Mannose: A Promising Player in Clinical and Biomedical Applications
Curr Drug Deliv. 2024 Jan 15. doi: 10.2174/0115672018275954231220101637. Online ahead of print.ABSTRACTMannose, an isomer of glucose, exhibits a distinct molecular structure with the same formula but a different atom arrangement, contributing to its specific biological functions. Widely distributed in body fluids and tissues, particularly in the nervous system, skin, testes, and retinas, mannose plays a crucial role as a direct precursor for glycoprotein synthesis. Glycoproteins, essential for immune regulation and glycosylation processes, underscore the significance of mannose in these physiological activities. The clinic...
Source: Current Drug Delivery - February 4, 2024 Category: Drugs & Pharmacology Authors: Sijing Chen Kana Wang Qiao Wang Source Type: research
Influence of Nano-Particulate Impurities and β-glucans on the Stability of Protein-Based Formulations
Curr Drug Deliv. 2024 Jan 30. doi: 10.2174/0115672018290111240119115306. Online ahead of print.ABSTRACTPharmaceutical grade sugars manufactured under Current Good Manufacturing Practice (cGMP) and complied with International Pharmaceutical Excipients Council (IPEC) quality standards, also contain a significant amount of nano-particulate impurities (NPIs). This review will focus on the origin of NPIs, the mechanism of their interference with Dynamic light scattering (DLS) and endotoxin tests, filtration technology to effectively reduce the NPIs, methodologies for analytical quantification of NPIs, guidance for setting the l...
Source: Current Drug Delivery - February 1, 2024 Category: Drugs & Pharmacology Authors: Soumya Ranjan Satapathy Rudra Narayan Sahoo Amit Kumar Nayak Source Type: research
Emerging Phytochemical Formulations for Management of Rheumatoid Arthritis: A Review
Curr Drug Deliv. 2024 Jan 30. doi: 10.2174/0115672018270434240105110330. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a T-cell-mediated chronic inflammatory disorder affecting 0.5-1% of the global population. The disease with unknown etiology causes slow destruction of joints, advancing to significant deterioration of an individual's quality of life. The present treatment strategy comprises the use of disease-modifying anti-rheumatic drugs (DMARDs) coupled with or without nonsteroidal anti-inflammatory drugs or glucocorticoids. Additionally, involves co-therapy of injectable biological DMARDs in case of persi...
Source: Current Drug Delivery - February 1, 2024 Category: Drugs & Pharmacology Authors: Prachi Pimple Jenny Shah Prabha Singh Source Type: research
Smart Ultrasound-responsive Polymers for Drug Delivery: An Overview on Advanced Stimuli-sensitive Materials and Techniques
The objective of this study is to offer valuable perspectives on the challenges that must be overcome to enable the effective implementation of these technologies. The primary objective of this comprehensive review is to furnish researchers, clinicians, and pharmaceutical scientists with a wealth of information that will serve as a guide for forthcoming developments in the development and enhancement of intelligent drug delivery systems that employ ultrasound-responsive polymers to attain superior therapeutic outcomes.PMID:38288800 | DOI:10.2174/0115672018283792240115053302 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 30, 2024 Category: Drugs & Pharmacology Authors: Mostafa Yazdan Seyed Morteza Naghib Source Type: research
A Comprehensive Review on Polyphenols Based Nanovesicular System for Topical Delivery
CONCLUSION: Polyphenol based nano-vesicular formulations have proved to be an effective system for topical delivery and henceforth, they might curtail the use of other skin therapies having limited applicability.PMID:38279739 | DOI:10.2174/0115672018265118231213094410 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 27, 2024 Category: Drugs & Pharmacology Authors: Anshu Singh Zeeshan Fatima Dipti Srivastava Source Type: research
Fiber Technology in Drug Delivery and Pharmaceuticals
Curr Drug Deliv. 2024 Jan 25. doi: 10.2174/0115672018279628231221105210. Online ahead of print.ABSTRACTThe field of fiber technology is a dynamic and innovative domain that offers novel solutions for controlled and targeted therapeutic interventions. This abstract provides an overview of key aspects within this field, encompassing a range of techniques, applications, commercial developments, intellectual property, and regulatory considerations. The foundational introduction establishes the significance of fiber-based drug delivery systems. Electrospinning, a pivotal technique, has been explored in this paper, along with it...
Source: Current Drug Delivery - January 27, 2024 Category: Drugs & Pharmacology Authors: Shivang Dhoundiyal Aditya Sharma Md Aftab Alam Source Type: research
Recent Developments in Tyrosine Kinase Inhibitor-based Nanotherapeutics for EGFR-resistant Non-small Cell Lung Cancer
Curr Drug Deliv. 2024 Jan 24. doi: 10.2174/0115672018278617231207051907. Online ahead of print.ABSTRACTThe advent of drug resistance in response to epidermal growth factor receptor (EGFR)- tyrosine kinase inhibitor (TKI) targeted therapy represents a serious challenge in the management of non-small cell lung cancer (NSCLC). These acquired resistance mutations, attributed to several advanced EGFR mutations and, necessitated the development of new-generation TKIs. Nanomedicine approaches provide a plausible way to address these problems by providing targeted delivery and sustained release, which have demonstrated success in ...
Source: Current Drug Delivery - January 26, 2024 Category: Drugs & Pharmacology Authors: Eknath Kole Krishna Jadhav Raghuraj Singh Shilpa Mandpe Ashwin Abhang Rahul K Verma Jitendra Naik Source Type: research
Recent Advancement in Inhaled Nano-drug Delivery for Pulmonary, Nasal, and Nose-to-brain Diseases
Curr Drug Deliv. 2024 Jan 24. doi: 10.2174/0115672018268047231207105652. Online ahead of print.ABSTRACTPulmonary, nasal, and nose-to-brain diseases involve clinical approaches, such as bronchodilators, inhaled steroids, oxygen therapy, antibiotics, antihistamines, nasal steroids, decongestants, intranasal drug delivery, neurostimulation, and surgery to treat patients. However, systemic medicines have serious adverse effects, necessitating the development of inhaled formulations that allow precise drug delivery to the airways with minimum systemic drug exposure. Particle size, surface charge, biocompatibility, drug capacity...
Source: Current Drug Delivery - January 26, 2024 Category: Drugs & Pharmacology Authors: Qiuxia Fu Yangjie Liu Cao Peng Tobias Achu Muluh Umer Anayyat Liu Liang Source Type: research
Convection-enhanced Diffusion: A Novel Tactics to Crack the BBB
Curr Drug Deliv. 2024 Jan 24. doi: 10.2174/0115672018266501231207095127. Online ahead of print.ABSTRACTAlthough the brain is very accessible to nutrition and oxygen, it can be difficult to deliver medications to malignant brain tumours. To get around some of these issues and enable the use of therapeutic pharmacological substances that wouldn't typically cross the blood-brain barrier (BBB), convection-enhanced delivery (CED) has been developed. It is a cutting-edge strategy that gets beyond the blood-brain barrier and enables targeted drug administration to treat different neurological conditions such as brain tumours, Par...
Source: Current Drug Delivery - January 26, 2024 Category: Drugs & Pharmacology Authors: Meenakshi Dhanawat None Garima Kashish Wilson Sumeet Gupta Rishabh Chalotra Nidhi Gupta Source Type: research
Current Trends in Nanotechnology-based Drug Delivery Systems for the Diagnosis and Treatment of Malaria: A Review
Curr Drug Deliv. 2024 Jan 23. doi: 10.2174/0115672018291253240115012327. Online ahead of print.ABSTRACTMalaria is still a major endemic disease transmitted in humans via Plasmodium-infected mosquitoes. The eradication of malarial parasites and the control measures have been rigorously and extensively deployed by local and international health organizations. Malaria's recurrence is a result of the failure to entirely eradicate it. The drawbacks related to malarial chemotherapy, non-specific targeting, multiple drug resistance, requirement of high doses, intolerable toxicity, indefinable complexity of Plasmodium's life cycle...
Source: Current Drug Delivery - January 24, 2024 Category: Drugs & Pharmacology Authors: Rohitas Deshmukh Bhuvaneshwari Dewangan Ranjit K Harwansh Rutvi Agrawal Akash Garg Himansu Chopra Source Type: research
Delivery Systems for Plasma-reactive Species and their Applications in the Field of Biomedicine
Curr Drug Deliv. 2024 Jan 19. doi: 10.2174/0115672018268207231124014915. Online ahead of print.ABSTRACTCold atmospheric plasma (CAP) is an ionized matter with potential applications in various medical fields, ranging from wound healing and disinfection to cancer treatment. CAP's clinical usefulness stems from its ability to act as an adjustable source of reactive oxygen and nitrogen species (RONS), which are known to function as pleiotropic signaling agents within cells. Plasma-activated species, such as RONS, have the potential to be consistently and precisely released by carriers, enabling their utilization in a wide arr...
Source: Current Drug Delivery - January 22, 2024 Category: Drugs & Pharmacology Authors: Esmaeil Biazar Farzaneh Aavani Reza Zeinali Bahareh Kheilnezhad Kiana Taheri Zahra Yahyaei Source Type: research
Dextran-based Drug Delivery Approaches for Lung Diseases: A Review
Curr Drug Deliv. 2024 Jan 12. doi: 10.2174/0115672018267737231116100812. Online ahead of print.ABSTRACTRespiratory disorders, such as tuberculosis, cystic fibrosis, chronic obstructive pulmonary disease, asthma, lung cancer, and pulmonary inflammation, are among the most prevalent ailments in today's world. Dextran, an exopolysaccharide formed by Leuconostoc mesenteroides (slimeproducing bacteria), and its derivatives are investigated for several therapeutic utilities. Dextranbased drug delivery system can become an innovative strategy in the treatment of several respiratory ailments as it offers numerous advantages, such ...
Source: Current Drug Delivery - January 20, 2024 Category: Drugs & Pharmacology Authors: Manisha Kumari Sanyam Sharma Navjot Kanwar Subh Naman Ashish Baldi Source Type: research
Transdermal Drug Delivery System of Linagliptin Sustained-release Microparticle Gels: In vitro Characterization and In vivo Evaluation
CONCLUSION: These findings signify that the LNG microparticle gel holds significant clinical value for providing sustained release and justifies its practical application.PMID:38243939 | DOI:10.2174/0115672018279370240103062944 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 20, 2024 Category: Drugs & Pharmacology Authors: Jiayan Liu Song Guo Shuai Hong Jingshu Piao Mingguan Piao Source Type: research
Controlled Release of Aspirin in the Body using Pectin-coated ZIF-8 Nanoparticles
CONCLUSION: The release of aspirin from ZIF-8/Asp@Pectin was studied using UV-Vis spectroscopy at 258 nm under in vitro conditions in HCl and PBS buffer solutions.PMID:38243940 | DOI:10.2174/0115672018288328240109064308 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 20, 2024 Category: Drugs & Pharmacology Authors: Fatemeh Shahidi M Reza Naimi-Jamal Azizollah Habibi Mohammad G Dekamin Source Type: research
Synergistic Antibacterial Effect of ZnO Nanoparticles and Antibiotics against Multidrug-Resistant Biofilm Bacteria
CONCLUSION: The findings of this study encourage the development of alternative therapies with high efficacy and low toxicity. ZnO nanoparticles have demonstrated promising results in overcoming multi-drug resistant bacteria and biofilms, and their combination with colistin has shown a significant reduction in toxicity. Further studies are needed to investigate the potential of ZnO nanoparticles as a viable alternative to conventional antibiotics.PMID:38231065 | DOI:10.2174/0115672018279213240110045557 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 17, 2024 Category: Drugs & Pharmacology Authors: Majed M Masadeh Noor M Bany-Ali Mai S Khanfar Karem H Alzoubi Majd M Massadeh Enaam M Almomani Source Type: research
