Transdermal Drug Delivery System of Linagliptin Sustained-release Microparticle Gels: In vitro Characterization and In vivo Evaluation
CONCLUSION: These findings signify that the LNG microparticle gel holds significant clinical value for providing sustained release and justifies its practical application.PMID:38243939 | DOI:10.2174/0115672018279370240103062944 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 20, 2024 Category: Drugs & Pharmacology Authors: Jiayan Liu Song Guo Shuai Hong Jingshu Piao Mingguan Piao Source Type: research
Controlled Release of Aspirin in the Body using Pectin-coated ZIF-8 Nanoparticles
CONCLUSION: The release of aspirin from ZIF-8/Asp@Pectin was studied using UV-Vis spectroscopy at 258 nm under in vitro conditions in HCl and PBS buffer solutions.PMID:38243940 | DOI:10.2174/0115672018288328240109064308 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 20, 2024 Category: Drugs & Pharmacology Authors: Fatemeh Shahidi M Reza Naimi-Jamal Azizollah Habibi Mohammad G Dekamin Source Type: research
Synergistic Antibacterial Effect of ZnO Nanoparticles and Antibiotics against Multidrug-Resistant Biofilm Bacteria
CONCLUSION: The findings of this study encourage the development of alternative therapies with high efficacy and low toxicity. ZnO nanoparticles have demonstrated promising results in overcoming multi-drug resistant bacteria and biofilms, and their combination with colistin has shown a significant reduction in toxicity. Further studies are needed to investigate the potential of ZnO nanoparticles as a viable alternative to conventional antibiotics.PMID:38231065 | DOI:10.2174/0115672018279213240110045557 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 17, 2024 Category: Drugs & Pharmacology Authors: Majed M Masadeh Noor M Bany-Ali Mai S Khanfar Karem H Alzoubi Majd M Massadeh Enaam M Almomani Source Type: research
A Comprehensive Review on Niosomes as a Strategy in Targeted Drug Delivery: Pharmaceutical, and Herbal Cosmetic Applications
This article aims to concentrate on the increase in the worldwide utilization of niosomal formulation. This overview presents a thorough perspective of niosomal investigation up until now, encompassing categories and production techniques, their significance in pharmaceutical transportation, and cosmetic use. The thorough literature review revealed that extensive attention has been given to developing nanocarriers for drug delivery as they hold immense endeavor to attain targeted delivery to the affected area simultaneously shielding the adjacent healthy tissue. Many reviews and research papers have been published that dem...
Source: Current Drug Delivery - January 17, 2024 Category: Drugs & Pharmacology Authors: Sakshi Saharawat Sushma Verma Source Type: research
From Vision Correction to Drug Delivery: Unraveling the Potential of Therapeutic Contact Lens
Curr Drug Deliv. 2024 Jan 11. doi: 10.2174/0115672018270396231213074746. Online ahead of print.ABSTRACTContact lenses (CLs) have become an essential tool in ocular drug delivery, providing effective treatment options for specific eye conditions. In recent advancements, Therapeutic CLs (TCLs) have emerged as a promising approach for maintaining therapeutic drug concentrations on the eye surface. TCLs offer unique attributes, including prolonged wear and a remarkable ability to enhance the bioavailability of loaded medications by more than 50%, thus gaining widespread usage. They have proven beneficial in pain management, me...
Source: Current Drug Delivery - January 12, 2024 Category: Drugs & Pharmacology Authors: Ankush Saini Mohit Sharma Indu Singh Rajan Swami Source Type: research
Nanostructured Lipid Carrier-mediated Transdermal Delivery System of Glibenclamide for Gestational Diabetes: Pharmacokinetic and Pharmacodynamic Evaluation
CONCLUSION: Transdermal patches incorporating NLCs hold promise for enhancing glibenclamide's therapeutic efficacy in GDM treatment. Improved skin permeation, sustained drug release, and enhanced bioavailability make NLC-based transdermal patches a potential alternative with better patient compliance.PMID:38213159 | DOI:10.2174/0115672018274038231212105440 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 12, 2024 Category: Drugs & Pharmacology Authors: Ashwini M Preethi Sudheer Bharani S Sogali Source Type: research
Novel Products as Promising Therapeutic Agents for Angiogenesis Inhibition
CONCLUSION: This review focuses on novel antiangiogenic agents that play a crucial role in controlling carcinogenesis.PMID:38204254 | DOI:10.2174/0115672018277869231217165048 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 11, 2024 Category: Drugs & Pharmacology Authors: Shaheen Sultana Shahnaz Sultana Shehla Nasar Mir Najib Ullah Ameeduzzafar Zafar Source Type: research
TPGS-mediated Transethosomes Enhance Transdermal Administration of Curcumin via Effects on Deformability and Stability
CONCLUSION: TPGS-mediated transethosomes exhibit significant transdermal advantages and enhanced anti-inflammatory effects, providing a new perspective for the transdermal delivery of curcumin.PMID:38204255 | DOI:10.2174/0115672018279577231208055415 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 11, 2024 Category: Drugs & Pharmacology Authors: Teng Guo Chenming Zhang Yuling Chen Yihan Wu Zhenda Liu Yongtai Zhang Nianping Feng Source Type: research
TPGS-modified Chitosan Nanoparticles of EGFR Inhibitor: Physicochemical and In vitro Evaluation against HepG2 Cell Lines
CONCLUSION: It was observed that the optimized GFN-NP1 formulation successfully internalized and inhibited the growth of HepG2 cells. Hence, it can be concluded that the prepared NPs can be a new therapeutic option for treating liver cancer.PMID:38204256 | DOI:10.2174/0115672018268315231206045504 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 11, 2024 Category: Drugs & Pharmacology Authors: Mahendra Singh None Alka Prashant Shukla Zhi-Hong Wen Chou-Yuan Ko Ramachandran Vinayagam Source Type: research
Overcoming Skin Barrier with Transfersomes: Opportunities, Challenges, and Applications
CONCLUSION: In comparison to other vesicular systems, transfersomes are more flexible, have greater skin penetration capability, can transport systemic medicines, and are more stable. Transfersomes are capable of delivering both hydrophilic and hydrophobic drugs, making them suitable for transdermal drug delivery. The developed transfersomal gel could be used to improve medicine delivery through the skin.PMID:38178667 | DOI:10.2174/0115672018272012231213100535 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 5, 2024 Category: Drugs & Pharmacology Authors: Bhupendra Dixena Rashmi Madhariya Anupama Panday Alpana Ram Akhlesh K Jain Source Type: research
Overcoming Skin Barrier with Transfersomes: Opportunities, Challenges, and Applications
CONCLUSION: In comparison to other vesicular systems, transfersomes are more flexible, have greater skin penetration capability, can transport systemic medicines, and are more stable. Transfersomes are capable of delivering both hydrophilic and hydrophobic drugs, making them suitable for transdermal drug delivery. The developed transfersomal gel could be used to improve medicine delivery through the skin.PMID:38178667 | DOI:10.2174/0115672018272012231213100535 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 5, 2024 Category: Drugs & Pharmacology Authors: Bhupendra Dixena Rashmi Madhariya Anupama Panday Alpana Ram Akhlesh K Jain Source Type: research
Overcoming Skin Barrier with Transfersomes: Opportunities, Challenges, and Applications
CONCLUSION: In comparison to other vesicular systems, transfersomes are more flexible, have greater skin penetration capability, can transport systemic medicines, and are more stable. Transfersomes are capable of delivering both hydrophilic and hydrophobic drugs, making them suitable for transdermal drug delivery. The developed transfersomal gel could be used to improve medicine delivery through the skin.PMID:38178667 | DOI:10.2174/0115672018272012231213100535 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 5, 2024 Category: Drugs & Pharmacology Authors: Bhupendra Dixena Rashmi Madhariya Anupama Panday Alpana Ram Akhlesh K Jain Source Type: research
Overcoming Skin Barrier with Transfersomes: Opportunities, Challenges, and Applications
CONCLUSION: In comparison to other vesicular systems, transfersomes are more flexible, have greater skin penetration capability, can transport systemic medicines, and are more stable. Transfersomes are capable of delivering both hydrophilic and hydrophobic drugs, making them suitable for transdermal drug delivery. The developed transfersomal gel could be used to improve medicine delivery through the skin.PMID:38178667 | DOI:10.2174/0115672018272012231213100535 (Source: Current Drug Delivery)
Source: Current Drug Delivery - January 5, 2024 Category: Drugs & Pharmacology Authors: Bhupendra Dixena Rashmi Madhariya Anupama Panday Alpana Ram Akhlesh K Jain Source Type: research
Recent Advancements in Bioelectronic Medicine: A Review
Curr Drug Deliv. 2024 Jan 3. doi: 10.2174/0115672018286832231218112557. Online ahead of print.ABSTRACTBioelectronic medicine is a multidisciplinary field that combines molecular medicine, neurology, engineering, and computer science to design devices for diagnosing and treating diseases. The advancements in bioelectronic medicine can improve the precision and personalization of illness treatment. Bioelectronic medicine can produce, suppress, and measure electrical activity in excitable tissue. Bioelectronic devices modify specific neural circuits using electrons rather than pharmaceuticals and use bioelectronic processes t...
Source: Current Drug Delivery - January 4, 2024 Category: Drugs & Pharmacology Authors: Sudipta Das Baishali Ghosh Rudra Narayan Sahoo Amit Kumar Nayak Source Type: research
Recent Advancements in Bioelectronic Medicine: A Review
Curr Drug Deliv. 2024 Jan 3. doi: 10.2174/0115672018286832231218112557. Online ahead of print.ABSTRACTBioelectronic medicine is a multidisciplinary field that combines molecular medicine, neurology, engineering, and computer science to design devices for diagnosing and treating diseases. The advancements in bioelectronic medicine can improve the precision and personalization of illness treatment. Bioelectronic medicine can produce, suppress, and measure electrical activity in excitable tissue. Bioelectronic devices modify specific neural circuits using electrons rather than pharmaceuticals and use bioelectronic processes t...
Source: Current Drug Delivery - January 4, 2024 Category: Drugs & Pharmacology Authors: Sudipta Das Baishali Ghosh Rudra Narayan Sahoo Amit Kumar Nayak Source Type: research
