Preclinical Pharmacokinetics and CYP Modulation Activity of Chebulinic Acid: A Potent Molecule Against Metabolic Disease
CONCLUSION: Altogether, pharmacokinetic parameters reveal CA to have an affinity to distribute across different extravascular tissues and induce rat liver CYP enzymes.PMID:37592800 | DOI:10.2174/1389200224666230817101950 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 18, 2023 Category: Drugs & Pharmacology Authors: Arpon Biswas Sarvesh Kumar Verma Shiv Kumar Tripti Mishra Mukesh Kumar Abhijit Deb Choudhury Sristi Agrawal Sachin Nashik Sanap Amol Chhatrapati Bisen Anjali Mishra Tadigoppula Narender Rabi Sankar Bhatta Source Type: research
In vivo Metabolism of Nifurtimox and the Drug-Drug Interaction Potential Including its Major Metabolites
CONCLUSION: This contemporary analysis of the complex metabolite profile and associated exposures emerging after oral dosing of nifurtimox in rats and humans, together with the expected low risk for clinically relevant DDIs, expands the understanding of this important anti-trypanosomal drug.PMID:37592798 | DOI:10.2174/1389200224666230817114758 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 18, 2023 Category: Drugs & Pharmacology Authors: Simone I Schulz Dieter Lang Gabriele Schmuck Michael Gerisch Michaela Bairlein Robert Fricke Heino Stass Source Type: research
Herbal Medicines as adjuvants for the treatment of chemotherapy-induced diarrhea
CONCLUSION: In clinical practise, herbal medications show potential as adjuvant treatments for gastrointestinal toxicities brought on by chemotherapy, particularly diarrhoea. Further well-designed clinical studies are needed to validate their efficacy, ensure safety, and explore potential drug-herb interactions.PMID:37592799 | DOI:10.2174/1389200224666230817102224 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 18, 2023 Category: Drugs & Pharmacology Authors: Zicong Zheng Songpol Srinual Jie Chen Li Li Ting Du Ming Hu Rongjin Sun Song Gao Source Type: research
Preclinical Pharmacokinetics and CYP Modulation Activity of Chebulinic Acid: A Potent Molecule Against Metabolic Disease
CONCLUSION: Altogether, pharmacokinetic parameters reveal CA to have an affinity to distribute across different extravascular tissues and induce rat liver CYP enzymes.PMID:37592800 | DOI:10.2174/1389200224666230817101950 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 18, 2023 Category: Drugs & Pharmacology Authors: Arpon Biswas Sarvesh Kumar Verma Shiv Kumar Tripti Mishra Mukesh Kumar Abhijit Deb Choudhury Sristi Agrawal Sachin Nashik Sanap Amol Chhatrapati Bisen Anjali Mishra Tadigoppula Narender Rabi Sankar Bhatta Source Type: research
In vivo Metabolism of Nifurtimox and the Drug-Drug Interaction Potential Including its Major Metabolites
CONCLUSION: This contemporary analysis of the complex metabolite profile and associated exposures emerging after oral dosing of nifurtimox in rats and humans, together with the expected low risk for clinically relevant DDIs, expands the understanding of this important anti-trypanosomal drug.PMID:37592798 | DOI:10.2174/1389200224666230817114758 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 18, 2023 Category: Drugs & Pharmacology Authors: Simone I Schulz Dieter Lang Gabriele Schmuck Michael Gerisch Michaela Bairlein Robert Fricke Heino Stass Source Type: research
Herbal Medicines as adjuvants for the treatment of chemotherapy-induced diarrhea
CONCLUSION: In clinical practise, herbal medications show potential as adjuvant treatments for gastrointestinal toxicities brought on by chemotherapy, particularly diarrhoea. Further well-designed clinical studies are needed to validate their efficacy, ensure safety, and explore potential drug-herb interactions.PMID:37592799 | DOI:10.2174/1389200224666230817102224 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 18, 2023 Category: Drugs & Pharmacology Authors: Zicong Zheng Songpol Srinual Jie Chen Li Li Ting Du Ming Hu Rongjin Sun Song Gao Source Type: research
Preclinical Pharmacokinetics and CYP Modulation Activity of Chebulinic Acid: A Potent Molecule Against Metabolic Disease
CONCLUSION: Altogether, pharmacokinetic parameters reveal CA to have an affinity to distribute across different extravascular tissues and induce rat liver CYP enzymes.PMID:37592800 | DOI:10.2174/1389200224666230817101950 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 18, 2023 Category: Drugs & Pharmacology Authors: Arpon Biswas Sarvesh Kumar Verma Shiv Kumar Tripti Mishra Mukesh Kumar Abhijit Deb Choudhury Sristi Agrawal Sachin Nashik Sanap Amol Chhatrapati Bisen Anjali Mishra Tadigoppula Narender Rabi Sankar Bhatta Source Type: research
In vivo Metabolism of Nifurtimox and the Drug-Drug Interaction Potential Including its Major Metabolites
CONCLUSION: This contemporary analysis of the complex metabolite profile and associated exposures emerging after oral dosing of nifurtimox in rats and humans, together with the expected low risk for clinically relevant DDIs, expands the understanding of this important anti-trypanosomal drug.PMID:37592798 | DOI:10.2174/1389200224666230817114758 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 18, 2023 Category: Drugs & Pharmacology Authors: Simone I Schulz Dieter Lang Gabriele Schmuck Michael Gerisch Michaela Bairlein Robert Fricke Heino Stass Source Type: research
Herbal Medicines as adjuvants for the treatment of chemotherapy-induced diarrhea
CONCLUSION: In clinical practise, herbal medications show potential as adjuvant treatments for gastrointestinal toxicities brought on by chemotherapy, particularly diarrhoea. Further well-designed clinical studies are needed to validate their efficacy, ensure safety, and explore potential drug-herb interactions.PMID:37592799 | DOI:10.2174/1389200224666230817102224 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 18, 2023 Category: Drugs & Pharmacology Authors: Zicong Zheng Songpol Srinual Jie Chen Li Li Ting Du Ming Hu Rongjin Sun Song Gao Source Type: research
Preclinical Pharmacokinetics and CYP Modulation Activity of Chebulinic Acid: A Potent Molecule Against Metabolic Disease
CONCLUSION: Altogether, pharmacokinetic parameters reveal CA to have an affinity to distribute across different extravascular tissues and induce rat liver CYP enzymes.PMID:37592800 | DOI:10.2174/1389200224666230817101950 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 18, 2023 Category: Drugs & Pharmacology Authors: Arpon Biswas Sarvesh Kumar Verma Shiv Kumar Tripti Mishra Mukesh Kumar Abhijit Deb Choudhury Sristi Agrawal Sachin Nashik Sanap Amol Chhatrapati Bisen Anjali Mishra Tadigoppula Narender Rabi Sankar Bhatta Source Type: research
In vivo Metabolism of Nifurtimox and the Drug-Drug Interaction Potential Including its Major Metabolites
CONCLUSION: This contemporary analysis of the complex metabolite profile and associated exposures emerging after oral dosing of nifurtimox in rats and humans, together with the expected low risk for clinically relevant DDIs, expands the understanding of this important anti-trypanosomal drug.PMID:37592798 | DOI:10.2174/1389200224666230817114758 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 18, 2023 Category: Drugs & Pharmacology Authors: Simone I Schulz Dieter Lang Gabriele Schmuck Michael Gerisch Michaela Bairlein Robert Fricke Heino Stass Source Type: research
Herbal Medicines as adjuvants for the treatment of chemotherapy-induced diarrhea
CONCLUSION: In clinical practise, herbal medications show potential as adjuvant treatments for gastrointestinal toxicities brought on by chemotherapy, particularly diarrhoea. Further well-designed clinical studies are needed to validate their efficacy, ensure safety, and explore potential drug-herb interactions.PMID:37592799 | DOI:10.2174/1389200224666230817102224 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 18, 2023 Category: Drugs & Pharmacology Authors: Zicong Zheng Songpol Srinual Jie Chen Li Li Ting Du Ming Hu Rongjin Sun Song Gao Source Type: research
Preclinical Pharmacokinetics and CYP Modulation Activity of Chebulinic Acid: A Potent Molecule Against Metabolic Disease
CONCLUSION: Altogether, pharmacokinetic parameters reveal CA to have an affinity to distribute across different extravascular tissues and induce rat liver CYP enzymes.PMID:37592800 | DOI:10.2174/1389200224666230817101950 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 18, 2023 Category: Drugs & Pharmacology Authors: Arpon Biswas Sarvesh Kumar Verma Shiv Kumar Tripti Mishra Mukesh Kumar Abhijit Deb Choudhury Sristi Agrawal Sachin Nashik Sanap Amol Chhatrapati Bisen Anjali Mishra Tadigoppula Narender Rabi Sankar Bhatta Source Type: research
Molecular Insights into the Mechanism of Modulatory Effects of Proton Pump Inhibitors on P-glycoprotein Mediated Drug Transport of Palbociclib and Ribociclib
CONCLUSION: The experimental evidence presented highlights the fact that proton pump inhibitors have potential to inhibit P-glycoprotein, giving rise to drug interactions with palbociclib and ribociclib. Hence, monitoring is required while proton pump inhibitors and cyclin-dependent kinase inhibitors are being co-administered to avoid adverse events.PMID:37581514 | DOI:10.2174/1389200224666230815122312 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 15, 2023 Category: Drugs & Pharmacology Authors: Mrunal Pradeep Desai Prajakta Harish Patil Sai Krishna Anand Vullendula Sumit Birangal G Gautham Shenoy Mahadev Rao Swapnil Jayant Dengale Krishnamurthy Bhat Jagadish Puralae Channabasavaiah Source Type: research
Molecular Insights into the Mechanism of Modulatory Effects of Proton Pump Inhibitors on P-glycoprotein Mediated Drug Transport of Palbociclib and Ribociclib
CONCLUSION: The experimental evidence presented highlights the fact that proton pump inhibitors have potential to inhibit P-glycoprotein, giving rise to drug interactions with palbociclib and ribociclib. Hence, monitoring is required while proton pump inhibitors and cyclin-dependent kinase inhibitors are being co-administered to avoid adverse events.PMID:37581514 | DOI:10.2174/1389200224666230815122312 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - August 15, 2023 Category: Drugs & Pharmacology Authors: Mrunal Pradeep Desai Prajakta Harish Patil Sai Krishna Anand Vullendula Sumit Birangal G Gautham Shenoy Mahadev Rao Swapnil Jayant Dengale Krishnamurthy Bhat Jagadish Puralae Channabasavaiah Source Type: research
