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Diabetic Wound: Pathophysiology, Complications and Treatment Strategies
Curr Protein Pept Sci. 2023 Oct 31. doi: 10.2174/0113892037276171231016103320. Online ahead of print.ABSTRACTDiabetic wound healing is expected to affect 25% of all diabetics, resulting in less severe external factors, economic costs, and less trauma. Topical formulations have been continually improved to achieve a range of amazing properties and have had a significant impact on the management of diabetic wounds. Topical insulin has become one of the most attractive and convenient wound healing techniques due to its excellent biocompatibility, water retention, and therapeutic properties. Multiple versatile topical insulins...
Source: Current Protein and Peptide Science - November 1, 2023 Category: Biochemistry Authors: Sunita Chauhan Monika Gulia Rahul Pratap Singh Vikas Jhawat Source Type: research

Biological Significance of EphB4 Expression in Cancer
This article addresses the structure and function of the EphB4 receptor, analyses its possibility as an anticancer therapeutic target, and summarises knowledge of EphB4 kinase inhibitors. To summarise, EphB4 is a difficult but potential treatment option for cancers.PMID:37909437 | DOI:10.2174/0113892037269589231017055642 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - November 1, 2023 Category: Biochemistry Authors: Asmat Ullah Anam Razzaq Chuanzan Zhou Najeeb Ullah Somia Shehzadi Tariq Aziz Mohammad Y Alfaifi Serag Eldin I Elbehairi Haroon Iqbal Source Type: research

A Novel Peptide COX52-69 Inhibits High Glucose-induced Insulin Secretion by Modulating BK Channel Activity
CONCLUSION: Our study provides a novel approach to modulate high glucose-stimulated insulin secretion in patients with hyperinsulinemia.PMID:37885106 | DOI:10.2174/0113892037249620231010063637 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - October 27, 2023 Category: Biochemistry Authors: Qian Lin Jingtao Liu Hengling Chen Wenwu Hu Weiqiong Lei Meijie Wang Xianguang Lin Yongning Zhang Huiting Ai Su Chen Chenhong Li Source Type: research

Advancements of the CRISPR/Cas9 System in the Treatment of Liver Cancer
Curr Protein Pept Sci. 2023 Oct 17. doi: 10.2174/0113892037238265231006051215. Online ahead of print.ABSTRACTIn recent years, the CRISPR/Cas9 system has become a rapidly advancing gene editing technology with significant advantages in various fields, particularly biomedicine. Liver cancer is a severe malignancy that threatens human health and is primarily treated with surgery, radiotherapy, and chemotherapy. However, surgery may not be suitable for advanced cases of liver cancer with distant metastases. Moreover, radiotherapy and chemotherapy have low specificity and numerous side effects that limit their effectiveness; th...
Source: Current Protein and Peptide Science - October 18, 2023 Category: Biochemistry Authors: Zhuoyu Li Ziming Han Source Type: research