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Research progress on hCNT3 structure/ function and nucleoside anticancer drugs
Curr Protein Pept Sci. 2023 Sep 5. doi: 10.2174/1389203724666230905110952. Online ahead of print.ABSTRACTMembrane protein human concentrative nucleoside transporter 3 (hCNT3) can not only transport extracellular nucleosides into the cell but also transport various nucleoside-derived anticancer drugs to the focus of infection for therapeutic effects. Typical nucleoside anticancer drugs, including fludarabine, cladabine, decitabine, and clofarabine, are recognized by hCNT3 and then delivered to the lesion site for their therapeutic effects. hCNT3 is highly conserved during the evolution from lower to higher vertebrates, whic...
Source: Current Protein and Peptide Science - September 6, 2023 Category: Biochemistry Authors: Xinru Yue Jianping Hu Xun Zhang Derong Zhang Lingkai Tang Zuoxin Ou Zhigang Zhang Yujie Cao Jing Li Li Liang Wei Liu Ying Li Source Type: research

PI3K signaling pathways as a molecular target for Glioblastoma Multiforme
Curr Protein Pept Sci. 2023 Aug 30. doi: 10.2174/1389203724666230830125102. Online ahead of print.ABSTRACTGlioblastoma multiforme (GBM) is the most common type of cancer that affects the central nervous system (CNS). It currently accounts for about 2% of diagnosed malignant tumors worldwide, with 296,000 new cases reported per year. The first-choice treatment consists of surgical resection, radiotherapy, and adjuvant chemotherapy, which increases patients' survival by 15 months. New clinical and pre-clinical research aims to improve this prognosis by proposing the search for new drugs that effectively eliminate cancer cell...
Source: Current Protein and Peptide Science - September 1, 2023 Category: Biochemistry Authors: Andressa Let ícia Lopes da Silva Thiago Pina Goes de Ara újo Shakira Cavalcante de Albuquerque Ferreira Anderson Brand ão Leite Jo ão Kaycke Sarmento da Silva Lilyana Waleska Nunes Albuquerque Ana Rachel Vasconcelos de Lima Herbert Charles Silva Barro Source Type: research

Mechanisms Involved in the Therapeutic Effect of Cannabinoid Compounds on Gliomas: A Review with Experimental Approach
CONCLUSION: The evaluated compounds exhibited favorable interactions with the analyzed enzy-matic targets, thus representing potential candidates for further in vitro and in vivo studies.PMID:37649287 | DOI:10.2174/1389203724666230830125423 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - August 31, 2023 Category: Biochemistry Authors: Hugo Fernandes Oliveira Pires Pablo Rayff da Silva Arthur Lins Dias Cleyton de Sousa Gomes Nat ália Ferreira de Sousa Aline Matilde Ferreira Dos Santos L ívia Roberta Pimenta Souza Jaisl ânia Lucena de Figueiredo Lima Mayara Cecile Nascimento Oliveira Source Type: research

In Silico and In vitro Analysis of Phenolic Acids for Identification of Potential DHFR Inhibitors as Antimicrobial and Anticancer Agents
CONCLUSION: In silico and in vitro results confirmed the good binding and inhibitory activity of some phenolic acids to the modeled target proteins. Among all the studied natural phenolic acids, chlorogenic acid, digallic acid, and rosmarinic acid appeared to be the most potential leads for future chemical alteration. This study can provide significant speculative guidance for the design and development of potent DHFR inhibitors in the future by using these compounds as leads.PMID:37641992 | DOI:10.2174/1389203724666230825142558 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - August 29, 2023 Category: Biochemistry Authors: Renu Sehrawat Priyanka Rathee Pooja Rathee Sarita Khatkar Esra Kupelli Akkol Anurag Khatkar Source Type: research

Intercellular Interactions Mediated by HGF And TGF- Β Promote the 3D Spherical and Xenograft Growth of Liver Cancer Cells
CONCLUSION: Collectively, these findings provide valuable insights into the interactions between fibroblasts and liver cancer cells, which may have therapeutic implications for the treatment of liver cancer.PMID:37642183 | DOI:10.2174/1389203724666230825100318 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - August 29, 2023 Category: Biochemistry Authors: Zheng Peng Xiaolan Lv Pengfei Zhang Qiao Chen Hongyu Zhang Jianlin Chen Xingxuan Ma Bohui Ouyang Meng Hao Haibo Tong Dongwei Guo Yi Luo Shigao Huang Source Type: research

Protein Engineering in Cyanobacterial Biotechnology: Tools and Recent Updates
Curr Protein Pept Sci. 2023 Aug 22. doi: 10.2174/1389203724666230822100104. Online ahead of print.ABSTRACTCyanobacteria have emerged as a microbial cell factory to produce a variety of bioproducts, including peptides and proteins. Cyanobacteria stand out among other organisms due to their photoautotrophic metabolism and ability to produce a wide range of metabolites and proteins. As photoautotrophic hosts can produce industrial compounds and proteins by using minimal resources such as sunlight, atmospheric carbon dioxide, and fewer nutrients, cyanobacteria are cost-effective industrial hosts. Therefore, the use of protein ...
Source: Current Protein and Peptide Science - August 23, 2023 Category: Biochemistry Authors: Swati Tyagi Srabani Kar Amit Srivastava Pratyoosh Shukla Source Type: research

BH3 Mimetic Peptides: An Effective Strategy to Complement Anticancer Therapy
Curr Protein Pept Sci. 2023 Aug 22. doi: 10.2174/1389203724666230822100131. Online ahead of print.ABSTRACTApoptosis, a natural process of programmed cell death, is a promising therapeutic target as the disruption of apoptosis evolves in many diseases including cancer. Several pieces of evidence indicate that errors in apoptotic pathways result in the imbalance between cell proliferation and death, allowing cells with genetic abnormalities to survive. The intrinsic and extrinsic pathways of apoptosis utilize different caspases to execute the event of cell death through the cleavage of hundreds of proteins. Proteins from the...
Source: Current Protein and Peptide Science - August 23, 2023 Category: Biochemistry Authors: Sundra Dhakshinamurthy Saraswathy Arumugam Mirunalini Kandasamy Karthikeyan Kumpati Premkumar Source Type: research

Unfolded Protein Response Signaling in Hepatic Stem Cell Activation in Liver Fibrosis
This article covers the involvement of the UPR signaling pathway in cellular damage in liver fibrosis and emphasizes the potential role of non-coding RNAs (ncRNA) in this process. Investigating the pathogenic pathways related to the ER/UPR stress axis that contribute to liver fibrosis can help to guide future drug therapy approaches.PMID:37608655 | DOI:10.2174/1389203724666230822085951 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - August 23, 2023 Category: Biochemistry Authors: Zohreh Salimi Mehdi Rostami Yaser Eshaghi Milasi Alireza Mafi Ramin Raoufinia Amirhossein Kiani Fariba Sakhaei Behrooz Ghezelbash Alexandra E Butler Maryam Mohammad-Sadeghipour Amirhossein Sahebkar Source Type: research