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Knockdown of Ubiquitin-Conjugating Enzyme E2 T Abolishes the Progression of Head and Neck Squamous Cell Carcinoma by Inhibiting NF- Κb Signaling and inducing Ferroptosis
CONCLUSION: Our study underscores the multifaceted role of UBE2T in HNSC, illuminating its potential as a biomarker and therapeutic target.PMID:38584528 | DOI:10.2174/0113892037287640240322084946 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - April 8, 2024 Category: Biochemistry Authors: Feng Cai Hongbo Xu Shilong Song Gengming Wang Yajun Zhang Jing Qian Lu Xu Source Type: research

A Review of the Common Neurodegenerative Disorders: Current Therapeutic Approaches and the Potential Role of Bioactive Peptides
Curr Protein Pept Sci. 2024 Mar 29. doi: 10.2174/0113892037275221240327042353. Online ahead of print.ABSTRACTNeurodegenerative disorders, which include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), represent a significant and growing global health challenge. Current therapies predominantly focus on symptom management rather than altering disease progression. In this review, we discuss the major therapeutic strategies in practice for these disorders, highlighting their limitations. For AD, the mainstay treatments are cholinesterase inhibitors and N-me...
Source: Current Protein and Peptide Science - April 1, 2024 Category: Biochemistry Authors: Kuldeep Singh Jeetendra Kumar Gupta Shivendra Kumar Urvashi Soni Source Type: research

Research Progress on Extracellular Matrix Involved in the Development of Preeclampsia
This article summarizes the recent studies on the involvement of ECM components, including small leucine-rich proteoglycans, syndecans, glypicans, laminins, fibronectin, collagen, and hyaluronic acid, in the development of PE. ECM plays various roles in PE development, most notably by controlling the activities of trophoblasts. The ECM is structurally stable and can serve as a biological diagnostic marker and therapeutic target for PE.PMID:38561606 | DOI:10.2174/0113892037284176240302052521 (Source: Current Protein and Peptide Science)
Source: Current Protein and Peptide Science - April 1, 2024 Category: Biochemistry Authors: Xin Wang Qi Zhang Yi Ren Chao Liu Huijie Gao Source Type: research

Phase Separation of Chromatin Structure-related Biomolecules: A Driving Force for Epigenetic Regulations
Curr Protein Pept Sci. 2024 Mar 27. doi: 10.2174/0113892037296216240301074253. Online ahead of print.ABSTRACTIntracellularly, membrane-less organelles are formed by spontaneous fusion and fission of macro-molecules in a process called phase separation, which plays an essential role in cellular activities. In certain disease states, such as cancers and neurodegenerative diseases, aberrant phase separations take place and participate in disease progression. Chromatin structure-related proteins, based on their characteristics and upon external stimuli, phase separate to exert functions like genome assembly, transcription regu...
Source: Current Protein and Peptide Science - March 29, 2024 Category: Biochemistry Authors: Jiao Wang Yuchen Chen Zixuan Xiao Xikai Liu Chengyu Liu Kun Huang Hong Chen Source Type: research