Comparative Analysis of the Gelsemium Alkaloids Metabolism in Human, Pig, Goat, and Rat Liver Microsomes
CONCLUSION: In this study, Gelsemium elegans metabolic patterns in different species are clarified and the in vitro metabolism of Gelsemium elegans is investigated. It is of great significance for its clinical development and rational application.PMID:38571358 | DOI:10.2174/0113892002298633240322071126 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 4, 2024 Category: Drugs & Pharmacology Authors: Yi-Rong Wang Meng-Ting Zuo Wen-Bo Xu Zhao-Ying Liu Source Type: research
Regulation of Gut Microbiota by Herbal Medicines
In conclusion, the gut microbiome is a critical player in maintaining human health, and its modulation by herbal medicines is a burgeoning area of research. Understanding the complex interactions between herbal compounds and gut microbiota will pave the way for innovative approaches to personalized healthcare and the development of herbal-based therapeutics aimed at promoting gut health and overall well-being.PMID:38571357 | DOI:10.2174/0113892002287336240328083220 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 4, 2024 Category: Drugs & Pharmacology Authors: Yogita Shinde Gitanjali Deokar Source Type: research
Comparative Analysis of the Gelsemium Alkaloids Metabolism in Human, Pig, Goat, and Rat Liver Microsomes
CONCLUSION: In this study, Gelsemium elegans metabolic patterns in different species are clarified and the in vitro metabolism of Gelsemium elegans is investigated. It is of great significance for its clinical development and rational application.PMID:38571358 | DOI:10.2174/0113892002298633240322071126 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 4, 2024 Category: Drugs & Pharmacology Authors: Yi-Rong Wang Meng-Ting Zuo Wen-Bo Xu Zhao-Ying Liu Source Type: research
Regulation of Gut Microbiota by Herbal Medicines
In conclusion, the gut microbiome is a critical player in maintaining human health, and its modulation by herbal medicines is a burgeoning area of research. Understanding the complex interactions between herbal compounds and gut microbiota will pave the way for innovative approaches to personalized healthcare and the development of herbal-based therapeutics aimed at promoting gut health and overall well-being.PMID:38571357 | DOI:10.2174/0113892002287336240328083220 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 4, 2024 Category: Drugs & Pharmacology Authors: Yogita Shinde Gitanjali Deokar Source Type: research
Comparative Analysis of the Gelsemium Alkaloids Metabolism in Human, Pig, Goat, and Rat Liver Microsomes
CONCLUSION: In this study, Gelsemium elegans metabolic patterns in different species are clarified and the in vitro metabolism of Gelsemium elegans is investigated. It is of great significance for its clinical development and rational application.PMID:38571358 | DOI:10.2174/0113892002298633240322071126 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 4, 2024 Category: Drugs & Pharmacology Authors: Yi-Rong Wang Meng-Ting Zuo Wen-Bo Xu Zhao-Ying Liu Source Type: research
Regulation of Gut Microbiota by Herbal Medicines
In conclusion, the gut microbiome is a critical player in maintaining human health, and its modulation by herbal medicines is a burgeoning area of research. Understanding the complex interactions between herbal compounds and gut microbiota will pave the way for innovative approaches to personalized healthcare and the development of herbal-based therapeutics aimed at promoting gut health and overall well-being.PMID:38571357 | DOI:10.2174/0113892002287336240328083220 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 4, 2024 Category: Drugs & Pharmacology Authors: Yogita Shinde Gitanjali Deokar Source Type: research
Comparative Analysis of the Gelsemium Alkaloids Metabolism in Human, Pig, Goat, and Rat Liver Microsomes
CONCLUSION: In this study, Gelsemium elegans metabolic patterns in different species are clarified and the in vitro metabolism of Gelsemium elegans is investigated. It is of great significance for its clinical development and rational application.PMID:38571358 | DOI:10.2174/0113892002298633240322071126 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 4, 2024 Category: Drugs & Pharmacology Authors: Yi-Rong Wang Meng-Ting Zuo Wen-Bo Xu Zhao-Ying Liu Source Type: research
Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems
CONCLUSION: Compared with CYP3A4*1, CYP3A4*18 has a greater metabolism of FK506, clarithromycin and ketoconazole can inhibit both the enzymatic activities of CYP3A4*1 and CYP3A4*18, consequently affecting the metabolism of FK506 and the inhibitory on CYP3A4*1 is stronger.PMID:38523538 | DOI:10.2174/0113892002286019240315052145 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Jinhua Wen Yuwei Xiao Menghua Zhao Chen Yang Weiqiang Hu Source Type: research
The Metabolism of the New Benzodiazepine Remimazolam
CONCLUSION: Besides the pharmacologically non-active metabolite CNS7054, no other clinically significant metabolite of remimazolam could be identified.PMID:38523539 | DOI:10.2174/0113892002301026240318060307 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Wolfgang Schmalix Karl-Uwe Petersen Marija Pesic Thomas St öhr Source Type: research
Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems
CONCLUSION: Compared with CYP3A4*1, CYP3A4*18 has a greater metabolism of FK506, clarithromycin and ketoconazole can inhibit both the enzymatic activities of CYP3A4*1 and CYP3A4*18, consequently affecting the metabolism of FK506 and the inhibitory on CYP3A4*1 is stronger.PMID:38523538 | DOI:10.2174/0113892002286019240315052145 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Jinhua Wen Yuwei Xiao Menghua Zhao Chen Yang Weiqiang Hu Source Type: research
The Metabolism of the New Benzodiazepine Remimazolam
CONCLUSION: Besides the pharmacologically non-active metabolite CNS7054, no other clinically significant metabolite of remimazolam could be identified.PMID:38523539 | DOI:10.2174/0113892002301026240318060307 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Wolfgang Schmalix Karl-Uwe Petersen Marija Pesic Thomas St öhr Source Type: research
Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems
CONCLUSION: Compared with CYP3A4*1, CYP3A4*18 has a greater metabolism of FK506, clarithromycin and ketoconazole can inhibit both the enzymatic activities of CYP3A4*1 and CYP3A4*18, consequently affecting the metabolism of FK506 and the inhibitory on CYP3A4*1 is stronger.PMID:38523538 | DOI:10.2174/0113892002286019240315052145 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Jinhua Wen Yuwei Xiao Menghua Zhao Chen Yang Weiqiang Hu Source Type: research
The Metabolism of the New Benzodiazepine Remimazolam
CONCLUSION: Besides the pharmacologically non-active metabolite CNS7054, no other clinically significant metabolite of remimazolam could be identified.PMID:38523539 | DOI:10.2174/0113892002301026240318060307 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Wolfgang Schmalix Karl-Uwe Petersen Marija Pesic Thomas St öhr Source Type: research
Effects of Clarithromycin and Ketoconazole on FK506 Metabolism in Different CYP3A4 Genotype Recombinant Metabolic Enzyme Systems
CONCLUSION: Compared with CYP3A4*1, CYP3A4*18 has a greater metabolism of FK506, clarithromycin and ketoconazole can inhibit both the enzymatic activities of CYP3A4*1 and CYP3A4*18, consequently affecting the metabolism of FK506 and the inhibitory on CYP3A4*1 is stronger.PMID:38523538 | DOI:10.2174/0113892002286019240315052145 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Jinhua Wen Yuwei Xiao Menghua Zhao Chen Yang Weiqiang Hu Source Type: research
The Metabolism of the New Benzodiazepine Remimazolam
CONCLUSION: Besides the pharmacologically non-active metabolite CNS7054, no other clinically significant metabolite of remimazolam could be identified.PMID:38523539 | DOI:10.2174/0113892002301026240318060307 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 25, 2024 Category: Drugs & Pharmacology Authors: Wolfgang Schmalix Karl-Uwe Petersen Marija Pesic Thomas St öhr Source Type: research
