Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke

CONCLUSIONS: Catalpol was excreted mainly through the urine. The drug-related substances were primarily concentrated in the stomach, large intestine, bladder, and kidney. Only the parent drug was detected in the plasma and urine, and M1 and M2 were detected in the feces. We speculate that the metabolism of catalpol in rats was mainly mediated by the intestinal flora, resulting in an aglycone-containing hemiacetal hydroxyl structure.PMID:37409552 | DOI:10.2174/1389200224666230705142901

Source: Current Drug Metabolism - July 6, 2023 Category: Drugs & Pharmacology Authors: Xinyu Ge Yuandong Zheng Yifei He Chong Chen Chen Yang Saiwei Lu Zhenyu Xuan Dafang Zhong Xingxing Diao Source Type: research