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Antimicrobial Peptides: Sources, Expression Systems, and Applications
Curr Protein Pept Sci. 2023 Jul 27. doi: 10.2174/1389203724666230727101636. Online ahead of print.ABSTRACTAntimicrobial peptides (AMPs) are widely sourced and have a variety of biological activities such as broad-spectrum antibacterial, antiviral, and anticancer. Since AMPs are less likely to cause drug resistance, they are expected to be an alternative to antibiotics. Compared with natural extraction and chemical synthesis methods, producing AMPs using genetic engineering is a hot research topic for the large-scale production of AMPs. This paper outlines the sources of AMPs, focuses on different expression systems, and re...
Source: Current Protein and Peptide Science - July 27, 2023 Category: Biochemistry Authors: Mengru Li Weitao Lu Yanyan Sun Chunming Dong Source Type: research

Phosphate Toxicity and Vascular Calcification in Chronic Kidney Disease: A Closer Look Utilizing Transmission Electron Microscopy
Curr Protein Pept Sci. 2023 Jul 26. doi: 10.2174/1389203724666230726151019. Online ahead of print.ABSTRACTHyperphosphatemia is independently linked with vascular calcification, cardiovascular disease, bone-mineral disease, progression of renal insufficiency, and all-cause mortality in chronic kidney disease (CKD) and end-stage renal disease (ESRD). The emerging importance of fibroblast growth factor-23 (FGF-23) and its co-factor Klotho play very important roles as phosphaturic hormones; however, phosphate levels rise due to a loss of renal Klotho production and the phosphaturic effects of the FGF-23/Klotho axis. Hyperphosp...
Source: Current Protein and Peptide Science - July 27, 2023 Category: Biochemistry Authors: Ying Yang Ke Yang Yuxin Xiong Yusong He Yuanyuan Zhou Melvin R Hayden Source Type: research

Bacterial pathogens: Potential source for antimicrobial peptides
Curr Protein Pept Sci. 2023 Jul 26. doi: 10.2174/1389203724666230726100303. Online ahead of print.ABSTRACTAs more antibiotics become ineffective due to drug-resistant bacteria, alternative therapies for infections must be prioritized. While pathogenic bacteria are a major threat, they also supply a massive reservoir of potential drugs for treating a wide range of illnesses. The concerning emergence of antimicrobial resistance and the rapidly dwindling therapeutic pipeline need the quick discovery and development of new antibiotics. Despite their great promise for natural product medicine development, pathogenic microorgani...
Source: Current Protein and Peptide Science - July 27, 2023 Category: Biochemistry Authors: Manaf AlMatar Osman Albarri Raja Lakhal Melda Meral I şıl Var Fatih K öksal Source Type: research

The Fulcrum of Demyelination in Multiple Sclerosis
Curr Protein Pept Sci. 2023 Jul 17. doi: 10.2174/1389203724666230717124101. Online ahead of print.ABSTRACTMultiple sclerosis (MS) is an autoimmune disorder that affects the central nervous system (CNS), including the brain, spinal cord, and optic nerves. The symptoms can vary from muscle weakness to vision loss. In the case of MS, the immune system attacks the myelin sheath, which protects the nerve fiber and causes inflammation resulting in demyelination. The myelin sheath has the composition of various proteins including membrane proteins and glycoproteins. The four main proteins namely Myelin Basic Protein (MBP), Myelin...
Source: Current Protein and Peptide Science - July 18, 2023 Category: Biochemistry Authors: Abinaya Ganesan Pooja Muralidharan Ramya L Source Type: research