Nutritional Therapy Strategies Targeting Tumor Energy Metabolism
Curr Drug Metab. 2023 Dec 28. doi: 10.2174/0113892002280203231213110634. Online ahead of print.ABSTRACTCancer is the second leading cause of mortality worldwide. The heightened nutrient uptake, particularly glucose, and elevated glycolysis observed in rapidly proliferating tumor cells highlight the potential targeting of energy metabolism pathways for the treatment of cancer. Numerous studies and clinical trials have demonstrated the efficacy of nutritional therapy in mitigating the adverse effects of chemotherapy and radiotherapy, enhancing treatment outcomes, prolonging survival, and improving the overall quality of life...
Source: Current Drug Metabolism - December 29, 2023 Category: Drugs & Pharmacology Authors: Taojia Chen Haining Yu Source Type: research
Nutritional Therapy Strategies Targeting Tumor Energy Metabolism
Curr Drug Metab. 2023 Dec 28. doi: 10.2174/0113892002280203231213110634. Online ahead of print.ABSTRACTCancer is the second leading cause of mortality worldwide. The heightened nutrient uptake, particularly glucose, and elevated glycolysis observed in rapidly proliferating tumor cells highlight the potential targeting of energy metabolism pathways for the treatment of cancer. Numerous studies and clinical trials have demonstrated the efficacy of nutritional therapy in mitigating the adverse effects of chemotherapy and radiotherapy, enhancing treatment outcomes, prolonging survival, and improving the overall quality of life...
Source: Current Drug Metabolism - December 29, 2023 Category: Drugs & Pharmacology Authors: Taojia Chen Haining Yu Source Type: research
Nutritional Therapy Strategies Targeting Tumor Energy Metabolism
Curr Drug Metab. 2023 Dec 28. doi: 10.2174/0113892002280203231213110634. Online ahead of print.ABSTRACTCancer is the second leading cause of mortality worldwide. The heightened nutrient uptake, particularly glucose, and elevated glycolysis observed in rapidly proliferating tumor cells highlight the potential targeting of energy metabolism pathways for the treatment of cancer. Numerous studies and clinical trials have demonstrated the efficacy of nutritional therapy in mitigating the adverse effects of chemotherapy and radiotherapy, enhancing treatment outcomes, prolonging survival, and improving the overall quality of life...
Source: Current Drug Metabolism - December 29, 2023 Category: Drugs & Pharmacology Authors: Taojia Chen Haining Yu Source Type: research
Nutritional Therapy Strategies Targeting Tumor Energy Metabolism
Curr Drug Metab. 2023 Dec 28. doi: 10.2174/0113892002280203231213110634. Online ahead of print.ABSTRACTCancer is the second leading cause of mortality worldwide. The heightened nutrient uptake, particularly glucose, and elevated glycolysis observed in rapidly proliferating tumor cells highlight the potential targeting of energy metabolism pathways for the treatment of cancer. Numerous studies and clinical trials have demonstrated the efficacy of nutritional therapy in mitigating the adverse effects of chemotherapy and radiotherapy, enhancing treatment outcomes, prolonging survival, and improving the overall quality of life...
Source: Current Drug Metabolism - December 29, 2023 Category: Drugs & Pharmacology Authors: Taojia Chen Haining Yu Source Type: research
Nutritional Therapy Strategies Targeting Tumor Energy Metabolism
Curr Drug Metab. 2023 Dec 28. doi: 10.2174/0113892002280203231213110634. Online ahead of print.ABSTRACTCancer is the second leading cause of mortality worldwide. The heightened nutrient uptake, particularly glucose, and elevated glycolysis observed in rapidly proliferating tumor cells highlight the potential targeting of energy metabolism pathways for the treatment of cancer. Numerous studies and clinical trials have demonstrated the efficacy of nutritional therapy in mitigating the adverse effects of chemotherapy and radiotherapy, enhancing treatment outcomes, prolonging survival, and improving the overall quality of life...
Source: Current Drug Metabolism - December 29, 2023 Category: Drugs & Pharmacology Authors: Taojia Chen Haining Yu Source Type: research
Nutritional Therapy Strategies Targeting Tumor Energy Metabolism
Curr Drug Metab. 2023 Dec 28. doi: 10.2174/0113892002280203231213110634. Online ahead of print.ABSTRACTCancer is the second leading cause of mortality worldwide. The heightened nutrient uptake, particularly glucose, and elevated glycolysis observed in rapidly proliferating tumor cells highlight the potential targeting of energy metabolism pathways for the treatment of cancer. Numerous studies and clinical trials have demonstrated the efficacy of nutritional therapy in mitigating the adverse effects of chemotherapy and radiotherapy, enhancing treatment outcomes, prolonging survival, and improving the overall quality of life...
Source: Current Drug Metabolism - December 29, 2023 Category: Drugs & Pharmacology Authors: Taojia Chen Haining Yu Source Type: research
Nutritional Therapy Strategies Targeting Tumor Energy Metabolism
Curr Drug Metab. 2023 Dec 28. doi: 10.2174/0113892002280203231213110634. Online ahead of print.ABSTRACTCancer is the second leading cause of mortality worldwide. The heightened nutrient uptake, particularly glucose, and elevated glycolysis observed in rapidly proliferating tumor cells highlight the potential targeting of energy metabolism pathways for the treatment of cancer. Numerous studies and clinical trials have demonstrated the efficacy of nutritional therapy in mitigating the adverse effects of chemotherapy and radiotherapy, enhancing treatment outcomes, prolonging survival, and improving the overall quality of life...
Source: Current Drug Metabolism - December 29, 2023 Category: Drugs & Pharmacology Authors: Taojia Chen Haining Yu Source Type: research
Reassessment of Radiation Exposure From Bone Scintigraphy
CONCLUSION: The fact that the doses of personnel and patient relatives in the study were below the legal limits shows that the study was carried out within a safe range. However, in terms of radiation protection, it is necessary to limit the time spent with the patient as much as possible and increase the distance. Since the dangers of low radiation dosages are unknown, there is a need to inform the patient's relatives and staff about the potential risks.PMID:38141186 | DOI:10.2174/0113892002274982231211102127 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - December 23, 2023 Category: Drugs & Pharmacology Authors: Handan Tanyildizi-K ökkülünk Ahmet Murat Şenişik Mahmut Y üksel Source Type: research
Comparative Pharmacokinetics of İntravenous Enrofloxacin in One- Six- And Twelve-Month-Old Sheep
CONCLUSION: The most important pharmacokinetic changes associated with aging in sheep are decreased Vdss and t1/2ʎz of ENR and the low ratio metabolizing of ENR to CIP. Pharmacokinetic/pharmacodynamic data showed that ENR after IV administration of 10 mg/kg dose provided the optimal AUC0-24/MIC90 ratios for E. coli, P. multocida and Mycoplasma spp. (>125) with MIC of 0.37 µg/mL and for S. aureus (>30) with MIC of 0.5 µg/mL in all ages of sheep.PMID:38141187 | DOI:10.2174/0113892002278220231208072351 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - December 23, 2023 Category: Drugs & Pharmacology Authors: Devran Coskun Orhan Corum Duygu Durna Corum Kamil Uney Source Type: research
The Impacts and Changes Related to the Cancer Drug Resistance Mechanism
CONCLUSION: This study provides valuable insights into the complexity of cancer drug resistance mechanisms, highlights evolving detection methods, and offers potential strategies to enhance treatment outcomes.PMID:38141188 | DOI:10.2174/0113892002266408231207150547 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - December 23, 2023 Category: Drugs & Pharmacology Authors: Prachi Varshney Vishal Sharma Devdhar Yadav Yogesh Kumar Amit Singh Naga Rani Kagithala Pramod Kumar Sharma Omji Porwal Neeraj Kumar Fuloria Pradeep Kumar Sharma Ashok Kumar Gupta Koteswara Rao Gsn Source Type: research
Reassessment of Radiation Exposure From Bone Scintigraphy
CONCLUSION: The fact that the doses of personnel and patient relatives in the study were below the legal limits shows that the study was carried out within a safe range. However, in terms of radiation protection, it is necessary to limit the time spent with the patient as much as possible and increase the distance. Since the dangers of low radiation dosages are unknown, there is a need to inform the patient's relatives and staff about the potential risks.PMID:38141186 | DOI:10.2174/0113892002274982231211102127 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - December 23, 2023 Category: Drugs & Pharmacology Authors: Handan Tanyildizi-K ökkülünk Ahmet Murat Şenişik Mahmut Y üksel Source Type: research
Comparative Pharmacokinetics of İntravenous Enrofloxacin in One- Six- And Twelve-Month-Old Sheep
CONCLUSION: The most important pharmacokinetic changes associated with aging in sheep are decreased Vdss and t1/2ʎz of ENR and the low ratio metabolizing of ENR to CIP. Pharmacokinetic/pharmacodynamic data showed that ENR after IV administration of 10 mg/kg dose provided the optimal AUC0-24/MIC90 ratios for E. coli, P. multocida and Mycoplasma spp. (>125) with MIC of 0.37 µg/mL and for S. aureus (>30) with MIC of 0.5 µg/mL in all ages of sheep.PMID:38141187 | DOI:10.2174/0113892002278220231208072351 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - December 23, 2023 Category: Drugs & Pharmacology Authors: Devran Coskun Orhan Corum Duygu Durna Corum Kamil Uney Source Type: research
The Impacts and Changes Related to the Cancer Drug Resistance Mechanism
CONCLUSION: This study provides valuable insights into the complexity of cancer drug resistance mechanisms, highlights evolving detection methods, and offers potential strategies to enhance treatment outcomes.PMID:38141188 | DOI:10.2174/0113892002266408231207150547 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - December 23, 2023 Category: Drugs & Pharmacology Authors: Prachi Varshney Vishal Sharma Devdhar Yadav Yogesh Kumar Amit Singh Naga Rani Kagithala Pramod Kumar Sharma Omji Porwal Neeraj Kumar Fuloria Pradeep Kumar Sharma Ashok Kumar Gupta Koteswara Rao Gsn Source Type: research
Reassessment of Radiation Exposure From Bone Scintigraphy
CONCLUSION: The fact that the doses of personnel and patient relatives in the study were below the legal limits shows that the study was carried out within a safe range. However, in terms of radiation protection, it is necessary to limit the time spent with the patient as much as possible and increase the distance. Since the dangers of low radiation dosages are unknown, there is a need to inform the patient's relatives and staff about the potential risks.PMID:38141186 | DOI:10.2174/0113892002274982231211102127 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - December 23, 2023 Category: Drugs & Pharmacology Authors: Handan Tanyildizi-K ökkülünk Ahmet Murat Şenişik Mahmut Y üksel Source Type: research
Comparative Pharmacokinetics of İntravenous Enrofloxacin in One- Six- And Twelve-Month-Old Sheep
CONCLUSION: The most important pharmacokinetic changes associated with aging in sheep are decreased Vdss and t1/2ʎz of ENR and the low ratio metabolizing of ENR to CIP. Pharmacokinetic/pharmacodynamic data showed that ENR after IV administration of 10 mg/kg dose provided the optimal AUC0-24/MIC90 ratios for E. coli, P. multocida and Mycoplasma spp. (>125) with MIC of 0.37 µg/mL and for S. aureus (>30) with MIC of 0.5 µg/mL in all ages of sheep.PMID:38141187 | DOI:10.2174/0113892002278220231208072351 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - December 23, 2023 Category: Drugs & Pharmacology Authors: Devran Coskun Orhan Corum Duygu Durna Corum Kamil Uney Source Type: research
