Engineered Exosomes for Drug Delivery in Cancer Therapy: A promising approach and application
Curr Drug Deliv. 2023 Jul 12. doi: 10.2174/1567201820666230712103942. Online ahead of print.ABSTRACTA significant amount of research effort is currently focused on investigating the role of exosomes in various cancers. These tiny vesicles, apart from acting as biomarkers, also play a crucial role in tumor formation and development. Several studies have demonstrated that exosomes can be a drug delivery vehicle for cancer therapy. In this paper, we highlight the key advantages of exosomes as a drug delivery candidate, with a particular focus on their low immunogenicity, natural targeting ability and suitable mechanical prope...
Source: Current Drug Delivery - July 13, 2023 Category: Drugs & Pharmacology Authors: Peiwen Fu Siqi Yin Huiying Cheng Wenrong Xu Jiajia Jiang Source Type: research
Nanotechnology-Based Drug Delivery For Alzheimer's And Parkinson's Diseases
Curr Drug Deliv. 2023 Jul 7. doi: 10.2174/1567201820666230707113405. Online ahead of print.ABSTRACTThe delivery of drugs to the brain is quite challenging in the treatment of the central nervous system [CNS) diseases due to the blood-brain barrier and the blood-cerebrospinal fluid barrier. However, significant developments in nanomaterials employed by nanoparticle drug-delivery systems have substantial potential to cross or bypass these barriers leading to enhanced therapeutic efficacies. Advances in nanoplatform, nanosystems based on lipids, polymers and inorganic materials have been extensively studied and applied in tre...
Source: Current Drug Delivery - July 10, 2023 Category: Drugs & Pharmacology Authors: Phuong-Trang Nguyen-Thi Thanh-Tam Ho Thuy Trang Nguyen Giau Van Vo Source Type: research
Novel vesicular bilosomal delivery systems for dermal/transdermal applications
Curr Drug Deliv. 2023 Jul 7. doi: 10.2174/1567201820666230707161206. Online ahead of print.ABSTRACTThe application of therapeutically active molecules through the dermal/transdermal route into the skin has evolved as an attractive formulation strategy in comparison to oral delivery systems for the treatment of various disease conditions. However, the delivery of drugs across the skin is limited due to poor permeability. Dermal/transdermal delivery is associated with ease of accessibility, enhanced safety, better patient compliance, and reduced variability in plasma drug concentrations. It has the ability to bypass the firs...
Source: Current Drug Delivery - July 10, 2023 Category: Drugs & Pharmacology Authors: Vasanti Suvarna Rashmi Mallya Kajal Deshmukh Bhakti Sawant Tabassum Asif Khan Abdelwahab Omri Source Type: research
Nanotechnology-Based Drug Delivery For Alzheimer's And Parkinson's Diseases
Curr Drug Deliv. 2023 Jul 7. doi: 10.2174/1567201820666230707113405. Online ahead of print.ABSTRACTThe delivery of drugs to the brain is quite challenging in the treatment of the central nervous system [CNS) diseases due to the blood-brain barrier and the blood-cerebrospinal fluid barrier. However, significant developments in nanomaterials employed by nanoparticle drug-delivery systems have substantial potential to cross or bypass these barriers leading to enhanced therapeutic efficacies. Advances in nanoplatform, nanosystems based on lipids, polymers and inorganic materials have been extensively studied and applied in tre...
Source: Current Drug Delivery - July 10, 2023 Category: Drugs & Pharmacology Authors: Phuong-Trang Nguyen-Thi Thanh-Tam Ho Thuy Trang Nguyen Giau Van Vo Source Type: research
Novel vesicular bilosomal delivery systems for dermal/transdermal applications
Curr Drug Deliv. 2023 Jul 7. doi: 10.2174/1567201820666230707161206. Online ahead of print.ABSTRACTThe application of therapeutically active molecules through the dermal/transdermal route into the skin has evolved as an attractive formulation strategy in comparison to oral delivery systems for the treatment of various disease conditions. However, the delivery of drugs across the skin is limited due to poor permeability. Dermal/transdermal delivery is associated with ease of accessibility, enhanced safety, better patient compliance, and reduced variability in plasma drug concentrations. It has the ability to bypass the firs...
Source: Current Drug Delivery - July 10, 2023 Category: Drugs & Pharmacology Authors: Vasanti Suvarna Rashmi Mallya Kajal Deshmukh Bhakti Sawant Tabassum Asif Khan Abdelwahab Omri Source Type: research
Nanotechnology-Based Drug Delivery For Alzheimer's And Parkinson's Diseases
Curr Drug Deliv. 2023 Jul 7. doi: 10.2174/1567201820666230707113405. Online ahead of print.ABSTRACTThe delivery of drugs to the brain is quite challenging in the treatment of the central nervous system [CNS) diseases due to the blood-brain barrier and the blood-cerebrospinal fluid barrier. However, significant developments in nanomaterials employed by nanoparticle drug-delivery systems have substantial potential to cross or bypass these barriers leading to enhanced therapeutic efficacies. Advances in nanoplatform, nanosystems based on lipids, polymers and inorganic materials have been extensively studied and applied in tre...
Source: Current Drug Delivery - July 10, 2023 Category: Drugs & Pharmacology Authors: Phuong-Trang Nguyen-Thi Thanh-Tam Ho Thuy Trang Nguyen Giau Van Vo Source Type: research
Novel vesicular bilosomal delivery systems for dermal/transdermal applications
Curr Drug Deliv. 2023 Jul 7. doi: 10.2174/1567201820666230707161206. Online ahead of print.ABSTRACTThe application of therapeutically active molecules through the dermal/transdermal route into the skin has evolved as an attractive formulation strategy in comparison to oral delivery systems for the treatment of various disease conditions. However, the delivery of drugs across the skin is limited due to poor permeability. Dermal/transdermal delivery is associated with ease of accessibility, enhanced safety, better patient compliance, and reduced variability in plasma drug concentrations. It has the ability to bypass the firs...
Source: Current Drug Delivery - July 10, 2023 Category: Drugs & Pharmacology Authors: Vasanti Suvarna Rashmi Mallya Kajal Deshmukh Bhakti Sawant Tabassum Asif Khan Abdelwahab Omri Source Type: research
Nanocarrier Mediated Intranasal Drug Delivery Systems for the Management of Parkinsonism: A Review
Curr Drug Deliv. 2023 Jun 16. doi: 10.2174/1567201820666230523114259. Online ahead of print.ABSTRACTThe transport of drugs to the brain becomes a key concern when treating disorders of the central nervous system. Parkinsonism is one of the major concerns across the world populations, which causes difficulty in coordination and balance. However, the blood-brain barrier is a significant barrier to achieving optimal brain concentration through oral, transdermal, and intravenous routes of administration. The intranasal route with nanocarrier-based formulations has shown potential for managing Parkinsonism disorder (PD). Direct...
Source: Current Drug Delivery - June 27, 2023 Category: Drugs & Pharmacology Authors: Archita Kapoor Abdul Hafeez Poonam Kushwaha Source Type: research
Nanocarrier Mediated Intranasal Drug Delivery Systems for the Management of Parkinsonism: A Review
Curr Drug Deliv. 2023 Jun 16. doi: 10.2174/1567201820666230523114259. Online ahead of print.ABSTRACTThe transport of drugs to the brain becomes a key concern when treating disorders of the central nervous system. Parkinsonism is one of the major concerns across the world populations, which causes difficulty in coordination and balance. However, the blood-brain barrier is a significant barrier to achieving optimal brain concentration through oral, transdermal, and intravenous routes of administration. The intranasal route with nanocarrier-based formulations has shown potential for managing Parkinsonism disorder (PD). Direct...
Source: Current Drug Delivery - June 27, 2023 Category: Drugs & Pharmacology Authors: Archita Kapoor Abdul Hafeez Poonam Kushwaha Source Type: research
Nanocarrier Mediated Intranasal Drug Delivery Systems for the Management of Parkinsonism: A Review
Curr Drug Deliv. 2023 Jun 16. doi: 10.2174/1567201820666230523114259. Online ahead of print.ABSTRACTThe transport of drugs to the brain becomes a key concern when treating disorders of the central nervous system. Parkinsonism is one of the major concerns across the world populations, which causes difficulty in coordination and balance. However, the blood-brain barrier is a significant barrier to achieving optimal brain concentration through oral, transdermal, and intravenous routes of administration. The intranasal route with nanocarrier-based formulations has shown potential for managing Parkinsonism disorder (PD). Direct...
Source: Current Drug Delivery - June 27, 2023 Category: Drugs & Pharmacology Authors: Archita Kapoor Abdul Hafeez Poonam Kushwaha Source Type: research
Nanocarrier Mediated Intranasal Drug Delivery Systems for the Management of Parkinsonism: A Review
Curr Drug Deliv. 2023 Jun 16. doi: 10.2174/1567201820666230523114259. Online ahead of print.ABSTRACTThe transport of drugs to the brain becomes a key concern when treating disorders of the central nervous system. Parkinsonism is one of the major concerns across the world populations, which causes difficulty in coordination and balance. However, the blood-brain barrier is a significant barrier to achieving optimal brain concentration through oral, transdermal, and intravenous routes of administration. The intranasal route with nanocarrier-based formulations has shown potential for managing Parkinsonism disorder (PD). Direct...
Source: Current Drug Delivery - June 27, 2023 Category: Drugs & Pharmacology Authors: Archita Kapoor Abdul Hafeez Poonam Kushwaha Source Type: research
Nanocarrier Mediated Intranasal Drug Delivery Systems for the Management of Parkinsonism: A Review
Curr Drug Deliv. 2023 Jun 16. doi: 10.2174/1567201820666230523114259. Online ahead of print.ABSTRACTThe transport of drugs to the brain becomes a key concern when treating disorders of the central nervous system. Parkinsonism is one of the major concerns across the world populations, which causes difficulty in coordination and balance. However, the blood-brain barrier is a significant barrier to achieving optimal brain concentration through oral, transdermal, and intravenous routes of administration. The intranasal route with nanocarrier-based formulations has shown potential for managing Parkinsonism disorder (PD). Direct...
Source: Current Drug Delivery - June 27, 2023 Category: Drugs & Pharmacology Authors: Archita Kapoor Abdul Hafeez Poonam Kushwaha Source Type: research
Nanocarrier Mediated Intranasal Drug Delivery Systems for the Management of Parkinsonism: A Review
Curr Drug Deliv. 2023 Jun 16. doi: 10.2174/1567201820666230523114259. Online ahead of print.ABSTRACTThe transport of drugs to the brain becomes a key concern when treating disorders of the central nervous system. Parkinsonism is one of the major concerns across the world populations, which causes difficulty in coordination and balance. However, the blood-brain barrier is a significant barrier to achieving optimal brain concentration through oral, transdermal, and intravenous routes of administration. The intranasal route with nanocarrier-based formulations has shown potential for managing Parkinsonism disorder (PD). Direct...
Source: Current Drug Delivery - June 27, 2023 Category: Drugs & Pharmacology Authors: Archita Kapoor Abdul Hafeez Poonam Kushwaha Source Type: research
Nanocarrier Mediated Intranasal Drug Delivery Systems for the Management of Parkinsonism: A Review
Curr Drug Deliv. 2023 Jun 16. doi: 10.2174/1567201820666230523114259. Online ahead of print.ABSTRACTThe transport of drugs to the brain becomes a key concern when treating disorders of the central nervous system. Parkinsonism is one of the major concerns across the world populations, which causes difficulty in coordination and balance. However, the blood-brain barrier is a significant barrier to achieving optimal brain concentration through oral, transdermal, and intravenous routes of administration. The intranasal route with nanocarrier-based formulations has shown potential for managing Parkinsonism disorder (PD). Direct...
Source: Current Drug Delivery - June 27, 2023 Category: Drugs & Pharmacology Authors: Archita Kapoor Abdul Hafeez Poonam Kushwaha Source Type: research
Nanocarrier Mediated Intranasal Drug Delivery Systems for the Management of Parkinsonism: A Review
Curr Drug Deliv. 2023 Jun 16. doi: 10.2174/1567201820666230523114259. Online ahead of print.ABSTRACTThe transport of drugs to the brain becomes a key concern when treating disorders of the central nervous system. Parkinsonism is one of the major concerns across the world populations, which causes difficulty in coordination and balance. However, the blood-brain barrier is a significant barrier to achieving optimal brain concentration through oral, transdermal, and intravenous routes of administration. The intranasal route with nanocarrier-based formulations has shown potential for managing Parkinsonism disorder (PD). Direct...
Source: Current Drug Delivery - June 27, 2023 Category: Drugs & Pharmacology Authors: Archita Kapoor Abdul Hafeez Poonam Kushwaha Source Type: research
