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Enzymatic Targets in the Anticancer Drug Discovery
Curr Protein Pept Sci. 2024;25(1):3. doi: 10.2174/138920372501240109145132.NO ABSTRACTPMID:38291875 | DOI:10.2174/138920372501240109145132 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - January 31, 2024 Category: Biochemistry Authors: Luciana Scotti Marcus T Scotti Source Type: research

A Review of the Leishmanicidal Properties of Lectins
The objective of the present work is to carry out a bibliographic review on lectins with leishmanicidal activity, emphasizing the advances and perspectives of research in this theme. Through the analysis of the selected studies, we were able to conclude that lectins have great potential for inhibiting the development of leishmaniasis. However, there are still few studies on this subject.PMID:38284715 | DOI:10.2174/0113892037275751231221053730 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - January 29, 2024 Category: Biochemistry Authors: Yasmim A Grangeiro Ana L E Santos Fl ávia E V Barbosa Renato R Roma Racquel O S Souza Cl áudio G L Silva Claudener S Teixeira Source Type: research

Heparin Oligosaccharides as Vasoactive Intestinal Peptide Inhibitors via their Binding Process Characterization
CONCLUSION: The binding between heparin oligosaccharides and VIP could block the binding between VIP and its receptor on tumor cells. Downloading the regulation of the expression level of cAMP could possibly further affect the subsequent activation of PKA. These non-anticoagulant heparin oligosaccharides may block the VIP-mediated cAMP/PKA signaling pathway and thus exert their antitumor activity.PMID:38284716 | DOI:10.2174/0113892037287189240122110819 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - January 29, 2024 Category: Biochemistry Authors: Meixin Li Yaqi Xue Lianli Chi Lan Jin Source Type: research

CTXP, The Major Cobra Toxin Peptide From Naja Naja Oxiana Venom; A Promising Target for Antivenom Agent Development
CONCLUSION: Surprisingly, the Anti-CTXP antibody could neutralize 8-LD50 of the CTXP peptide. These results identified CTXP (a 7 kDa peptide) as a potential target for the development of novel efficient antivenom agents.PMID:38275046 | DOI:10.2174/0113892037277589231128103032 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - January 26, 2024 Category: Biochemistry Authors: Mohammad Hosseininejad Chafi Mohsen Eslamnezhad-Namin Mansoureh Shahbazi Dastjerdeh Mohammad Reza Zareinejad Akbar Oghalaie Kamran Pooshang Bagheri Fatemeh Kazemi-Lomedasht Gholamreza Karimi Mehdi Razzaghi-Abyaneh Sima Sadat Seyedjavadi Mahdi Behdani Source Type: research

Current Stage and Future Perspectives for Homology Modeling, Molecular Dynamics Simulations, Machine Learning with Molecular Dynamics, and Quantum Computing for Intrinsically Disordered Proteins and Proteins with Intrinsically Disordered Regions
Curr Protein Pept Sci. 2024;25(2):163-171. doi: 10.2174/0113892037281184231123111223.ABSTRACTThe structural ensembles of intrinsically disordered proteins (IDPs) and proteins with intrinsically disordered regions (IDRs) cannot be easily characterized using conventional experimental techniques. Computational techniques complement experiments and provide useful insights into the structural ensembles of IDPs and proteins with IDRs. Herein, we discuss computational techniques such as homology modeling, molecular dynamics simulations, machine learning with molecular dynamics, and quantum computing that can be applied to the stu...
Source: Current Protein and Peptide Science - January 26, 2024 Category: Biochemistry Authors: Orkid Coskuner-Weber Vladimir N Uversky Source Type: research

Markers of Oxidative Stress and Tyrosinase Activity in Melasma Patients: A Biochemical Investigation
CONCLUSIONS: Increased oxidative stress may affect tyrosinase activity and eumelanin synthesis via the anabolic pathway of melanin synthesis, according to our findings. In conclusion, we discovered a negative relationship between antioxidants and tyrosinase activity.PMID:38275092 | DOI:10.2174/0113892037269116231115065458 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - January 26, 2024 Category: Biochemistry Authors: Shweta Katiyar Dhananjay Yadav Sanjeev K Singh Source Type: research

Global Emergence of SARS-CoV2 Infection and Scientific Interventions to Contain its Spread
Curr Protein Pept Sci. 2024 Jan 23. doi: 10.2174/0113892037274719231212044235. Online ahead of print.ABSTRACTThe global pandemic caused by COVID-19 posed a significant challenge to public health, necessitating rapid scientific interventions to tackle the spread of infection. The review discusses the key areas of research on COVID-19 including viral genomics, epidemiology, pathogenesis, diagnostics, and therapeutics. The genome sequencing of the virus facilitated the tracking of its evolution, transmission dynamics, and identification of variants. Epidemiological studies have provided insights into disease spread, risk fact...
Source: Current Protein and Peptide Science - January 24, 2024 Category: Biochemistry Authors: Himanshu Ajmera Sudarshan Singh Lakhawat Naveen Malik Akhilesh Kumar Jasvinder Singh Bhatti Vikram Kumar Himanshu Gogoi Sunil Kumar Jaswal Sanjeev Chandel Pushpender Kumar Sharma Source Type: research

CBX8 Promotes Epithelial-mesenchymal Transition, Migration, and Invasion of Lung Cancer through Wnt/ β-catenin Signaling Pathway
CONCLUSION: Collectively, these data demonstrated that CBX8 induced EMT through Wnt/β-- catenin signaling, driving migration and invasion of LC cells.PMID:38265409 | DOI:10.2174/0113892037273375231204080906 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - January 24, 2024 Category: Biochemistry Authors: Xiaoping Cai Yuankai Lv Jiongwei Pan Zhuo Cao Junzhi Zhang Yuling Li Hao Zheng Source Type: research

Neurokinin B Administration Induces Dose Dependent Proliferation of Seminal Vesicles in Adult Rats
Conclusion: Continuous administration of Neurokinin B and Senktide effect positively while SB222200 have detrimental effects on cellular morphology, epithelial height and seminal fructose levels in seminal vesicles. Effects of peptide treatments depicted a reversal towards control group when rats were kept without any treatment.PMID:38243941 | DOI:10.2174/0113892037264538231128072614 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - January 20, 2024 Category: Biochemistry Authors: Muhammad Haris Ramzan Mohsin Shah Faiqa Ramzan Source Type: research

Molecular Characterization, Expression and In Situ Hybridization Analysis of a Pedal Peptide/Orcokinin-type Neuropeptide in Cuttlefish Sepiella japonica
CONCLUSION: The study indicated that Sj-PP/OK may be involved in the neuroendocrine regulation in cephalopods, providing primary theoretical basis for further studies of its regulation role in reproduction.PMID:38243942 | DOI:10.2174/0113892037255378231101065721 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - January 20, 2024 Category: Biochemistry Authors: Gong Li Jiayin Qiu Huimin Cao Libing Zheng Changfeng Chi Shuang Li Xu Zhou Source Type: research

Recent Advances in Molecular Imprinting for Proteins on Magnetic Microspheres
Curr Protein Pept Sci. 2024 Jan 4. doi: 10.2174/0113892037277894231208065403. Online ahead of print.ABSTRACTThe separation of proteins in biological samples plays an essential role in the development of disease detection, drug discovery, and biological analysis. Protein imprinted polymers (PIPs) serve as a tool to capture target proteins specifically and selectively from complex media for separation purposes. Whereas conventional molecularly imprinted polymer is time-consuming in terms of incubation studies and solvent removal, magnetic particles are introduced using their magnetic properties for sedimentation and separati...
Source: Current Protein and Peptide Science - January 5, 2024 Category: Biochemistry Authors: Jing Zhang Shujie Yuan Shujuan Beng Wenhui Luo Xiaoqun Wang Lei Wang Can Peng Source Type: research