From soap bubbles to multicellular organisms: Unraveling the role of cell adhesion and physical constraints in tile pattern formation and tissue morphogenesis
Dev Biol. 2023 Nov 22;506:1-6. doi: 10.1016/j.ydbio.2023.11.007. Online ahead of print.ABSTRACTTile patterns, in which numerous cells are arranged in a regular pattern, are found in a variety of multicellular organisms and play important functional roles. Such regular arrangements of cells are regulated by various cell adhesion molecules. On the other hand, cell shape is also known to be regulated by physical constraints similar to those of soap bubbles. In particular, circumference minimization plays an important role, and cell adhesion negatively affects this process, thereby regulating tissue morphogenesis based on phys...
Source: Developmental Biology - November 23, 2023 Category: Biology Authors: Hideru Togashi Steven Ray Davis Makoto Sato Source Type: research
Sox9 is associated with two distinct patterning events during snake lung morphogenesis
Dev Biol. 2023 Nov 21:S0012-1606(23)00189-6. doi: 10.1016/j.ydbio.2023.11.006. Online ahead of print.ABSTRACTThe evolutionary forces that allowed species adaptation to different terrestrial environments and led to great diversity in body shape and size required acquisition of innovative strategies of pattern formation during organogenesis. An extreme example is the formation of highly elongated viscera in snakes. What developmental patterning strategies allowed it to overcome the space constraints of the snake's body to meet physiological demands? Here we show that the corn snake uses a Sox2-Sox9 developmental tool kit com...
Source: Developmental Biology - November 23, 2023 Category: Biology Authors: Benjamin J van Soldt Brian D Metscher Michael K Richardson Wellington V Cardoso Source Type: research
From soap bubbles to multicellular organisms: Unraveling the role of cell adhesion and physical constraints in tile pattern formation and tissue morphogenesis
Dev Biol. 2023 Nov 22;506:1-6. doi: 10.1016/j.ydbio.2023.11.007. Online ahead of print.ABSTRACTTile patterns, in which numerous cells are arranged in a regular pattern, are found in a variety of multicellular organisms and play important functional roles. Such regular arrangements of cells are regulated by various cell adhesion molecules. On the other hand, cell shape is also known to be regulated by physical constraints similar to those of soap bubbles. In particular, circumference minimization plays an important role, and cell adhesion negatively affects this process, thereby regulating tissue morphogenesis based on phys...
Source: Developmental Biology - November 23, 2023 Category: Biology Authors: Hideru Togashi Steven Ray Davis Makoto Sato Source Type: research
Sox9 is associated with two distinct patterning events during snake lung morphogenesis
Dev Biol. 2023 Nov 21:S0012-1606(23)00189-6. doi: 10.1016/j.ydbio.2023.11.006. Online ahead of print.ABSTRACTThe evolutionary forces that allowed species adaptation to different terrestrial environments and led to great diversity in body shape and size required acquisition of innovative strategies of pattern formation during organogenesis. An extreme example is the formation of highly elongated viscera in snakes. What developmental patterning strategies allowed it to overcome the space constraints of the snake's body to meet physiological demands? Here we show that the corn snake uses a Sox2-Sox9 developmental tool kit com...
Source: Developmental Biology - November 23, 2023 Category: Biology Authors: Benjamin J van Soldt Brian D Metscher Michael K Richardson Wellington V Cardoso Source Type: research
From soap bubbles to multicellular organisms: Unraveling the role of cell adhesion and physical constraints in tile pattern formation and tissue morphogenesis
Dev Biol. 2023 Nov 21:S0012-1606(23)00190-2. doi: 10.1016/j.ydbio.2023.11.007. Online ahead of print.ABSTRACTTile patterns, in which numerous cells are arranged in a regular pattern, are found in a variety of multicellular organisms and play important functional roles. Such regular arrangements of cells are regulated by various cell adhesion molecules. On the other hand, cell shape is also known to be regulated by physical constraints similar to those of soap bubbles. In particular, circumference minimization plays an important role, and cell adhesion negatively affects this process, thereby regulating tissue morphogenesis...
Source: Developmental Biology - November 23, 2023 Category: Biology Authors: Hideru Togashi Steven Ray Davis Makoto Sato Source Type: research
Sox9 is associated with two distinct patterning events during snake lung morphogenesis
Dev Biol. 2023 Nov 21:S0012-1606(23)00189-6. doi: 10.1016/j.ydbio.2023.11.006. Online ahead of print.ABSTRACTThe evolutionary forces that allowed species adaptation to different terrestrial environments and led to great diversity in body shape and size required acquisition of innovative strategies of pattern formation during organogenesis. An extreme example is the formation of highly elongated viscera in snakes. What developmental patterning strategies allowed it to overcome the space constraints of the snake's body to meet physiological demands? Here we show that the corn snake uses a Sox2-Sox9 developmental tool kit com...
Source: Developmental Biology - November 23, 2023 Category: Biology Authors: Benjamin J van Soldt Brian D Metscher Michael K Richardson Wellington V Cardoso Source Type: research
From soap bubbles to multicellular organisms: Unraveling the role of cell adhesion and physical constraints in tile pattern formation and tissue morphogenesis
Dev Biol. 2023 Nov 21:S0012-1606(23)00190-2. doi: 10.1016/j.ydbio.2023.11.007. Online ahead of print.ABSTRACTTile patterns, in which numerous cells are arranged in a regular pattern, are found in a variety of multicellular organisms and play important functional roles. Such regular arrangements of cells are regulated by various cell adhesion molecules. On the other hand, cell shape is also known to be regulated by physical constraints similar to those of soap bubbles. In particular, circumference minimization plays an important role, and cell adhesion negatively affects this process, thereby regulating tissue morphogenesis...
Source: Developmental Biology - November 23, 2023 Category: Biology Authors: Hideru Togashi Steven Ray Davis Makoto Sato Source Type: research
Sox9 is associated with two distinct patterning events during snake lung morphogenesis
Dev Biol. 2023 Nov 21:S0012-1606(23)00189-6. doi: 10.1016/j.ydbio.2023.11.006. Online ahead of print.ABSTRACTThe evolutionary forces that allowed species adaptation to different terrestrial environments and led to great diversity in body shape and size required acquisition of innovative strategies of pattern formation during organogenesis. An extreme example is the formation of highly elongated viscera in snakes. What developmental patterning strategies allowed it to overcome the space constraints of the snake's body to meet physiological demands? Here we show that the corn snake uses a Sox2-Sox9 developmental tool kit com...
Source: Developmental Biology - November 23, 2023 Category: Biology Authors: Benjamin J van Soldt Brian D Metscher Michael K Richardson Wellington V Cardoso Source Type: research
From soap bubbles to multicellular organisms: Unraveling the role of cell adhesion and physical constraints in tile pattern formation and tissue morphogenesis
Dev Biol. 2023 Nov 21:S0012-1606(23)00190-2. doi: 10.1016/j.ydbio.2023.11.007. Online ahead of print.ABSTRACTTile patterns, in which numerous cells are arranged in a regular pattern, are found in a variety of multicellular organisms and play important functional roles. Such regular arrangements of cells are regulated by various cell adhesion molecules. On the other hand, cell shape is also known to be regulated by physical constraints similar to those of soap bubbles. In particular, circumference minimization plays an important role, and cell adhesion negatively affects this process, thereby regulating tissue morphogenesis...
Source: Developmental Biology - November 23, 2023 Category: Biology Authors: Hideru Togashi Steven Ray Davis Makoto Sato Source Type: research
Sox9 is associated with two distinct patterning events during snake lung morphogenesis
Dev Biol. 2023 Nov 21:S0012-1606(23)00189-6. doi: 10.1016/j.ydbio.2023.11.006. Online ahead of print.ABSTRACTThe evolutionary forces that allowed species adaptation to different terrestrial environments and led to great diversity in body shape and size required acquisition of innovative strategies of pattern formation during organogenesis. An extreme example is the formation of highly elongated viscera in snakes. What developmental patterning strategies allowed it to overcome the space constraints of the snake's body to meet physiological demands? Here we show that the corn snake uses a Sox2-Sox9 developmental tool kit com...
Source: Developmental Biology - November 23, 2023 Category: Biology Authors: Benjamin J van Soldt Brian D Metscher Michael K Richardson Wellington V Cardoso Source Type: research
Mask exhibits trxG-like behavior and associates with H3K27ac marked chromatin
Dev Biol. 2023 Nov 18;505:130-140. doi: 10.1016/j.ydbio.2023.11.005. Online ahead of print.ABSTRACTThe Trithorax group (trxG) proteins counteract the repressive effect of Polycomb group (PcG) complexes and maintain transcriptional memory of active states of key developmental genes. Although chromatin structure and modifications appear to play a fundamental role in this process, it is not clear how trxG prevents PcG-silencing and heritably maintains an active gene expression state. Here, we report a hitherto unknown role of Drosophila Multiple ankyrin repeats single KH domain (Mask), which emerged as one of the candidate tr...
Source: Developmental Biology - November 19, 2023 Category: Biology Authors: Ammad Shaukat Mahnoor Hussain Bakhtiari Daim Shiraz Chaudhry Muhammad Haider Farooq Khan Jawad Akhtar Ahmed Hassan Abro Muhammad Abdul Haseeb Aaminah Sarwar Khalida Mazhar Zain Umer Muhammad Tariq Source Type: research
Mask exhibits trxG-like behavior and associates with H3K27ac marked chromatin
Dev Biol. 2023 Nov 17:S0012-1606(23)00188-4. doi: 10.1016/j.ydbio.2023.11.005. Online ahead of print.ABSTRACTThe Trithorax group (trxG) proteins counteract the repressive effect of Polycomb group (PcG) complexes and maintain transcriptional memory of active states of key developmental genes. Although chromatin structure and modifications appear to play a fundamental role in this process, it is not clear how trxG prevents PcG-silencing and heritably maintains an active gene expression state. Here, we report a hitherto unknown role of Drosophila Multiple ankyrin repeats single KH domain (Mask), which emerged as one of the ca...
Source: Developmental Biology - November 19, 2023 Category: Biology Authors: Ammad Shaukat Mahnoor Hussain Bakhtiari Daim Shiraz Chaudhry Muhammad Haider Farooq Khan Jawad Akhtar Ahmed Hassan Abro Muhammad Abdul Haseeb Aaminah Sarwar Khalida Mazhar Zain Umer Muhammad Tariq Source Type: research
Mask exhibits trxG-like behavior and associates with H3K27ac marked chromatin
Dev Biol. 2023 Nov 17:S0012-1606(23)00188-4. doi: 10.1016/j.ydbio.2023.11.005. Online ahead of print.ABSTRACTThe Trithorax group (trxG) proteins counteract the repressive effect of Polycomb group (PcG) complexes and maintain transcriptional memory of active states of key developmental genes. Although chromatin structure and modifications appear to play a fundamental role in this process, it is not clear how trxG prevents PcG-silencing and heritably maintains an active gene expression state. Here, we report a hitherto unknown role of Drosophila Multiple ankyrin repeats single KH domain (Mask), which emerged as one of the ca...
Source: Developmental Biology - November 19, 2023 Category: Biology Authors: Ammad Shaukat Mahnoor Hussain Bakhtiari Daim Shiraz Chaudhry Muhammad Haider Farooq Khan Jawad Akhtar Ahmed Hassan Abro Muhammad Abdul Haseeb Aaminah Sarwar Khalida Mazhar Zain Umer Muhammad Tariq Source Type: research
The ftz upstream element drives late ftz stripes but is not required for regulation of ftz target genes
Dev Biol. 2023 Nov 15:S0012-1606(23)00187-2. doi: 10.1016/j.ydbio.2023.11.004. Online ahead of print.ABSTRACTThe regulation of gene expression in precise, rapidly changing spatial patterns is essential for embryonic development. Multiple enhancers have been identified for the evolving expression patterns of the cascade of Drosophila segmentation genes that establish the basic body plan of the fly. Classic reporter transgene experiments identified multiple cis-regulatory elements (CREs) that are sufficient to direct various aspects of the evolving expression pattern of the pair-rule gene fushi tarazu (ftz). These include en...
Source: Developmental Biology - November 17, 2023 Category: Biology Authors: Mathew D Fischera Patricia Graham Leslie Pick Source Type: research
The ftz upstream element drives late ftz stripes but is not required for regulation of ftz target genes
Dev Biol. 2023 Nov 15:S0012-1606(23)00187-2. doi: 10.1016/j.ydbio.2023.11.004. Online ahead of print.ABSTRACTThe regulation of gene expression in precise, rapidly changing spatial patterns is essential for embryonic development. Multiple enhancers have been identified for the evolving expression patterns of the cascade of Drosophila segmentation genes that establish the basic body plan of the fly. Classic reporter transgene experiments identified multiple cis-regulatory elements (CREs) that are sufficient to direct various aspects of the evolving expression pattern of the pair-rule gene fushi tarazu (ftz). These include en...
Source: Developmental Biology - November 17, 2023 Category: Biology Authors: Mathew D Fischera Patricia Graham Leslie Pick Source Type: research
