Synthesis and biomedical applications of DNA hydrogel
Curr Drug Metab. 2023 Jul 10. doi: 10.2174/1389200224666230710124838. Online ahead of print.ABSTRACTDeoxyribonucleic acid (DNA), as a natural polymer material, carries almost all the genetic information and is recognized as one of the most intelligent natural polymers. In the past 20 years, there have been many exciting advances in the synthesis of hydrogels using DNA as the main backbone or cross-linking agent. Different methods, such as physical entanglement and chemical cross-linking, have been developed to perform the gelation of DNA hydrogels. The good designability, biocompatibility, designable responsiveness, biodeg...
Source: Current Drug Metabolism - July 11, 2023 Category: Drugs & Pharmacology Authors: Qi Zhang Shiyu Lin Junyu Shi Source Type: research
Synthesis and biomedical applications of DNA hydrogel
Curr Drug Metab. 2023 Jul 10. doi: 10.2174/1389200224666230710124838. Online ahead of print.ABSTRACTDeoxyribonucleic acid (DNA), as a natural polymer material, carries almost all the genetic information and is recognized as one of the most intelligent natural polymers. In the past 20 years, there have been many exciting advances in the synthesis of hydrogels using DNA as the main backbone or cross-linking agent. Different methods, such as physical entanglement and chemical cross-linking, have been developed to perform the gelation of DNA hydrogels. The good designability, biocompatibility, designable responsiveness, biodeg...
Source: Current Drug Metabolism - July 11, 2023 Category: Drugs & Pharmacology Authors: Qi Zhang Shiyu Lin Junyu Shi Source Type: research
Synthesis and biomedical applications of DNA hydrogel
Curr Drug Metab. 2023 Jul 10. doi: 10.2174/1389200224666230710124838. Online ahead of print.ABSTRACTDeoxyribonucleic acid (DNA), as a natural polymer material, carries almost all the genetic information and is recognized as one of the most intelligent natural polymers. In the past 20 years, there have been many exciting advances in the synthesis of hydrogels using DNA as the main backbone or cross-linking agent. Different methods, such as physical entanglement and chemical cross-linking, have been developed to perform the gelation of DNA hydrogels. The good designability, biocompatibility, designable responsiveness, biodeg...
Source: Current Drug Metabolism - July 11, 2023 Category: Drugs & Pharmacology Authors: Qi Zhang Shiyu Lin Junyu Shi Source Type: research
Synthesis and biomedical applications of DNA hydrogel
Curr Drug Metab. 2023 Jul 10. doi: 10.2174/1389200224666230710124838. Online ahead of print.ABSTRACTDeoxyribonucleic acid (DNA), as a natural polymer material, carries almost all the genetic information and is recognized as one of the most intelligent natural polymers. In the past 20 years, there have been many exciting advances in the synthesis of hydrogels using DNA as the main backbone or cross-linking agent. Different methods, such as physical entanglement and chemical cross-linking, have been developed to perform the gelation of DNA hydrogels. The good designability, biocompatibility, designable responsiveness, biodeg...
Source: Current Drug Metabolism - July 11, 2023 Category: Drugs & Pharmacology Authors: Qi Zhang Shiyu Lin Junyu Shi Source Type: research
Synthesis and biomedical applications of DNA hydrogel
Curr Drug Metab. 2023 Jul 10. doi: 10.2174/1389200224666230710124838. Online ahead of print.ABSTRACTDeoxyribonucleic acid (DNA), as a natural polymer material, carries almost all the genetic information and is recognized as one of the most intelligent natural polymers. In the past 20 years, there have been many exciting advances in the synthesis of hydrogels using DNA as the main backbone or cross-linking agent. Different methods, such as physical entanglement and chemical cross-linking, have been developed to perform the gelation of DNA hydrogels. The good designability, biocompatibility, designable responsiveness, biodeg...
Source: Current Drug Metabolism - July 11, 2023 Category: Drugs & Pharmacology Authors: Qi Zhang Shiyu Lin Junyu Shi Source Type: research
Synthesis and biomedical applications of DNA hydrogel
Curr Drug Metab. 2023 Jul 10. doi: 10.2174/1389200224666230710124838. Online ahead of print.ABSTRACTDeoxyribonucleic acid (DNA), as a natural polymer material, carries almost all the genetic information and is recognized as one of the most intelligent natural polymers. In the past 20 years, there have been many exciting advances in the synthesis of hydrogels using DNA as the main backbone or cross-linking agent. Different methods, such as physical entanglement and chemical cross-linking, have been developed to perform the gelation of DNA hydrogels. The good designability, biocompatibility, designable responsiveness, biodeg...
Source: Current Drug Metabolism - July 11, 2023 Category: Drugs & Pharmacology Authors: Qi Zhang Shiyu Lin Junyu Shi Source Type: research
Synthesis and biomedical applications of DNA hydrogel
Curr Drug Metab. 2023 Jul 10. doi: 10.2174/1389200224666230710124838. Online ahead of print.ABSTRACTDeoxyribonucleic acid (DNA), as a natural polymer material, carries almost all the genetic information and is recognized as one of the most intelligent natural polymers. In the past 20 years, there have been many exciting advances in the synthesis of hydrogels using DNA as the main backbone or cross-linking agent. Different methods, such as physical entanglement and chemical cross-linking, have been developed to perform the gelation of DNA hydrogels. The good designability, biocompatibility, designable responsiveness, biodeg...
Source: Current Drug Metabolism - July 11, 2023 Category: Drugs & Pharmacology Authors: Qi Zhang Shiyu Lin Junyu Shi Source Type: research
Synthesis and biomedical applications of DNA hydrogel
Curr Drug Metab. 2023 Jul 10. doi: 10.2174/1389200224666230710124838. Online ahead of print.ABSTRACTDeoxyribonucleic acid (DNA), as a natural polymer material, carries almost all the genetic information and is recognized as one of the most intelligent natural polymers. In the past 20 years, there have been many exciting advances in the synthesis of hydrogels using DNA as the main backbone or cross-linking agent. Different methods, such as physical entanglement and chemical cross-linking, have been developed to perform the gelation of DNA hydrogels. The good designability, biocompatibility, designable responsiveness, biodeg...
Source: Current Drug Metabolism - July 11, 2023 Category: Drugs & Pharmacology Authors: Qi Zhang Shiyu Lin Junyu Shi Source Type: research
Synthesis and biomedical applications of DNA hydrogel
Curr Drug Metab. 2023 Jul 10. doi: 10.2174/1389200224666230710124838. Online ahead of print.ABSTRACTDeoxyribonucleic acid (DNA), as a natural polymer material, carries almost all the genetic information and is recognized as one of the most intelligent natural polymers. In the past 20 years, there have been many exciting advances in the synthesis of hydrogels using DNA as the main backbone or cross-linking agent. Different methods, such as physical entanglement and chemical cross-linking, have been developed to perform the gelation of DNA hydrogels. The good designability, biocompatibility, designable responsiveness, biodeg...
Source: Current Drug Metabolism - July 11, 2023 Category: Drugs & Pharmacology Authors: Qi Zhang Shiyu Lin Junyu Shi Source Type: research
Computational Structural Validation of CYP2C9 Mutations and Evaluation of Machine Learning Algorithms in Predicting the Therapeutic Outcomes of Warfarin
CONCLUSION: We evaluated various MLAs in predicting the critical outcome measures associated with warfarin and observed CYP2C9 as the most critical predictor variable. The results of our study provide insight into the molecular basis of warfarin and the CYP2C9 gene. A prospective study validating the MLAs is urgently needed.PMID:37409551 | DOI:10.2174/1389200224666230705124329 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 6, 2023 Category: Drugs & Pharmacology Authors: Kannan Sridharan Thirumal Kumar Suchetha Manikandan Gaurav Prasanna Lalitha G Rashed Al Banna George Priya Doss Source Type: research
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke
CONCLUSIONS: Catalpol was excreted mainly through the urine. The drug-related substances were primarily concentrated in the stomach, large intestine, bladder, and kidney. Only the parent drug was detected in the plasma and urine, and M1 and M2 were detected in the feces. We speculate that the metabolism of catalpol in rats was mainly mediated by the intestinal flora, resulting in an aglycone-containing hemiacetal hydroxyl structure.PMID:37409552 | DOI:10.2174/1389200224666230705142901 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 6, 2023 Category: Drugs & Pharmacology Authors: Xinyu Ge Yuandong Zheng Yifei He Chong Chen Chen Yang Saiwei Lu Zhenyu Xuan Dafang Zhong Xingxing Diao Source Type: research
Computational Structural Validation of CYP2C9 Mutations and Evaluation of Machine Learning Algorithms in Predicting the Therapeutic Outcomes of Warfarin
CONCLUSION: We evaluated various MLAs in predicting the critical outcome measures associated with warfarin and observed CYP2C9 as the most critical predictor variable. The results of our study provide insight into the molecular basis of warfarin and the CYP2C9 gene. A prospective study validating the MLAs is urgently needed.PMID:37409551 | DOI:10.2174/1389200224666230705124329 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 6, 2023 Category: Drugs & Pharmacology Authors: Kannan Sridharan Thirumal Kumar Suchetha Manikandan Gaurav Prasanna Lalitha G Rashed Al Banna George Priya Doss Source Type: research
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke
CONCLUSIONS: Catalpol was excreted mainly through the urine. The drug-related substances were primarily concentrated in the stomach, large intestine, bladder, and kidney. Only the parent drug was detected in the plasma and urine, and M1 and M2 were detected in the feces. We speculate that the metabolism of catalpol in rats was mainly mediated by the intestinal flora, resulting in an aglycone-containing hemiacetal hydroxyl structure.PMID:37409552 | DOI:10.2174/1389200224666230705142901 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 6, 2023 Category: Drugs & Pharmacology Authors: Xinyu Ge Yuandong Zheng Yifei He Chong Chen Chen Yang Saiwei Lu Zhenyu Xuan Dafang Zhong Xingxing Diao Source Type: research
Computational Structural Validation of CYP2C9 Mutations and Evaluation of Machine Learning Algorithms in Predicting the Therapeutic Outcomes of Warfarin
CONCLUSION: We evaluated various MLAs in predicting the critical outcome measures associated with warfarin and observed CYP2C9 as the most critical predictor variable. The results of our study provide insight into the molecular basis of warfarin and the CYP2C9 gene. A prospective study validating the MLAs is urgently needed.PMID:37409551 | DOI:10.2174/1389200224666230705124329 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 6, 2023 Category: Drugs & Pharmacology Authors: Kannan Sridharan Thirumal Kumar Suchetha Manikandan Gaurav Prasanna Lalitha G Rashed Al Banna George Priya Doss Source Type: research
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke
CONCLUSIONS: Catalpol was excreted mainly through the urine. The drug-related substances were primarily concentrated in the stomach, large intestine, bladder, and kidney. Only the parent drug was detected in the plasma and urine, and M1 and M2 were detected in the feces. We speculate that the metabolism of catalpol in rats was mainly mediated by the intestinal flora, resulting in an aglycone-containing hemiacetal hydroxyl structure.PMID:37409552 | DOI:10.2174/1389200224666230705142901 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 6, 2023 Category: Drugs & Pharmacology Authors: Xinyu Ge Yuandong Zheng Yifei He Chong Chen Chen Yang Saiwei Lu Zhenyu Xuan Dafang Zhong Xingxing Diao Source Type: research
