Current Opinion in Allergy and Clinical Immunology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Economic burden of drug-induced anaphylaxis: what can we do better?
Purpose of review This systematic review evaluates published data related to the economic burden of drug-induced anaphylaxis (DIA) to understand preventive cost saving measures that could reduce the burden of these conditions. Recent findings Although DIA has a relevant societal impact, there are limited and heterogenous available data related to its cost. Direct costs related to the management of acute phase of DIA was estimated by $529.6 to $3125, depending on the number of emergency room visits/hospitalizations, emergency kits and transports in ambulance. Direct costs of investigations of DIA varied from $288...
Source: Current Opinion in Allergy and Clinical Immunology - July 27, 2022 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Paul Whitaker and Luciana K. Tanno Source Type: research

Pathology of T-cell-mediated drug hypersensitivity reactions and impact of tolerance mechanisms on patient susceptibility
Purpose of review T-cell-mediated drug hypersensitivity is responsible for significant morbidity and mortality, and represents a substantial clinical concern. The purpose of this article is to focus on T-cell reactions and discuss recent advances in disease pathogenesis by exploring the impact of tolerance mechanisms in determining susceptibility in genetically predisposed patients. Recent findings Certain drugs preferentially activate pathogenic T cells that have defined pathways of effector function. Thus, a critical question is what extenuating factors influence the direction of immune activation. A large eff...
Source: Current Opinion in Allergy and Clinical Immunology - July 27, 2022 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Paul Whitaker and Luciana K. Tanno Source Type: research

Management of adverse reactions induced by chemotherapy drugs
Purpose of review There is a broad spectrum of chemotherapy-induced adverse reactions. Hypersensitivity reactions are being extensively studied as they can affect the ideal treatment. The goal of this review is to describe the current management of adverse reactions to chemotherapy, focusing on hypersensitivity events. Recent findings The range of possible desensitization protocols is increasing, as well as the delabeling algorithms and diagnostic tools. One-bag desensitization protocols, omalizumab use in immediate hypersensitivity reactions, slow desensitization protocols in nonimmediate hypersensitivity react...
Source: Current Opinion in Allergy and Clinical Immunology - July 27, 2022 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Paul Whitaker and Luciana K. Tanno Source Type: research

Global patterns of drug allergy-induced fatalities: a wake-up call to prevent avoidable deaths
Purpose of review To identify patterns and key issues though a systematic review in order to support prevention strategies and reduce avoidable deaths related to drug-induced anaphylaxis (DAF). Recent findings DAF rate has been estimated by 0.13–0.53/106 population/year. General global trends of DAF are increasing over time, mostly occurring at healthcare settings (62%) with a similar gender distribution and an average age of 53 years. Antibiotics, anaesthetics, radio-contrast media and NSAIDs were the most frequently implicated agents. Main comorbidities were personal history of drug allergy, cardiovascul...
Source: Current Opinion in Allergy and Clinical Immunology - July 27, 2022 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Paul Whitaker and Luciana K. Tanno Source Type: research

Editorial: Drug allergy
No abstract available (Source: Current Opinion in Allergy and Clinical Immunology)
Source: Current Opinion in Allergy and Clinical Immunology - July 27, 2022 Category: Allergy & Immunology Tags: DRUG ALLERGY: Edited by Paul Whitaker and Luciana K. Tanno Source Type: research

Editorial introductions
No abstract available (Source: Current Opinion in Allergy and Clinical Immunology)
Source: Current Opinion in Allergy and Clinical Immunology - July 27, 2022 Category: Allergy & Immunology Tags: EDITORIAL INTRODUCTIONS Source Type: research

Emerging approaches in the diagnosis and therapy in shellfish allergy
Purpose of review Despite the high prevalence of shellfish allergy, the clinical management of seafood allergy has remained unchanged over decades. Here, we examined the current status in the diagnosis and clinical management of shellfish allergy and highlighted the imminent need for more specific diagnostic methods, as well as effective and safe therapeutic approaches for shellfish allergy. Recent findings With the advancement in the molecular identifications and definition of reactive epitopes of shellfish allergens, new diagnostic designs such as component-resolved diagnosis, basophil activation test (BAT) an...
Source: Current Opinion in Allergy and Clinical Immunology - June 1, 2022 Category: Allergy & Immunology Tags: FOOD ALLERGY: Edited by Alessandro Fiocchi and Motohiro Ebisawa Source Type: research

Recent advances in the diagnosis and management of tree nut and seed allergy
Purpose of review Tree nut (TN) and seed allergies are frequent, and their prevalence appears to be on the rise. Allergic reactions associated with these foods are more frequently severe, and these allergies tend to persist into adulthood, consequently affecting quality of life. In this review, we summarize recent advances in diagnostic modalities and management strategies for TN/seed-allergic patients. Recent findings Clinical manifestations of TN and seed allergy range from asymptomatic sensitization to severe anaphylactic reactions. The use of emerging diagnostic tools such as component resolved diagnostics (...
Source: Current Opinion in Allergy and Clinical Immunology - June 1, 2022 Category: Allergy & Immunology Tags: FOOD ALLERGY: Edited by Alessandro Fiocchi and Motohiro Ebisawa Source Type: research

Current insights: a systemic review of therapeutic options for peanut allergy
Purpose of review With increasing prevalence of peanut allergy (PA) globally and the greater risk of potential reactions occurring due to the leading role of nuts in food products, PA has become a significant public health concern over the past decade, affecting up to 5 million of the US adult population. This review details updates and advances in prevalence, diagnosis, and immunotherapies that have occurred over the past year. Recent findings Therapeutic and diagnostic advances remain at the forefront of research and have continued to push the food allergy (FA) field forward to provide a promising role in the ...
Source: Current Opinion in Allergy and Clinical Immunology - June 1, 2022 Category: Allergy & Immunology Tags: FOOD ALLERGY: Edited by Alessandro Fiocchi and Motohiro Ebisawa Source Type: research

Cow's milk allergy
Purpose of review To highlight the most recent insights on cow's milk allergy (CMA), its treatment, and management. Recent findings CMA is one of the most common food allergies among children. Burdened by the risk for fatal reaction, CMA may imply also a severe impairment of health-related quality of life at individual and family level as well as well as individual and societal costs. The updated Diagnosis and Rationale for Action against Cow's Milk Allergy series is going to provide a series of manuscripts that will offer a comprehensive state-of-the-art specifically on CMA, including international evidence-bas...
Source: Current Opinion in Allergy and Clinical Immunology - June 1, 2022 Category: Allergy & Immunology Tags: FOOD ALLERGY: Edited by Alessandro Fiocchi and Motohiro Ebisawa Source Type: research

Molecular diagnosis contribution for personalized medicine
Purpose of review The purpose of the current review is to highlight the most recent findings in molecular allergy and its applicability in precision medicine for allergic patients. Recent findings Molecular allergy provides useful information in areas of respiratory allergy (house dust mites, pet dander and pollen allergy), food allergy (tree nuts, peanuts, fruits and vegetables), hymenoptera venom allergy and others, in order to improve management of patients. Regional differences in sensitization profiles, assay characteristics and interpretation of molecular sensitization in relation to whole extracts and tot...
Source: Current Opinion in Allergy and Clinical Immunology - June 1, 2022 Category: Allergy & Immunology Tags: PERSONALIZED MEDICINE: Edited by Henry Milgrom and René Maximiliano Gómez Source Type: research

Drug allergy desensitization is not a unique recipe
Purpose of review Drug desensitization is the only therapeutic option for patients with drug allergies who need to receive the drugs they are allergic to, and it is especially critical in patients with an urgent need for chemotherapy, biologics, or antibiotics, where equally effective alternatives might not be available. However, drug desensitization is not a cookbook where anyone with no experience or specific training can find a general recipe. This review article will approach the singularities that make personalized and highly specialized care essential in this field. Recent findings Drug desensitization nee...
Source: Current Opinion in Allergy and Clinical Immunology - June 1, 2022 Category: Allergy & Immunology Tags: PERSONALIZED MEDICINE: Edited by Henry Milgrom and René Maximiliano Gómez Source Type: research

Personalized management for unmet needs with food allergy
Purpose of review Patients with food allergies are at risk of experiencing accidental allergic symptoms in real life. Low thresholds may be a risk factor for accidental allergic reactions. Therefore, the evaluation of this threshold is required for the management of food allergies. We have suggested a management approach to identify the threshold dose and the consumable dose, considering patient age and the severity of food allergies. Recent findings A younger age is a risk factor for accidental allergic reactions, and school-age children are likely to have a lower quality of life (QOL) than younger children. Ad...
Source: Current Opinion in Allergy and Clinical Immunology - June 1, 2022 Category: Allergy & Immunology Tags: PERSONALIZED MEDICINE: Edited by Henry Milgrom and René Maximiliano Gómez Source Type: research

Atopic dermatitis endotypes: knowledge for personalized medicine
Purpose of review Endotypes are clinically relevant phenotypes that can be explained by molecular mechanisms, and are defined to predict the development, progression, prognosis and responses to treatment on the individual level. This review summarizes atopic dermatitis phenotypes, endotypes and their potential application for personalized medicine. Recent findings Atopic dermatitis can be classified into several phenotypes according to disease courses that likely have common pathophysiology. The genotype is important to define endotypes, but the value of genotype alone remains somewhat limited in most atopic der...
Source: Current Opinion in Allergy and Clinical Immunology - June 1, 2022 Category: Allergy & Immunology Tags: PERSONALIZED MEDICINE: Edited by Henry Milgrom and René Maximiliano Gómez Source Type: research

Editorial introductions
No abstract available (Source: Current Opinion in Allergy and Clinical Immunology)
Source: Current Opinion in Allergy and Clinical Immunology - June 1, 2022 Category: Allergy & Immunology Tags: EDITORIAL INTRODUCTIONS Source Type: research