Emerging Role of Non-collagenous Bone Proteins as Osteokines in Extraosseous Tissues
Curr Protein Pept Sci. 2023 Nov 1. doi: 10.2174/0113892037268414231017074054. Online ahead of print.ABSTRACTBone is a unique tissue, composed of various types of cells embedded in a calcified extracellular matrix (ECM), whose dynamic structure consists of organic and inorganic compounds produced by bone cells. The main inorganic component is represented by hydroxyapatite, whilst the organic ECM is primarily made up of type I collagen and non-collagenous proteins. These proteins play an important role in bone homeostasis, calcium regulation, and maintenance of the hematopoietic niche. Recent advances in bone biology have hi...
Source: Current Protein and Peptide Science - November 8, 2023 Category: Biochemistry Authors: Kenda Jawich Rana Hadakie Souhaib Jamal Rana Habeeb Sahar Al Fahoum Alberto Ferlin Luca De Toni Source Type: research

Emerging Role of Non-collagenous Bone Proteins as Osteokines in Extraosseous Tissues
Curr Protein Pept Sci. 2023 Nov 1. doi: 10.2174/0113892037268414231017074054. Online ahead of print.ABSTRACTBone is a unique tissue, composed of various types of cells embedded in a calcified extracellular matrix (ECM), whose dynamic structure consists of organic and inorganic compounds produced by bone cells. The main inorganic component is represented by hydroxyapatite, whilst the organic ECM is primarily made up of type I collagen and non-collagenous proteins. These proteins play an important role in bone homeostasis, calcium regulation, and maintenance of the hematopoietic niche. Recent advances in bone biology have hi...
Source: Current Protein and Peptide Science - November 8, 2023 Category: Biochemistry Authors: Kenda Jawich Rana Hadakie Souhaib Jamal Rana Habeeb Sahar Al Fahoum Alberto Ferlin Luca De Toni Source Type: research

Emerging Role of Non-collagenous Bone Proteins as Osteokines in Extraosseous Tissues
Curr Protein Pept Sci. 2023 Nov 1. doi: 10.2174/0113892037268414231017074054. Online ahead of print.ABSTRACTBone is a unique tissue, composed of various types of cells embedded in a calcified extracellular matrix (ECM), whose dynamic structure consists of organic and inorganic compounds produced by bone cells. The main inorganic component is represented by hydroxyapatite, whilst the organic ECM is primarily made up of type I collagen and non-collagenous proteins. These proteins play an important role in bone homeostasis, calcium regulation, and maintenance of the hematopoietic niche. Recent advances in bone biology have hi...
Source: Current Protein and Peptide Science - November 8, 2023 Category: Biochemistry Authors: Kenda Jawich Rana Hadakie Souhaib Jamal Rana Habeeb Sahar Al Fahoum Alberto Ferlin Luca De Toni Source Type: research

Emerging Role of Non-collagenous Bone Proteins as Osteokines in Extraosseous Tissues
Curr Protein Pept Sci. 2023 Nov 1. doi: 10.2174/0113892037268414231017074054. Online ahead of print.ABSTRACTBone is a unique tissue, composed of various types of cells embedded in a calcified extracellular matrix (ECM), whose dynamic structure consists of organic and inorganic compounds produced by bone cells. The main inorganic component is represented by hydroxyapatite, whilst the organic ECM is primarily made up of type I collagen and non-collagenous proteins. These proteins play an important role in bone homeostasis, calcium regulation, and maintenance of the hematopoietic niche. Recent advances in bone biology have hi...
Source: Current Protein and Peptide Science - November 8, 2023 Category: Biochemistry Authors: Kenda Jawich Rana Hadakie Souhaib Jamal Rana Habeeb Sahar Al Fahoum Alberto Ferlin Luca De Toni Source Type: research

Emerging Role of Non-collagenous Bone Proteins as Osteokines in Extraosseous Tissues
Curr Protein Pept Sci. 2023 Nov 1. doi: 10.2174/0113892037268414231017074054. Online ahead of print.ABSTRACTBone is a unique tissue, composed of various types of cells embedded in a calcified extracellular matrix (ECM), whose dynamic structure consists of organic and inorganic compounds produced by bone cells. The main inorganic component is represented by hydroxyapatite, whilst the organic ECM is primarily made up of type I collagen and non-collagenous proteins. These proteins play an important role in bone homeostasis, calcium regulation, and maintenance of the hematopoietic niche. Recent advances in bone biology have hi...
Source: Current Protein and Peptide Science - November 8, 2023 Category: Biochemistry Authors: Kenda Jawich Rana Hadakie Souhaib Jamal Rana Habeeb Sahar Al Fahoum Alberto Ferlin Luca De Toni Source Type: research

Design and Simulation of the Microcantilever Biosensor for MITF Antigen and D5 Monoclonal Antibody İnteraction Finite Element Analysis, and Experimental
CONCLUSION: The fact that the results of the simulation study overlap with the experimental and mathematical results allows us to get much cheaper and faster answers compared to expensive and time-consuming experimental approaches.PMID:37921167 | DOI:10.2174/0113892037259122231013153546 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - November 3, 2023 Category: Biochemistry Authors: Pelin Akcal ı K übra Kelleci Sevil Ozer Source Type: research

Bioconjugation Techniques for Enhancing Stability and Targeting Efficiency of Protein and Peptide Therapeutics
Curr Protein Pept Sci. 2023 Oct 25. doi: 10.2174/0113892037268777231013154850. Online ahead of print.ABSTRACTBioconjugation techniques have emerged as powerful tools for enhancing the stability and targeting efficiency of protein and peptide therapeutics. This review provides a comprehensive analysis of the various bioconjugation strategies employed in the field. The introduction highlights the significance of bioconjugation techniques in addressing stability and targeting challenges associated with protein and peptide-based drugs. Chemical and enzymatic bioconjugation methods are discussed, along with crosslinking strateg...
Source: Current Protein and Peptide Science - November 3, 2023 Category: Biochemistry Authors: Tanuja Bisht Anupriya Adhikari Shivanand Patil Shivang Dhoundiyal Source Type: research

Design and Simulation of the Microcantilever Biosensor for MITF Antigen and D5 Monoclonal Antibody İnteraction Finite Element Analysis, and Experimental
CONCLUSION: The fact that the results of the simulation study overlap with the experimental and mathematical results allows us to get much cheaper and faster answers compared to expensive and time-consuming experimental approaches.PMID:37921167 | DOI:10.2174/0113892037259122231013153546 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - November 3, 2023 Category: Biochemistry Authors: Pelin Akcal ı K übra Kelleci Sevil Ozer Source Type: research

Bioconjugation Techniques for Enhancing Stability and Targeting Efficiency of Protein and Peptide Therapeutics
Curr Protein Pept Sci. 2023 Oct 25. doi: 10.2174/0113892037268777231013154850. Online ahead of print.ABSTRACTBioconjugation techniques have emerged as powerful tools for enhancing the stability and targeting efficiency of protein and peptide therapeutics. This review provides a comprehensive analysis of the various bioconjugation strategies employed in the field. The introduction highlights the significance of bioconjugation techniques in addressing stability and targeting challenges associated with protein and peptide-based drugs. Chemical and enzymatic bioconjugation methods are discussed, along with crosslinking strateg...
Source: Current Protein and Peptide Science - November 3, 2023 Category: Biochemistry Authors: Tanuja Bisht Anupriya Adhikari Shivanand Patil Shivang Dhoundiyal Source Type: research

Design and Simulation of the Microcantilever Biosensor for MITF Antigen and D5 Monoclonal Antibody İnteraction Finite Element Analysis, and Experimental
CONCLUSION: The fact that the results of the simulation study overlap with the experimental and mathematical results allows us to get much cheaper and faster answers compared to expensive and time-consuming experimental approaches.PMID:37921167 | DOI:10.2174/0113892037259122231013153546 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - November 3, 2023 Category: Biochemistry Authors: Pelin Akcal ı K übra Kelleci Sevil Ozer Source Type: research

Bioconjugation Techniques for Enhancing Stability and Targeting Efficiency of Protein and Peptide Therapeutics
Curr Protein Pept Sci. 2023 Oct 25. doi: 10.2174/0113892037268777231013154850. Online ahead of print.ABSTRACTBioconjugation techniques have emerged as powerful tools for enhancing the stability and targeting efficiency of protein and peptide therapeutics. This review provides a comprehensive analysis of the various bioconjugation strategies employed in the field. The introduction highlights the significance of bioconjugation techniques in addressing stability and targeting challenges associated with protein and peptide-based drugs. Chemical and enzymatic bioconjugation methods are discussed, along with crosslinking strateg...
Source: Current Protein and Peptide Science - November 3, 2023 Category: Biochemistry Authors: Tanuja Bisht Anupriya Adhikari Shivanand Patil Shivang Dhoundiyal Source Type: research

Design and Simulation of the Microcantilever Biosensor for MITF Antigen and D5 Monoclonal Antibody İnteraction Finite Element Analysis, and Experimental
CONCLUSION: The fact that the results of the simulation study overlap with the experimental and mathematical results allows us to get much cheaper and faster answers compared to expensive and time-consuming experimental approaches.PMID:37921167 | DOI:10.2174/0113892037259122231013153546 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - November 3, 2023 Category: Biochemistry Authors: Pelin Akcal ı K übra Kelleci Sevil Ozer Source Type: research

Bioconjugation Techniques for Enhancing Stability and Targeting Efficiency of Protein and Peptide Therapeutics
Curr Protein Pept Sci. 2023 Oct 25. doi: 10.2174/0113892037268777231013154850. Online ahead of print.ABSTRACTBioconjugation techniques have emerged as powerful tools for enhancing the stability and targeting efficiency of protein and peptide therapeutics. This review provides a comprehensive analysis of the various bioconjugation strategies employed in the field. The introduction highlights the significance of bioconjugation techniques in addressing stability and targeting challenges associated with protein and peptide-based drugs. Chemical and enzymatic bioconjugation methods are discussed, along with crosslinking strateg...
Source: Current Protein and Peptide Science - November 3, 2023 Category: Biochemistry Authors: Tanuja Bisht Anupriya Adhikari Shivanand Patil Shivang Dhoundiyal Source Type: research

Design and Simulation of the Microcantilever Biosensor for MITF Antigen and D5 Monoclonal Antibody İnteraction Finite Element Analysis, and Experimental
CONCLUSION: The fact that the results of the simulation study overlap with the experimental and mathematical results allows us to get much cheaper and faster answers compared to expensive and time-consuming experimental approaches.PMID:37921167 | DOI:10.2174/0113892037259122231013153546 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - November 3, 2023 Category: Biochemistry Authors: Pelin Akcal ı K übra Kelleci Sevil Ozer Source Type: research

Bioconjugation Techniques for Enhancing Stability and Targeting Efficiency of Protein and Peptide Therapeutics
Curr Protein Pept Sci. 2023 Oct 25. doi: 10.2174/0113892037268777231013154850. Online ahead of print.ABSTRACTBioconjugation techniques have emerged as powerful tools for enhancing the stability and targeting efficiency of protein and peptide therapeutics. This review provides a comprehensive analysis of the various bioconjugation strategies employed in the field. The introduction highlights the significance of bioconjugation techniques in addressing stability and targeting challenges associated with protein and peptide-based drugs. Chemical and enzymatic bioconjugation methods are discussed, along with crosslinking strateg...
Source: Current Protein and Peptide Science - November 3, 2023 Category: Biochemistry Authors: Tanuja Bisht Anupriya Adhikari Shivanand Patil Shivang Dhoundiyal Source Type: research