Phage-inspired strategies to combat antibacterial resistance
Crit Rev Microbiol. 2024 Mar;50(2):196-211. doi: 10.1080/1040841X.2023.2181056. Epub 2023 Feb 21.ABSTRACTAntimicrobial resistance (AMR) in clinically priority pathogensis now a major threat to public health worldwide. Phages are bacterial parasites that efficiently infect or kill specific strains and represent the most abundant biological entities on earth, showing great attraction as potential antibacterial therapeutics in combating AMR. This review provides a summary of phage-inspired strategies to combat AMR. We firstly cover the phage diversity, and then explain the biological principles of phage therapy that support t...
Source: Critical Reviews in Microbiology - February 24, 2024 Category: Microbiology Authors: Mianzhi Wang Junxuan Zhang Jingyi Wei Lei Jiang Li Jiang Yongxue Sun Zhenling Zeng Zhiqiang Wang Source Type: research
Phage-inspired strategies to combat antibacterial resistance
Crit Rev Microbiol. 2024 Mar;50(2):196-211. doi: 10.1080/1040841X.2023.2181056. Epub 2023 Feb 21.ABSTRACTAntimicrobial resistance (AMR) in clinically priority pathogensis now a major threat to public health worldwide. Phages are bacterial parasites that efficiently infect or kill specific strains and represent the most abundant biological entities on earth, showing great attraction as potential antibacterial therapeutics in combating AMR. This review provides a summary of phage-inspired strategies to combat AMR. We firstly cover the phage diversity, and then explain the biological principles of phage therapy that support t...
Source: Critical Reviews in Microbiology - February 24, 2024 Category: Microbiology Authors: Mianzhi Wang Junxuan Zhang Jingyi Wei Lei Jiang Li Jiang Yongxue Sun Zhenling Zeng Zhiqiang Wang Source Type: research
Phage-inspired strategies to combat antibacterial resistance
Crit Rev Microbiol. 2024 Mar;50(2):196-211. doi: 10.1080/1040841X.2023.2181056. Epub 2023 Feb 21.ABSTRACTAntimicrobial resistance (AMR) in clinically priority pathogensis now a major threat to public health worldwide. Phages are bacterial parasites that efficiently infect or kill specific strains and represent the most abundant biological entities on earth, showing great attraction as potential antibacterial therapeutics in combating AMR. This review provides a summary of phage-inspired strategies to combat AMR. We firstly cover the phage diversity, and then explain the biological principles of phage therapy that support t...
Source: Critical Reviews in Microbiology - February 24, 2024 Category: Microbiology Authors: Mianzhi Wang Junxuan Zhang Jingyi Wei Lei Jiang Li Jiang Yongxue Sun Zhenling Zeng Zhiqiang Wang Source Type: research
Phage-inspired strategies to combat antibacterial resistance
Crit Rev Microbiol. 2024 Mar;50(2):196-211. doi: 10.1080/1040841X.2023.2181056. Epub 2023 Feb 21.ABSTRACTAntimicrobial resistance (AMR) in clinically priority pathogensis now a major threat to public health worldwide. Phages are bacterial parasites that efficiently infect or kill specific strains and represent the most abundant biological entities on earth, showing great attraction as potential antibacterial therapeutics in combating AMR. This review provides a summary of phage-inspired strategies to combat AMR. We firstly cover the phage diversity, and then explain the biological principles of phage therapy that support t...
Source: Critical Reviews in Microbiology - February 24, 2024 Category: Microbiology Authors: Mianzhi Wang Junxuan Zhang Jingyi Wei Lei Jiang Li Jiang Yongxue Sun Zhenling Zeng Zhiqiang Wang Source Type: research
Water and mosquitoes as key components of the infective cycle of < em > Francisella tularensis < /em > in Europe: a review
Crit Rev Microbiol. 2024 Feb 23:1-15. doi: 10.1080/1040841X.2024.2319040. Online ahead of print.ABSTRACTFrancisella tularensis is the pathogen of tularemia, a zoonotic disease that have a broad range of hosts. Its epidemiology is related to aquatic environments, particularly in the subspecies holarctica. In this review, we explore the role of water and mosquitoes in the epidemiology of Francisella in Europe. F. tularensis epidemiology has been linked to natural waters, where its persistence has been associated with biofilm and amebas. In Sweden and Finland, the European countries where most human cases have been reported, ...
Source: Critical Reviews in Microbiology - February 23, 2024 Category: Microbiology Authors: Daniel Herrera-Rodr íguez Sara Jare ño-Moreno Clara Buch-Cardona Fran çois Mougeot Juan Jos é Luque-Larena Dolors Vidal Source Type: research
Water and mosquitoes as key components of the infective cycle of < em > Francisella tularensis < /em > in Europe: a review
Crit Rev Microbiol. 2024 Feb 23:1-15. doi: 10.1080/1040841X.2024.2319040. Online ahead of print.ABSTRACTFrancisella tularensis is the pathogen of tularemia, a zoonotic disease that have a broad range of hosts. Its epidemiology is related to aquatic environments, particularly in the subspecies holarctica. In this review, we explore the role of water and mosquitoes in the epidemiology of Francisella in Europe. F. tularensis epidemiology has been linked to natural waters, where its persistence has been associated with biofilm and amebas. In Sweden and Finland, the European countries where most human cases have been reported, ...
Source: Critical Reviews in Microbiology - February 23, 2024 Category: Microbiology Authors: Daniel Herrera-Rodr íguez Sara Jare ño-Moreno Clara Buch-Cardona Fran çois Mougeot Juan Jos é Luque-Larena Dolors Vidal Source Type: research
Peeling off the layers from microbial dark matter (MDM): recent advances, future challenges, and opportunities
Crit Rev Microbiol. 2024 Feb 22:1-21. doi: 10.1080/1040841X.2024.2319669. Online ahead of print.ABSTRACTMicrobes represent the most common organisms on Earth; however, less than 2% of microbial species in the environment can undergo cultivation for study under laboratory conditions, and the rest of the enigmatic, microbial world remains mysterious, constituting a kind of "microbial dark matter" (MDM). In the last two decades, remarkable progress has been made in culture-dependent and culture-independent techniques. More recently, studies of MDM have relied on culture-independent techniques to recover genetic material throu...
Source: Critical Reviews in Microbiology - February 22, 2024 Category: Microbiology Authors: Sajid Iqbal Farida Begum Ihsan Ullah Nasir Jalal Peter Shaw Source Type: research
Peeling off the layers from microbial dark matter (MDM): recent advances, future challenges, and opportunities
Crit Rev Microbiol. 2024 Feb 22:1-21. doi: 10.1080/1040841X.2024.2319669. Online ahead of print.ABSTRACTMicrobes represent the most common organisms on Earth; however, less than 2% of microbial species in the environment can undergo cultivation for study under laboratory conditions, and the rest of the enigmatic, microbial world remains mysterious, constituting a kind of "microbial dark matter" (MDM). In the last two decades, remarkable progress has been made in culture-dependent and culture-independent techniques. More recently, studies of MDM have relied on culture-independent techniques to recover genetic material throu...
Source: Critical Reviews in Microbiology - February 22, 2024 Category: Microbiology Authors: Sajid Iqbal Farida Begum Ihsan Ullah Nasir Jalal Peter Shaw Source Type: research
Antibiotic resistance: a global crisis, problems and solutions
Crit Rev Microbiol. 2024 Feb 21:1-26. doi: 10.1080/1040841X.2024.2313024. Online ahead of print.ABSTRACTHealthy state is priority in today's world which can be achieved using effective medicines. But due to overuse and misuse of antibiotics, a menace of resistance has increased in pathogenic microbes. World Health Organization (WHO) has announced ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) as the top priority pathogens as these have developed resistance against certain antibiotics. To combat such a global issue...
Source: Critical Reviews in Microbiology - February 21, 2024 Category: Microbiology Authors: Rupesh Aggarwal Pooja Mahajan Sameeksha Pandiya Aayushi Bajaj Shailendra Kumar Verma Puja Yadav Arun S Kharat Asad Ullah Khan Meenakshi Dua Atul Kumar Johri Source Type: research
Antibiotic resistance: a global crisis, problems and solutions
Crit Rev Microbiol. 2024 Feb 21:1-26. doi: 10.1080/1040841X.2024.2313024. Online ahead of print.ABSTRACTHealthy state is priority in today's world which can be achieved using effective medicines. But due to overuse and misuse of antibiotics, a menace of resistance has increased in pathogenic microbes. World Health Organization (WHO) has announced ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter spp.) as the top priority pathogens as these have developed resistance against certain antibiotics. To combat such a global issue...
Source: Critical Reviews in Microbiology - February 21, 2024 Category: Microbiology Authors: Rupesh Aggarwal Pooja Mahajan Sameeksha Pandiya Aayushi Bajaj Shailendra Kumar Verma Puja Yadav Arun S Kharat Asad Ullah Khan Meenakshi Dua Atul Kumar Johri Source Type: research
Tumor-targeting bacteria as immune stimulants - the future of cancer immunotherapy?
Crit Rev Microbiol. 2024 Feb 12:1-16. doi: 10.1080/1040841X.2024.2311653. Online ahead of print.ABSTRACTCancer immunotherapies have been widely hailed as a breakthrough for cancer treatment in the last decade, epitomized by the unprecedented results observed with checkpoint blockade. Even so, only a minority of patients currently achieve durable remissions. In general, responsive patients appear to have either a high number of tumor neoantigens, a preexisting immune cell infiltrate in the tumor microenvironment, or an 'immune-active' transcriptional profile, determined in part by the presence of a type I interferon gene si...
Source: Critical Reviews in Microbiology - February 12, 2024 Category: Microbiology Authors: Alexandra M Mowday Jella M van de Laak Zhe Fu Kimiora L Henare Ludwig Dubois Philippe Lambin Jan Theys Adam V Patterson Source Type: research
Tumor-targeting bacteria as immune stimulants - the future of cancer immunotherapy?
Crit Rev Microbiol. 2024 Feb 12:1-16. doi: 10.1080/1040841X.2024.2311653. Online ahead of print.ABSTRACTCancer immunotherapies have been widely hailed as a breakthrough for cancer treatment in the last decade, epitomized by the unprecedented results observed with checkpoint blockade. Even so, only a minority of patients currently achieve durable remissions. In general, responsive patients appear to have either a high number of tumor neoantigens, a preexisting immune cell infiltrate in the tumor microenvironment, or an 'immune-active' transcriptional profile, determined in part by the presence of a type I interferon gene si...
Source: Critical Reviews in Microbiology - February 12, 2024 Category: Microbiology Authors: Alexandra M Mowday Jella M van de Laak Zhe Fu Kimiora L Henare Ludwig Dubois Philippe Lambin Jan Theys Adam V Patterson Source Type: research
Tumor-targeting bacteria as immune stimulants - the future of cancer immunotherapy?
Crit Rev Microbiol. 2024 Feb 12:1-16. doi: 10.1080/1040841X.2024.2311653. Online ahead of print.ABSTRACTCancer immunotherapies have been widely hailed as a breakthrough for cancer treatment in the last decade, epitomized by the unprecedented results observed with checkpoint blockade. Even so, only a minority of patients currently achieve durable remissions. In general, responsive patients appear to have either a high number of tumor neoantigens, a preexisting immune cell infiltrate in the tumor microenvironment, or an 'immune-active' transcriptional profile, determined in part by the presence of a type I interferon gene si...
Source: Critical Reviews in Microbiology - February 12, 2024 Category: Microbiology Authors: Alexandra M Mowday Jella M van de Laak Zhe Fu Kimiora L Henare Ludwig Dubois Philippe Lambin Jan Theys Adam V Patterson Source Type: research
Tumor-targeting bacteria as immune stimulants - the future of cancer immunotherapy?
Crit Rev Microbiol. 2024 Feb 12:1-16. doi: 10.1080/1040841X.2024.2311653. Online ahead of print.ABSTRACTCancer immunotherapies have been widely hailed as a breakthrough for cancer treatment in the last decade, epitomized by the unprecedented results observed with checkpoint blockade. Even so, only a minority of patients currently achieve durable remissions. In general, responsive patients appear to have either a high number of tumor neoantigens, a preexisting immune cell infiltrate in the tumor microenvironment, or an 'immune-active' transcriptional profile, determined in part by the presence of a type I interferon gene si...
Source: Critical Reviews in Microbiology - February 12, 2024 Category: Microbiology Authors: Alexandra M Mowday Jella M van de Laak Zhe Fu Kimiora L Henare Ludwig Dubois Philippe Lambin Jan Theys Adam V Patterson Source Type: research
Tumor-targeting bacteria as immune stimulants - the future of cancer immunotherapy?
Crit Rev Microbiol. 2024 Feb 12:1-16. doi: 10.1080/1040841X.2024.2311653. Online ahead of print.ABSTRACTCancer immunotherapies have been widely hailed as a breakthrough for cancer treatment in the last decade, epitomized by the unprecedented results observed with checkpoint blockade. Even so, only a minority of patients currently achieve durable remissions. In general, responsive patients appear to have either a high number of tumor neoantigens, a preexisting immune cell infiltrate in the tumor microenvironment, or an 'immune-active' transcriptional profile, determined in part by the presence of a type I interferon gene si...
Source: Critical Reviews in Microbiology - February 12, 2024 Category: Microbiology Authors: Alexandra M Mowday Jella M van de Laak Zhe Fu Kimiora L Henare Ludwig Dubois Philippe Lambin Jan Theys Adam V Patterson Source Type: research
