Loss of function of phosphatidylserine synthase causes muscle atrophy in Drosophila
Dev Biol. 2024 Mar 26:S0012-1606(24)00088-5. doi: 10.1016/j.ydbio.2024.03.006. Online ahead of print.ABSTRACTMaintenance of appropriate muscle mass is crucial for physical activity and metabolism. Aging and various pathological conditions can cause sarcopenia, a condition characterized by muscle mass decline. Although sarcopenia has been actively studied, the mechanisms underlying muscle atrophy are not well understood. Thus, we aimed to investigate the role of Phosphatidylserine synthase (Pss) in muscle development and homeostasis in Drosophila. The results showed that muscle-specific Pss knockdown decreased exercise capa...
Source: Developmental Biology - March 28, 2024 Category: Biology Authors: Sangseob Kim Hyun Heo Seung-Hae Kwon Jae H Park Gyunghee Lee Sang-Hak Jeon Source Type: research
Characterization of the development of the high-acuity area of the chick retina
Dev Biol. 2024 Mar 26:S0012-1606(24)00087-3. doi: 10.1016/j.ydbio.2024.03.005. Online ahead of print.ABSTRACTThe fovea is a small region within the central retina that is responsible for our high acuity daylight vision. Chickens also have a high acuity area (HAA), and are one of the few species that enables studies of the mechanisms of HAA development, due to accessible embryonic tissue and methods to readily perturb gene expression. To enable such studies, we characterized the development of the chick HAA using single molecule fluorescent in situ hybridization (smFISH), along with more classical methods. We found that Fgf...
Source: Developmental Biology - March 28, 2024 Category: Biology Authors: Jiho Choi Heer V Joisher Hasreet K Gill Lucas Lin Constance Cepko Source Type: research
Loss of function of phosphatidylserine synthase causes muscle atrophy in Drosophila
Dev Biol. 2024 Mar 26:S0012-1606(24)00088-5. doi: 10.1016/j.ydbio.2024.03.006. Online ahead of print.ABSTRACTMaintenance of appropriate muscle mass is crucial for physical activity and metabolism. Aging and various pathological conditions can cause sarcopenia, a condition characterized by muscle mass decline. Although sarcopenia has been actively studied, the mechanisms underlying muscle atrophy are not well understood. Thus, we aimed to investigate the role of Phosphatidylserine synthase (Pss) in muscle development and homeostasis in Drosophila. The results showed that muscle-specific Pss knockdown decreased exercise capa...
Source: Developmental Biology - March 28, 2024 Category: Biology Authors: Sangseob Kim Hyun Heo Seung-Hae Kwon Jae H Park Gyunghee Lee Sang-Hak Jeon Source Type: research
Characterization of the development of the high-acuity area of the chick retina
Dev Biol. 2024 Mar 26:S0012-1606(24)00087-3. doi: 10.1016/j.ydbio.2024.03.005. Online ahead of print.ABSTRACTThe fovea is a small region within the central retina that is responsible for our high acuity daylight vision. Chickens also have a high acuity area (HAA), and are one of the few species that enables studies of the mechanisms of HAA development, due to accessible embryonic tissue and methods to readily perturb gene expression. To enable such studies, we characterized the development of the chick HAA using single molecule fluorescent in situ hybridization (smFISH), along with more classical methods. We found that Fgf...
Source: Developmental Biology - March 28, 2024 Category: Biology Authors: Jiho Choi Heer V Joisher Hasreet K Gill Lucas Lin Constance Cepko Source Type: research
Loss of function of phosphatidylserine synthase causes muscle atrophy in Drosophila
Dev Biol. 2024 Mar 26:S0012-1606(24)00088-5. doi: 10.1016/j.ydbio.2024.03.006. Online ahead of print.ABSTRACTMaintenance of appropriate muscle mass is crucial for physical activity and metabolism. Aging and various pathological conditions can cause sarcopenia, a condition characterized by muscle mass decline. Although sarcopenia has been actively studied, the mechanisms underlying muscle atrophy are not well understood. Thus, we aimed to investigate the role of Phosphatidylserine synthase (Pss) in muscle development and homeostasis in Drosophila. The results showed that muscle-specific Pss knockdown decreased exercise capa...
Source: Developmental Biology - March 28, 2024 Category: Biology Authors: Sangseob Kim Hyun Heo Seung-Hae Kwon Jae H Park Gyunghee Lee Sang-Hak Jeon Source Type: research
Characterization of the development of the high-acuity area of the chick retina
Dev Biol. 2024 Mar 26:S0012-1606(24)00087-3. doi: 10.1016/j.ydbio.2024.03.005. Online ahead of print.ABSTRACTThe fovea is a small region within the central retina that is responsible for our high acuity daylight vision. Chickens also have a high acuity area (HAA), and are one of the few species that enables studies of the mechanisms of HAA development, due to accessible embryonic tissue and methods to readily perturb gene expression. To enable such studies, we characterized the development of the chick HAA using single molecule fluorescent in situ hybridization (smFISH), along with more classical methods. We found that Fgf...
Source: Developmental Biology - March 28, 2024 Category: Biology Authors: Jiho Choi Heer V Joisher Hasreet K Gill Lucas Lin Constance Cepko Source Type: research
Graded FGF activity patterns distinct cell types within the apical sensory organ of the sea anemone Nematostella vectensis
Dev Biol. 2024 Mar 21:S0012-1606(24)00036-8. doi: 10.1016/j.ydbio.2024.02.010. Online ahead of print.ABSTRACTBilaterian animals have evolved complex sensory organs comprised of distinct cell types that function coordinately to sense the environment. Each sensory unit has a defined architecture built from component cell types, including sensory cells, non-sensory support cells, and dedicated sensory neurons. Whether this characteristic cellular composition is present in the sensory organs of non-bilaterian animals is unknown. Here, we interrogate the cell type composition and gene regulatory networks controlling development...
Source: Developmental Biology - March 23, 2024 Category: Biology Authors: Keith Z Sabin Shiyuan Chen Eric M Hill Kyle J Weaver Jacob Yonke MaryEllen Kirkman William B Redwine Anna M L Klompen Xia Zhao Fengli Guo Mary Cathleen McKinney Jessica L Dewey Matthew C Gibson Source Type: research
Graded FGF activity patterns distinct cell types within the apical sensory organ of the sea anemone Nematostella vectensis
Dev Biol. 2024 Mar 21:S0012-1606(24)00036-8. doi: 10.1016/j.ydbio.2024.02.010. Online ahead of print.ABSTRACTBilaterian animals have evolved complex sensory organs comprised of distinct cell types that function coordinately to sense the environment. Each sensory unit has a defined architecture built from component cell types, including sensory cells, non-sensory support cells, and dedicated sensory neurons. Whether this characteristic cellular composition is present in the sensory organs of non-bilaterian animals is unknown. Here, we interrogate the cell type composition and gene regulatory networks controlling development...
Source: Developmental Biology - March 23, 2024 Category: Biology Authors: Keith Z Sabin Shiyuan Chen Eric M Hill Kyle J Weaver Jacob Yonke MaryEllen Kirkman William B Redwine Anna M L Klompen Xia Zhao Fengli Guo Mary Cathleen McKinney Jessica L Dewey Matthew C Gibson Source Type: research
Graded FGF activity patterns distinct cell types within the apical sensory organ of the sea anemone Nematostella vectensis
Dev Biol. 2024 Mar 21:S0012-1606(24)00036-8. doi: 10.1016/j.ydbio.2024.02.010. Online ahead of print.ABSTRACTBilaterian animals have evolved complex sensory organs comprised of distinct cell types that function coordinately to sense the environment. Each sensory unit has a defined architecture built from component cell types, including sensory cells, non-sensory support cells, and dedicated sensory neurons. Whether this characteristic cellular composition is present in the sensory organs of non-bilaterian animals is unknown. Here, we interrogate the cell type composition and gene regulatory networks controlling development...
Source: Developmental Biology - March 23, 2024 Category: Biology Authors: Keith Z Sabin Shiyuan Chen Eric M Hill Kyle J Weaver Jacob Yonke MaryEllen Kirkman William B Redwine Anna M L Klompen Xia Zhao Fengli Guo Mary Cathleen McKinney Jessica L Dewey Matthew C Gibson Source Type: research
Graded FGF activity patterns distinct cell types within the apical sensory organ of the sea anemone Nematostella vectensis
Dev Biol. 2024 Mar 21:S0012-1606(24)00036-8. doi: 10.1016/j.ydbio.2024.02.010. Online ahead of print.ABSTRACTBilaterian animals have evolved complex sensory organs comprised of distinct cell types that function coordinately to sense the environment. Each sensory unit has a defined architecture built from component cell types, including sensory cells, non-sensory support cells, and dedicated sensory neurons. Whether this characteristic cellular composition is present in the sensory organs of non-bilaterian animals is unknown. Here, we interrogate the cell type composition and gene regulatory networks controlling development...
Source: Developmental Biology - March 23, 2024 Category: Biology Authors: Keith Z Sabin Shiyuan Chen Eric M Hill Kyle J Weaver Jacob Yonke MaryEllen Kirkman William B Redwine Anna M L Klompen Xia Zhao Fengli Guo Mary Cathleen McKinney Jessica L Dewey Matthew C Gibson Source Type: research
Graded FGF activity patterns distinct cell types within the apical sensory organ of the sea anemone Nematostella vectensis
Dev Biol. 2024 Mar 21:S0012-1606(24)00036-8. doi: 10.1016/j.ydbio.2024.02.010. Online ahead of print.ABSTRACTBilaterian animals have evolved complex sensory organs comprised of distinct cell types that function coordinately to sense the environment. Each sensory unit has a defined architecture built from component cell types, including sensory cells, non-sensory support cells, and dedicated sensory neurons. Whether this characteristic cellular composition is present in the sensory organs of non-bilaterian animals is unknown. Here, we interrogate the cell type composition and gene regulatory networks controlling development...
Source: Developmental Biology - March 23, 2024 Category: Biology Authors: Keith Z Sabin Shiyuan Chen Eric M Hill Kyle J Weaver Jacob Yonke MaryEllen Kirkman William B Redwine Anna M L Klompen Xia Zhao Fengli Guo Mary Cathleen McKinney Jessica L Dewey Matthew C Gibson Source Type: research
A function of spalt major as a sequence-specific DNA binding transcription factor mediates repression of knirps in the Drosophila wing imaginal disc
Dev Biol. 2024 Mar 15;510:40-49. doi: 10.1016/j.ydbio.2024.03.004. Online ahead of print.ABSTRACTThe Spalt transcriptional regulators participate in a variety of cell fate decisions during multicellular development. Vertebrate Spalt proteins have been mostly associated to the organization of heterochromatic regions, but they also contribute regulatory functions through binding to A/T rich motives present in their target genes. The developmental processes in which the Drosophila spalt genes participate are well known through genetic analysis, but the mechanism by which the Spalt proteins regulate transcription are still unk...
Source: Developmental Biology - March 17, 2024 Category: Biology Authors: Cristina M Ostal é Alicia Del Prado Mercedes Mart ín Nuria Esteban Ana L ópez-Varea Jose F de Celis Source Type: research
A function of spalt major as a sequence-specific DNA binding transcription factor mediates repression of knirps in the Drosophila wing imaginal disc
Dev Biol. 2024 Mar 15:S0012-1606(24)00086-1. doi: 10.1016/j.ydbio.2024.03.004. Online ahead of print.ABSTRACTThe Spalt transcriptional regulators participate in a variety of cell fate decisions during multicellular development. Vertebrate Spalt proteins have been mostly associated to the organization of heterochromatic regions, but they also contribute regulatory functions through binding to A/T rich motives present in their target genes. The developmental processes in which the Drosophila spalt genes participate are well known through genetic analysis, but the mechanism by which the Spalt proteins regulate transcription a...
Source: Developmental Biology - March 17, 2024 Category: Biology Authors: Cristina M Ostal é Alicia Del Prado Mercedes Mart ín Nuria Esteban Ana L ópez-Varea Jose F de Celis Source Type: research
A function of spalt major as a sequence-specific DNA binding transcription factor mediates repression of knirps in the Drosophila wing imaginal disc
Dev Biol. 2024 Mar 15:S0012-1606(24)00086-1. doi: 10.1016/j.ydbio.2024.03.004. Online ahead of print.ABSTRACTThe Spalt transcriptional regulators participate in a variety of cell fate decisions during multicellular development. Vertebrate Spalt proteins have been mostly associated to the organization of heterochromatic regions, but they also contribute regulatory functions through binding to A/T rich motives present in their target genes. The developmental processes in which the Drosophila spalt genes participate are well known through genetic analysis, but the mechanism by which the Spalt proteins regulate transcription a...
Source: Developmental Biology - March 17, 2024 Category: Biology Authors: Cristina M Ostal é Alicia Del Prado Mercedes Mart ín Nuria Esteban Ana L ópez-Varea Jose F de Celis Source Type: research
A function of spalt major as a sequence-specific DNA binding transcription factor mediates repression of knirps in the Drosophila wing imaginal disc
Dev Biol. 2024 Mar 15:S0012-1606(24)00086-1. doi: 10.1016/j.ydbio.2024.03.004. Online ahead of print.ABSTRACTThe Spalt transcriptional regulators participate in a variety of cell fate decisions during multicellular development. Vertebrate Spalt proteins have been mostly associated to the organization of heterochromatic regions, but they also contribute regulatory functions through binding to A/T rich motives present in their target genes. The developmental processes in which the Drosophila spalt genes participate are well known through genetic analysis, but the mechanism by which the Spalt proteins regulate transcription a...
Source: Developmental Biology - March 17, 2024 Category: Biology Authors: Cristina M Ostal é Alicia Del Prado Mercedes Mart ín Nuria Esteban Ana L ópez-Varea Jose F de Celis Source Type: research
