Graded FGF activity patterns distinct cell types within the apical sensory organ of the sea anemone Nematostella vectensis
Dev Biol. 2024 Mar 21:S0012-1606(24)00036-8. doi: 10.1016/j.ydbio.2024.02.010. Online ahead of print.ABSTRACTBilaterian animals have evolved complex sensory organs comprised of distinct cell types that function coordinately to sense the environment. Each sensory unit has a defined architecture built from component cell types, including sensory cells, non-sensory support cells, and dedicated sensory neurons. Whether this characteristic cellular composition is present in the sensory organs of non-bilaterian animals is unknown. Here, we interrogate the cell type composition and gene regulatory networks controlling development...
Source: Developmental Biology - March 23, 2024 Category: Biology Authors: Keith Z Sabin Shiyuan Chen Eric M Hill Kyle J Weaver Jacob Yonke MaryEllen Kirkman William B Redwine Anna M L Klompen Xia Zhao Fengli Guo Mary Cathleen McKinney Jessica L Dewey Matthew C Gibson Source Type: research
A function of spalt major as a sequence-specific DNA binding transcription factor mediates repression of knirps in the Drosophila wing imaginal disc
Dev Biol. 2024 Mar 15;510:40-49. doi: 10.1016/j.ydbio.2024.03.004. Online ahead of print.ABSTRACTThe Spalt transcriptional regulators participate in a variety of cell fate decisions during multicellular development. Vertebrate Spalt proteins have been mostly associated to the organization of heterochromatic regions, but they also contribute regulatory functions through binding to A/T rich motives present in their target genes. The developmental processes in which the Drosophila spalt genes participate are well known through genetic analysis, but the mechanism by which the Spalt proteins regulate transcription are still unk...
Source: Developmental Biology - March 17, 2024 Category: Biology Authors: Cristina M Ostal é Alicia Del Prado Mercedes Mart ín Nuria Esteban Ana L ópez-Varea Jose F de Celis Source Type: research
A function of spalt major as a sequence-specific DNA binding transcription factor mediates repression of knirps in the Drosophila wing imaginal disc
Dev Biol. 2024 Mar 15:S0012-1606(24)00086-1. doi: 10.1016/j.ydbio.2024.03.004. Online ahead of print.ABSTRACTThe Spalt transcriptional regulators participate in a variety of cell fate decisions during multicellular development. Vertebrate Spalt proteins have been mostly associated to the organization of heterochromatic regions, but they also contribute regulatory functions through binding to A/T rich motives present in their target genes. The developmental processes in which the Drosophila spalt genes participate are well known through genetic analysis, but the mechanism by which the Spalt proteins regulate transcription a...
Source: Developmental Biology - March 17, 2024 Category: Biology Authors: Cristina M Ostal é Alicia Del Prado Mercedes Mart ín Nuria Esteban Ana L ópez-Varea Jose F de Celis Source Type: research
A function of spalt major as a sequence-specific DNA binding transcription factor mediates repression of knirps in the Drosophila wing imaginal disc
Dev Biol. 2024 Mar 15:S0012-1606(24)00086-1. doi: 10.1016/j.ydbio.2024.03.004. Online ahead of print.ABSTRACTThe Spalt transcriptional regulators participate in a variety of cell fate decisions during multicellular development. Vertebrate Spalt proteins have been mostly associated to the organization of heterochromatic regions, but they also contribute regulatory functions through binding to A/T rich motives present in their target genes. The developmental processes in which the Drosophila spalt genes participate are well known through genetic analysis, but the mechanism by which the Spalt proteins regulate transcription a...
Source: Developmental Biology - March 17, 2024 Category: Biology Authors: Cristina M Ostal é Alicia Del Prado Mercedes Mart ín Nuria Esteban Ana L ópez-Varea Jose F de Celis Source Type: research
A function of spalt major as a sequence-specific DNA binding transcription factor mediates repression of knirps in the Drosophila wing imaginal disc
Dev Biol. 2024 Mar 15:S0012-1606(24)00086-1. doi: 10.1016/j.ydbio.2024.03.004. Online ahead of print.ABSTRACTThe Spalt transcriptional regulators participate in a variety of cell fate decisions during multicellular development. Vertebrate Spalt proteins have been mostly associated to the organization of heterochromatic regions, but they also contribute regulatory functions through binding to A/T rich motives present in their target genes. The developmental processes in which the Drosophila spalt genes participate are well known through genetic analysis, but the mechanism by which the Spalt proteins regulate transcription a...
Source: Developmental Biology - March 17, 2024 Category: Biology Authors: Cristina M Ostal é Alicia Del Prado Mercedes Mart ín Nuria Esteban Ana L ópez-Varea Jose F de Celis Source Type: research
A function of spalt major as a sequence-specific DNA binding transcription factor mediates repression of knirps in the Drosophila wing imaginal disc
Dev Biol. 2024 Mar 15:S0012-1606(24)00086-1. doi: 10.1016/j.ydbio.2024.03.004. Online ahead of print.ABSTRACTThe Spalt transcriptional regulators participate in a variety of cell fate decisions during multicellular development. Vertebrate Spalt proteins have been mostly associated to the organization of heterochromatic regions, but they also contribute regulatory functions through binding to A/T rich motives present in their target genes. The developmental processes in which the Drosophila spalt genes participate are well known through genetic analysis, but the mechanism by which the Spalt proteins regulate transcription a...
Source: Developmental Biology - March 17, 2024 Category: Biology Authors: Cristina M Ostal é Alicia Del Prado Mercedes Mart ín Nuria Esteban Ana L ópez-Varea Jose F de Celis Source Type: research
Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development
Dev Biol. 2024 Mar 14:S0012-1606(24)00081-2. doi: 10.1016/j.ydbio.2024.03.002. Online ahead of print.ABSTRACTThe voltage gated (Kv) slow-inactivating delayed rectifier channel regulates the development of hollow organs of the zebrafish. The functional channel consists of the tetramer of electrically active Kcnb1 (Kv2.1) subunits and Kcng4b (Kv6.4) modulatory or electrically silent subunits. The two mutations in zebrafish kcng4b gene - kcng4b-C1 and kcng4b-C2 (Gasanov et al., 2021) - have been studied during ear development using electrophysiology, developmental biology and in silico structural modelling. kcng4b-C1 mutation...
Source: Developmental Biology - March 16, 2024 Category: Biology Authors: Justyna J ędrychowska Vitya Vardanyan Milosz Wieczor Antoni Marciniak Jacek Czub Razieh Amini Ruchi Jain Hongyuan Shen Hyungwon Choi Jacek Kuznicki Vladimir Korzh Source Type: research
Mutant analysis of Kcng4b reveals how the different functional states of the voltage-gated potassium channel regulate ear development
Dev Biol. 2024 Mar 14:S0012-1606(24)00081-2. doi: 10.1016/j.ydbio.2024.03.002. Online ahead of print.ABSTRACTThe voltage gated (Kv) slow-inactivating delayed rectifier channel regulates the development of hollow organs of the zebrafish. The functional channel consists of the tetramer of electrically active Kcnb1 (Kv2.1) subunits and Kcng4b (Kv6.4) modulatory or electrically silent subunits. The two mutations in zebrafish kcng4b gene - kcng4b-C1 and kcng4b-C2 (Gasanov et al., 2021) - have been studied during ear development using electrophysiology, developmental biology and in silico structural modelling. kcng4b-C1 mutation...
Source: Developmental Biology - March 16, 2024 Category: Biology Authors: Justyna J ędrychowska Vitya Vardanyan Milosz Wieczor Antoni Marciniak Jacek Czub Razieh Amini Ruchi Jain Hongyuan Shen Hyungwon Choi Jacek Kuznicki Vladimir Korzh Source Type: research
Optimizing CRISPR/Cas9 approaches in the polymorphic tunicate Ciona intestinalis
Dev Biol. 2024 Mar 13:S0012-1606(24)00085-X. doi: 10.1016/j.ydbio.2024.03.003. Online ahead of print.ABSTRACTCRISPR/Cas9 became a powerful tool for genetic engineering and in vivo knockout also in the invertebrate chordate Ciona intestinalis. Ciona (ascidians, tunicates) is an important model organism because it shares developmental features with the vertebrates, considered the sister group of tunicates, and offers outstanding experimental advantages: a compact genome and an invariant developmental cell lineage that, combined with electroporation mediated transgenesis allows for precise and cell type specific targeting in ...
Source: Developmental Biology - March 15, 2024 Category: Biology Authors: Alessandro Pennati Milo š Jakobi Fan Zeng Luca Ciampa Ute Rothb ächer Source Type: research
Avian model systems 11 conference 11-14 September 2023
Dev Biol. 2024 Mar 8:S0012-1606(24)00037-X. doi: 10.1016/j.ydbio.2024.02.011. Online ahead of print.NO ABSTRACTPMID:38462050 | DOI:10.1016/j.ydbio.2024.02.011 (Source: Developmental Biology)
Source: Developmental Biology - March 10, 2024 Category: Biology Authors: F Schubert S Dietrich conference chairs Source Type: research
Avian model systems 11 conference 11-14 September 2023
Dev Biol. 2024 Mar 8:S0012-1606(24)00037-X. doi: 10.1016/j.ydbio.2024.02.011. Online ahead of print.NO ABSTRACTPMID:38462050 | DOI:10.1016/j.ydbio.2024.02.011 (Source: Developmental Biology)
Source: Developmental Biology - March 10, 2024 Category: Biology Authors: F Schubert S Dietrich conference chairs Source Type: research
Avian model systems 11 conference 11-14 September 2023
Dev Biol. 2024 Mar 8:S0012-1606(24)00037-X. doi: 10.1016/j.ydbio.2024.02.011. Online ahead of print.NO ABSTRACTPMID:38462050 | DOI:10.1016/j.ydbio.2024.02.011 (Source: Developmental Biology)
Source: Developmental Biology - March 10, 2024 Category: Biology Authors: F Schubert S Dietrich conference chairs Source Type: research
Avian model systems 11 conference 11-14 September 2023
Dev Biol. 2024 Mar 8:S0012-1606(24)00037-X. doi: 10.1016/j.ydbio.2024.02.011. Online ahead of print.NO ABSTRACTPMID:38462050 | DOI:10.1016/j.ydbio.2024.02.011 (Source: Developmental Biology)
Source: Developmental Biology - March 10, 2024 Category: Biology Authors: F Schubert S Dietrich conference chairs Source Type: research
Avian model systems 11 conference 11-14 September 2023
Dev Biol. 2024 Mar 8:S0012-1606(24)00037-X. doi: 10.1016/j.ydbio.2024.02.011. Online ahead of print.NO ABSTRACTPMID:38462050 | DOI:10.1016/j.ydbio.2024.02.011 (Source: Developmental Biology)
Source: Developmental Biology - March 10, 2024 Category: Biology Authors: F Schubert S Dietrich conference chairs Source Type: research
Anatomy, development and regeneration of zebrafish elasmoid scales
Dev Biol. 2024 Mar 6:S0012-1606(24)00080-0. doi: 10.1016/j.ydbio.2024.03.001. Online ahead of print.ABSTRACTVertebrate skin appendages - particularly avian feathers and mammalian hairs, glands and teeth - are perennially useful systems for investigating fundamental mechanisms of development. The most common type of skin appendage in teleost fishes is the elasmoid scale, yet this structure has received much less attention than the skin appendages of tetrapods. Elasmoid scales are thin, overlapping plates of partially mineralized extracellular matrices, deposited in the skin in a hexagonal pattern by a specialized population...
Source: Developmental Biology - March 8, 2024 Category: Biology Authors: Andrew J Aman David M Parichy Source Type: research
