ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling
Dev Biol. 2023 Aug 10:S0012-1606(23)00141-0. doi: 10.1016/j.ydbio.2023.08.002. Online ahead of print.ABSTRACTCraniofacial development is orchestrated by transcription factor-driven regulatory networks, epigenetic modifications, and signaling pathways. Signaling molecules and their receptors rely on endo-lysosomal trafficking to prevent accumulation on the plasma membrane. ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is recruited to endosomal membranes enabling degradation of such endosomal cargoes. Studies in vitro and in invertebrate models established the requirements of the ESCRT machinery in mem...
Source: Developmental Biology - August 12, 2023 Category: Biology Authors: Viviana Hermosilla Aguayo Peter Martin Nuo Tian James Zheng Robert Aho Marta Losa Licia Selleri Source Type: research

ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling
Dev Biol. 2023 Aug 10:S0012-1606(23)00141-0. doi: 10.1016/j.ydbio.2023.08.002. Online ahead of print.ABSTRACTCraniofacial development is orchestrated by transcription factor-driven regulatory networks, epigenetic modifications, and signaling pathways. Signaling molecules and their receptors rely on endo-lysosomal trafficking to prevent accumulation on the plasma membrane. ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is recruited to endosomal membranes enabling degradation of such endosomal cargoes. Studies in vitro and in invertebrate models established the requirements of the ESCRT machinery in mem...
Source: Developmental Biology - August 12, 2023 Category: Biology Authors: Viviana Hermosilla Aguayo Peter Martin Nuo Tian James Zheng Robert Aho Marta Losa Licia Selleri Source Type: research

ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling
Dev Biol. 2023 Aug 10:S0012-1606(23)00141-0. doi: 10.1016/j.ydbio.2023.08.002. Online ahead of print.ABSTRACTCraniofacial development is orchestrated by transcription factor-driven regulatory networks, epigenetic modifications, and signaling pathways. Signaling molecules and their receptors rely on endo-lysosomal trafficking to prevent accumulation on the plasma membrane. ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is recruited to endosomal membranes enabling degradation of such endosomal cargoes. Studies in vitro and in invertebrate models established the requirements of the ESCRT machinery in mem...
Source: Developmental Biology - August 12, 2023 Category: Biology Authors: Viviana Hermosilla Aguayo Peter Martin Nuo Tian James Zheng Robert Aho Marta Losa Licia Selleri Source Type: research

ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling
Dev Biol. 2023 Aug 10:S0012-1606(23)00141-0. doi: 10.1016/j.ydbio.2023.08.002. Online ahead of print.ABSTRACTCraniofacial development is orchestrated by transcription factor-driven regulatory networks, epigenetic modifications, and signaling pathways. Signaling molecules and their receptors rely on endo-lysosomal trafficking to prevent accumulation on the plasma membrane. ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is recruited to endosomal membranes enabling degradation of such endosomal cargoes. Studies in vitro and in invertebrate models established the requirements of the ESCRT machinery in mem...
Source: Developmental Biology - August 12, 2023 Category: Biology Authors: Viviana Hermosilla Aguayo Peter Martin Nuo Tian James Zheng Robert Aho Marta Losa Licia Selleri Source Type: research

ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling
Dev Biol. 2023 Aug 10:S0012-1606(23)00141-0. doi: 10.1016/j.ydbio.2023.08.002. Online ahead of print.ABSTRACTCraniofacial development is orchestrated by transcription factor-driven regulatory networks, epigenetic modifications, and signaling pathways. Signaling molecules and their receptors rely on endo-lysosomal trafficking to prevent accumulation on the plasma membrane. ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is recruited to endosomal membranes enabling degradation of such endosomal cargoes. Studies in vitro and in invertebrate models established the requirements of the ESCRT machinery in mem...
Source: Developmental Biology - August 12, 2023 Category: Biology Authors: Viviana Hermosilla Aguayo Peter Martin Nuo Tian James Zheng Robert Aho Marta Losa Licia Selleri Source Type: research

Cooption of regulatory modules for tektin paralogs during ciliary band formation in a marine annelid larva
Dev Biol. 2023 Aug 7:S0012-1606(23)00138-0. doi: 10.1016/j.ydbio.2023.07.006. Online ahead of print.ABSTRACTTektins are a highly conserved family of coiled-coil domain containing proteins known to play a role in structure, stability and function of cilia and flagella. Tektin proteins are thought to form filaments which run the length of the axoneme along the inner surface of the A tubule of each microtubule doublet. Phylogenetic analyses suggest that the tektin family arose via duplications from a single tektin gene in a unicellular organism giving rise to four and five tektin genes in bilaterians and in spiralians, respec...
Source: Developmental Biology - August 9, 2023 Category: Biology Authors: Benjamin R Bastin Steffanie M Meha Lalith Khindurangala Stephan Q Schneider Source Type: research

Cooption of regulatory modules for tektin paralogs during ciliary band formation in a marine annelid larva
Dev Biol. 2023 Aug 7:S0012-1606(23)00138-0. doi: 10.1016/j.ydbio.2023.07.006. Online ahead of print.ABSTRACTTektins are a highly conserved family of coiled-coil domain containing proteins known to play a role in structure, stability and function of cilia and flagella. Tektin proteins are thought to form filaments which run the length of the axoneme along the inner surface of the A tubule of each microtubule doublet. Phylogenetic analyses suggest that the tektin family arose via duplications from a single tektin gene in a unicellular organism giving rise to four and five tektin genes in bilaterians and in spiralians, respec...
Source: Developmental Biology - August 9, 2023 Category: Biology Authors: Benjamin R Bastin Steffanie M Meha Lalith Khindurangala Stephan Q Schneider Source Type: research

Cooption of regulatory modules for tektin paralogs during ciliary band formation in a marine annelid larva
Dev Biol. 2023 Aug 7:S0012-1606(23)00138-0. doi: 10.1016/j.ydbio.2023.07.006. Online ahead of print.ABSTRACTTektins are a highly conserved family of coiled-coil domain containing proteins known to play a role in structure, stability and function of cilia and flagella. Tektin proteins are thought to form filaments which run the length of the axoneme along the inner surface of the A tubule of each microtubule doublet. Phylogenetic analyses suggest that the tektin family arose via duplications from a single tektin gene in a unicellular organism giving rise to four and five tektin genes in bilaterians and in spiralians, respec...
Source: Developmental Biology - August 9, 2023 Category: Biology Authors: Benjamin R Bastin Steffanie M Meha Lalith Khindurangala Stephan Q Schneider Source Type: research

Opposing effects of ecdysone signaling regulate neuroblast proliferation to ensure coordination of brain and organism development
Dev Biol. 2023 Aug 5:S0012-1606(23)00140-9. doi: 10.1016/j.ydbio.2023.08.001. Online ahead of print.ABSTRACTGrowth regulation must be robust to ensure correct final size, but also adaptative to adjust to less favorable environmental conditions. Developmental coordination between whole-organism and the brain is particularly important, as the brain is a critical organ with little adaptability. Brain growth mainly depends on neural stem cell (NSC) proliferation to generate differentiated neural cells, it is however unclear how organism developmental progression is coordinated with NSCs. Here we demonstrate that the steroid ho...
Source: Developmental Biology - August 7, 2023 Category: Biology Authors: Andreia C Oliveira CatarinaC F Homem Source Type: research

Opposing effects of ecdysone signaling regulate neuroblast proliferation to ensure coordination of brain and organism development
Dev Biol. 2023 Aug 5:S0012-1606(23)00140-9. doi: 10.1016/j.ydbio.2023.08.001. Online ahead of print.ABSTRACTGrowth regulation must be robust to ensure correct final size, but also adaptative to adjust to less favorable environmental conditions. Developmental coordination between whole-organism and the brain is particularly important, as the brain is a critical organ with little adaptability. Brain growth mainly depends on neural stem cell (NSC) proliferation to generate differentiated neural cells, it is however unclear how organism developmental progression is coordinated with NSCs. Here we demonstrate that the steroid ho...
Source: Developmental Biology - August 7, 2023 Category: Biology Authors: Andreia C Oliveira CatarinaC F Homem Source Type: research

The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus
Dev Biol. 2023 Jul 31:S0012-1606(23)00139-2. doi: 10.1016/j.ydbio.2023.07.007. Online ahead of print.ABSTRACTThe external globus pallidus (GPe) is an essential component of the basal ganglia, a group of subcortical nuclei that are involved in control of action. Changes in the firing of GPe neurons are associated with both passive and active body movements. Aberrant activity of GPe neurons has been linked to motor symptoms of a variety of movement disorders, such as Parkinson's Disease, Huntington's disease and dystonia. Recent studies have helped delineate functionally distinct subtypes of GABAergic GPe projection neurons....
Source: Developmental Biology - August 2, 2023 Category: Biology Authors: Shiona Biswas C Savio Chan John L R Rubenstein Lin Gan Source Type: research

The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus
Dev Biol. 2023 Jul 31:S0012-1606(23)00139-2. doi: 10.1016/j.ydbio.2023.07.007. Online ahead of print.ABSTRACTThe external globus pallidus (GPe) is an essential component of the basal ganglia, a group of subcortical nuclei that are involved in control of action. Changes in the firing of GPe neurons are associated with both passive and active body movements. Aberrant activity of GPe neurons has been linked to motor symptoms of a variety of movement disorders, such as Parkinson's Disease, Huntington's disease and dystonia. Recent studies have helped delineate functionally distinct subtypes of GABAergic GPe projection neurons....
Source: Developmental Biology - August 2, 2023 Category: Biology Authors: Shiona Biswas C Savio Chan John L R Rubenstein Lin Gan Source Type: research

The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus
Dev Biol. 2023 Jul 31:S0012-1606(23)00139-2. doi: 10.1016/j.ydbio.2023.07.007. Online ahead of print.ABSTRACTThe external globus pallidus (GPe) is an essential component of the basal ganglia, a group of subcortical nuclei that are involved in control of action. Changes in the firing of GPe neurons are associated with both passive and active body movements. Aberrant activity of GPe neurons has been linked to motor symptoms of a variety of movement disorders, such as Parkinson's Disease, Huntington's disease and dystonia. Recent studies have helped delineate functionally distinct subtypes of GABAergic GPe projection neurons....
Source: Developmental Biology - August 2, 2023 Category: Biology Authors: Shiona Biswas C Savio Chan John L R Rubenstein Lin Gan Source Type: research

The transcription regulator Lmo3 is required for the development of medial ganglionic eminence derived neurons in the external globus pallidus
Dev Biol. 2023 Jul 31:S0012-1606(23)00139-2. doi: 10.1016/j.ydbio.2023.07.007. Online ahead of print.ABSTRACTThe external globus pallidus (GPe) is an essential component of the basal ganglia, a group of subcortical nuclei that are involved in control of action. Changes in the firing of GPe neurons are associated with both passive and active body movements. Aberrant activity of GPe neurons has been linked to motor symptoms of a variety of movement disorders, such as Parkinson's Disease, Huntington's disease and dystonia. Recent studies have helped delineate functionally distinct subtypes of GABAergic GPe projection neurons....
Source: Developmental Biology - August 2, 2023 Category: Biology Authors: Shiona Biswas C Savio Chan John L R Rubenstein Lin Gan Source Type: research

Developmental origin of the mammalian premaxilla
Dev Biol. 2023 Jul 29:S0012-1606(23)00137-9. doi: 10.1016/j.ydbio.2023.07.005. Online ahead of print.ABSTRACTThe evolution of jaws has played a major role in the success of vertebrate expansion into a wide variety of ecological niches. A fundamental, yet unresolved, question in craniofacial biology is about the origin of the premaxilla, the most distal bone present in the upper jaw of all amniotes. Recent reports have suggested that the mammalian premaxilla is derived from embryonic maxillary prominences rather than the frontonasal ectomesenchyme as previously shown in studies of chicken embryos. However, whether mammalian...
Source: Developmental Biology - July 31, 2023 Category: Biology Authors: PaulP R Iyyanar Chuanqi Qin Nirpesh Adhikari Han Liu Yueh-Chiang Hu Rulang Jiang Yu Lan Source Type: research