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Research Progress on Extracellular Matrix Involved in the Development of Preeclampsia
This article summarizes the recent studies on the involvement of ECM components, including small leucine-rich proteoglycans, syndecans, glypicans, laminins, fibronectin, collagen, and hyaluronic acid, in the development of PE. ECM plays various roles in PE development, most notably by controlling the activities of trophoblasts. The ECM is structurally stable and can serve as a biological diagnostic marker and therapeutic target for PE.PMID:38561606 | DOI:10.2174/0113892037284176240302052521 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - April 1, 2024 Category: Biochemistry Authors: Xin Wang Qi Zhang Yi Ren Chao Liu Huijie Gao Source Type: research

A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Bioactive Peptides
Curr Protein Pept Sci. 2024 Mar 29. doi: 10.2174/0113892037275221240327042353. Online ahead of print.ABSTRACTNeurodegenerative disorders, which include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), represent a significant and growing global health challenge. Current therapies predominantly focus on symptom management rather than altering disease progression. In this review, we discuss the major therapeutic strategies in practice for these disorders, highlighting their limitations. For AD, the mainstay treatments are cholinesterase inhibitors and N-me...
Source: Current Protein and Peptide Science - April 1, 2024 Category: Biochemistry Authors: Kuldeep Singh Jeetendra Kumar Gupta Shivendra Kumar Urvashi Soni Source Type: research

Phase Separation of Chromatin Structure-related Biomolecules: A Driving Force for Epigenetic Regulations
Curr Protein Pept Sci. 2024 Mar 27. doi: 10.2174/0113892037296216240301074253. Online ahead of print.ABSTRACTIntracellularly, membrane-less organelles are formed by spontaneous fusion and fission of macro-molecules in a process called phase separation, which plays an essential role in cellular activities. In certain disease states, such as cancers and neurodegenerative diseases, aberrant phase separations take place and participate in disease progression. Chromatin structure-related proteins, based on their characteristics and upon external stimuli, phase separate to exert functions like genome assembly, transcription regu...
Source: Current Protein and Peptide Science - March 29, 2024 Category: Biochemistry Authors: Jiao Wang Yuchen Chen Zixuan Xiao Xikai Liu Chengyu Liu Kun Huang Hong Chen Source Type: research

A Review on Anaplastic Lymphoma Kinase (ALK) Rearrangements and Mutations: Implications for Gastric Carcinogenesis and Target Therapy
Curr Protein Pept Sci. 2024 Feb 28. doi: 10.2174/0113892037291318240130103348. Online ahead of print.ABSTRACTGastric adenocarcinoma is a complex disease with diverse genetic modifications, including Anaplastic Lymphoma Kinase (ALK) gene changes. The ALK gene is located on chromosome 2p23 and encodes a receptor tyrosine kinase that plays a crucial role in embryonic development and cellular differentiation. ALK alterations can result from gene fusion, mutation, amplification, or overexpression in gastric adenocarcinoma. Fusion occurs when the ALK gene fuses with another gene, resulting in a chimeric protein with constitutive...
Source: Current Protein and Peptide Science - February 29, 2024 Category: Biochemistry Authors: Felipe Pantoja Mesquita Luina Benevides Lima Emerson Lucena da Silva Pedro Filho Noronha Souza Maria Elisabete Amaral de Moraes Rommel Mario Rodrigues Burbano Raquel Carvalho Montenegro Source Type: research