Computational Structural Validation of CYP2C9 Mutations and Evaluation of Machine Learning Algorithms in Predicting the Therapeutic Outcomes of Warfarin
CONCLUSION: We evaluated various MLAs in predicting the critical outcome measures associated with warfarin and observed CYP2C9 as the most critical predictor variable. The results of our study provide insight into the molecular basis of warfarin and the CYP2C9 gene. A prospective study validating the MLAs is urgently needed.PMID:37409551 | DOI:10.2174/1389200224666230705124329 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 6, 2023 Category: Drugs & Pharmacology Authors: Kannan Sridharan Thirumal Kumar Suchetha Manikandan Gaurav Prasanna Lalitha G Rashed Al Banna George Priya Doss Source Type: research
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke
CONCLUSIONS: Catalpol was excreted mainly through the urine. The drug-related substances were primarily concentrated in the stomach, large intestine, bladder, and kidney. Only the parent drug was detected in the plasma and urine, and M1 and M2 were detected in the feces. We speculate that the metabolism of catalpol in rats was mainly mediated by the intestinal flora, resulting in an aglycone-containing hemiacetal hydroxyl structure.PMID:37409552 | DOI:10.2174/1389200224666230705142901 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 6, 2023 Category: Drugs & Pharmacology Authors: Xinyu Ge Yuandong Zheng Yifei He Chong Chen Chen Yang Saiwei Lu Zhenyu Xuan Dafang Zhong Xingxing Diao Source Type: research
Computational Structural Validation of CYP2C9 Mutations and Evaluation of Machine Learning Algorithms in Predicting the Therapeutic Outcomes of Warfarin
CONCLUSION: We evaluated various MLAs in predicting the critical outcome measures associated with warfarin and observed CYP2C9 as the most critical predictor variable. The results of our study provide insight into the molecular basis of warfarin and the CYP2C9 gene. A prospective study validating the MLAs is urgently needed.PMID:37409551 | DOI:10.2174/1389200224666230705124329 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 6, 2023 Category: Drugs & Pharmacology Authors: Kannan Sridharan Thirumal Kumar Suchetha Manikandan Gaurav Prasanna Lalitha G Rashed Al Banna George Priya Doss Source Type: research
Pharmacokinetics, Mass Balance, Tissue Distribution, and Metabolism of [3H]Catalpol in Rats: the Main Bioactive Component of Rehmannia glutinosa for the Treatment of Ischemic Stroke
CONCLUSIONS: Catalpol was excreted mainly through the urine. The drug-related substances were primarily concentrated in the stomach, large intestine, bladder, and kidney. Only the parent drug was detected in the plasma and urine, and M1 and M2 were detected in the feces. We speculate that the metabolism of catalpol in rats was mainly mediated by the intestinal flora, resulting in an aglycone-containing hemiacetal hydroxyl structure.PMID:37409552 | DOI:10.2174/1389200224666230705142901 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - July 6, 2023 Category: Drugs & Pharmacology Authors: Xinyu Ge Yuandong Zheng Yifei He Chong Chen Chen Yang Saiwei Lu Zhenyu Xuan Dafang Zhong Xingxing Diao Source Type: research
The application of nucleic acid nanomaterials in the treatment of mitochondrial dysfunction
Curr Drug Metab. 2023 Jun 14. doi: 10.2174/1389200224666230614115655. Online ahead of print.ABSTRACTMitochondrial dysfunction is considered highly related to the development and progression of diseases, including cancer, metabolism disturbance, and neurodegeneration. Traditional pharmacological approach for mitochondrial dysfunction treatment has off-target and dose-dependent side effects, which leads to the emergence of mitochondrial gene therapy by regulating coding or noncoding genes by using nucleic acid sequences such as oligonucleotides, peptide nucleic acids, rRNA, siRNA, etc. To avoid size heterogeneity and potenti...
Source: Current Drug Metabolism - June 15, 2023 Category: Drugs & Pharmacology Authors: Lan Yao Hai Qing Tao Zhang Source Type: research
