Molecular aspects of regeneration in insects
This report highlights the major breakthrough research on wound healing and tissue regeneration. Exploring and reviewing the molecular basis of regeneration can be helpful in the area of regenerative medicine advancements. The understanding gathered from this framework can potentially contribute to hypothesis designing with implications in the field of synthetic biology and human health.PMID:38160963 | DOI:10.1016/j.ydbio.2023.12.011 (Source: Developmental Biology)
Source: Developmental Biology - December 31, 2023 Category: Biology Authors: Shivali Pandita Sanchita Singh Sanjay Kumar Bajpai Geetanjali Mishra Gauri Saxena Praveen C Verma Source Type: research
Molecular aspects of regeneration in insects
This report highlights the major breakthrough research on wound healing and tissue regeneration. Exploring and reviewing the molecular basis of regeneration can be helpful in the area of regenerative medicine advancements. The understanding gathered from this framework can potentially contribute to hypothesis designing with implications in the field of synthetic biology and human health.PMID:38160963 | DOI:10.1016/j.ydbio.2023.12.011 (Source: Developmental Biology)
Source: Developmental Biology - December 31, 2023 Category: Biology Authors: Shivali Pandita Sanchita Singh Sanjay Kumar Bajpai Geetanjali Mishra Gauri Saxena Praveen C Verma Source Type: research
Molecular aspects of regeneration in insects
This report highlights the major breakthrough research on wound healing and tissue regeneration. Exploring and reviewing the molecular basis of regeneration can be helpful in the area of regenerative medicine advancements. The understanding gathered from this framework can potentially contribute to hypothesis designing with implications in the field of synthetic biology and human health.PMID:38160963 | DOI:10.1016/j.ydbio.2023.12.011 (Source: Developmental Biology)
Source: Developmental Biology - December 31, 2023 Category: Biology Authors: Shivali Pandita Sanchita Singh Sanjay Kumar Bajpai Geetanjali Mishra Gauri Saxena Praveen C Verma Source Type: research
Molecular aspects of regeneration in insects
This report highlights the major breakthrough research on wound healing and tissue regeneration. Exploring and reviewing the molecular basis of regeneration can be helpful in the area of regenerative medicine advancements. The understanding gathered from this framework can potentially contribute to hypothesis designing with implications in the field of synthetic biology and human health.PMID:38160963 | DOI:10.1016/j.ydbio.2023.12.011 (Source: Developmental Biology)
Source: Developmental Biology - December 31, 2023 Category: Biology Authors: Shivali Pandita Sanchita Singh Sanjay Kumar Bajpai Geetanjali Mishra Gauri Saxena Praveen C Verma Source Type: research
Anp32e protects against accumulation of H2A.Z at Sox motif containing promoters during zebrafish gastrulation
Dev Biol. 2023 Dec 28:S0012-1606(23)00212-9. doi: 10.1016/j.ydbio.2023.12.010. Online ahead of print.ABSTRACTEpigenetic regulation of chromatin states is crucial for proper gene expression programs and progression during development, but precise mechanisms by which epigenetic factors influence differentiation remain poorly understood. Here we find that the histone variant H2A.Z accumulates at Sox motif-containing promoters during zebrafish gastrulation while neighboring genes become transcriptionally active. These changes coincide with reduced expression of anp32e, the H2A.Z histone removal chaperone, suggesting that loss ...
Source: Developmental Biology - December 30, 2023 Category: Biology Authors: Fabian N Halblander Fanju W Meng Patrick J Murphy Source Type: research
Claudin-3 in the non-neural ectoderm is essential for neural fold fusion in chicken embryos
Dev Biol. 2023 Dec 26:S0012-1606(23)00211-7. doi: 10.1016/j.ydbio.2023.12.009. Online ahead of print.ABSTRACTThe neural tube, the embryonic precursor to the brain and spinal cord, begins as a flat sheet of epithelial cells, divided into non-neural and neural ectoderm. Proper neural tube closure requires that the edges of the neural ectoderm, the neural folds, to elevate upwards and fuse along the dorsal midline of the embryo. We have previously shown that members of the claudin protein family are required for the early phases of chick neural tube closure. Claudins are transmembrane proteins, localized in apical tight junct...
Source: Developmental Biology - December 28, 2023 Category: Biology Authors: Elizabeth-Ann Legere Amanda I Baumholtz Jean-Fran çois Boisclair Lachance Madison Archer J örg Piontek Aimee K Ryan Source Type: research
Claudin-3 in the non-neural ectoderm is essential for neural fold fusion in chicken embryos
Dev Biol. 2023 Dec 26:S0012-1606(23)00211-7. doi: 10.1016/j.ydbio.2023.12.009. Online ahead of print.ABSTRACTThe neural tube, the embryonic precursor to the brain and spinal cord, begins as a flat sheet of epithelial cells, divided into non-neural and neural ectoderm. Proper neural tube closure requires that the edges of the neural ectoderm, the neural folds, to elevate upwards and fuse along the dorsal midline of the embryo. We have previously shown that members of the claudin protein family are required for the early phases of chick neural tube closure. Claudins are transmembrane proteins, localized in apical tight junct...
Source: Developmental Biology - December 28, 2023 Category: Biology Authors: Elizabeth-Ann Legere Amanda I Baumholtz Jean-Fran çois Boisclair Lachance Madison Archer J örg Piontek Aimee K Ryan Source Type: research
Claudin-3 in the non-neural ectoderm is essential for neural fold fusion in chicken embryos
Dev Biol. 2023 Dec 26:S0012-1606(23)00211-7. doi: 10.1016/j.ydbio.2023.12.009. Online ahead of print.ABSTRACTThe neural tube, the embryonic precursor to the brain and spinal cord, begins as a flat sheet of epithelial cells, divided into non-neural and neural ectoderm. Proper neural tube closure requires that the edges of the neural ectoderm, the neural folds, to elevate upwards and fuse along the dorsal midline of the embryo. We have previously shown that members of the claudin protein family are required for the early phases of chick neural tube closure. Claudins are transmembrane proteins, localized in apical tight junct...
Source: Developmental Biology - December 28, 2023 Category: Biology Authors: Elizabeth-Ann Legere Amanda I Baumholtz Jean-Fran çois Boisclair Lachance Madison Archer J örg Piontek Aimee K Ryan Source Type: research
Claudin-3 in the non-neural ectoderm is essential for neural fold fusion in chicken embryos
Dev Biol. 2023 Dec 26:S0012-1606(23)00211-7. doi: 10.1016/j.ydbio.2023.12.009. Online ahead of print.ABSTRACTThe neural tube, the embryonic precursor to the brain and spinal cord, begins as a flat sheet of epithelial cells, divided into non-neural and neural ectoderm. Proper neural tube closure requires that the edges of the neural ectoderm, the neural folds, to elevate upwards and fuse along the dorsal midline of the embryo. We have previously shown that members of the claudin protein family are required for the early phases of chick neural tube closure. Claudins are transmembrane proteins, localized in apical tight junct...
Source: Developmental Biology - December 28, 2023 Category: Biology Authors: Elizabeth-Ann Legere Amanda I Baumholtz Jean-Fran çois Boisclair Lachance Madison Archer J örg Piontek Aimee K Ryan Source Type: research
Regenerative loss in the animal kingdom as viewed from the mouse digit tip and heart
Dev Biol. 2023 Dec 23:S0012-1606(23)00210-5. doi: 10.1016/j.ydbio.2023.12.008. Online ahead of print.ABSTRACTThe myriad regenerative abilities across the animal kingdom have fascinated us for centuries. Recent advances in developmental, molecular, and cellular biology have allowed us to unearth a surprising diversity of mechanisms through which these processes occur. Developing an all-encompassing theory of animal regeneration has thus proved a complex endeavor. In this chapter, we frame the evolution and loss of animal regeneration within the broad developmental constraints that may physiologically inhibit regenerative ab...
Source: Developmental Biology - December 25, 2023 Category: Biology Authors: Fayth Hui Tan Marianne E Bronner Source Type: research
Regenerative loss in the animal kingdom as viewed from the mouse digit tip and heart
Dev Biol. 2023 Dec 23:S0012-1606(23)00210-5. doi: 10.1016/j.ydbio.2023.12.008. Online ahead of print.ABSTRACTThe myriad regenerative abilities across the animal kingdom have fascinated us for centuries. Recent advances in developmental, molecular, and cellular biology have allowed us to unearth a surprising diversity of mechanisms through which these processes occur. Developing an all-encompassing theory of animal regeneration has thus proved a complex endeavor. In this chapter, we frame the evolution and loss of animal regeneration within the broad developmental constraints that may physiologically inhibit regenerative ab...
Source: Developmental Biology - December 25, 2023 Category: Biology Authors: Fayth Hui Tan Marianne E Bronner Source Type: research
Regenerative loss in the animal kingdom as viewed from the mouse digit tip and heart
Dev Biol. 2023 Dec 23:S0012-1606(23)00210-5. doi: 10.1016/j.ydbio.2023.12.008. Online ahead of print.ABSTRACTThe myriad regenerative abilities across the animal kingdom have fascinated us for centuries. Recent advances in developmental, molecular, and cellular biology have allowed us to unearth a surprising diversity of mechanisms through which these processes occur. Developing an all-encompassing theory of animal regeneration has thus proved a complex endeavor. In this chapter, we frame the evolution and loss of animal regeneration within the broad developmental constraints that may physiologically inhibit regenerative ab...
Source: Developmental Biology - December 25, 2023 Category: Biology Authors: Fayth Hui Tan Marianne E Bronner Source Type: research
The IRE1/Xbp1 axis restores ER and tissue homeostasis perturbed by excess Notch in Drosophila
In this study, we show that V5-tagged or untagged exogenous Notch is retained in the ER when overexpressed in fly tissues. Furthermore, we show that Notch retention in the ER leads to robust ER enlargement and elicits a rough eye phenotype. Gain-of-function of unfolded protein response (UPR) factors IRE1 or spliced Xbp1 (Xbp1-s) alleviates Notch accumulation in the ER, restores ER morphology and ameliorates the rough eye phenotype. Our results uncover a pivotal role of the IRE1/Xbp1 axis in regulating the detrimental effect of ER-localized excess Notch protein during development and tissue homeostasis.PMID:38142805 | DOI:1...
Source: Developmental Biology - December 24, 2023 Category: Biology Authors: Yu Li Dongyue Liu Haochuan Wang Xuejing Zhang Bingwei Lu Shuangxi Li Source Type: research
The IRE1/Xbp1 axis restores ER and tissue homeostasis perturbed by excess Notch in Drosophila
In this study, we show that V5-tagged or untagged exogenous Notch is retained in the ER when overexpressed in fly tissues. Furthermore, we show that Notch retention in the ER leads to robust ER enlargement and elicits a rough eye phenotype. Gain-of-function of unfolded protein response (UPR) factors IRE1 or spliced Xbp1 (Xbp1-s) alleviates Notch accumulation in the ER, restores ER morphology and ameliorates the rough eye phenotype. Our results uncover a pivotal role of the IRE1/Xbp1 axis in regulating the detrimental effect of ER-localized excess Notch protein during development and tissue homeostasis.PMID:38142805 | DOI:1...
Source: Developmental Biology - December 24, 2023 Category: Biology Authors: Yu Li Dongyue Liu Haochuan Wang Xuejing Zhang Bingwei Lu Shuangxi Li Source Type: research
Mechanical stress can regulate temporomandibular joint cavitation via signalling pathways
Dev Biol. 2023 Dec 17:S0012-1606(23)00208-7. doi: 10.1016/j.ydbio.2023.12.006. Online ahead of print.ABSTRACTThe temporomandibular joint (TMJ), composed of temporal fossa, mandibular condyle and a fibrocartilage disc with upper and lower cavities, is the biggest synovial joint and biomechanical hinge of the craniomaxillofacial musculoskeletal system. The initial events that give rise to TMJ cavities across diverse species are not fully understood. Most studies focus on the pivotal role of molecules such as Indian hedgehog (Ihh) and hyaluronic acid (HA) in TMJ cavitation. Although biologists have observed that mechanical st...
Source: Developmental Biology - December 19, 2023 Category: Biology Authors: Yilin She Rong Ren Nan Jiang Source Type: research
