The Role of CYPs and Transporters in the Biotransformation and Transport of the Anti-hepatitis C Antiviral Agents Asunaprevir, Daclatasvir, and Beclabuvir: Impact of Liver Disease, Race and Drug-drug Interactions on Safety and Efficacy
This article reviews the biotransformation and disposition of these drugs in relation to the safety and efficacy of therapy. CYP3A4 and 3A5 catalyze the oxidative biotransformation of the drugs, while P-glycoprotein mediates their efflux from tissues. Asunaprevir is also a substrate for the influx transporters OATP1B1 and OATP2B1 and the efflux transporter MRP2, while beclabuvir is also a substrate for the efflux transporter BCRP. Liver disease decreases the expression of CYPs and transporters that mediate drug metabolism and disposition. Serum asunaprevir concentrations, but not those of daclatasvir or beclabuvir, are inc...
Source: Current Drug Metabolism - March 5, 2024 Category: Drugs & Pharmacology Authors: Michael Murray Source Type: research
The Role of CYPs and Transporters in the Biotransformation and Transport of the Anti-hepatitis C Antiviral Agents Asunaprevir, Daclatasvir, and Beclabuvir: Impact of Liver Disease, Race and Drug-drug Interactions on Safety and Efficacy
This article reviews the biotransformation and disposition of these drugs in relation to the safety and efficacy of therapy. CYP3A4 and 3A5 catalyze the oxidative biotransformation of the drugs, while P-glycoprotein mediates their efflux from tissues. Asunaprevir is also a substrate for the influx transporters OATP1B1 and OATP2B1 and the efflux transporter MRP2, while beclabuvir is also a substrate for the efflux transporter BCRP. Liver disease decreases the expression of CYPs and transporters that mediate drug metabolism and disposition. Serum asunaprevir concentrations, but not those of daclatasvir or beclabuvir, are inc...
Source: Current Drug Metabolism - March 5, 2024 Category: Drugs & Pharmacology Authors: Michael Murray Source Type: research
A Combination of Magnoflorine and Spinosin Improves the Antidepressant effects on CUMS Mouse Model
CONCLUSIONS: The present study demonstrated that a combination of MAG and SPI had a synergistic antidepressant effect in CUMS mouse model.PMID:38415474 | DOI:10.2174/0113892002284230240213064248 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 28, 2024 Category: Drugs & Pharmacology Authors: Fenghe Bi Zhihui Wang Yijing Guo Menglin Xia Xuehui Zhu Wei Qiao Source Type: research
A Combination of Magnoflorine and Spinosin Improves the Antidepressant effects on CUMS Mouse Model
CONCLUSIONS: The present study demonstrated that a combination of MAG and SPI had a synergistic antidepressant effect in CUMS mouse model.PMID:38415474 | DOI:10.2174/0113892002284230240213064248 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 28, 2024 Category: Drugs & Pharmacology Authors: Fenghe Bi Zhihui Wang Yijing Guo Menglin Xia Xuehui Zhu Wei Qiao Source Type: research
A Combination of Magnoflorine and Spinosin Improves the Antidepressant effects on CUMS Mouse Model
CONCLUSIONS: The present study demonstrated that a combination of MAG and SPI had a synergistic antidepressant effect in CUMS mouse model.PMID:38415474 | DOI:10.2174/0113892002284230240213064248 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 28, 2024 Category: Drugs & Pharmacology Authors: Fenghe Bi Zhihui Wang Yijing Guo Menglin Xia Xuehui Zhu Wei Qiao Source Type: research
A Combination of Magnoflorine and Spinosin Improves the Antidepressant effects on CUMS Mouse Model
CONCLUSIONS: The present study demonstrated that a combination of MAG and SPI had a synergistic antidepressant effect in CUMS mouse model.PMID:38415474 | DOI:10.2174/0113892002284230240213064248 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 28, 2024 Category: Drugs & Pharmacology Authors: Fenghe Bi Zhihui Wang Yijing Guo Menglin Xia Xuehui Zhu Wei Qiao Source Type: research
A Combination of Magnoflorine and Spinosin Improves the Antidepressant effects on CUMS Mouse Model
CONCLUSIONS: The present study demonstrated that a combination of MAG and SPI had a synergistic antidepressant effect in CUMS mouse model.PMID:38415474 | DOI:10.2174/0113892002284230240213064248 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 28, 2024 Category: Drugs & Pharmacology Authors: Fenghe Bi Zhihui Wang Yijing Guo Menglin Xia Xuehui Zhu Wei Qiao Source Type: research
A Combination of Magnoflorine and Spinosin Improves the Antidepressant effects on CUMS Mouse Model
CONCLUSIONS: The present study demonstrated that a combination of MAG and SPI had a synergistic antidepressant effect in CUMS mouse model.PMID:38415474 | DOI:10.2174/0113892002284230240213064248 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 28, 2024 Category: Drugs & Pharmacology Authors: Fenghe Bi Zhihui Wang Yijing Guo Menglin Xia Xuehui Zhu Wei Qiao Source Type: research
Recent Advances in Hepatic Metabolic Regulation by the Nuclear Factor Rev-erb ɑ
In conclusion, this paper aims to understand better the role and mechanism of Rev-erbɑ in regulating drug metabolism, lipid, glucose homeostasis, obesity, and metabolic disorders syndrome, which explores how to target Rev-erbɑ to guide the design and development of new drugs and provide scientific reference for the molecular mechanism of new drug development, rational drug use, and drug interaction.PMID:38409696 | DOI:10.2174/0113892002290055240212074758 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 27, 2024 Category: Drugs & Pharmacology Authors: Qi Zhang Yutong Chen Jingqi Li Haishan Xia Yongbin Tong Yuyu Liu Source Type: research
Effect of High Altitude Environment on Pharmacokinetic and Pharmacodynamic of Warfarin in Rats
CONCLUSION: High altitude environment inhibited the metabolism and increased the absorption of warfarin in rats and increased the effect of anticoagulant effect, suggesting that the optimal dose of warfarin for patients at high altitude should be reassessed.PMID:38409697 | DOI:10.2174/0113892002277930240201101256 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - February 27, 2024 Category: Drugs & Pharmacology Authors: Xiaojing Zhang Hongfang Mu Yan Zhong Rong Wang Wenbin Li Source Type: research
Drug-Protein Interactions Prediction Models Using Feature Selection and Classification Techniques
CONCLUSION: This comprehensive approach aims to overcome the limitations of existing methods and provide more reliable and efficient predictions in drug-protein interaction studies.PMID:38270152 | DOI:10.2174/0113892002268739231211063718 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: T Idhaya A Suruliandi S P Raja Source Type: research
Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans
CONCLUSION: The results suggest that the likelihood of potential clinical DDIs arising from tricyclic antidepressant inhibition on morphine glucuronidation is low.PMID:38270153 | DOI:10.2174/0113892002270594231212090958 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: Verawan Uchaipichat Source Type: research
Drug-Protein Interactions Prediction Models Using Feature Selection and Classification Techniques
CONCLUSION: This comprehensive approach aims to overcome the limitations of existing methods and provide more reliable and efficient predictions in drug-protein interaction studies.PMID:38270152 | DOI:10.2174/0113892002268739231211063718 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: T Idhaya A Suruliandi S P Raja Source Type: research
Inhibitory Effects of Tricyclic Antidepressants on Human Liver Microsomal Morphine Glucuronidation: Application of IVIVE to Predict Potential Drug-Drug Interactions in Humans
CONCLUSION: The results suggest that the likelihood of potential clinical DDIs arising from tricyclic antidepressant inhibition on morphine glucuronidation is low.PMID:38270153 | DOI:10.2174/0113892002270594231212090958 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: Verawan Uchaipichat Source Type: research
Drug-Protein Interactions Prediction Models Using Feature Selection and Classification Techniques
CONCLUSION: This comprehensive approach aims to overcome the limitations of existing methods and provide more reliable and efficient predictions in drug-protein interaction studies.PMID:38270152 | DOI:10.2174/0113892002268739231211063718 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - January 25, 2024 Category: Drugs & Pharmacology Authors: T Idhaya A Suruliandi S P Raja Source Type: research
