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Hypoxia A Typical Target in Human Lung Cancer Therapy
Curr Protein Pept Sci. 2023 Nov 29. doi: 10.2174/0113892037252820231114045234. Online ahead of print.ABSTRACTLung cancer (LC) is the leading cause of cancer-related death globally. Comprehensive knowledge of the cellular and molecular etiology of LC is perilous for the development of active treatment approaches. Hypoxia in cancer is linked with malignancy, and its phenotype is implicated in the hypoxic reaction, which is being studied as a prospective cancer treatment target. The hypervascularization of the tumor is the main feature of human LC, and hypoxia is a major stimulator of neo-angiogenesis. It was seen that low ox...
Source: Current Protein and Peptide Science - November 30, 2023 Category: Biochemistry Authors: Asmat Ullah Somia Shehzadi Najeeb Ullah Touseef Nawaz Haroon Iqbal Tariq Aziz Source Type: research

Kenaf Seed Cysteine Protease (KSCP) Inhibits the Intrinsic Pathway of the Blood Coagulation Cascade and Platelet Aggregation
CONCLUSION: KSCP purified from kenaf seed extract showed antithrombotic potential. Hence, it could be a better candidate for the management of thrombotic complications.PMID:38031777 | DOI:10.2174/0113892037265109231114065204 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - November 30, 2023 Category: Biochemistry Authors: Sujatha M Hanumegowda Chandramma Srinivasa Ashwini Shivaiah Manjula M Venkatappa Rohith L Shankar Ramesh K Lakshmaiah Sathisha J Gonchigar Devaraja Sannaningaiah Source Type: research

Reduced Tumor Volume and Increased Necrosis of Human Breast Tumor Xenograft in Mice Pretreated by a Cocktail of Three Specific Anti-HER2 scFvs
CONCLUSION: Pre-treatment with a 20 mg/kg anti-HER2 scFv cocktail resulted in a significant reduction in tumor volume and increased necrotic area in a human breast cancer xenograft model, indicating the remarkable anti-tumor effect of the cocktail in vivo.PMID:38018211 | DOI:10.2174/0113892037269645231031095145 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - November 29, 2023 Category: Biochemistry Authors: Foroogh Nejatollahi Elham Nadimi Ali Noorafshan Setareh Moazen Ali Mohammad Alizadeh Solmaz Khalighfard Amirhossein Sahebkar Source Type: research

Soluble Factors Associated with Denervation-induced Skeletal Muscle Atrophy
Curr Protein Pept Sci. 2023 Nov 24. doi: 10.2174/0113892037189827231018092036. Online ahead of print.ABSTRACTSkeletal muscle tissue has the critical function of mechanical support protecting the body. In addition, its functions are strongly influenced by the balanced synthesis and degradation processes of structural and regulatory proteins. The inhibition of protein synthesis and/or the activation of catabolism generally determines a pathological state or condition called muscle atrophy, a reduction in muscle mass that results in partial or total loss of function. It has been established that many pathophysiological condit...
Source: Current Protein and Peptide Science - November 29, 2023 Category: Biochemistry Authors: Marianny Portal Claudio Cabello-Verrugio Source Type: research

Development and Challenges of Cyclic Peptides for Immunomodulation
Curr Protein Pept Sci. 2023 Nov 21. doi: 10.2174/0113892037272528231030074158. Online ahead of print.ABSTRACTCyclic peptides are polypeptide chains formed by cyclic sequences of amide bonds between protein-derived or non-protein-derived amino acids. Compared to linear peptides, cyclic peptides offer several unique advantages, such as increased stability, stronger affinity, improved selectivity, and reduced toxicity. Cyclic peptide has been proved to have a promising application prospect in the medical field. In addition, this paper mainly describes that cyclic peptides play an important role in anti-cancer, anti-inflammato...
Source: Current Protein and Peptide Science - November 22, 2023 Category: Biochemistry Authors: Xianqiong Jiang Li Gao Zhilong Li Yan Shen Zhi-Hua Lin Source Type: research

Bcl-2 Family Proteins in Therapeutic Arena for Cancers
Curr Protein Pept Sci. 2023;24(10):781-782. doi: 10.2174/138920372410231020092906.NO ABSTRACTPMID:37990570 | DOI:10.2174/138920372410231020092906 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - November 22, 2023 Category: Biochemistry Authors: T Sivaraman Source Type: research

Corrigendum to: β-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly and Interaction with Lipids
Curr Protein Pept Sci. 2023;24(10):878. doi: 10.2174/138920372410231115093314.ABSTRACTThe authors declare after the publication of the article titled 'β-Barrel Membrane Bacterial Proteins: Structure, Function, Assembly and Interaction with Lipids'', published in Current Protein and Peptide Science, 2007, 8, 63-82 [1], that a reference by Koebnik was inadvertently omitted. The missing reference has now been included as: Original: All donors and acceptors are saturated intrasegmentally in -helices or intersegmentally in -barrels by the formation of hydrogen bonds between adjacent -strands [1]. [1] Rosenbusch, J.P. (1988) Ze...
Source: Current Protein and Peptide Science - November 22, 2023 Category: Biochemistry Authors: Stefania Galdiero Massimiliano Galdiero Carlo Pedone Source Type: research