda Masashi Demura Mitsuhiro Kometani Shigehiro Karashima Daisuke Aono Seigo Konishi Shin-Ichi Horike Makiko Meguro-Horike Takashi Yoneda Yoshiyu Takeda Source Type: research
Encapsulated human islets in alginate fiber maintain long-term functionality
Endocr J. 2023 Dec 22. doi: 10.1507/endocrj.EJ23-0474. Online ahead of print.ABSTRACTMaintenance of islet function after in vitro culture is crucial for both transplantation and research. Here we evaluated the effects of encapsulation in alginate fiber on the function of human islets which were distributed by the Alberta Islet Distribution Program. Encapsulated human islets from 15 deceased donors were cultured under 5.5 or 25 mM glucose conditions in vitro. The amounts of C-peptide and glucagon secreted from encapsulated islets into the culture media were measured periodically, and immunohistochemical studies were perform...
Source: Endocrine Journal - December 24, 2023 Category: Endocrinology Authors: Junko Nishida Takahiro Tsuno Shigeharu G Yabe Tatsuya Kin Satsuki Fukuda Fujie Takeda Jun Shirakawa Hitoshi Okochi Source Type: research
Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism
We examined the mRNA level and methylation status of the HSD11B1 promoter region in the adipose tissue of patients with primary aldosteronism (PA). We compared 10 tissue specimens from patients with PA caused by aldosterone-producing adenoma (APA) with 8 adipose tissue specimens from patients with subclinical Cushing's syndrome (SCS) caused by cortisol-producing adenomas, 4 tissue specimens from patients with Cushing's adenoma (Cu), or 7 tissue specimens from patients with non-functioning adrenal adenoma (NFA). PA, SCS, and Cu were diagnosed according to the guideline of the Japan Endocrine Society. The mRNA level of HSD11...
Source: Endocrine Journal - December 24, 2023 Category: Endocrinology Authors: Yoshimichi Takeda Masashi Demura Mitsuhiro Kometani Shigehiro Karashima Daisuke Aono Seigo Konishi Shin-Ichi Horike Makiko Meguro-Horike Takashi Yoneda Yoshiyu Takeda Source Type: research
Encapsulated human islets in alginate fiber maintain long-term functionality
Endocr J. 2023 Dec 22. doi: 10.1507/endocrj.EJ23-0474. Online ahead of print.ABSTRACTMaintenance of islet function after in vitro culture is crucial for both transplantation and research. Here we evaluated the effects of encapsulation in alginate fiber on the function of human islets which were distributed by the Alberta Islet Distribution Program. Encapsulated human islets from 15 deceased donors were cultured under 5.5 or 25 mM glucose conditions in vitro. The amounts of C-peptide and glucagon secreted from encapsulated islets into the culture media were measured periodically, and immunohistochemical studies were perform...
Source: Endocrine Journal - December 24, 2023 Category: Endocrinology Authors: Junko Nishida Takahiro Tsuno Shigeharu G Yabe Tatsuya Kin Satsuki Fukuda Fujie Takeda Jun Shirakawa Hitoshi Okochi Source Type: research
Epigenetic alterations of 11beta-hydroxysteroid dehydrogenase 1 gene in the adipose tissue of patients with primary aldosteronism
We examined the mRNA level and methylation status of the HSD11B1 promoter region in the adipose tissue of patients with primary aldosteronism (PA). We compared 10 tissue specimens from patients with PA caused by aldosterone-producing adenoma (APA) with 8 adipose tissue specimens from patients with subclinical Cushing's syndrome (SCS) caused by cortisol-producing adenomas, 4 tissue specimens from patients with Cushing's adenoma (Cu), or 7 tissue specimens from patients with non-functioning adrenal adenoma (NFA). PA, SCS, and Cu were diagnosed according to the guideline of the Japan Endocrine Society. The mRNA level of HSD11...
Source: Endocrine Journal - December 24, 2023 Category: Endocrinology Authors: Yoshimichi Takeda Masashi Demura Mitsuhiro Kometani Shigehiro Karashima Daisuke Aono Seigo Konishi Shin-Ichi Horike Makiko Meguro-Horike Takashi Yoneda Yoshiyu Takeda Source Type: research
Positive association between proinsulin and fatty liver index in people with type 2 diabetes
Endocr J. 2023 Dec 19. doi: 10.1507/endocrj.EJ23-0403. Online ahead of print.ABSTRACTThe post-hoc study, derived from our previous prospective observational study, investigated the association between fasting serum proinsulin levels and hepatic steatosis in people with type 2 diabetes. The severity of hepatic steatosis was assessed using the fatty liver index. A total of 268 participants were divided into three groups: low (n = 110), moderate (n = 75), and high fatty liver index (n = 83). In both the crude and age/sex-adjusted analysis, logarithm-transformed proinsulin was significantly higher in the high fatty liver index...
Source: Endocrine Journal - December 20, 2023 Category: Endocrinology Authors: Akinobu Nakamura Aika Miya Yuka Suzuki Hiroshi Nomoto Hiraku Kameda Kyu Yong Cho So Nagai Tatsuya Atsumi Source Type: research
Definition, criteria, and core concepts of guidelines for the management of obesity disease in Japan
Endocr J. 2023 Dec 20. doi: 10.1507/endocrj.EJ23-0593. Online ahead of print.ABSTRACTTo identify those who might benefit from weight reduction within a large population of obese individuals, Japan Society for the Study of Obesity (JASSO) advocated the concept of "obesity disease." Here we summarize the definition, criteria, and core concepts for the management of obesity disease based on JASSO's latest guideline. JASSO defines obesity as excessive fat storage in adipose tissue associated with a BMI of ≥25 kg/m2. The threshold BMI of obesity is low as compared to Western countries given that Japanese individuals tend to d...
Source: Endocrine Journal - December 20, 2023 Category: Endocrinology Authors: Wataru Ogawa Yushi Hirota Shigeru Miyazaki Tadashi Nakamura Yoshihiro Ogawa Iichiro Shimomura Toshimasa Yamauchi Koutaro Yokote Creation Committee for Guidelines for the Management of Obesity Disease 2022 by Japan Society for the Study of Obesity (JASSO) Source Type: research
Positive association between proinsulin and fatty liver index in people with type 2 diabetes
Endocr J. 2023 Dec 19. doi: 10.1507/endocrj.EJ23-0403. Online ahead of print.ABSTRACTThe post-hoc study, derived from our previous prospective observational study, investigated the association between fasting serum proinsulin levels and hepatic steatosis in people with type 2 diabetes. The severity of hepatic steatosis was assessed using the fatty liver index. A total of 268 participants were divided into three groups: low (n = 110), moderate (n = 75), and high fatty liver index (n = 83). In both the crude and age/sex-adjusted analysis, logarithm-transformed proinsulin was significantly higher in the high fatty liver index...
Source: Endocrine Journal - December 20, 2023 Category: Endocrinology Authors: Akinobu Nakamura Aika Miya Yuka Suzuki Hiroshi Nomoto Hiraku Kameda Kyu Yong Cho So Nagai Tatsuya Atsumi Source Type: research
Definition, criteria, and core concepts of guidelines for the management of obesity disease in Japan
Endocr J. 2023 Dec 20. doi: 10.1507/endocrj.EJ23-0593. Online ahead of print.ABSTRACTTo identify those who might benefit from weight reduction within a large population of obese individuals, Japan Society for the Study of Obesity (JASSO) advocated the concept of "obesity disease." Here we summarize the definition, criteria, and core concepts for the management of obesity disease based on JASSO's latest guideline. JASSO defines obesity as excessive fat storage in adipose tissue associated with a BMI of ≥25 kg/m2. The threshold BMI of obesity is low as compared to Western countries given that Japanese individuals tend to d...
Source: Endocrine Journal - December 20, 2023 Category: Endocrinology Authors: Wataru Ogawa Yushi Hirota Shigeru Miyazaki Tadashi Nakamura Yoshihiro Ogawa Iichiro Shimomura Toshimasa Yamauchi Koutaro Yokote Creation Committee for Guidelines for the Management of Obesity Disease 2022 by Japan Society for the Study of Obesity (JASSO) Source Type: research
Positive association between proinsulin and fatty liver index in people with type 2 diabetes
Endocr J. 2023 Dec 19. doi: 10.1507/endocrj.EJ23-0403. Online ahead of print.ABSTRACTThe post-hoc study, derived from our previous prospective observational study, investigated the association between fasting serum proinsulin levels and hepatic steatosis in people with type 2 diabetes. The severity of hepatic steatosis was assessed using the fatty liver index. A total of 268 participants were divided into three groups: low (n = 110), moderate (n = 75), and high fatty liver index (n = 83). In both the crude and age/sex-adjusted analysis, logarithm-transformed proinsulin was significantly higher in the high fatty liver index...
Source: Endocrine Journal - December 20, 2023 Category: Endocrinology Authors: Akinobu Nakamura Aika Miya Yuka Suzuki Hiroshi Nomoto Hiraku Kameda Kyu Yong Cho So Nagai Tatsuya Atsumi Source Type: research
Definition, criteria, and core concepts of guidelines for the management of obesity disease in Japan
Endocr J. 2023 Dec 20. doi: 10.1507/endocrj.EJ23-0593. Online ahead of print.ABSTRACTTo identify those who might benefit from weight reduction within a large population of obese individuals, Japan Society for the Study of Obesity (JASSO) advocated the concept of "obesity disease." Here we summarize the definition, criteria, and core concepts for the management of obesity disease based on JASSO's latest guideline. JASSO defines obesity as excessive fat storage in adipose tissue associated with a BMI of ≥25 kg/m2. The threshold BMI of obesity is low as compared to Western countries given that Japanese individuals tend to d...
Source: Endocrine Journal - December 20, 2023 Category: Endocrinology Authors: Wataru Ogawa Yushi Hirota Shigeru Miyazaki Tadashi Nakamura Yoshihiro Ogawa Iichiro Shimomura Toshimasa Yamauchi Koutaro Yokote Creation Committee for Guidelines for the Management of Obesity Disease 2022 by Japan Society for the Study of Obesity (JASSO) Source Type: research
Positive association between proinsulin and fatty liver index in people with type 2 diabetes
Endocr J. 2023 Dec 19. doi: 10.1507/endocrj.EJ23-0403. Online ahead of print.ABSTRACTThe post-hoc study, derived from our previous prospective observational study, investigated the association between fasting serum proinsulin levels and hepatic steatosis in people with type 2 diabetes. The severity of hepatic steatosis was assessed using the fatty liver index. A total of 268 participants were divided into three groups: low (n = 110), moderate (n = 75), and high fatty liver index (n = 83). In both the crude and age/sex-adjusted analysis, logarithm-transformed proinsulin was significantly higher in the high fatty liver index...
Source: Endocrine Journal - December 20, 2023 Category: Endocrinology Authors: Akinobu Nakamura Aika Miya Yuka Suzuki Hiroshi Nomoto Hiraku Kameda Kyu Yong Cho So Nagai Tatsuya Atsumi Source Type: research
Definition, criteria, and core concepts of guidelines for the management of obesity disease in Japan
Endocr J. 2023 Dec 20. doi: 10.1507/endocrj.EJ23-0593. Online ahead of print.ABSTRACTTo identify those who might benefit from weight reduction within a large population of obese individuals, Japan Society for the Study of Obesity (JASSO) advocated the concept of "obesity disease." Here we summarize the definition, criteria, and core concepts for the management of obesity disease based on JASSO's latest guideline. JASSO defines obesity as excessive fat storage in adipose tissue associated with a BMI of ≥25 kg/m2. The threshold BMI of obesity is low as compared to Western countries given that Japanese individuals tend to d...
Source: Endocrine Journal - December 20, 2023 Category: Endocrinology Authors: Wataru Ogawa Yushi Hirota Shigeru Miyazaki Tadashi Nakamura Yoshihiro Ogawa Iichiro Shimomura Toshimasa Yamauchi Koutaro Yokote Creation Committee for Guidelines for the Management of Obesity Disease 2022 by Japan Society for the Study of Obesity (JASSO) Source Type: research
