Current Opinion in Allergy and Clinical Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Basophil activation test in food allergy: is it ready for real-time?
Purpose of review Utilization of basophil activation in the diagnosis and monitoring of food allergy has gained increasing recognition. An ex-vivo functional assay, basophil activation reflects clinical reactivity, thereby providing clinically relevant insights. Moreover, as a biomarker of reactivity and tolerance, basophil activation testing (BAT) may provide a useful tool for management of food allergies. Despite its utility, significant limitations of BAT have prevented widespread use. Addressing these limitations will increase the future application and adoption of BAT in food allergy. Recent findings A numb...
Source: Current Opinion in Allergy and Clinical Immunology - September 2, 2021 Category: Allergy & Immunology Tags: ANAPHYLAXIS AND INSECT ALLERGY: Edited by Gianenrico Senna and Mariana Castells Source Type: research

Anaphylaxis viewed by experts: unmet needs
Purpose of review The purpose of the review is to identify unmet needs in the management of anaphylaxis, covering aspects such as epidemiology, diagnosis, treatment and prevention. Recent findings Redefinition of clinical diagnostic criteria may allow a better identification of anaphylaxis. International diagnostic coding system improvement will be major step for future policies and epidemiological studies. Digital health can aid in managing anaphylaxis. Summary Anaphylaxis is a medical emergency; current data show that frequently identification of the reaction, acute and long-term management, are not opt...
Source: Current Opinion in Allergy and Clinical Immunology - September 2, 2021 Category: Allergy & Immunology Tags: ANAPHYLAXIS AND INSECT ALLERGY: Edited by Gianenrico Senna and Mariana Castells Source Type: research

Mast cell activation syndrome: is anaphylaxis part of the phenotype? A systematic review
Purpose of review Mast cell activation syndrome (MCAS) and anaphylaxis are the result of a spontaneous or triggered pathological degranulation of mast cells (MCs) and might have as substrate normal or pathological MCs (increased burden, aberrant MCs or both). Recent findings This review summarizes the most recent evidence on immunoglobulin E (IgE)-mediated and non IgE-mediated mechanisms underlying MC activation and degranulation and highlights the importance of standardized diagnostic criteria for MCAS. Application of these criteria implies that in most cases the clinical presentation of MCAS meets the diagnost...
Source: Current Opinion in Allergy and Clinical Immunology - September 2, 2021 Category: Allergy & Immunology Tags: ANAPHYLAXIS AND INSECT ALLERGY: Edited by Gianenrico Senna and Mariana Castells Source Type: research

Immunization practices and risk of anaphylaxis: a current update, comprehensive of COVID-19 vaccination data
Purpose of review This review aims to provide an updated report in regards to the correlation between vaccines and anaphylaxis and the related risk in the population. Recent findings Initial reports showed higher incidence of anaphylaxis following messenger RNA COVID-19 vaccines compared with ‘routine’ vaccinations, likely influenced by the great attention paid to these ‘new’ vaccines. However, anaphylaxis has still to be considered quite rare and its incidence will be systematically reconsidered in the light of additional data collected. Summary Adverse reactions to vaccines are commonly reported...
Source: Current Opinion in Allergy and Clinical Immunology - September 2, 2021 Category: Allergy & Immunology Tags: ANAPHYLAXIS AND INSECT ALLERGY: Edited by Gianenrico Senna and Mariana Castells Source Type: research

Anaphylaxis and Coronavirus Disease 2019 vaccine: a danger relationship?
Purpose of review Anaphylactic reactions reported after Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) RNA vaccines were expected to be more frequent in atopic subjects and attributed to its polyethylene glycol component. Recent findings Anaphylaxis to SARS-CoV2 RNA vaccines is no more frequent than in any vaccine and direct proofs for the role of its polyethylene glycol component are lacking. Summary Vaccines against coronavirus disease 2019 (COVID-19) are an essential global intervention to control the current pandemic situation. Anaphylactic reactions have rapidly been reported after SARS-...
Source: Current Opinion in Allergy and Clinical Immunology - September 2, 2021 Category: Allergy & Immunology Tags: ANAPHYLAXIS AND INSECT ALLERGY: Edited by Gianenrico Senna and Mariana Castells Source Type: research

Editorial introductions
No abstract available (Source: Current Opinion in Allergy and Clinical Immunology)
Source: Current Opinion in Allergy and Clinical Immunology - September 2, 2021 Category: Allergy & Immunology Tags: EDITORIAL INTRODUCTIONS Source Type: research

Vaccine allergy: evidence to consider for COVID-19 vaccines
Purpose of review Whereas the COVID-19 pandemic has changed our lives worldwide, we hope that vaccination can combat the disease. We propose how to evaluate suspected severe allergic reactions to the vaccines so that as many as possible may be safely vaccinated. Recent findings Rare cases of severe allergic reactions after COVID-19 vaccination have been observed, seemingly at a higher frequency than for other vaccines. Few excipients are likely to have caused these reactions. IgE-mediated reactions to polyethylene glycol (PEG) and its derivatives are the most suspected, albeit hitherto unproven, causes. We sugge...
Source: Current Opinion in Allergy and Clinical Immunology - July 14, 2021 Category: Allergy & Immunology Tags: PHARMACOTHERAPY AND EVIDENCE BASED MEDICINE: Edited by Enrico Compalati and Derek Chu Source Type: research

Optimal use of intranasal corticosteroids and intranasal saline, is there a clear answer?
Purpose of review Chronic rhinosinusitis (CRS) is a prevalent condition that poses a significant burden on both quality of life and healthcare utilization. Notwithstanding the heterogenous nature of CRS endotypes and phenotypes, isotonic saline and corticosteroids are recommended as first line medical therapy by recent clinical guidelines. We provide an overview of recent studies of topical saline and corticosteroids for people with CRS and emphasize areas of unmet needs. Recent findings Recent trials suggest exhalation delivery systems of corticosteroid are effective and well tolerated but did not involve compa...
Source: Current Opinion in Allergy and Clinical Immunology - July 14, 2021 Category: Allergy & Immunology Tags: PHARMACOTHERAPY AND EVIDENCE BASED MEDICINE: Edited by Enrico Compalati and Derek Chu Source Type: research

Evidence-based management of eczema: five things that should be done more and five things that should be dropped
Purpose of review We provide readers with an evidence-informed opinion on current treatments for eczema (atopic dermatitis) with the intention of improving patient care. We suggest five treatment aspects that should be promoted and five that should be demoted. Evidence sources include key randomized controlled trials and systematic reviews. Recent findings Under-treatment of eczema can be countered by more aggressive use of topical therapies including the ‘get control then keep control’ regimen, and systemics for severe disease, supplemented with good patient education. Topical corticosteroids should be used...
Source: Current Opinion in Allergy and Clinical Immunology - July 14, 2021 Category: Allergy & Immunology Tags: PHARMACOTHERAPY AND EVIDENCE BASED MEDICINE: Edited by Enrico Compalati and Derek Chu Source Type: research

Precision medicine for cow's milk immunotherapy in clinical practice
Purpose of review Several novel immunotherapies have recently been reported for the treatment of cow's milk allergy (CMA). However, systematic methods for the selection of immunotherapy in clinical practice have not been investigated. In this review, we have provided suggestions for safe and effective immunotherapy for patients with CMA. Recent findings Recent studies on cow's milk immunotherapy, using lower target doses, heated or baked cow's milk, combination treatment with adjuvants, or various routes of immunotherapy, included school-aged children with severe allergies, infants, and patients with mild CMA. T...
Source: Current Opinion in Allergy and Clinical Immunology - July 14, 2021 Category: Allergy & Immunology Tags: PHARMACOTHERAPY AND EVIDENCE BASED MEDICINE: Edited by Enrico Compalati and Derek Chu Source Type: research

Novel therapies and the potential for a personalized approach to atopic dermatitis
Purpose of review To provide a cutting-edge overview of recent developments in topical and systemic therapeutic approaches for the treatment of atopic dermatitis (AD). Recent findings Growing knowledge about key pathways in AD and stratification of patient's subgroups have set the basis for a new era of targeted topical and systemic therapy in AD. Different aspects have to be considered in the decision process for topical versus systemic therapy. Further on, co-factors from the patient's side as well as the side of the substances determine the choice of a particular drug/drug type. Tailored medicine in AD ...
Source: Current Opinion in Allergy and Clinical Immunology - July 14, 2021 Category: Allergy & Immunology Tags: PHARMACOTHERAPY AND EVIDENCE BASED MEDICINE: Edited by Enrico Compalati and Derek Chu Source Type: research

Real-life studies in allergen immunotherapy
Purpose of review Real-life (or real-world) studies can provide information that cannot be derived from randomized controlled trials. This approach is currently becoming of relevance for many treatments. In recent years, the real-life method has been applied also to allergen immunotherapy, providing new insights on it. We reviewed herein the available literature on the argument. Recent findings Several prospective and retrospective studies on allergen immunotherapy in the real-world setting have been published, mostly in the last 5 years. Most of them focused on adverse events, compliance, and the long term/pr...
Source: Current Opinion in Allergy and Clinical Immunology - July 14, 2021 Category: Allergy & Immunology Tags: PHARMACOTHERAPY AND EVIDENCE BASED MEDICINE: Edited by Enrico Compalati and Derek Chu Source Type: research

Role of tissue-resident memory T cells in the pathophysiology of allergic contact dermatitis
Purpose of review We bring updated knowledge on tissue-resident memory T cells (TRM), underlining their major role in the recurrence and the severity of allergic contact dermatitis (ACD). Recent findings ACD is a frequently encountered skin disease. It is defined as a delayed-type hypersensitivity reaction initiated by the recruitment of antigen-specific T cells into the skin of sensitized patients. ACD lesions tend to develop on already-exposed areas and worsen over time. That clinical observation has raised questions on the contribution of TRM to ACD recurrence and severity. TRM are memory T cells that persist...
Source: Current Opinion in Allergy and Clinical Immunology - July 14, 2021 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Miguel Blanca and Paul Whitaker Source Type: research

Classifying cephalosporins: from generation to cross-reactivity
Purpose of review To review the most recent literature studying the classifications, immunochemistry, and crossreactivity of allergy reactions to cephalosporins. Recent findings Over the last five years, research interest has focused on three areas related to cephalosporin allergy: cross-reactivity among cephalosporins and with other beta-lactams; the incidence of adverse reactions in penicillin allergy patients or in reported penicillin allergy labels; and new cephalosporins structures involved in the immunological recognition. Summary Meta-analysis of a substantial number of studies shows that cephalosp...
Source: Current Opinion in Allergy and Clinical Immunology - July 14, 2021 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Miguel Blanca and Paul Whitaker Source Type: research

Drug allergy management in the elderly
Purpose of review Drug allergy management has previously not been emphasized in the elderly. However, the geriatric population poses several unique characteristics, challenges for drug allergy testing and considerations in the management. Especially in the era of COVID-19, the elderly population is a vulnerable cohort and reviewing the management during this unprecedented time is both timely and relevant. Recent findings In recent years, larger scale studies focusing on the epidemiology and prevalence trends of drug allergies among older adults has been summarized in this review. Emphasis on anaphylaxis in the o...
Source: Current Opinion in Allergy and Clinical Immunology - July 14, 2021 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Miguel Blanca and Paul Whitaker Source Type: research