Monoclonal antibodies and antibody-drug conjugates as emerging therapeutics for breast cancer treatment
Curr Drug Deliv. 2023 Jul 31. doi: 10.2174/1567201820666230731094258. Online ahead of print.ABSTRACTWhen breast cells divide and multiply out of control, it is called breast cancer. Symptoms include lump formation in the breast, a change in the texture or color of the breast, or a discharge from the nipple. Local or systemic therapy is frequently used to treat breast cancer. Surgical and radiation procedures limited to the affected area are examples of local management. There has been significant worldwide progress in the development of monoclonal antibodies (mAbs) since 1986, when the first therapeutic mAb, Orthoclone OKT...
Source: Current Drug Delivery - July 31, 2023 Category: Drugs & Pharmacology Authors: Swati Saini Nisha Gulati Rajendra Awasthi Vimal Arora Sachin Singh Shobhit Kumar Gaurav Gupta Kamal Dua Rakesh Pahwa Harish Dureja Source Type: research
Monoclonal antibodies and antibody-drug conjugates as emerging therapeutics for breast cancer treatment
Curr Drug Deliv. 2023 Jul 31. doi: 10.2174/1567201820666230731094258. Online ahead of print.ABSTRACTWhen breast cells divide and multiply out of control, it is called breast cancer. Symptoms include lump formation in the breast, a change in the texture or color of the breast, or a discharge from the nipple. Local or systemic therapy is frequently used to treat breast cancer. Surgical and radiation procedures limited to the affected area are examples of local management. There has been significant worldwide progress in the development of monoclonal antibodies (mAbs) since 1986, when the first therapeutic mAb, Orthoclone OKT...
Source: Current Drug Delivery - July 31, 2023 Category: Drugs & Pharmacology Authors: Swati Saini Nisha Gulati Rajendra Awasthi Vimal Arora Sachin Singh Shobhit Kumar Gaurav Gupta Kamal Dua Rakesh Pahwa Harish Dureja Source Type: research
An Insight on Skin Cancer About Different Targets With Update on Clinical Trials and Investigational Drugs
Curr Drug Deliv. 2023 Jul 26. doi: 10.2174/1567201820666230726150642. Online ahead of print.ABSTRACTCancer is a diverse disease caused by transcriptional changes involving genetic and epigenetic features that influence a huge variety of genes and proteins. Skin cancer is a potentially fatal disease that affects equally men and women globally and is characterized by many molecular changes. Despite the availability of various improved approaches for detecting and treating skin cancer, it continues to be the leading cause of death throughout society. This review highlights a general overview of skin cancer, with an emphasis o...
Source: Current Drug Delivery - July 27, 2023 Category: Drugs & Pharmacology Authors: Suraj Vishwas Swarnali Das Paul Deepika Singh Source Type: research
Advances in Enzyme-responsive Supramolecular In situ Self-assembled Peptide for Drug Delivery
Curr Drug Deliv. 2023 Jul 26. doi: 10.2174/1567201820666230726151607. Online ahead of print.ABSTRACTBecause of low immunogenicity, ease of modification, and inherent biosafety, peptides have been well recognized as vehicles to deliver therapeutic agents to targeted regions with improved pharmacokinetic characteristics. Enzyme-responsive self-assembled peptides (ERSAPs) show superiority over their naive forms due to their enhanced targeting efficacy and long-retention property. In this review, we have summarized recent advances in the therapeutic application of ERSAPs, mainly focusing on their self-therapeutic properties an...
Source: Current Drug Delivery - July 27, 2023 Category: Drugs & Pharmacology Authors: Wentao Xu Xiaowen Qin Yang Liu Jun Chen Yuguang Wang Source Type: research
An Insight on Skin Cancer About Different Targets With Update on Clinical Trials and Investigational Drugs
Curr Drug Deliv. 2023 Jul 26. doi: 10.2174/1567201820666230726150642. Online ahead of print.ABSTRACTCancer is a diverse disease caused by transcriptional changes involving genetic and epigenetic features that influence a huge variety of genes and proteins. Skin cancer is a potentially fatal disease that affects equally men and women globally and is characterized by many molecular changes. Despite the availability of various improved approaches for detecting and treating skin cancer, it continues to be the leading cause of death throughout society. This review highlights a general overview of skin cancer, with an emphasis o...
Source: Current Drug Delivery - July 27, 2023 Category: Drugs & Pharmacology Authors: Suraj Vishwas Swarnali Das Paul Deepika Singh Source Type: research
Advances in Enzyme-responsive Supramolecular In situ Self-assembled Peptide for Drug Delivery
Curr Drug Deliv. 2023 Jul 26. doi: 10.2174/1567201820666230726151607. Online ahead of print.ABSTRACTBecause of low immunogenicity, ease of modification, and inherent biosafety, peptides have been well recognized as vehicles to deliver therapeutic agents to targeted regions with improved pharmacokinetic characteristics. Enzyme-responsive self-assembled peptides (ERSAPs) show superiority over their naive forms due to their enhanced targeting efficacy and long-retention property. In this review, we have summarized recent advances in the therapeutic application of ERSAPs, mainly focusing on their self-therapeutic properties an...
Source: Current Drug Delivery - July 27, 2023 Category: Drugs & Pharmacology Authors: Wentao Xu Xiaowen Qin Yang Liu Jun Chen Yuguang Wang Source Type: research
An Insight on Skin Cancer About Different Targets With Update on Clinical Trials and Investigational Drugs
Curr Drug Deliv. 2023 Jul 26. doi: 10.2174/1567201820666230726150642. Online ahead of print.ABSTRACTCancer is a diverse disease caused by transcriptional changes involving genetic and epigenetic features that influence a huge variety of genes and proteins. Skin cancer is a potentially fatal disease that affects equally men and women globally and is characterized by many molecular changes. Despite the availability of various improved approaches for detecting and treating skin cancer, it continues to be the leading cause of death throughout society. This review highlights a general overview of skin cancer, with an emphasis o...
Source: Current Drug Delivery - July 27, 2023 Category: Drugs & Pharmacology Authors: Suraj Vishwas Swarnali Das Paul Deepika Singh Source Type: research
Advances in Enzyme-responsive Supramolecular In situ Self-assembled Peptide for Drug Delivery
Curr Drug Deliv. 2023 Jul 26. doi: 10.2174/1567201820666230726151607. Online ahead of print.ABSTRACTBecause of low immunogenicity, ease of modification, and inherent biosafety, peptides have been well recognized as vehicles to deliver therapeutic agents to targeted regions with improved pharmacokinetic characteristics. Enzyme-responsive self-assembled peptides (ERSAPs) show superiority over their naive forms due to their enhanced targeting efficacy and long-retention property. In this review, we have summarized recent advances in the therapeutic application of ERSAPs, mainly focusing on their self-therapeutic properties an...
Source: Current Drug Delivery - July 27, 2023 Category: Drugs & Pharmacology Authors: Wentao Xu Xiaowen Qin Yang Liu Jun Chen Yuguang Wang Source Type: research
An Insight on Skin Cancer About Different Targets With Update on Clinical Trials and Investigational Drugs
Curr Drug Deliv. 2023 Jul 26. doi: 10.2174/1567201820666230726150642. Online ahead of print.ABSTRACTCancer is a diverse disease caused by transcriptional changes involving genetic and epigenetic features that influence a huge variety of genes and proteins. Skin cancer is a potentially fatal disease that affects equally men and women globally and is characterized by many molecular changes. Despite the availability of various improved approaches for detecting and treating skin cancer, it continues to be the leading cause of death throughout society. This review highlights a general overview of skin cancer, with an emphasis o...
Source: Current Drug Delivery - July 27, 2023 Category: Drugs & Pharmacology Authors: Suraj Vishwas Swarnali Das Paul Deepika Singh Source Type: research
Advances in Enzyme-responsive Supramolecular In situ Self-assembled Peptide for Drug Delivery
Curr Drug Deliv. 2023 Jul 26. doi: 10.2174/1567201820666230726151607. Online ahead of print.ABSTRACTBecause of low immunogenicity, ease of modification, and inherent biosafety, peptides have been well recognized as vehicles to deliver therapeutic agents to targeted regions with improved pharmacokinetic characteristics. Enzyme-responsive self-assembled peptides (ERSAPs) show superiority over their naive forms due to their enhanced targeting efficacy and long-retention property. In this review, we have summarized recent advances in the therapeutic application of ERSAPs, mainly focusing on their self-therapeutic properties an...
Source: Current Drug Delivery - July 27, 2023 Category: Drugs & Pharmacology Authors: Wentao Xu Xiaowen Qin Yang Liu Jun Chen Yuguang Wang Source Type: research
Ultrasound-Mediated PLGA-PEI Nanobubbles Carrying STAT6 SiRNA Enhances NSCLC Treatment via Repolarizing Tumor-associated Macrophages from M2 to M1 Phenotypes
CONCLUSION: UMND enhanced PLGA-PEI NBs-STAT6 siRNA to repolarize TAMs from the M2 to the M1 phenotype, thus treating NSCLC. These findings provide a promising therapeutic approach for enhancing NSCLC immunotherapy.PMID:37491853 | DOI:10.2174/1567201820666230724151545 (Source: Current Drug Delivery)
Source: Current Drug Delivery - July 26, 2023 Category: Drugs & Pharmacology Authors: Hong Shu Wenhao Lv Zhi-Jian Ren Hui Li Tiantian Dong Yao Zhang Fang Nie Source Type: research
Preparation and Evaluation of the In situ Gel-forming Chitosan Hydrogels for Nasal Delivery of Morphine in a Single Unit dose in Rats to Enhance the Analgesic Responses
CONCLUSION: These data reveal that the IN-chitosan hydrogel could induce fast and prolonged analgesic effects of morphine compare to the IN/IP-Free Mor, which could be considered as an in situ gel-forming thermosensitive chitosan hydrogel for nasal delivery of wide ranges of therapeutic agents.PMID:37491854 | DOI:10.2174/1567201820666230724161205 (Source: Current Drug Delivery)
Source: Current Drug Delivery - July 26, 2023 Category: Drugs & Pharmacology Authors: Hossein Kamali Mohsen Tafaghodi Farhad Eisvand S Mohammad Ahmadi-Soleimani Mina Khajouee Hosnieh Ghazizadeh Jafar Mosafer Source Type: research
Ultrasound-Mediated PLGA-PEI Nanobubbles Carrying STAT6 SiRNA Enhances NSCLC Treatment via Repolarizing Tumor-associated Macrophages from M2 to M1 Phenotypes
CONCLUSION: UMND enhanced PLGA-PEI NBs-STAT6 siRNA to repolarize TAMs from the M2 to the M1 phenotype, thus treating NSCLC. These findings provide a promising therapeutic approach for enhancing NSCLC immunotherapy.PMID:37491853 | DOI:10.2174/1567201820666230724151545 (Source: Current Drug Delivery)
Source: Current Drug Delivery - July 26, 2023 Category: Drugs & Pharmacology Authors: Hong Shu Wenhao Lv Zhi-Jian Ren Hui Li Tiantian Dong Yao Zhang Fang Nie Source Type: research
Preparation and Evaluation of the In situ Gel-forming Chitosan Hydrogels for Nasal Delivery of Morphine in a Single Unit dose in Rats to Enhance the Analgesic Responses
CONCLUSION: These data reveal that the IN-chitosan hydrogel could induce fast and prolonged analgesic effects of morphine compare to the IN/IP-Free Mor, which could be considered as an in situ gel-forming thermosensitive chitosan hydrogel for nasal delivery of wide ranges of therapeutic agents.PMID:37491854 | DOI:10.2174/1567201820666230724161205 (Source: Current Drug Delivery)
Source: Current Drug Delivery - July 26, 2023 Category: Drugs & Pharmacology Authors: Hossein Kamali Mohsen Tafaghodi Farhad Eisvand S Mohammad Ahmadi-Soleimani Mina Khajouee Hosnieh Ghazizadeh Jafar Mosafer Source Type: research
Chitosan Oligosaccharide Modified Bovine Serum Albumin Nanoparticles for Improving Oral Bioavailability of Naringenin
CONCLUSION: BSA-COS@Nar NPs could improve the in vivo bioavailability of naringenin.PMID:37464826 | DOI:10.2174/1567201820666230718143726 (Source: Current Drug Delivery)
Source: Current Drug Delivery - July 19, 2023 Category: Drugs & Pharmacology Authors: Ruiyue Fang Yiqi Liao Huishuang Qiu Yuxin Liu Shiyuan Lin Hui Chen Source Type: research
