Nanotechnology-Based Drug Delivery For Alzheimer's And Parkinson's Diseases

Curr Drug Deliv. 2023 Jul 7. doi: 10.2174/1567201820666230707113405. Online ahead of print.ABSTRACTThe delivery of drugs to the brain is quite challenging in the treatment of the central nervous system [CNS) diseases due to the blood-brain barrier and the blood-cerebrospinal fluid barrier. However, significant developments in nanomaterials employed by nanoparticle drug-delivery systems have substantial potential to cross or bypass these barriers leading to enhanced therapeutic efficacies. Advances in nanoplatform, nanosystems based on lipids, polymers and inorganic materials have been extensively studied and applied in treating Alzheimer's and Parkinson's diseases. In this review, various types of brain drug delivery nanocarriers are classified, summarized, and their potential as drug delivery systems in Alzheimer's and Parkinson's diseases is discussed. Finally, challenges facing the clinical translation of nanoparticles from bench to bedside are highlighted.PMID:37424345 | DOI:10.2174/1567201820666230707113405
Source: Current Drug Delivery - Category: Drugs & Pharmacology Authors: Source Type: research