New insights into lumicrine secreted signalling that regulates the function of the mammalian male reproductive tract
Dev Biol. 2023 Aug 31:S0012-1606(23)00144-6. doi: 10.1016/j.ydbio.2023.08.005. Online ahead of print.NO ABSTRACTPMID:37659466 | DOI:10.1016/j.ydbio.2023.08.005 (Source: Developmental Biology)
Source: Developmental Biology - September 2, 2023 Category: Biology Authors: Daiji Kiyozumi Source Type: research

Transient impacts of UV-B irradiation on whole body regeneration in a colonial urochordate
Dev Biol. 2023 Aug 22;503:83-94. doi: 10.1016/j.ydbio.2023.08.006. Online ahead of print.ABSTRACTWithin the chordates, only some colonial ascidians experience whole body regeneration (WBR), where amputated small colonial fragments containing blood-vessels have the capability to regenerate the entire functional adult zooid within 1-3 weeks. Studying WBR in small colonial fragments taken at different blastogenic stages (the weekly developmental process characteristic to botryllid ascidians) from the ascidian Botrylloides leachii, about half of the fragments were able to complete regeneration (cWBR) three weeks following sepa...
Source: Developmental Biology - August 24, 2023 Category: Biology Authors: Andy Qarri Baruch Rinkevich Source Type: research

Transient impacts of UV-B irradiation on whole body regeneration in a colonial urochordate
Dev Biol. 2023 Aug 22;503:83-94. doi: 10.1016/j.ydbio.2023.08.006. Online ahead of print.ABSTRACTWithin the chordates, only some colonial ascidians experience whole body regeneration (WBR), where amputated small colonial fragments containing blood-vessels have the capability to regenerate the entire functional adult zooid within 1-3 weeks. Studying WBR in small colonial fragments taken at different blastogenic stages (the weekly developmental process characteristic to botryllid ascidians) from the ascidian Botrylloides leachii, about half of the fragments were able to complete regeneration (cWBR) three weeks following sepa...
Source: Developmental Biology - August 24, 2023 Category: Biology Authors: Andy Qarri Baruch Rinkevich Source Type: research

Transient impacts of UV-B irradiation on whole body regeneration in a colonial urochordate
Dev Biol. 2023 Aug 22;503:83-94. doi: 10.1016/j.ydbio.2023.08.006. Online ahead of print.ABSTRACTWithin the chordates, only some colonial ascidians experience whole body regeneration (WBR), where amputated small colonial fragments containing blood-vessels have the capability to regenerate the entire functional adult zooid within 1-3 weeks. Studying WBR in small colonial fragments taken at different blastogenic stages (the weekly developmental process characteristic to botryllid ascidians) from the ascidian Botrylloides leachii, about half of the fragments were able to complete regeneration (cWBR) three weeks following sepa...
Source: Developmental Biology - August 24, 2023 Category: Biology Authors: Andy Qarri Baruch Rinkevich Source Type: research

Transient impacts of UV-B irradiation on whole body regeneration in a colonial urochordate
Dev Biol. 2023 Aug 22;503:83-94. doi: 10.1016/j.ydbio.2023.08.006. Online ahead of print.ABSTRACTWithin the chordates, only some colonial ascidians experience whole body regeneration (WBR), where amputated small colonial fragments containing blood-vessels have the capability to regenerate the entire functional adult zooid within 1-3 weeks. Studying WBR in small colonial fragments taken at different blastogenic stages (the weekly developmental process characteristic to botryllid ascidians) from the ascidian Botrylloides leachii, about half of the fragments were able to complete regeneration (cWBR) three weeks following sepa...
Source: Developmental Biology - August 24, 2023 Category: Biology Authors: Andy Qarri Baruch Rinkevich Source Type: research

Transient impacts of UV-B irradiation on whole body regeneration in a colonial urochordate
Dev Biol. 2023 Aug 22:S0012-1606(23)00145-8. doi: 10.1016/j.ydbio.2023.08.006. Online ahead of print.ABSTRACTWithin the chordates, only some colonial ascidians experience whole body regeneration (WBR), where amputated small colonial fragments containing blood-vessels have the capability to regenerate the entire functional adult zooid within 1-3 weeks. Studying WBR in small colonial fragments taken at different blastogenic stages (the weekly developmental process characteristic to botryllid ascidians) from the ascidian Botrylloides leachii, about half of the fragments were able to complete regeneration (cWBR) three weeks fo...
Source: Developmental Biology - August 24, 2023 Category: Biology Authors: Andy Qarri Baruch Rinkevich Source Type: research

Transient impacts of UV-B irradiation on whole body regeneration in a colonial urochordate
Dev Biol. 2023 Aug 22:S0012-1606(23)00145-8. doi: 10.1016/j.ydbio.2023.08.006. Online ahead of print.ABSTRACTWithin the chordates, only some colonial ascidians experience whole body regeneration (WBR), where amputated small colonial fragments containing blood-vessels have the capability to regenerate the entire functional adult zooid within 1-3 weeks. Studying WBR in small colonial fragments taken at different blastogenic stages (the weekly developmental process characteristic to botryllid ascidians) from the ascidian Botrylloides leachii, about half of the fragments were able to complete regeneration (cWBR) three weeks fo...
Source: Developmental Biology - August 24, 2023 Category: Biology Authors: Andy Qarri Baruch Rinkevich Source Type: research

Transient impacts of UV-B irradiation on whole body regeneration in a colonial urochordate
Dev Biol. 2023 Aug 22:S0012-1606(23)00145-8. doi: 10.1016/j.ydbio.2023.08.006. Online ahead of print.ABSTRACTWithin the chordates, only some colonial ascidians experience whole body regeneration (WBR), where amputated small colonial fragments containing blood-vessels have the capability to regenerate the entire functional adult zooid within 1-3 weeks. Studying WBR in small colonial fragments taken at different blastogenic stages (the weekly developmental process characteristic to botryllid ascidians) from the ascidian Botrylloides leachii, about half of the fragments were able to complete regeneration (cWBR) three weeks fo...
Source: Developmental Biology - August 24, 2023 Category: Biology Authors: Andy Qarri Baruch Rinkevich Source Type: research

Transient impacts of UV-B irradiation on whole body regeneration in a colonial urochordate
Dev Biol. 2023 Aug 22:S0012-1606(23)00145-8. doi: 10.1016/j.ydbio.2023.08.006. Online ahead of print.ABSTRACTWithin the chordates, only some colonial ascidians experience whole body regeneration (WBR), where amputated small colonial fragments containing blood-vessels have the capability to regenerate the entire functional adult zooid within 1-3 weeks. Studying WBR in small colonial fragments taken at different blastogenic stages (the weekly developmental process characteristic to botryllid ascidians) from the ascidian Botrylloides leachii, about half of the fragments were able to complete regeneration (cWBR) three weeks fo...
Source: Developmental Biology - August 24, 2023 Category: Biology Authors: Andy Qarri Baruch Rinkevich Source Type: research

Patterning of solute carrier (SLC) expression in sea urchin embryos reveals mesodermal cell diversity
Dev Biol. 2023 Aug 21:S0012-1606(23)00143-4. doi: 10.1016/j.ydbio.2023.08.004. Online ahead of print.ABSTRACTWithin the developing embryo is a microcosm of cell type diversity. Single cell RNA-sequencing (scRNA-seq) is used to reveal cell types, typically by grouping cells according to their gene regulatory states. However, both across and within these regulatory states are additional layers of cellular diversity represented by the differential expression of genes that govern cell function. Here, we analyzed scRNA-seq data representing the late gastrula stage of Strongylocentrotus purpuratus (purple sea urchin) to understa...
Source: Developmental Biology - August 23, 2023 Category: Biology Authors: Yoon Lee Evan Tjeerdema Svenja Kling Nathan Chang Amro Hamdoun Source Type: research

Tmed10 deficiency results in impaired exocrine pancreatic differentiation in zebrafish larvae
Dev Biol. 2023 Aug 17:S0012-1606(23)00142-2. doi: 10.1016/j.ydbio.2023.08.003. Online ahead of print.ABSTRACTTransmembrane p24 trafficking protein 10 (TMED10) is a conserved vesicle trafficking protein. It is dysregulated in Alzheimer disease and plays a pivotal role in the pathogenesis of Alzheimer disease. In addition to the brain, TMED10 is highly expressed in the exocrine pancreas; however, its biological functions and underlying mechanisms remain largely unknown. We studied reduced Tmed10 in zebrafish embryos by morpholino oligonucleotide knockdown and CRISPR-Cas9 mutagenesis. Tmed10-deficient embryos showed extensive...
Source: Developmental Biology - August 19, 2023 Category: Biology Authors: Zewen Tao Di Yang Rui Ni Source Type: research

Tmed10 deficiency results in impaired exocrine pancreatic differentiation in zebrafish larvae
Dev Biol. 2023 Aug 17:S0012-1606(23)00142-2. doi: 10.1016/j.ydbio.2023.08.003. Online ahead of print.ABSTRACTTransmembrane p24 trafficking protein 10 (TMED10) is a conserved vesicle trafficking protein. It is dysregulated in Alzheimer disease and plays a pivotal role in the pathogenesis of Alzheimer disease. In addition to the brain, TMED10 is highly expressed in the exocrine pancreas; however, its biological functions and underlying mechanisms remain largely unknown. We studied reduced Tmed10 in zebrafish embryos by morpholino oligonucleotide knockdown and CRISPR-Cas9 mutagenesis. Tmed10-deficient embryos showed extensive...
Source: Developmental Biology - August 19, 2023 Category: Biology Authors: Zewen Tao Di Yang Rui Ni Source Type: research

Tmed10 deficiency results in impaired exocrine pancreatic differentiation in zebrafish larvae
Dev Biol. 2023 Aug 17:S0012-1606(23)00142-2. doi: 10.1016/j.ydbio.2023.08.003. Online ahead of print.ABSTRACTTransmembrane p24 trafficking protein 10 (TMED10) is a conserved vesicle trafficking protein. It is dysregulated in Alzheimer disease and plays a pivotal role in the pathogenesis of Alzheimer disease. In addition to the brain, TMED10 is highly expressed in the exocrine pancreas; however, its biological functions and underlying mechanisms remain largely unknown. We studied reduced Tmed10 in zebrafish embryos by morpholino oligonucleotide knockdown and CRISPR-Cas9 mutagenesis. Tmed10-deficient embryos showed extensive...
Source: Developmental Biology - August 19, 2023 Category: Biology Authors: Zewen Tao Di Yang Rui Ni Source Type: research

Tmed10 deficiency results in impaired exocrine pancreatic differentiation in zebrafish larvae
Dev Biol. 2023 Aug 17:S0012-1606(23)00142-2. doi: 10.1016/j.ydbio.2023.08.003. Online ahead of print.ABSTRACTTransmembrane p24 trafficking protein 10 (TMED10) is a conserved vesicle trafficking protein. It is dysregulated in Alzheimer disease and plays a pivotal role in the pathogenesis of Alzheimer disease. In addition to the brain, TMED10 is highly expressed in the exocrine pancreas; however, its biological functions and underlying mechanisms remain largely unknown. We studied reduced Tmed10 in zebrafish embryos by morpholino oligonucleotide knockdown and CRISPR-Cas9 mutagenesis. Tmed10-deficient embryos showed extensive...
Source: Developmental Biology - August 19, 2023 Category: Biology Authors: Zewen Tao Di Yang Rui Ni Source Type: research

ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling
Dev Biol. 2023 Aug 10:S0012-1606(23)00141-0. doi: 10.1016/j.ydbio.2023.08.002. Online ahead of print.ABSTRACTCraniofacial development is orchestrated by transcription factor-driven regulatory networks, epigenetic modifications, and signaling pathways. Signaling molecules and their receptors rely on endo-lysosomal trafficking to prevent accumulation on the plasma membrane. ESCRT (Endosomal Sorting Complexes Required for Transport) machinery is recruited to endosomal membranes enabling degradation of such endosomal cargoes. Studies in vitro and in invertebrate models established the requirements of the ESCRT machinery in mem...
Source: Developmental Biology - August 12, 2023 Category: Biology Authors: Viviana Hermosilla Aguayo Peter Martin Nuo Tian James Zheng Robert Aho Marta Losa Licia Selleri Source Type: research