Oral host-microbe interactions investigated in 3D organotypic models
Crit Rev Microbiol. 2023 May 11:1-20. doi: 10.1080/1040841X.2023.2211665. Online ahead of print.ABSTRACTThe oral cavity is inhabited by abundant microbes which continuously interact with the host and influence the host's health. Such host-microbe interactions (HMI) are dynamic and complex processes involving e.g. oral tissues, microbial communities and saliva. Due to difficulties in mimicking the in vivo complexity, it is still unclear how exactly HMI influence the transition between healthy status and disease conditions in the oral cavity. As an advanced approach, three-dimensional (3D) organotypic oral tissues (epitheliu...
Source: Critical Reviews in Microbiology - May 11, 2023 Category: Microbiology Authors: Lin Shang Dongmei Deng Bastiaan P Krom Susan Gibbs Source Type: research
Oral host-microbe interactions investigated in 3D organotypic models
Crit Rev Microbiol. 2023 May 11:1-20. doi: 10.1080/1040841X.2023.2211665. Online ahead of print.ABSTRACTThe oral cavity is inhabited by abundant microbes which continuously interact with the host and influence the host's health. Such host-microbe interactions (HMI) are dynamic and complex processes involving e.g. oral tissues, microbial communities and saliva. Due to difficulties in mimicking the in vivo complexity, it is still unclear how exactly HMI influence the transition between healthy status and disease conditions in the oral cavity. As an advanced approach, three-dimensional (3D) organotypic oral tissues (epitheliu...
Source: Critical Reviews in Microbiology - May 11, 2023 Category: Microbiology Authors: Lin Shang Dongmei Deng Bastiaan P Krom Susan Gibbs Source Type: research
Oral host-microbe interactions investigated in 3D organotypic models
Crit Rev Microbiol. 2023 May 11:1-20. doi: 10.1080/1040841X.2023.2211665. Online ahead of print.ABSTRACTThe oral cavity is inhabited by abundant microbes which continuously interact with the host and influence the host's health. Such host-microbe interactions (HMI) are dynamic and complex processes involving e.g. oral tissues, microbial communities and saliva. Due to difficulties in mimicking the in vivo complexity, it is still unclear how exactly HMI influence the transition between healthy status and disease conditions in the oral cavity. As an advanced approach, three-dimensional (3D) organotypic oral tissues (epitheliu...
Source: Critical Reviews in Microbiology - May 11, 2023 Category: Microbiology Authors: Lin Shang Dongmei Deng Bastiaan P Krom Susan Gibbs Source Type: research
Oral host-microbe interactions investigated in 3D organotypic models
Crit Rev Microbiol. 2023 May 11:1-20. doi: 10.1080/1040841X.2023.2211665. Online ahead of print.ABSTRACTThe oral cavity is inhabited by abundant microbes which continuously interact with the host and influence the host's health. Such host-microbe interactions (HMI) are dynamic and complex processes involving e.g. oral tissues, microbial communities and saliva. Due to difficulties in mimicking the in vivo complexity, it is still unclear how exactly HMI influence the transition between healthy status and disease conditions in the oral cavity. As an advanced approach, three-dimensional (3D) organotypic oral tissues (epitheliu...
Source: Critical Reviews in Microbiology - May 11, 2023 Category: Microbiology Authors: Lin Shang Dongmei Deng Bastiaan P Krom Susan Gibbs Source Type: research
Oral host-microbe interactions investigated in 3D organotypic models
Crit Rev Microbiol. 2023 May 11:1-20. doi: 10.1080/1040841X.2023.2211665. Online ahead of print.ABSTRACTThe oral cavity is inhabited by abundant microbes which continuously interact with the host and influence the host's health. Such host-microbe interactions (HMI) are dynamic and complex processes involving e.g. oral tissues, microbial communities and saliva. Due to difficulties in mimicking the in vivo complexity, it is still unclear how exactly HMI influence the transition between healthy status and disease conditions in the oral cavity. As an advanced approach, three-dimensional (3D) organotypic oral tissues (epitheliu...
Source: Critical Reviews in Microbiology - May 11, 2023 Category: Microbiology Authors: Lin Shang Dongmei Deng Bastiaan P Krom Susan Gibbs Source Type: research
Evolutionary principles for modifying pathogen virulence
Crit Rev Microbiol. 2023 May 5:1-12. doi: 10.1080/1040841X.2023.2203766. Online ahead of print.ABSTRACTCurrent methods for combatting infectious diseases are largely limited to the prevention of infection, enhancing host immunity (via vaccination), and administration of small molecules to slow the growth of or kill pathogens (e.g. antimicrobials). Beyond efforts to deter the rise of antimicrobial resistance, little consideration is given to pathogen evolution. Natural selection will favor different levels of virulence under different circumstances. Experimental studies and a wealth of theoretical work have identified many ...
Source: Critical Reviews in Microbiology - May 5, 2023 Category: Microbiology Authors: Tom Fieldman Source Type: research
Evolutionary principles for modifying pathogen virulence
Crit Rev Microbiol. 2023 May 5:1-12. doi: 10.1080/1040841X.2023.2203766. Online ahead of print.ABSTRACTCurrent methods for combatting infectious diseases are largely limited to the prevention of infection, enhancing host immunity (via vaccination), and administration of small molecules to slow the growth of or kill pathogens (e.g. antimicrobials). Beyond efforts to deter the rise of antimicrobial resistance, little consideration is given to pathogen evolution. Natural selection will favor different levels of virulence under different circumstances. Experimental studies and a wealth of theoretical work have identified many ...
Source: Critical Reviews in Microbiology - May 5, 2023 Category: Microbiology Authors: Tom Fieldman Source Type: research
Evolutionary principles for modifying pathogen virulence
Crit Rev Microbiol. 2023 May 5:1-12. doi: 10.1080/1040841X.2023.2203766. Online ahead of print.ABSTRACTCurrent methods for combatting infectious diseases are largely limited to the prevention of infection, enhancing host immunity (via vaccination), and administration of small molecules to slow the growth of or kill pathogens (e.g. antimicrobials). Beyond efforts to deter the rise of antimicrobial resistance, little consideration is given to pathogen evolution. Natural selection will favor different levels of virulence under different circumstances. Experimental studies and a wealth of theoretical work have identified many ...
Source: Critical Reviews in Microbiology - May 5, 2023 Category: Microbiology Authors: Tom Fieldman Source Type: research
Evolutionary principles for modifying pathogen virulence
Crit Rev Microbiol. 2023 May 5:1-12. doi: 10.1080/1040841X.2023.2203766. Online ahead of print.ABSTRACTCurrent methods for combatting infectious diseases are largely limited to the prevention of infection, enhancing host immunity (via vaccination), and administration of small molecules to slow the growth of or kill pathogens (e.g. antimicrobials). Beyond efforts to deter the rise of antimicrobial resistance, little consideration is given to pathogen evolution. Natural selection will favor different levels of virulence under different circumstances. Experimental studies and a wealth of theoretical work have identified many ...
Source: Critical Reviews in Microbiology - May 5, 2023 Category: Microbiology Authors: Tom Fieldman Source Type: research
Evolutionary principles for modifying pathogen virulence
Crit Rev Microbiol. 2023 May 5:1-12. doi: 10.1080/1040841X.2023.2203766. Online ahead of print.ABSTRACTCurrent methods for combatting infectious diseases are largely limited to the prevention of infection, enhancing host immunity (via vaccination), and administration of small molecules to slow the growth of or kill pathogens (e.g. antimicrobials). Beyond efforts to deter the rise of antimicrobial resistance, little consideration is given to pathogen evolution. Natural selection will favor different levels of virulence under different circumstances. Experimental studies and a wealth of theoretical work have identified many ...
Source: Critical Reviews in Microbiology - May 5, 2023 Category: Microbiology Authors: Tom Fieldman Source Type: research
Evolutionary principles for modifying pathogen virulence
Crit Rev Microbiol. 2023 May 5:1-12. doi: 10.1080/1040841X.2023.2203766. Online ahead of print.ABSTRACTCurrent methods for combatting infectious diseases are largely limited to the prevention of infection, enhancing host immunity (via vaccination), and administration of small molecules to slow the growth of or kill pathogens (e.g. antimicrobials). Beyond efforts to deter the rise of antimicrobial resistance, little consideration is given to pathogen evolution. Natural selection will favor different levels of virulence under different circumstances. Experimental studies and a wealth of theoretical work have identified many ...
Source: Critical Reviews in Microbiology - May 5, 2023 Category: Microbiology Authors: Tom Fieldman Source Type: research
Antibiotic resistance in the microbiota of periodontitis patients: an update of current findings
Crit Rev Microbiol. 2023 May 4:1-12. doi: 10.1080/1040841X.2023.2197481. Online ahead of print.ABSTRACTSystemic antibiotics are an effective adjunct in the treatment of periodontitis, but their judicious use is necessary as antimicrobial resistance is a growing global concern. This review aims to explore the current understanding and insight related to antibiotic resistance in the subgingival microbiota of periodontitis patients. A search of MEDLINE (PubMed) was carried out from 1 January 2012 to 25 November 2021 for studies related to antibiotic resistance in periodontitis patients. Of the 90 articles identified, 12 studi...
Source: Critical Reviews in Microbiology - May 4, 2023 Category: Microbiology Authors: Ethan Ng John Rong Hao Tay Sean Kuan Boey Marja L Laine Sa šo Ivanovski Chaminda Jayampath Seneviratne Source Type: research
Exploring halophilic environments as a source of new antibiotics
Crit Rev Microbiol. 2023 Apr 20:1-30. doi: 10.1080/1040841X.2023.2197491. Online ahead of print.ABSTRACTMicrobial natural products from microbes in extreme environments, including haloarchaea, and halophilic bacteria, possess a huge capacity to produce novel antibiotics. Additionally, enhanced isolation techniques and improved tools for genomic mining have expanded the efficiencies in the antibiotic discovery process. This review article provides a detailed overview of known antimicrobial compounds produced by halophiles from all three domains of life. We summarize that while halophilic bacteria, in particular actinomycete...
Source: Critical Reviews in Microbiology - April 20, 2023 Category: Microbiology Authors: Thomas P Thompson Brendan F Gilmore Source Type: research
Exploring halophilic environments as a source of new antibiotics
Crit Rev Microbiol. 2023 Apr 20:1-30. doi: 10.1080/1040841X.2023.2197491. Online ahead of print.ABSTRACTMicrobial natural products from microbes in extreme environments, including haloarchaea, and halophilic bacteria, possess a huge capacity to produce novel antibiotics. Additionally, enhanced isolation techniques and improved tools for genomic mining have expanded the efficiencies in the antibiotic discovery process. This review article provides a detailed overview of known antimicrobial compounds produced by halophiles from all three domains of life. We summarize that while halophilic bacteria, in particular actinomycete...
Source: Critical Reviews in Microbiology - April 20, 2023 Category: Microbiology Authors: Thomas P Thompson Brendan F Gilmore Source Type: research
Exploring halophilic environments as a source of new antibiotics
Crit Rev Microbiol. 2023 Apr 20:1-30. doi: 10.1080/1040841X.2023.2197491. Online ahead of print.ABSTRACTMicrobial natural products from microbes in extreme environments, including haloarchaea, and halophilic bacteria, possess a huge capacity to produce novel antibiotics. Additionally, enhanced isolation techniques and improved tools for genomic mining have expanded the efficiencies in the antibiotic discovery process. This review article provides a detailed overview of known antimicrobial compounds produced by halophiles from all three domains of life. We summarize that while halophilic bacteria, in particular actinomycete...
Source: Critical Reviews in Microbiology - April 20, 2023 Category: Microbiology Authors: Thomas P Thompson Brendan F Gilmore Source Type: research
