Computational Structural Validation of CYP2C9 Mutations and Evaluation of Machine Learning Algorithms in Predicting the Therapeutic Outcomes of Warfarin

CONCLUSION: We evaluated various MLAs in predicting the critical outcome measures associated with warfarin and observed CYP2C9 as the most critical predictor variable. The results of our study provide insight into the molecular basis of warfarin and the CYP2C9 gene. A prospective study validating the MLAs is urgently needed.PMID:37409551 | DOI:10.2174/1389200224666230705124329

Source: Current Drug Metabolism - July 6, 2023 Category: Drugs & Pharmacology Authors: Kannan Sridharan Thirumal Kumar Suchetha Manikandan Gaurav Prasanna Lalitha G Rashed Al Banna George Priya Doss Source Type: research