Integrated animal experiments and network pharmacology for investigating therapeutic effect of celastrol-loaded liposomes on NAFLD
CONCLUSION: Celastrol has the potential to treat NAFLD, and its possible targets have been identified through network pharmacological screening, which provides a certain basis for the follow-up researches.PMID:37565560 | DOI:10.2174/1567201821666230810094643 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 11, 2023 Category: Drugs & Pharmacology Authors: Jingbin Shi Ninghui Ma Ningchao Luo Jingyi Huang Shujun Xu Yang Xiong Source Type: research
A Novel Etanercept-Loaded Nano-emulsion for Targeted Treatment of Inflammatory Arthritis via Draining Lymph Node
CONCLUSION: NEs/EN effectively improve the effectiveness of EN in the treatment of RA. Our work provides an experimental foundation for expanding the clinical application of EN.PMID:37565561 | DOI:10.2174/1567201821666230810115230 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 11, 2023 Category: Drugs & Pharmacology Authors: Chenglong Li Guanting Lu Yue Jiang Huaiyu Su Chen Li Source Type: research
Integrated animal experiments and network pharmacology for investigating therapeutic effect of celastrol-loaded liposomes on NAFLD
CONCLUSION: Celastrol has the potential to treat NAFLD, and its possible targets have been identified through network pharmacological screening, which provides a certain basis for the follow-up researches.PMID:37565560 | DOI:10.2174/1567201821666230810094643 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 11, 2023 Category: Drugs & Pharmacology Authors: Jingbin Shi Ninghui Ma Ningchao Luo Jingyi Huang Shujun Xu Yang Xiong Source Type: research
A Novel Etanercept-Loaded Nano-emulsion for Targeted Treatment of Inflammatory Arthritis via Draining Lymph Node
CONCLUSION: NEs/EN effectively improve the effectiveness of EN in the treatment of RA. Our work provides an experimental foundation for expanding the clinical application of EN.PMID:37565561 | DOI:10.2174/1567201821666230810115230 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 11, 2023 Category: Drugs & Pharmacology Authors: Chenglong Li Guanting Lu Yue Jiang Huaiyu Su Chen Li Source Type: research
Integrated animal experiments and network pharmacology for investigating therapeutic effect of celastrol-loaded liposomes on NAFLD
CONCLUSION: Celastrol has the potential to treat NAFLD, and its possible targets have been identified through network pharmacological screening, which provides a certain basis for the follow-up researches.PMID:37565560 | DOI:10.2174/1567201821666230810094643 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 11, 2023 Category: Drugs & Pharmacology Authors: Jingbin Shi Ninghui Ma Ningchao Luo Jingyi Huang Shujun Xu Yang Xiong Source Type: research
A Novel Etanercept-Loaded Nano-emulsion for Targeted Treatment of Inflammatory Arthritis via Draining Lymph Node
CONCLUSION: NEs/EN effectively improve the effectiveness of EN in the treatment of RA. Our work provides an experimental foundation for expanding the clinical application of EN.PMID:37565561 | DOI:10.2174/1567201821666230810115230 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 11, 2023 Category: Drugs & Pharmacology Authors: Chenglong Li Guanting Lu Yue Jiang Huaiyu Su Chen Li Source Type: research
Integrated animal experiments and network pharmacology for investigating therapeutic effect of celastrol-loaded liposomes on NAFLD
CONCLUSION: Celastrol has the potential to treat NAFLD, and its possible targets have been identified through network pharmacological screening, which provides a certain basis for the follow-up researches.PMID:37565560 | DOI:10.2174/1567201821666230810094643 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 11, 2023 Category: Drugs & Pharmacology Authors: Jingbin Shi Ninghui Ma Ningchao Luo Jingyi Huang Shujun Xu Yang Xiong Source Type: research
A Novel Etanercept-Loaded Nano-emulsion for Targeted Treatment of Inflammatory Arthritis via Draining Lymph Node
CONCLUSION: NEs/EN effectively improve the effectiveness of EN in the treatment of RA. Our work provides an experimental foundation for expanding the clinical application of EN.PMID:37565561 | DOI:10.2174/1567201821666230810115230 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 11, 2023 Category: Drugs & Pharmacology Authors: Chenglong Li Guanting Lu Yue Jiang Huaiyu Su Chen Li Source Type: research
Triptolide nanoemulsion gel as a transdermal drug delivery system: preparation, pharmacokinetics, and rheumatoid arthritis evaluation
CONCLUSION: The TP-NE gel is a promising local delivery method for rheumatoid arthritis (RA)-associated edema and inflammation and can serve as a prospective platform for percutaneous TP administration.PMID:37559533 | DOI:10.2174/1567201821666230808114519 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 10, 2023 Category: Drugs & Pharmacology Authors: Meng Yang Dishun Yang Lu Han Zhimin Fan Jiyong Liu Yongfang Yuan Source Type: research
Triptolide nanoemulsion gel as a transdermal drug delivery system: preparation, pharmacokinetics, and rheumatoid arthritis evaluation
CONCLUSION: The TP-NE gel is a promising local delivery method for rheumatoid arthritis (RA)-associated edema and inflammation and can serve as a prospective platform for percutaneous TP administration.PMID:37559533 | DOI:10.2174/1567201821666230808114519 (Source: Current Drug Delivery)
Source: Current Drug Delivery - August 10, 2023 Category: Drugs & Pharmacology Authors: Meng Yang Dishun Yang Lu Han Zhimin Fan Jiyong Liu Yongfang Yuan Source Type: research
The blood-prostate barrier: an obstacle to drug delivery into the prostate
Curr Drug Deliv. 2023 Aug 7. doi: 10.2174/1567201821666230807152520. Online ahead of print.ABSTRACTThe blood-prostate barrier (BPB), a non-static physical barrier, stands as an obstacle between the prostate stroma and the lumen of the prostate gland tube. The barrier has the ability to dynamically regulate and strictly control the mass exchange between the blood and the prostate, thereby limiting drug penetration into the prostate. The basement membrane, fibrous stromal layer, capillary endothelial cell, prostatic ductal epithelial cell, lipid layer, etc., have been confirmed to be involved in the composition of the barrie...
Source: Current Drug Delivery - August 8, 2023 Category: Drugs & Pharmacology Authors: Yixuan Mou Min Cao Dahong Zhang Source Type: research
The blood-prostate barrier: an obstacle to drug delivery into the prostate
Curr Drug Deliv. 2023 Aug 7. doi: 10.2174/1567201821666230807152520. Online ahead of print.ABSTRACTThe blood-prostate barrier (BPB), a non-static physical barrier, stands as an obstacle between the prostate stroma and the lumen of the prostate gland tube. The barrier has the ability to dynamically regulate and strictly control the mass exchange between the blood and the prostate, thereby limiting drug penetration into the prostate. The basement membrane, fibrous stromal layer, capillary endothelial cell, prostatic ductal epithelial cell, lipid layer, etc., have been confirmed to be involved in the composition of the barrie...
Source: Current Drug Delivery - August 8, 2023 Category: Drugs & Pharmacology Authors: Yixuan Mou Min Cao Dahong Zhang Source Type: research
The blood-prostate barrier: an obstacle to drug delivery into the prostate
Curr Drug Deliv. 2023 Aug 7. doi: 10.2174/1567201821666230807152520. Online ahead of print.ABSTRACTThe blood-prostate barrier (BPB), a non-static physical barrier, stands as an obstacle between the prostate stroma and the lumen of the prostate gland tube. The barrier has the ability to dynamically regulate and strictly control the mass exchange between the blood and the prostate, thereby limiting drug penetration into the prostate. The basement membrane, fibrous stromal layer, capillary endothelial cell, prostatic ductal epithelial cell, lipid layer, etc., have been confirmed to be involved in the composition of the barrie...
Source: Current Drug Delivery - August 8, 2023 Category: Drugs & Pharmacology Authors: Yixuan Mou Min Cao Dahong Zhang Source Type: research
Monoclonal antibodies and antibody-drug conjugates as emerging therapeutics for breast cancer treatment
Curr Drug Deliv. 2023 Jul 31. doi: 10.2174/1567201820666230731094258. Online ahead of print.ABSTRACTWhen breast cells divide and multiply out of control, it is called breast cancer. Symptoms include lump formation in the breast, a change in the texture or color of the breast, or a discharge from the nipple. Local or systemic therapy is frequently used to treat breast cancer. Surgical and radiation procedures limited to the affected area are examples of local management. There has been significant worldwide progress in the development of monoclonal antibodies (mAbs) since 1986, when the first therapeutic mAb, Orthoclone OKT...
Source: Current Drug Delivery - July 31, 2023 Category: Drugs & Pharmacology Authors: Swati Saini Nisha Gulati Rajendra Awasthi Vimal Arora Sachin Singh Shobhit Kumar Gaurav Gupta Kamal Dua Rakesh Pahwa Harish Dureja Source Type: research
Monoclonal antibodies and antibody-drug conjugates as emerging therapeutics for breast cancer treatment
Curr Drug Deliv. 2023 Jul 31. doi: 10.2174/1567201820666230731094258. Online ahead of print.ABSTRACTWhen breast cells divide and multiply out of control, it is called breast cancer. Symptoms include lump formation in the breast, a change in the texture or color of the breast, or a discharge from the nipple. Local or systemic therapy is frequently used to treat breast cancer. Surgical and radiation procedures limited to the affected area are examples of local management. There has been significant worldwide progress in the development of monoclonal antibodies (mAbs) since 1986, when the first therapeutic mAb, Orthoclone OKT...
Source: Current Drug Delivery - July 31, 2023 Category: Drugs & Pharmacology Authors: Swati Saini Nisha Gulati Rajendra Awasthi Vimal Arora Sachin Singh Shobhit Kumar Gaurav Gupta Kamal Dua Rakesh Pahwa Harish Dureja Source Type: research
